keyword
MENU ▼
Read by QxMD icon Read
search

HINTS

keyword
https://www.readbyqxmd.com/read/29457859/post-infectious-acute-glomerulonephritis-with-podocytopathy-induced-by-parvovirus-b19-infection
#1
Satoshi Hara, Masayoshi Hirata, Kiyoaki Ito, Ichiro Mizushima, Hiroshi Fujii, Kazunori Yamada, Michio Nagata, Mitsuhiro Kawano
Human parvovirus B19 infection causes a variety of glomerular diseases such as post-infectious acute glomerulonephritis and collapsing glomerulopathy. Although each of these appears independently, it has not been fully determined why parvovirus B19 provokes such a variety of different glomerular phenotypes. Here, we report a 68-year-old Japanese man who showed endocapillary proliferative glomerulonephritis admixed with podocytopathy in association with parvovirus B19 infection. The patient showed acute onset of heavy proteinuria, microscopic hematuria and kidney dysfunction with arthralgia and oliguria after close contact with a person suffering from erythema infectiosum...
February 19, 2018: Pathology International
https://www.readbyqxmd.com/read/29456117/extraordinary-daytime-only-urinary-frequency-in-childhood-prevalence-diagnosis-and-management
#2
Pierluigi Marzuillo, Mario Diplomatico, Rosaria Marotta, Laura Perrone, Emanuele Miraglia Del Giudice, Cesare Polito, Angela La Manna, Stefano Guarino
INTRODUCTION: Since standardization of the ICCS terminology, only two small case series of children with extraordinary daytime only urinary frequency (EDOUF) have been published. The aims of the present study were i) to describe a large cohort of children affected by EDOUF, to evaluate its rate among the main micturition pediatric disturbances, and to determine if there is different EDOUF onset among seasons; ii) to investigate possible associations with urodynamic abnormalities by non-invasive techniques; iii) to evaluate whether postponing micturition exercise (PME) can objectively verify the anamnestic data hinting at the EDOUF diagnosis; and iv) to determine the effect of postponing micturition at home...
February 9, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29455954/the-peroxisome-proliferator-activated-receptor-%C3%AE-is-dispensable-for-cold-induced-adipose-tissue-browning-in-mice
#3
Merel Defour, Wieneke Dijk, Philip Ruppert, Emmani B M Nascimento, Patrick Schrauwen, Sander Kersten
OBJECTIVE: Chronic cold exposure causes white adipose tissue (WAT) to adopt features of brown adipose tissue (BAT), a process known as browning. Previous studies have hinted at a possible role for the transcription factor Peroxisome Proliferator-Activated Receptor alpha (PPARα) in cold-induced browning. Here we aimed to investigate the importance of PPARα in driving transcriptional changes during cold-induced browning in mice. METHODS: Male wildtype and PPARα-/- mice were housed at thermoneutrality (28 °C) or cold (5 °C) for 10 days...
February 9, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29453546/a-drosophila-model-to-decipher-the-toxicity-of-nanoparticles-taken-through-oral-routes
#4
S Aurosman Pappus, Monalisa Mishra
In recent era, nanoparticles (NPs) are widely used in food, medicine and body implants. Besides it's wide use being a foreign particle it may have some noxious effect on the body. To understand the mechanistic role of NPs toxicity, Drosophila appeared to be a superior model organism. Toxicity of several nanoparticles were accessed using Drosophila. The NPs, after oral route of exposure enter into the gut, crosses the barrier of peritrophic membrane and induces apoptosis. The toxicity of NPs within gut resulted in developmental delay, with decrease in pupa count, fly hatching along with weight loss...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453033/the-social-attribution-task-multiple-choice-sat-mc-psychometric-comparison-with-social-cognitive-measures-for-schizophrenia-research
#5
Jason K Johannesen, Joanna M Fiszdon, Andrea Weinstein, David Ciosek, Morris D Bell
The Social Attribution Task-Multiple Choice (SAT-MC) tests the ability to extract social themes from viewed object motion. This form of animacy perception is thought to aid the development of social inference, but appears impaired in schizophrenia. The current study was undertaken to examine psychometric equivalence of two forms of the SAT-MC and to compare their performance against social cognitive tests recommended for schizophrenia research. Thirty-two schizophrenia (SZ) and 30 substance use disorder (SUD) participants completed both SAT-MC forms, the Bell-Lysaker Emotion Recognition Task (BLERT), Hinting Task, The Awareness of Social Inference Test (TASIT), Ambiguous Intentions and Hostility Questionnaire (AIHQ) and questionnaire measures of interpersonal function...
