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https://www.readbyqxmd.com/read/29666465/molecular-epidemiology-of-lung-cancer-in-iran-implications-for-drug-development-and-cancer-prevention
#1
REVIEW
Zahra Fathi, Nicholas L Syn, Jian-Guo Zhou, Raheleh Roudi
Epidemiological studies undertaken over the past decades reveal a gradual but progressive increase in the incidence and mortality attributable to lung cancer in the Islamic Republic of Iran, a sovereign state geographically situated at the crossroads of Central Eurasia and Western Asia. We identified references published in English and Persian through searches of PubMed, EMBASE, Web of Science, Scopus, and the Scientific Information Database (SID)-a specialized Iranian database, which indexes Iranian scientific journals-between inception and 15 September 2017...
April 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29666215/control-of-pancreatic-%C3%AE-cell-bioenergetics
#2
REVIEW
Charles Affourtit, Ben Alberts, Jonathan Barlow, Jane E Carré, Anthony G Wynne
The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual as it implies that ATP flux is governed, to a significant extent, by ATP supply, while it is predominantly demand-driven in other cell types. Metabolic control is generally shared between different processes, but potential control of ATP consumption over β-cell bioenergetics has been largely ignored to date...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29659569/targeted-next-generation-sequencing-identifies-functionally-deleterious-germline-mutations-in-novel-genes-in-early-onset-familial-prostate-cancer
#3
Paula Paulo, Sofia Maia, Carla Pinto, Pedro Pinto, Augusta Monteiro, Ana Peixoto, Manuel R Teixeira
Considering that mutations in known prostate cancer (PrCa) predisposition genes, including those responsible for hereditary breast/ovarian cancer and Lynch syndromes, explain less than 5% of early-onset/familial PrCa, we have sequenced 94 genes associated with cancer predisposition using next generation sequencing (NGS) in a series of 121 PrCa patients. We found monoallelic truncating/functionally deleterious mutations in seven genes, including ATM and CHEK2, which have previously been associated with PrCa predisposition, and five new candidate PrCa associated genes involved in cancer predisposing recessive disorders, namely RAD51C, FANCD2, FANCI, CEP57 and RECQL4...
April 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29659482/educational-attainment-and-smoking-status-in-a-national-sample-of-american-adults-evidence-for-the-blacks-diminished-return
#4
Shervin Assari, Ritesh Mistry
BACKGROUND: Although higher socioeconomic status (SES) indicators such as educational attainment are linked with health behaviors, the Blacks’ Diminished Return theory posits that the protective effects of SES are systemically smaller for Blacks than Whites. AIMS: To explore the Black/White differences in the association between education and smoking. METHODS: This cross-sectional study used the Health Information National Trends Survey (HINTS) 2017 ( n = 3217)...
April 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29658519/biomechanical-evaluation-of-tendon-connection-with-novel-suture-techniques
#5
Zhe Chen, Jun Wang, Jia-Sen Wei, Zhao-Yang Hou, Min Li, Qi-Xin Chen
PURPOSE: Achilles tendon rupture is a severe injury with poor curative effect due to its anatomical characteristic and mechanical peculiarity. Internal fixation of limited loop (IFLL) with steel-wire has been applied on patients with tendon rupture to fix the broken ends before physical rehabilitation. The purpose of this study is to investigate the biomechanical property and radiological characteristic of such suture technique for the repairment of tendon rupture. METHODS: Tendons of pigs' hint feet were separated for the biomechanical study...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29656088/-ne-nnipadua-mmpe-the-body-hates-it-exploring-the-lived-experience-of-food-allergy-in-sub-saharan-africa
#6
George A Atiim, Susan J Elliott, Ann E Clarke
Allergic diseases have closely followed the rise of non-communicable diseases (NCDs) especially in western societies. As prevalence of NCD is increasing in sub-Saharan Africa (SSA), researchers are hinting that the same future may hold for (food) allergic disease in this world region. Already, researchers are beginning to record prevalence, though with little attention to the social experience of individuals and parents with food allergic children. This paper presents the first qualitative analysis of the daily realities of adults and parents of children with allergies in SSA using Ghana as a case study...
