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Maryam Sina, Freya MacMillan, Tinashe Dune, Navodya Balasuriya, Nouran Khouri, Ngan Nguyen, Vasyngpong Jongvisal, Xiang Hui Lay, David Simmons
BACKGROUND: Poor diabetes management prior to conception, results in increased rates of fetal malformations and other adverse pregnancy outcomes. We describe the development of an integrated, pre-pregnancy management strategy to improve pregnancy outcomes among women of reproductive age with diabetes in a multi-ethnic district. METHODS: The strategy included (i) a narrative literature review of contraception and pre-pregnancy interventions for women with diabetes and development of a draft plan; (ii) a chart review of pregnancy outcomes (e...
October 15, 2018: BMC Pregnancy and Childbirth
Craig A Bollig, Jeffrey B Jorgensen, Robert P Zitsch, Laura M Dooley
Objective To determine if the routine use of intraoperative frozen section (iFS) results in cost savings among patients with nodules >4 cm with nonmalignant cytology undergoing a thyroid lobectomy. Study Design Case series with chart review; cost minimization analysis. Setting Single academic center. Subjects and Methods Records were reviewed on a consecutive sample of 48 patients with thyroid nodules >4 cm and nonmalignant cytology who were undergoing thyroid lobectomy in which iFS was performed between 2010 and 2015...
October 16, 2018: Otolaryngology—Head and Neck Surgery
Lorraine A T Boakye, Mitchell S Fourman, Nicholas T Spina, Dann Laudermilch, Joon Y Lee
Study Design: Level III retrospective cross-sectional study. Purpose: To define and characterize the presentation, symptom duration, and patient/surgical risk factors associated with 'postdecompressive neuropathy (PDN).' Overview of Literature: PDN is characterized by lower extremity radicular pain that is 'different' from pre-surgical radiculopathy or claudication pain. Although it is a common constellation of postoperative symptoms, PDN is incompletely characterized and poorly understood...
October 16, 2018: Asian Spine Journal
Mahmood Ali Arbash, Ashik Mohsin Parambathkandi, Abdul Moeen Baco, Abduljabbar Alhammoud
Study Design: Retrospective review. Purpose: To detect the effect of cannulated (poly-axial head) and solid (mono-axial head) screws on the local kyphotic angle, vertebral body height, and superior and inferior angles between the screw and the rod in the surgical management of thoracolumbar fractures. Overview of Literature: Biomechanics studies showed that the ultimate load, yield strength, and cycles to failure were significantly lower with cannulated (poly-axial head) pedicle comparing to solid core (mono-axial head)...
October 16, 2018: Asian Spine Journal
Stanley Cho, Elizabeth Spencer, Robert Hirten, Ari Grinspan, Marla C Dubinsky
OBJECTIVES: Recurrent Clostridium difficile infection (RCDI) increases morbidity and mortality in patients with inflammatory bowel disease (IBD). Fecal microbiota transplant (FMT) is known to be very effective for RCDI in non-IBD patients with cure rates up to 91%. The same success rates of FMT have not been reported in IBD patients with RCDI, and the data in pediatrics is limited. We aimed to determine the effectiveness of FMT for RCDI in established pediatric IBD patients. METHODS: We performed a retrospective chart review of pediatric patients with IBD and RCDI (≥3 episodes) who underwent FMT via colonoscopy at a tertiary care IBD center...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
Amee Baird, Olivia Brancatisano, Rebecca Gelding, William Forde Thompson
BACKGROUND: Music evoked autobiographical memories (MEAMs) have been documented in people with Alzheimer's disease (AD), but it is unclear whether music is more effective than other familiar stimuli at evoking memories. OBJECTIVE: To explore the frequency and specificity of memories in response to famous songs compared with photographs of famous events (photograph evoked autobiographical memories, PEAMs), and whether stimuli from the period of the reminiscence bump (10-30 years of age) were more likely to elicit memories...
