Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu, Jinsong Yan
The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the expression of IL3Rα (CD123) on B-ALL cell membranes. Interleukin 3 (IL-3) supplementation promotes the proliferation of EP300-ZNF348-positive B-ALL cells by activating STAT5. Conditional knockdown of IL3RA in EP300-ZF384-positive cells inhibited the proliferation in vitro, and induced a significant increase in overall survival of mice, which is attributed to impaired propagation ability of leukemia cells...
April 2, 2024: Cell Communication and Signaling: CCS