March 23, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29651636/aflatoxin-m-1-detoxification-ability-of-probiotic-lactobacilli-of-indian-origin-in-in-vitro-digestion-model
#7
Rohit Panwar, Narendra Kumar, Vipul Kashyap, Chand Ram, Rajeev Kapila
Aflatoxin M1 (AFM1 ) is known to be a potent carcinogen and continues to pose a public health concern through the consumption of contaminated dairy foods. It is anticipated that consumption of lactic acid bacteria capable of binding aflatoxins can reduce the risk of AFM1 on human health to a certain extent. Seldom reports have hinted the possibility of using lactic acid bacteria for the biological detoxification of AFM1 . Hence, the present study was conducted to assess the ability of selected probiotic Lactobacillus strains for their AFM1 binding ability in PBS and to reduce its bioaccessibility in artificially contaminated skim milk using an in vitro digestion model...
April 12, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29651265/an-initial-cross-cultural-comparison-of-adult-playfulness-in-mainland-china-and-german-speaking-countries
#8
Dandan Pang, René T Proyer
Compared with playfulness in infants and children, playfulness in adults is relatively under-studied. Although there is no empirical research comparing differences in adult playfulness across cultures, one might expect variations between Western and Eastern societies such as China. While playfulness is typically seen as a positive trait in Western culture, there are hints in Chinese culture that being playful has negative connotations (e.g., associations with laziness and seeing play as the opposite of work)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29650679/real-time-observation-of-flexible-domain-movements-in-crispr-cas9
#9
Saki Osuka, Kazushi Isomura, Shohei Kajimoto, Tomotaka Komori, Hiroshi Nishimasu, Tomohiro Shima, Osamu Nureki, Sotaro Uemura
The CRISPR-associated protein Cas9 is widely used for genome editing because it cleaves target DNA through the assistance of a single-guide RNA (sgRNA). Structural studies have revealed the multi-domain architecture of Cas9 and suggested sequential domain movements of Cas9 upon binding to the sgRNA and the target DNA These studies also hinted at the flexibility between domains; however, it remains unclear whether these flexible movements occur in solution. Here, we directly observed dynamic fluctuations of multiple Cas9 domains, using single-molecule FRET We found that the flexible domain movements allow Cas9 to adopt transient conformations beyond those captured in the crystal structures...
April 12, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29649288/autofluorescence-study-and-selected-cyanidin-quantification-in-the-jewel-orchids-anoectochilus-sp-and-ludisia-discolor
#10
Ranjetta Poobathy, Rahmad Zakaria, Vikneswaran Murugaiyah, Sreeramanan Subramaniam
Anoectochilus sp. and Ludisia discolor are known as Jewel orchids. Both species are terrestrial wild orchids that grow in shaded areas of forests. The Jewel orchids are renowned for the beauty of their leaves, which are dark-green laced with silvery or golden veins. The orchids are used as a cure in various parts of Asia. Overharvesting and anthropogenic disturbances threaten the existence of the Jewel orchids in the wild, necessitating human intervention in their survival. An understanding of the structure and adaptations of a plant may assist in its survival when propagated outside of its habitat...
2018: PloS One
https://www.readbyqxmd.com/read/29649038/the-effect-and-mechanism-of-millepachine-disrupted-spindle-assembly-in-tumor-cells
#11
Wenshuang Wu, Feng Liu, Anping Su, Yanping Gong, Wanjun Zhao, Yang Liu, Haoyu Ye, Jingqiang Zhu
Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment. Previous studies showed that MIL was a novel cancer drug candidate with a special structure. To provide reference for the research and development of MIL, we further investigated the mechanism of MIL inducing G2/M arrest and found MIL disrupted spindle assembly in tumor cells. In this study, we investigated the disrupting spindle assembly effects of MIL with a focus on its potential mechanism of action. First, we indicated that MIL did not inhibit microtubule polymerization from the results of in-vivo microtubule nucleation assay and microtubule polymerization in-vitro assay but delayed this process by inhibiting the production of ATP in tumor cells...
June 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29648552/role-of-ni-sup-2-sup-d-sup-8-sup-ions-on-electrical-optical-and-magnetic-properties-in-cds-nanowires-for-optoelectronic-and-spintronic-applications
#12
Muhammad Arshad Kamran
For the first time, 1D Ni ions doped CdS nanowires (NWs) were synthesized via chemical vapour deposition (CVD). The synthesized Cd0.886Ni0.114S NWs were single crystalline. We have reported here, investigation of optical, electrical and magnetic properties of prepared NWs for optoelectronic and spintronic applications. Successful incorporation of Ni ions in an individual CdS NW has been confirmed through several characterization tools: significant higher angle and phonon modes shift were observed in the XRD and Raman spectra...
