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Catherine J Choi, Wensi Tao, Ravi Doddapaneni, Zenith Acosta-Torres, Nathan W Blessing, Bradford W Lee, Daniel Pelaez, Sara T Wester
Purpose: We characterize the effect of bimatoprost on orbital adipose tissue in thyroid-associated orbitopathy (TAO) with clinicopathologic correlation. Methods: Orbital adipose-derived stem cells (OASCs) from types 1 and 2 TAO and control patients with and without exposure to 1 μm bimatoprost were examined via immunohistochemistry, RT-PCR, and Western blot for cell viability, migration capacity, lipid content, adipocyte morphology, mitochondrial content, and levels of adipogenic markers...
December 3, 2018: Investigative Ophthalmology & Visual Science
Máire A Conrad, Chrystalle Katte Carreon, Noor Dawany, Pierre Russo, Judith R Kelsen
Background and Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies...
December 14, 2018: Journal of Crohn's & Colitis
Addison M Demer, Karl K Vance, Nikoo Cheraghi, Hilary C Reich, Peter K Lee
BACKGROUND: There are limited published data comparing wide local excision (WLE) with Mohs micrographic surgery (MMS) for the treatment of melanoma. OBJECTIVE: To describe a novel treatment algorithm for the surgical management of head and neck melanoma and compare rates of local recurrence for tumors treated with either MMS using immunohistochemistry or WLE. MATERIALS AND METHODS: A 10-year retrospective chart review including all in situ and invasive melanomas of the head and neck treated at one institution from January 2004 to June 2013...
December 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Hyuck Hoon Kwon, Sun Chul Choi, Gyeong-Hun Park, Jae Yoon Jung
BACKGROUND: Thread lifting with absorbable sutures has recently gained prominence for rejuvenating ptotic and sagging soft tissues in aging face. A barbed, delayed absorbable polyglyconate monofilament shows significantly high tensile loads with superior flexibility and elasticity. OBJECTIVE: To evaluate the safety and efficacy of novel thread lifting regimen with barbed polyglyconate suture for counteracting the descent and laxity of the aging face. METHODS: A retrospective chart review was conducted for 25 Korean patients with mild to moderate facial skin laxity receiving thread lifting procedures using barbed polyglyconate suture...
December 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Till D Lerch, Eduardo N Novais, Florian Schmaranzer, Kai Ziebarth, Simon D Steppacher, Moritz Tannast, Klaus A Siebenrock
BACKGROUND: Prophylactic pinning of the asymptomatic and normal-appearing contralateral hip in patients with unilateral slipped capital femoral epiphysis (SCFE) remains controversial. Understanding the minimal 10-year clinical, functional, and radiographic outcomes of the contralateral asymptomatic hip in unilateral SCFE may be helpful in the decision regarding whether the benefits associated with potentially preventing a SCFE are outweighed by the risk of additional surgery. QUESTIONS/PURPOSES: Among patients with SCFE treated with prophylactic pinning of the asymptomatic and contralateral hip, we sought (1) to determine the complications and reoperations; (2) to evaluate the development of cam deformities and the frequency and severity of osteoarthritis progression; and (3) to characterize hip pain and function as measured by the Harris hip score (HHS) and the Hip Disability and Osteoarthritis Outcome Score (HOOS) at minimal 10-year followup...
December 13, 2018: Clinical Orthopaedics and related Research
J S Hao, M Chen, B Liu, Y Yang, W Liu, J Zhang
Objective: To summarize the clinical characteristics and clinical treatment of congenital cholesteatoma (CC) of the middle ear in children, provide early diagnosis methods and explore standardized diagnosis and treatment plan. Method: A retrospective chart review of 94 patients with a diagnosis of middle ear cholesteatoma, in Beijing Children's Hospital, between 2009 and 2015 was carried on. 14 patients with CC were identified using the criteria proposed by Levenson, and were divided into two groups according to the course of disease...