February 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29452584/high-phosphorus-intake-and-gut-related-parameters-results-of-a-randomized-placebo-controlled-human-intervention-study
#6
Ulrike Trautvetter, Amélia Camarinha-Silva, Gerhard Jahreis, Stefan Lorkowski, Michael Glei
BACKGROUND: In recent years, high phosphate intakes were discussed critically. In the small intestine, a part of the ingested phosphate and calcium precipitates to amorphous calcium phosphate (ACP), which in turn can precipitate other intestinal substances, thus leading to a beneficial modulation of the intestinal environment. Therefore, we analysed faecal samples obtained from a human intervention study regarding gut-related parameters. METHODS: Sixty-two healthy subjects (men, n = 30; women, n = 32) completed the double-blind, placebo-controlled and parallel designed study (mean age: 29 ± 7 years; mean BMI: 24 ± 3 kg/m 2 )...
February 16, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29452406/negative-association-between-sclerostin-and-insl3-in-isolated-human-osteocytes-and-in-klinefelter-syndrome-new-hints-for-testis-bone-crosstalk
#7
Andrea Di Nisio, Luca De Toni, Maria Santa Rocca, Marco Ghezzi, Riccardo Selice, Giuseppe Taglialavoro, Alberto Ferlin, Carlo Foresta
Context/Objective: The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insuline-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study we aimed to investigate the relationship between INSL3 and Sclerostin, an osteocyte-specific protein that negatively regulates bone formation. Design/Setting: Serum sclerostin and INSL3 levels were evaluated in Klinefelter Syndrome (KS) and healthy controls...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29451335/mesenchymal-stem-cells-protect-against-hypoxia-ischemia-brain-damage-by-enhancing-autophagy-through-bdnf-mtor-signaling-pathway
#8
Zhen Zheng, Li Zhang, Yi Qu, Guoguang Xiao, Shiping Li, Shan Bao, Richard Lu, Dezhi Mu
Hypoxic-ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE. Previous study showed that mesenchymal stem cells (MSCs) can exert neuroprotective effects for brain damage, but its mechanism remains elusive. Using in-vitro co-culture of rat cortical primary neurons and MSCs in HI conditions, we demonstrated that MSCs help increase BDNF and autophagy markers (LC3II and Beclin1) in the cultures and decrease cells death (LDH levels)...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29449813/non-nucleotide-agonists-triggering-p2x7-receptor-activation-and-pore-formation
#9
REVIEW
Francesco Di Virgilio, Anna L Giuliani, Valentina Vultaggio-Poma, Simonetta Falzoni, Alba C Sarti
The P2X7 receptor (P2X7R) is a ligand-gated plasma membrane ion channel belonging to the P2X receptor subfamily activated by extracellular nucleotides. General consensus holds that the physiological (and maybe the only) agonist is ATP. However, scattered evidence generated over the last several years suggests that ATP might not be the only agonist, especially at inflammatory sites. Solid data show that NAD + covalently modifies the P2X7R of mouse T lymphocytes, thus lowering the ATP threshold for activation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29443755/argininemia-as-a-cause-of-severe-chronic-stunting-and-partial-growth-hormone-deficiency-pghd-a-case-report
#10
Xiaotang Cai, Dan Yu, Yongmei Xie, Hui Zhou
RATIONALE: Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations - including spastic diplegia, deterioration in cognitive function, and epilepsy - appear in later childhood. PATIENT CONCERNS: A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441842/crowding-in-the-first-intermediate-host-does-not-affect-infection-probability-in-the-second-host-in-two-helminths
#11
D P Benesh
When many worms co-infect the same host, their average size is often reduced. This negative density-dependent growth is called the crowding effect. Crowding has been reported many times for worms in their intermediate hosts, but rarely have the fitness consequences of crowding been examined. This study tested whether larval crowding reduces establishment success in the next host for two parasites with complex life cycles, the nematode Camallanus lacustris and the cestode Schistocephalus solidus. Infected copepods, the first host, were fed to sticklebacks, the second host...
February 14, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29441492/health-system-efficiency-a-fragmented-picture-based-on-oecd-data
#12
Andreas Behr, Katja Theune
BACKGROUND: Globally, health expenditure as a percentage of GDP has increased in recent years, so evaluating the health care systems used in different countries is an important tool for identifying best practices and improving inefficient health care systems. OBJECTIVE: We investigate health system efficiency at the country level based on OECD health data. We focus on several aspects of health care systems to identify specific inefficiencies within them. This information hints at potential policy interventions that could improve specific parts of a country's health care system...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29439322/cerebrospinal-fluid-biomarkers-are-differentially-related-to-structural-and-functional-changes-in-dementia-of-the-alzheimer-s-type
#13
Charles B Malpas, Michael M Saling, Dennis Velakoulis, Patricia Desmond, Rodney J Hicks, Henrik Zetterberg, Kaj Blennow, Terence J O'Brien
The two cardinal pathologies of Alzheimer's disease (AD) develop according to distinct anatomical trajectories. Cerebral tau-related pathology first accumulates in the mesial temporal region, while amyloid-related pathology first appears in neocortex. The eventual distributions of these pathologies reflect their anatomical origins. An implication is that the cardinal pathologies might exert preferential effects on the structurofunctional brain changes observed in AD. We investigated this hypothesis in 39 patients with dementia of the Alzheimer's type...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29437603/atherosclerotic-calcification-wnt-is-the-hint
#14
Isabella Albanese, Kashif Khan, Bianca Barratt, Hamood Al-Kindi, Adel Schwertani
No abstract text is available yet for this article.