April 12, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29629204/vats-group-eras-registry
#13
REVIEW
Jacopo Vannucci, Stefano Costi, Alberto Matricardi, Elisa Scarnecchia, Andrea Droghetti
Enhanced recovery after surgery (ERAS) is a multimodal, polyhedral approach to surgical management for patients undergoing surgical therapy. Since ERAS is not a specific procedure, these protocols are not exclusively created for particular clinical settings but they are prone to be adapted to a large variety of healthcare programs after surgery. ERAS Society was the platform in which a new multidisciplinary methodology to promote a fast recovery, a considerable patient involvement and resource optimization has been developed...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29627531/crp-genetic-variants-are-associated-with-mortality-and-depressive-symptoms-in-chronic-heart-failure-patients
#14
S Kittel-Schneider, M Kaspar, D Berliner, H Weber, J Deckert, G Ertl, S Störk, C Angermann, A Reif
OBJECTIVE: Heart failure (HF) is a complex medical condition with a multitude of genetic and other factors being involved in the pathogenesis. Emerging evidence points to an involvement of inflammatory mechanisms at least in subgroups of patients. The same is true for depression and depressive symptoms, which have a high prevalence in HF patients and are risk factors for the development and outcomes of cardiovascular disease. METHODS: In 936 patients of the Interdisciplinary Network Heart Failure (INH) program, CRP and IL-6 protein blood levels were measured and genetic variants (single nucleotide polymorphisms) of the CRP and IL6 gene analyzed regarding their influence on mortality...
April 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29626100/devil-in-disguise-hints-and-pitfalls-in-diagnosis-of-peripartum-cardiomyopathy
#15
EDITORIAL
Johann Bauersachs, Tobias Koenig
No abstract text is available yet for this article.
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29624714/two-cases-of-discrete-adenoid-pseudogland-formation-within-benign-intradermal-melanocytic-nevi
#16
Jonathan C Banta, Justin P Bandino
We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost Kaposiform) change hinted at melanocytic origin, and was confirmed with a positive MART-1 immunohistochemical stain...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29624433/pharmacological-potential-of-methylxanthines-retrospective-analysis-and-future-expectations
#17
João Monteiro, Marco G Alves, Pedro F Oliveira, Branca M Silva
Methylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. The supposedly relatively low toxicity of methylxanthines, combined with the many beneficial effects that have been attributed to these compounds through time, generated a justified attention and a very prolific ground for dedicated scientific reports...
April 6, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29623727/myxoid-emboli
#18
Badr AbdullGaffar, Krysztof Waslewski
Emboli are common clinicopathologic findings. Recognition of the type of arterial emboli could be the first clue to the original source. Emboli with myxomatous changes are rare. Myxoma-like features in mural organizing thrombi have been reported. The most challenging differential diagnosis is between embolic cardiac myxomas and myxomatous thromboemboli. Emboli from sarcomas and arteriosclerotic plaques with myxoid features are also potential pitfalls. There is scarcity of studies focusing on myxoid emboli and their clinical and pathologic importance...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29623686/effect-of-a-montmorillonite-bentonite-based-product-on-faecal-parameters-of-horses
#19
K Gerstner, A Liesegang
Free faecal water (fluid excreted separate from normal faeces) is a common problem of unknown origin in horses. Multifactorial causes are assumed. This study assessed the effect of a commercial product (EMP) sold to help support intestinal health of horses, particularly regarding the occurrence of free faecal water. The hypothesis was that water-binding capacity and microbial activity are improved in the large intestine of horses fed EMP. EMP contained montmorillonite-bentonite, whey and extracts from hop and absinthium...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29623077/influenza-activated-ilc1s-contribute-to-antiviral-immunity-partially-influenced-by-differential-gitr-expression
#20
Neha Vashist, Stephanie Trittel, Thomas Ebensen, Benedict J Chambers, Carlos A Guzmán, Peggy Riese
Innate lymphoid cells (ILCs) represent diversified subsets of effector cells as well as immune regulators of mucosal immunity and are classified into group 1 ILCs, group 2 ILCs, and group 3 ILCs. Group 1 ILCs encompass natural killer (NK) cells and non-NK ILCs (ILC1s) and mediate their functionality via the rapid production of IFN-γ and TNF-α. The current knowledge of ILC1s mainly associates them to inflammatory processes. Much less is known about their regulation during infection and their capacity to interact with cells of the adaptive immune system...
2018: Frontiers in Immunology
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