October 6, 2018: Journal of Alzheimer's Disease: JAD
Matthew H Greene, Bryan D Harris, Whitney J Nesbitt, Marley L Watson, Patty W Wright, Thomas R Talbot, George E Nelson
Background: Vancomycin-resistant enterococcus (VRE) causes substantial health care-associated infection with increasing reports of resistance to daptomycin or linezolid. We conducted a case-control study reporting 81 cases of daptomycin and linezolid-nonsusceptible VRE (DLVRE), a resistance pattern not previously reported. Methods: We reviewed VRE isolates from June 2010 through June 2015 for nonsusceptibility to both daptomycin (minimum inhibitory concentration [MIC] > 4) and linezolid (MIC ≥ 4)...
October 2018: Open Forum Infectious Diseases
Pattarawadee Prayuenyong, John A Taylor, Stephanie E Pearson, Rachel Gomez, Poulam M Patel, Deborah A Hall, Anand V Kasbekar, David M Baguley
Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer. Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects...
2018: Frontiers in Oncology
Harry Menon, Adip Pillai, Jeanine Aussenberg-Rodriguez, John Ambrose, Irini Youssef, Elizabeth A Griffiths, Omar Al Ustwani
Background: Most hospitals still use unfractionated heparin (UFH) as the primary agent for venous thromboembolism (VTE) prophylaxis in the hospital setting due to ease of use and insignificant cost. However, the risk of heparin-induced thrombocytopenia (HIT) has led some groups to favor other options for therapeutic and prophylactic anticoagulation. This is particularly relevant in light of recent data demonstrating a lower rate of HIT in patients receiving enoxaparin compared with UFH...
October 2018: Avicenna Journal of Medicine
Alison D Early, Sarah Adelson, Craig J Miller, Thomas F Mauger
Objective: To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods: This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t -test...
2018: Clinical Ophthalmology
Narongsak Nakwan, Suksham Jain, Kishore Kumar, Shigeharu Hosono, Majeda Hammoud, Yasser Yahia Elsayed, Shabina Ariff, Babar Hasan, Waqar Khowaja, Poom Woei Bing
OBJECTIVES: To explore the incidence, etiologies, diagnostic methods, treatment options and outcomes in neonates with persistent pulmonary hypertension of the newborn (PPHN) and to identify mortality risk factors in a study from six Asian countries. METHODS: A retrospective chart review of patients with documented PPHN from seven centers in six Asian countries (Japan, Kuwait, India, Pakistan, Singapore, and Thailand) between 1 January, 2014 and 31 December, 2016, was performed...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Krista McKinnon, Jennifer Jupp, Sunita Ghosh, Carol Digout, Stephanie Eason, Marcel Romanick
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) impacts quality of life for patients. Guidelines for emetogenicity classification and prevention of CINV in children were recently published and endorsed by pediatric oncology organizations. PROCEDURE: A multicenter chart review was performed at four Canadian pediatric oncology centers examining rates of prescribing adherence to CINV guidelines between January 2012 and December 2015. Eligible patients received their first chemotherapy course of highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC)...
October 14, 2018: Pediatric Blood & Cancer
Pushpa Shivaram, Asif Padiyath, Shasha Bai, Jeffrey M Gossett, R Thomas Collins
The arterial switch operation (ASO) in complete transposition of the great arteries (TGA) has increased long-term survival. Annual follow-up echocardiograms are recommended, but evidence-based guidelines do not exist. We sought to assess how often a patient with TGA after ASO who had no symptoms or change in physical exam underwent an intervention based solely on echocardiographic changes. We retrospectively reviewed all records from patients with TGA and a history of ASO followed at our institution between November 1983 and January 2015...
September 8, 2018: American Journal of Cardiology
Hadi Hassankhani, Amin Soheili, Samad S Vahdati, Farough A Mozaffari, Justin F Fraser, Neda Gilani
STUDY OBJECTIVE: We evaluate the extent and nature of treatment delays and the contributing factors influencing them for patients with acute ischemic stroke, as well as main barriers to stroke care in an Iranian emergency department (ED). METHODS: A retrospective chart review was conducted on 394 patients with acute ischemic stroke who were referred to the ED of a tertiary academic medical center in northwest Iran from March 21 to June 21, 2017. The steps of this review process included instrument development, medical records retrieval, data extraction, and data verification...