July 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Justin B Jin, John C Carter, Daniel W Sheehan, David J Birnkrant
OBJECTIVE: To determine the prevalence of discordant cardiopulmonary function among patients with Duchenne muscular dystrophy (DMD) in our clinic. METHODS: Retrospective chart review from 1999 to 2017. INCLUSION CRITERIA: DMD patients age ≥ 18 years, alive, with discordant cardiopulmonary function. No patients received glucocorticoid therapy. Discordant cardiopulmonary function was defined as either: good heart function (EF ≥ 40%) and bad lung function (FVC < 1 L) (Group A); or, bad heart function (EF < 40%) and good lung function (FVC ≥ 1 L) (Group B)...
December 14, 2018: Pediatric Pulmonology
Amit Ritter, Gideon Bachar, Raphael Feinmesser, Thomas Shpitzer, Aron Popovtzer, Naomi Rabinovics
BACKGROUND: Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck. METHODS: A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck. RESULTS: Of 3339 organ recipients, 259 patients developed 697 head and neck NMSC...
December 14, 2018: Head & Neck
David W Corpman, Farzad Masroor, Diane M Carpenter, Sundeep Nayak, Deepak Gurushanthaiah, Kevin H Wang
BACKGROUND: Surveillance positron emission tomography-computed tomography (PET/CT) is commonly used for treatment assessment of radiation therapy in head and neck cancer. However, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV+OPSCC) patients represent a unique subpopulation, for which the utility of surveillance PET/CT has not been well studied. METHODS: In this retrospective chart review comprising 233 HPV+OPSCC patients, we evaluated surveillance PET/CT for diagnostic accuracy, downstream clinical impact, and survival...
December 14, 2018: Head & Neck
Ryan A Rimmer, Alexander N Duffy, Alexander M Knops, Mindy R Rabinowitz, Ian J Koszewski, Marc R Rosen, Timothy Ortlip, Ryan N Heffelfinger, Hermes G Garcia, James J Evans, Gurston G Nyquist, Joseph M Curry
OBJECTIVES/HYPOTHESIS: Chronic frontal sinus infection is managed with a combination of medical and surgical interventions. Frontal bone osteomyelitis due to recurrent infection following trauma or prior open surgery may require more significant debridement. Free tissue transfer may allow for extensive debridement with replacement of tissue, and definitive eradication of osteomyelitis. STUDY DESIGN: Retrospective chart review. METHODS: Patients undergoing free flap obliteration of the frontal sinus for frontal bone osteomyelitis at a single institution were included in the study...
December 14, 2018: Laryngoscope
David F L Liew, Jessica L Y Leung, Bonnia Liu, Jonathan Cebon, Albert G Frauman, Russell R C Buchanan
AIM: To investigate whether any patient or treatment characteristics are associated with the development of rheumatic immune-related adverse events (irAEs) following programmed cell death protein 1 (PD-1) inhibitor therapy for cancer. METHOD: This was a retrospective chart review of all patients who were dispensed nivolumab or pembrolizumab at a single center before 1 January, 2017, with follow-up until 1 July, 2017. Patients with any diagnosis of a non-cutaneous irAE were identified, regardless of severity, and rheumatic irAEs were characterized...
November 22, 2018: International Journal of Rheumatic Diseases
Skyler W Nielsen, Jayne R Stevens, Gregory J Stevens, Jagatkumar Patel, Robert L Eller
OBJECTIVES/HYPOTHESIS: Isolated case studies have shown improper sterilization or contamination of equipment from anesthesia carts can lead to transmission of disease and even death. Citing this literature, national accrediting agencies mandated all instruments in the otolaryngology airway carts at San Antonio Military Medical Center be packaged to prevent contamination. This study sought to determine the infection and safety implications of packaged airway cart instruments. STUDY DESIGN: Retrospective chart review...
December 13, 2018: Laryngoscope
Julina Ongkasuwan, Danielle Devore, Sarah Hollas, Jennifer Yan
OBJECTIVE: Complaints of dysphonia and dysphagia frequently require rigid or flexible laryngoscopy in the office to aid in diagnosis. For young children, flexible laryngoscopy can be uncomfortable and often requires multiple adults to restrain the child. Rigid laryngoscopy does not result in crying but does require patient cooperation; thus, it is used primarily in adults. This project describes our experience using rigid laryngoscopy in a pediatric cohort. METHODS: This was a retrospective chart review of patients at a pediatric voice clinic who underwent laryngoscopy from December 2011 through March 2017...
