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https://www.readbyqxmd.com/read/29691317/cholesterol-signaling-in-single-cells-lessons-from-star-and-sm-fish
#1
REVIEW
Colin R Jefcoate, Jinwoo Lee
Cholesterol is an important regulator of cell signaling, both through direct impacts on cell membranes and through oxy-metabolites that activate specific receptors (steroids, hydroxy-cholesterols, bile acids). Cholesterol moves slowly through and between cell membranes with the assistance of specific binding proteins and transfer processes. The prototype cholesterol regulator is the Steroidogenesis Acute Regulatory (STAR), which moves cholesterol into mitochondria, where steroid synthesis is initiated by cytochrome P450 11A1 in multiple endocrine cell types...
May 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29691046/exploring-molecular-mysteries-of-the-adrenal-gland-start-with-the-basics
#2
EDITORIAL
Victor A Ferraris
No abstract text is available yet for this article.
April 5, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29690985/-delayed-diagnosis-of-adrenal-crisis
#3
Theis Chang Gielstrup, Esben Søndergaard, Jesper Fjølner
Adrenal crisis is a life-threatening emergency with excess mortality of patients with adrenal insufficiency. This case report is about delayed diagnosis of a patient with unknown primary adrenal insufficiency, reduced consciousness and shock.
April 9, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29689708/expression-of-adiponectin-and-leptin-receptors-in-adrenal-incidentaloma-patients-with-subclinical-hormone-secretion
#4
Anna Babińska, Rafał Pȩksa, Renata Świa Tkowska-Stodulska, Piotr Wiśniewski, Krzysztof Sworczak
BACKGROUND: The role of adopokines in adrenal tumors' hormonal activity remains unclear. Obesity may induce arterial hypertension, disorders of carbohydrate metabolism, and is a risk factor of cardiovascular disease. In patients with subclinical hormone secretion by the adrenal cortex or medulla the risk of metabolic disease is increased. OBJECTIVE: Authors of this retrospective study selected 78 patients with subclinical hormone secretion out of all adrenal incidentaloma patients hospitalized in the Department of Endocrinology and Internal Medicine between 1995 and 2014...
April 10, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29689248/urinary-steroid-profiling-by-gas-chromatography-mass-spectrometry-early-features-of-malignancy-in-patients-with-adrenal-incidentalomas
#5
Z R Shafigullina, L I Velikanova, N V Vorokhobina, S B Shustov, A A Lisitsin, E V Malevanaia, M O Buinova, E A Bessonova, D O Kirsanov
No abstract text is available yet for this article.
April 21, 2018: Steroids
https://www.readbyqxmd.com/read/29687091/the-occurrence-of-apparent-bilateral-aldosterone-suppression-in-adrenal-vein-sampling-for-primary-aldosteronism
#6
Yui Shibayama, Norio Wada, Mitsuhide Naruse, Isao Kurihara, Hiroshi Ito, Takashi Yoneda, Yoshiyu Takeda, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichijo, Hisashi Fukuda, Takuyuki Katabami, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Yuichi Ohno, Masakatsu Sone, Megumi Fujita, Katsutoshi Takahashi, Hirotaka Shibata, Kohei Kamemura, Yuichi Fujii, Koichi Yamamoto, Tomoko Suzuki
Context: In adrenal venous sampling (AVS) for patients with primary aldosteronism (PA), apparent bilateral aldosterone suppression (ABAS), defined as lower aldosterone/cortisol ratios in the bilateral adrenal veins than that in the inferior vena cava, is occasionally experienced. ABAS is uninterpretable with respect to lateralization of excess aldosterone production. We previously reported that ABAS was not a rare phenomenon and was significantly reduced after adrenocorticotropic hormone (ACTH) administration...
May 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29686001/biological-sex-modulates-the-adrenal-and-blood-pressure-responses-to-angiotensin-ii
#7
Mohammad Zaki Shukri, Jia Wei Tan, Worapaka Manosroi, Luminita H Pojoga, Alicia Rivera, Jonathan S Williams, Ellen W Seely, Gail K Adler, Iris Z Jaffe, Richard H Karas, Gordon H Williams, Jose R Romero
The relationship between biological sex and aldosterone on blood pressure (BP) is unclear. We hypothesized that sex would modify the interaction between aldosterone and vascular responses to salt intake and angiotensin II (AngII). To test this hypothesis, in 1592 subjects from the well-controlled Hypertensive Pathotype cohort, we compared responses of women and men to chronic (BP and aldosterone levels in response to dietary salt) and acute (BP, renal plasma flow, and aldosterone responses to AngII infusion) manipulations...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29685454/pathophysiology-of-glucocorticoid-signaling
#8
Géraldine Vitellius, Séverine Trabado, Jérôme Bouligand, Brigitte Delemer, Marc Lombès
Glucocorticoids (GC), such as cortisol or dexamethasone, control various physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert most of their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene). GC signaling follows several consecutive steps leading to target gene transactivation, including ligand binding, nuclear translocation of ligand-activated GR complexes, DNA binding, coactivator interaction and recruitment of functional transcriptional machinery...