October 11, 2018: Annals of Emergency Medicine
Filippo Giovannetti, Federico Mussa, Paolo Priore, Mirko Scagnet, Elena Arcovio, Valentino Valentini, Lorenzo Genitori
OBJECT: At present, a minimally invasive endoscopic endonasal approach is considered an efficient option for lesions affecting the anterior and middle skull base with sellar and parasellar region involvement. In this study we will retrospectively analyze the pediatric patients that we have been treating in the same medical center for the past four years, using an endoscopic approach in the skull base. METHODS: We performed a retrospective chart and imaging review of pediatric patients who underwent endoscopic endonasal skull base surgery (ESBS) at the Meyer Children's Hospital, (Azienda Ospedaliero Universitaria Meyer), in Florence, from January 2012 to July 2016...
September 24, 2018: Journal of Cranio-maxillo-facial Surgery
Manabu Yasuda, Toshiyuki Kobayashi
OBJECTIVE: Patients attempted suicide by psychotropic drug overdose and require medical care have increased, becoming a serious problem in Japan. This study investigated the characteristics of patients who attempted suicide by overdose and required emergency care, with a focus on quantity of drugs taken. METHODS: We conducted a clinical survey of 98 patients examined at the emergency centre of the psychiatric department of Jichi Medical University Hospital and hospitalized for attempted suicide by drug overdose from January 1, 2012 to December 31, 2014...
October 6, 2018: Asian Journal of Psychiatry
Romain Guery, Anoosha Habibi, Jean-Benoît Arlet, François Lionnet, Victoire de Lastours, Jean-Winoc Decousser, Jean-Luc Mainardi, Keyvan Razazi, Laurence Baranes, Pablo Bartolucci, Bertrand Godeau, Fréderic Galacteros, Marc Michel, Matthieu Mahevas
BACKGROUND: Non-typhoidal salmonellosis (NTS) often occurs in children with sickle-cell disease (SCD) and remains a significant cause of mortality in developing countries. However, there is lack of reports on the clinical presentation, outcome and complications of NTS in adults with SCD. METHODS: We performed a chart review between 2006 and 2016 of adults SCD diagnosed with NTS in 3 referral centers monitoring approximately 3500 SCD adults. RESULTS: Twenty-three episodes of NTS were diagnosed among 22 SCD adults...
October 14, 2018: Infectious Diseases
Gustavo Deza, Jaime Notario, Anna Lopez-Ferrer, Eva Vilarrasa, Marta Ferran, Elena Del Alcazar, José-Manuel Carrascosa, Marina Corral, Montserrat Salleras, Miquel Ribera, Lluís Puig, Ramon M Pujol, David Vidal, Fernando Gallardo
BACKGROUND: Ixekizumab (anti-IL17A) is effective as treatment for moderate to severe plaque psoriasis, but real-life data on effectiveness and safety are currently very limited. OBJECTIVE: To evaluate the efficacy and safety of ixekizumab in a cohort of real-life plaque psoriasis patients. METHODS: Retrospective chart review of 100 patients with moderate to severe plaque psoriasis treated with ixekizumab at 7 Spanish dermatological centers...
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Waqas Alam, Khan Muhammad Yaqub, Mobasher Ahmad Saeed
OBJECTIVE: To determine frequency of maternal hypotension during spinal anaesthesia for elective caesarean section by comparing fixed dose with height and weight-adjusted dose of hyperbaric 0.5% bupivacaine. METHODS: This randomised controlled trial was carried out at Pakistan Naval Ship Shifa Hospital, Karachi, and comprised patients with singleton pregnancy who were randomly divided into two groups. After preloading with 10ml/kg of Ringers lactate, Group A received fixed dose of 10mg of 0...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Haris Hakeem, Ammar Zaman Khan, Kashif Aziz, Ayesha Abbasi, Anam Haider, Bushra Moiz, Mohammad Wasay
OBJECTIVE: To assess the time in therapeutic range in patients on warfarin anti-coagulation therapy. METHODS: The retrospective chart review was conducted at Aga Khan University Hospital, Karachi, and comprised data of patients having undergone anti-coagulation with warfarin from January 2013 to April 2015. To determine the mean time in therapeutic range, Rosendaal method was used. Association of time in therapeutic range with the composite outcome, bleeding and thromboembolic events was also assessed...
September 2018: JPMA. the Journal of the Pakistan Medical Association
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