December 13, 2018: Laryngoscope
Konstantin V Grigoryan, Megha M Tollefson, Meredith A Olson, Catherine C Newman
BACKGROUND: Tinea capitis is a common pediatric dermatophyte infection. Its main pathogen in the United States is Trichophyton tonsurans accounting for greater than 95% of the infections. Other pathogens including Trichophyton violaceum and Trichophyton soudanense are common in Africa. Although rare in the United States, their prevalence is increasing, possibly because of immigration patterns. We evaluated the demographic characteristics, treatments, and resolution among pediatric patients with T...
December 13, 2018: International Journal of Dermatology
Alex G Karanevich, Luke J Weisbrod, Omar Jawdat, Richard J Barohn, Byron J Gajewski, Jianghua He, Jeffrey M Statland
BACKGROUND: To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes. METHODS: We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS patients from the University of Kansas Medical Center EMR. The completeness and integrity of the data extraction were verified by manual chart review...
December 14, 2018: BMC Neurology
M Elzain, I Elimam, S Barry
While suicide and injury account for increased mortality, a large volume of premature deaths in psychiatry are due to medical conditions. The Royal College of Psychiatrists recommend that every new psychiatric admission should have a thorough physical examination within 24 hours of their admission. We randomly reviewed charts of 50 new admission to the Acute Psychiatric Unit to check the adherence to these guidelines. Forty patients (80%) had complete physical examination, nine patients (18%) had incomplete physical examination, and one patient (2%) had no physical examination in the Re Audit...
September 10, 2018: Irish Medical Journal
Jordan T Jones, Nasreen Talib, Daniel Lovell, Mara L Becker
BACKGROUND: Arthropathy of Down syndrome (DA) is largely under-recognized, with an average 2-year delay in diagnosis. Most patients present with polyarthritis, and treatment has historically been challenging. OBJECTIVES: Our objective was to investigate the clinical features and treatment of DA in the largest cohort reported to date. METHODS: In a retrospective chart review at two tertiary care hospitals, International Classification of Diseases, ninth revision, clinical modification (ICD-9-CM) codes for Down syndrome (DS) and juvenile idiopathic arthritis (JIA), between 1 January 1995 and 31 December 2015, were identified and charts reviewed...
December 13, 2018: Paediatric Drugs
Mina Tohidi, Tiffany Lung, David Yen
Background: Routine investigations for asymptomatic patients undergoing low-risk surgery contribute little value to perioperative care, but these tests are still ordered in many centres. The primary purpose of this retrospective cohort study was to determine the prevalence of preoperative bloodwork for elective lumbar laminectomy and its association with intraoperative and postoperative complications. Secondary objectives were to determine the prevalence of intraoperative tranexamic acid administration, length of stay, and 30-day readmission...
September 2018: Journal of Spine Surgery (Hong Kong)
Darshan Vora, Matthew Kinnard, David Falk, Michael Hoy, Sachin Gupta, Christine Piper, Warren Yu, Faisal Siddiqui, Joseph O'Brien
Background: Instrumented lumbar fusion can be accomplished through open or minimally invasive techniques. The focus of this study was to compare perioperative narcotic usage and length of hospital stay between patients undergoing open versus minimally invasive spinal surgery (MISS). Methods: A retrospective chart review was performed on 110 patients who underwent instrumented lumbar fusion over 2 years at our institution. These patients were divided into two groups: those that received open transforaminal interbody fusion (n=69), and those whose surgeries were performed minimally invasively with lateral lumbar transpsoas interbody fusion (LLIF) and percutaneous pedicle screws (n=41)...
September 2018: Journal of Spine Surgery (Hong Kong)
Judith Sebestyen VanSickle, Tarak Srivastava, Uri S Alon
Background . Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. Objective . The goals of our study were to identify risk factors for short-term complications and long-term outcomes of chronic kidney disease (CKD) in Shiga toxin-producing Escherichia coli (STEC)-HUS and other diarrhea positive (D+ ) HUS. Methods . Retrospective chart review was obtained of 58 pediatric patients treated for STEC-HUS and other D+ HUS between February 2002 and January 2011. Results ...
2018: Global Pediatric Health
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