April 20, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29685132/acth-independent-cushing-s-syndrome-with-bilateral-cortisol-secreting-adrenal-adenomas-a-case-report-and-review-of-literatures
#9
Jia Wei, Sheyu Li, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Kaiyun Ren, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li
BACKGROUND: Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS) with bilateral cortisol-secreting adenomas has been rarely reported in the literatures. Precise recognition and management of this disorder constitute a challenge to clinicians due to the difficulty of exact location of the functional lesions. CASE PRESENTATION: We herein report a new case of a Chinese female patient with a complaint of exertional dyspnea for over 10 years. ACTH-independent CS was diagnosed based on undetectable ACTH and unsuppressed cortisol levels by dexamethasone...
April 23, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29685115/acquired-modification-of-sphingosine-1-phosphate-lyase-activity-is-not-related-to-adrenal-insufficiency
#10
Gulin Sunter, Ece Oge Enver, Azad Akbarzade, Serap Turan, Pinar Vatansever, Dilek Ince Gunal, Goncagul Haklar, Abdullah Bereket, Kadriye Agan, Tulay Guran
BACKGROUND: Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by fingolimod which is an oral drug for relapsing multiple sclerosis (MS). Effects of this treatment on adrenal function has not yet been evaluated. We aimed to test adrenal function of MS patients receiving long-term fingolimod treatment...
April 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29684806/indocyanine-green-identification-for-tumor-infiltration-or-metastasis-originating-from-hepatocellular-carcinoma
#11
Atsushi Nanashima, Tetsuro Tominaga, Yorihisa Sumida, Shuichi Tobinaga, Takeshi Nagayasu
INTRODUCTION: The indocyanine green-photodynamic eye (ICG-PDE) system is useful to detect small hypervascular liver tumors, hepatocellular carcinoma (HCC), on the liver surface. This system may be also applied to improve determining the location of metastasis or tumor thrombus (TT). We herein report three case reports. ICG was administered preoperatively for functional testing and images of the tumor were observed during hepatectomy using a PDE camera. CASE SERIES: The patient in case 1 exhibited advanced HCC with TT in the portal trunk...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29684711/hypothalamic-pituitary-adrenal-axis-activity-in-the-comorbidity-between-obsessive-compulsive-disorder-and-major-depression
#12
Javier Labad, Virginia Soria, Neus Salvat-Pujol, Cinto Segalàs, Eva Real, Mikel Urretavizcaya, Aida de Arriba-Arnau, Alex Ferrer, José M Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, Pino Alonso, José M Menchón
Major depressive disorder (MDD) is the most common psychiatric comorbidity in patients with obsessive-compulsive disorder (OCD). Hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been described in both disorders and might play a role in the association between them. We aimed to study the role of HPA axis activity in the comorbidity between OCD and MDD, while controlling for psychopathological dimensions such as anxiety and depressive symptoms. We studied 324 participants belonging to four diagnostic groups: 1) MDD (n = 101), 2) OCD with comorbid MDD (n = 33), 3) OCD without MDD (n = 52), and 4) healthy subjects (n = 138)...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29684512/functional-characterization-and-molecular-modeling-of-the-mutations-in-cyp21a2-gene-from-patients-with-congenital-adrenal-hyperplasia
#13
Ragini Khajuria, Rama Walia, Anil Bhansali, Rajendra Prasad
Steroid 21-Hydroxylase deficiency is an inherited autosomal recessive metabolic disorder of the adrenal steroidogenesis caused due to mutations in the CYP21A2 gene in 95% of CAH cases. Notably, the de novo mutations arise at the rate of 3-5%, therefore the functional characterization is of utmost importance for categorization of the novel mutations. Herein, we have functionally characterized the CYP21A2 missense mutations viz., p. F306V and p. H365 N. Notably, both the mutations were harbored by the patients exhibiting the non classical phenotype...
April 20, 2018: Biochimie
https://www.readbyqxmd.com/read/29684370/analytical-validation-and-investigation-on-reference-intervals-of-aldosterone-and-renin-in-chinese-han-population-by-using-fully-automated-chemiluminescence-immunoassays
#14
Lingyan Deng, Zhigang Xiong, Huijun Li, Xiaomei Lei, Liming Cheng
BACKGROUND: The aldosterone/renin ratio (ARR) is recommended to screen for primary aldosteronism (PA) in hypertension. We estimated fully automated chemiluminescence immunoassays (CLIA) for plasma aldosterone concentrations (PAC) and plasma direct renin concentrations (PRC) and investigated their reference intervals in Chinese Han population. METHODS: PAC and PRC were measured on a fully automated analyzer (LIAISON XL, DiaSorin, Italy). Performance characteristics were estimated according to CLSI proved guidelines...