February 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29436833/photochemically-powered-agcl-janus-micromotors-as-a-model-system-to-understand-ionic-self-diffusiophoresis
#15
Chao Zhou, Hepeng Zhang, Jinyao Tang, Wei Wang
Micromotors are an emerging class of micromachines that could find potential applications in biomedicine, environmental remediation and microscale self-assembly. Understanding their propulsion mechanisms holds the key to their future development. This is especially true for a popular category of micromotors that are driven by asymmetric surface photochemical reactions. Many of these micromotors release ionic species, and are propelled via a mechanism termed ionic self-diffusiophoresis. But exactly how it operates remains vague...
February 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29435643/effectiveness-and-baseline-factors-associated-to-fingolimod-response-in-a-real-world-study-on-multiple-sclerosis-patients
#16
F Esposito, L Ferrè, F Clarelli, M A Rocca, G Sferruzza, L Storelli, M Radaelli, F Sangalli, L Moiola, B Colombo, F Martinelli Boneschi, G Comi, M Filippi, V Martinelli
BACKGROUND: Treatment choice in multiple sclerosis (MS) is crucial for optimizing risk-benefit profile. OBJECTIVE: To assess fingolimod (FTY) effectiveness and identify baseline features associated to disease activity in a large Italian cohort of Relapsing-Remitting (RR) MS patients. METHODS: Three-hundred sixty-seven RRMS patients starting FTY treatment at San Raffaele Hospital (Milan-Italy) underwent clinical and MRI evaluations for 2 years...
February 12, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29432420/in-vitro-studies-of-rickettsia-host-cell-interactions-confocal-laser-scanning-microscopy-of-rickettsia-helvetica-infected-eukaryotic-cell-lines
#17
Stephanie Speck, Tanja Kern, Karin Aistleitner, Meik Dilcher, Gerhard Dobler, Sandra Essbauer
Rickettsia (R.) helvetica is the most prevalent rickettsia found in Ixodes ricinus ticks in Germany. Several studies reported antibodies against R. helvetica up to 12.5% in humans investigated, however, fulminant clinical cases are rare indicating a rather low pathogenicity compared to other rickettsiae. We investigated growth characteristics of R. helvetica isolate AS819 in two different eukaryotic cell lines with focus on ultra-structural changes of host cells during infection determined by confocal laser scanning microscopy...
February 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29430180/color-preferences-in-participants-with-high-or-low-hypnotic-susceptibility
#18
Enyan Yu, Junpeng Zhu, Yunfei Tan, Zhengluan Liao, Yaju Qiu, Bingren Zhang, Chu Wang, Wei Wang
Purpose: Color preferences vary among normal individuals and psychiatric patients, and this might be related to their different levels of hypnotic susceptibility. We hypothesized that individuals with higher hypnotic susceptibility prefer more arousing colors such as red. Patients and methods: Out of 440 participants, we selected 70 with higher (HIGH) and 66 with lower (LOW) hypnotic susceptibilities, and asked them to undergo the Stanford Hypnotic Susceptibility Scale: Form C (SHSSC) test, then to order their preferences of 11 colors...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29427796/the-influence-of-different-illumination-parameters-on-protoporphyrin-ix-induced-cell-death-in-squamous-cell-carcinoma-cells
#19
B Novak, L Heesen, N Schary, H Lübbert
BACKGROUND: Topical photodynamic therapy (PDT) is a highly effective therapy especially for extended cancerized fields of the skin. Whenever extended fields are treated pain management is advisable. Light source mediated pain management can be performed by reducing fluence rates, as long as this does not compromise efficacy. METHODS: Two squamous cell carcinoma cell lines (A431 and SCC-13) were subjected to in vitro PDT using two different ALA concentrations and synthesis intervals and protoporphyrin IX (PpIX) synthesis was assessed...
February 7, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29426262/the-relationship-between-theory-of-mind-and-insight-in-obsessive-compulsive-disorder
#20
Rıza Gökçer Tulacı, Eylem Şahin Cankurtaran, Kadir Özdel, Nefise Öztürk, Erkan Kuru, İlker Özdemir
BACKGROUND: It is known that obsessive-compulsive disorder (OCD) patients with poor insight display more severe neuropsychological impairments than other patients with OCD. There are limited studies of OCD and theory of mind (ToM). AIM: To investigate ToM skills in patients with OCD and the relationship between insight and ToM skills by comparing OCD patients with good and poor insight. METHODS: Eighty patients with OCD and 80 healthy controls completed the structured clinical interview for DSM-IV axis I disorders, the Yale Brown Obsessive-Compulsive Scale, the Beck Anxiety and Beck Depression Inventories, and the Brown Assessment of Beliefs Scale...
February 9, 2018: Nordic Journal of Psychiatry
keyword
keyword
16278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"