April 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29683470/in-vivo-toxicity-of-the-ribosome-inactivating-lectin-ebulin-f-in-elderly-mice
#15
Manuel Garrosa, Pilar Jiménez, Damián Córdoba-Díaz, Verónica García-Recio, Sara Gayoso, María Ángeles Rojo, Manuel J Gayoso, Tomás Girbés
Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young animals and with other RIPs. Female Swiss mice aged 6 and 12 months of age were intraperitoneally injected with a single dose from 1.4 to 4.5 mg/kg ebulin f. Heart, stomach, intestines, lung, kidney, liver, spleen, pancreas, adrenal gland, uterus, ovary and brain were studied...
April 23, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29682808/stress-alcohol-and-infection-during-early-development-a-brief-review-of-common-outcomes-and-mechanisms
#16
REVIEW
Pablo Nicolás Surkin, Heather Brenhouse, Terrence Deak, Ana Clara Liberman, Mercedes Lasaga
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during early stages of life such as infancy or adolescence can induce adaptations in multiple physiological systems, including the reproductive axis (HPG), the hypothalamic-pituitary-adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioral responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (peri-natal, juvenile, adolescent periods) and how developmental timing of early life stress confers unique physiological adaptations that may persist across the lifespan...
April 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29682773/mortality-data-from-the-european-adrenal-insufficiency-registry-patient-characterization-and-associations
#17
Marcus Quinkler, Bertil Ekman, Pinggao Zhang, Andrea M Isidori, Robert D Murray
OBJECTIVE: Mortality from primary and secondary adrenal insufficiency (AI; PAI and SAI, respectively) is 2-3-fold higher than in the general population. Mortality relates to cardiovascular disease, acute adrenal crisis (AC), cancer and infections; however, there has been little further characterization of patients who have died. DESIGN/METHODS: We analysed real-world data from 2034 patients (801 PAI, 1233 SAI) in the European Adrenal Insufficiency Registry (EU-AIR; NCT01661387)...
April 22, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29682767/ghrelin-as-a-potential-molecular-marker-of-adrenal-carcinogenesis-in-vivo-and-in-vitro-evidence
#18
Hanna Komarowska, Marcin Ruciński, Marianna Tyczewska, Nadia Sawicka-Gutaj, Marta Szyszka, Aleksandra Hernik, Anna Klimont, Paulina Milecka, Laura Migasiuk, Mateusz Biczysko, Ilona Idasiak-Piechocka, Marek Karczewski, Marek Ruchała
CONTEXT: Adrenal tumors belong to one of the most prevalent neoplasms. It is a heterogeneous group with different etiology, clinical manifestation, and prognosis. Its histopathologic diagnosis is difficult and identification of differentiation markers for tumorigenesis is extremely valuable for diagnosis. DESIGN: To assess ghrelin expression and the relationship among ghrelin, IGF2, and the clinicopathological characteristics of adrenal tumors. To investigate the influence of ghrelin on ACC cell line proliferation...
April 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29682594/the-role-of-leptin-in-maintaining-plasma-glucose-during-starvation
#19
Rachel J Perry, Gerald I Shulman
For 20 years it has been known that concentrations of leptin, a hormone produced by the white adipose tissue (WAT) largely in proportion to body fat, drops precipitously with starvation, particularly in lean humans and animals. The role of leptin to suppress the thyroid and reproductive axes during a prolonged fast has been well defined; however, the impact of leptin on metabolic regulation has been incompletely understood. However emerging evidence suggests that, in starvation, hypoleptinemia increases activity of the hypothalamic-pituitary-adrenal axis, promoting WAT lipolysis, increasing hepatic acetyl-CoA concentrations, and maintaining euglycemia...
March 2018: Postdoc Journal
https://www.readbyqxmd.com/read/29682390/hydatid-cyst-of-the-adrenal-gland-is-radical-surgery-necessary-for-recurrent-hydatid-disease
#20
Sami Akbulut, Mehmet Yilmaz
Hydatid cyst disease caused by E. granulosus is a zoonotic disease that may involve many body tissues and organs, mainly liver. Adrenal glands are rarely involved even in regions where hydatid cyst disease is endemic. A limited number of studies have been reported on adrenal gland involvement by hydatid cyst disease. Herein, we aimed to report a recurrent case of adrenal hydatid cyst that was misdiagnosed as a hepatic hydatid cyst. A 16-year-old boy with a history of partial cyst excision and evacuation for perforated adrenal hydatid cyst disease three years ago presented to our outpatient clinic with nonspecific abdominal pain...
2018: Case Reports in Surgery
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