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H Pylori Cancer

Mika Miura, Masahiko Ohtaka, Mitsuhiko Hanawa, Atsuko Kitahashi, Yuichi Hirose, Kazuhiko Takaso, Yoshioki Yoda, Ichiro Takayama, Zentarou Yamagata, Nobuyuki Enomoto
The LZ test "Eiken" for H. pylori antibody (LZ test) was examined. In patients with an antibody titer of ≥3.0U/mL and <10.0U/mL among 698 patients who underwent breath tests, the status of H. pylori infection was assessed from the results of the 13 C urea breath test and the findings of gastric mucosal atrophy by performing an upper gastrointestinal endoscopy. A positive 13 C urea breath test was observed in 22.3% of these patients (156/698, 95% confidence interval 19.4-25.6%), and gastric mucosal atrophy of C-2 or greater was observed in 39...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Bohye Park, Joo Weon Lim, Hyeyoung Kim
Helicobacter pylori (H pylori) colonizes the human stomach and increases the risk of gastric diseases including gastric cancer. H pylori increases reactive oxygen species (ROS), which activate Janus-activator kinase 1 (Jak1)/signal transducers and activators of transcription 3 (Stat3) in gastric epithelial cells. ROS mediate hyperproliferation, a hallmark of carcinogenesis, by activating Wnt/β-catenin signaling in various cells. Lycopene is a potent antioxidant exhibiting anticancer effects. We hypothesized that lycopene may inhibit H pylori-induced hyperproliferation by suppressing ROS-mediated activation of Jak1/Stat3 and Wnt/β-catenin signaling, and β-catenin target gene expression in gastric epithelial cells...
July 21, 2018: Nutrition Research
Ryan Morgan, Michael Cassidy, Susanna W L DeGeus, Jennifer Tseng, David McAneny, Teviah Sachs
INTRODUCTION: Gastric cancer is decreasing nationally but remains pervasive globally. We evaluated our experience with gastric cancer at a safety-net hospital with a substantial immigrant population. METHODS: Demographics, pathology, and treatment were analyzed for gastric adenocarcinoma at our institution (2004-2017). Chi-square analyses were performed for dependence of staging on demographics. Survival was evaluated with Kaplan-Meier and Cox regression analyses...
August 10, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Zareen Sultana, Biswabandhu Bankura, Arup Kumar Pattanayak, Debmalya Sengupta, Mainak Sengupta, Makhan Lal Saha, Chinmay Kumar Panda, Madhusudan Das
Interleukin 1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) are key inflammatory cytokines whose polymorphisms have been correlated with increased susceptibility to gastric cancer (GC). Since geographical and racial differences exist in cancer rates, our study was aimed to evaluate the first possible association of polymorphisms in these genes with GC risk in West Bengal, India. Polymorphisms in IL-1β and TNF-α genes were genotyped in 120 GC patients and 135 healthy individuals. Combined effect of the SNPs in both genes with GC risk was determined through allele dosage analysis (ADA) and the survival data were analyzed by Log Rank Test...
August 9, 2018: Environmental and Molecular Mutagenesis
David Y Graham, Muhammad Miftahussurur
The stomach contents contain of both acid and proteolytic enzymes. How the stomach digests food without damaging itself remained a topic of investigation for decades. One candidate was gastric urease, which neutralized acid by producing ammonia from urea diffusing from the blood and potentially could protect the stomach. Discovery that gastric urease was not mammalian resulted in a research hiatus until discovery that gastric urease was produce by Helicobacter pylori which caused gastritis, peptic ulcer and gastric cancer...
September 2018: Journal of Advanced Research
Renfei Zhu, Cheng Gao, Liuhua Wang, Guoxin Zhang, Weiming Zhang, Zhihong Zhang, Lizong Shen, Shoulin Wang
Background: Persistent Helicobacter pylori ( H. pylori ) infection leads to various gastric diseases. Multiple studies have demonstrated that aryl hydrocarbon receptor (AHR) plays roles in the antibacterial response and aryl hydrocarbon receptor repressor (AHRR) is downregulated in stomach cancer. However, the role of AHR or AHRR in H. pylori -related gastric diseases remains unclear. Aims: To investigate whether AHR or AHRR is involved in H. pylori -related gastric diseases. Methods: Patients with gastritis or gastric adenocarcinoma were enrolled randomly, and gastric tissue specimens were diagnosed pathologically...
2018: Journal of Cancer
Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Oran Kwon, Hyesook Kim, Jeongseon Kim
Although the incidence of gastric cancer (GC) has declined, it remains the second most common cancer in Korea. As a class of phytochemicals, carotenoids are fat-soluble pigments that are abundant in fruits and vegetables and have health-promoting properties, including cancer prevention effects. This case-control study investigated the effects of total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC...
August 7, 2018: Nutrients
Haim Shmuely, Baruch Brenner, David Groshar, Nir Hadari, Ofer Purim, Meital Nidam, Merab Eligalashvili, Jacob Yahav, Hanna Bernstine
BACKGROUND: Evidence has been emerging that Helicobacter pylori may also impact colorectal cancer (CRC). Positron emission tomography/computed tomography (PET/CT) imaging can predict overall survival in CRC patients. OBJECTIVES: To determine a possible association between H. pylori seropositivity and all-cause mortality among CRC patients evaluated by PET/CT scans. METHODS: This prospective cohort study was comprised of 110 consecutive CRC patients who had undergone a PET/CT evaluation in a tertiary academic medical center...
August 2018: Israel Medical Association Journal: IMAJ
Fayaz Ahmad Wani, Gulnaz Bashir, Mushtaq Ahmad Khan, Showkat Ali Zargar, Zubaida Rasool, Qurteeba Qadri
Background: Helicobacter pylori infection is recognised as type 1 carcinogen by the International Agency of Research on Cancer. Previous studies in our hospital have revealed high prevalence of H. pylori in our population with a high recurrence rate after completion of treatment. This prompted us to undertake this study. Aim: This study aimed to determine common gene mutations leading to resistance to clarithromycin, metronidazole, tetracycline and quinolones in H...
April 2018: Indian Journal of Medical Microbiology
Marisa Claudia Alvarez, Julien Fernandes, Valérie Michel, Eliette Touati, Marcelo Lima Ribeiro
BACKGROUND: GATA factors, which constitute a family of transcription regulatory proteins, participate in gastrointestinal development. Trefoil factor 1 (TFF1) plays a crucial role in mucosal defense and healing, and evidence suggests that GATA-5 mediated its regulation. Gastric cancer is a multiple-step process triggered by Helicobacter pylori and is characterized by accumulation of molecular and epigenetic alteration. The aim of this study was to evaluate the effect of H. pylori infection on the regulation of GATA-5 and TFF1 in vitro and in vivo...
August 6, 2018: Digestive Diseases and Sciences
Sergio Lario, Anna Brunet-Vega, María E Quílez, María J Ramírez-Lázaro, Juan J Lozano, Lorena García-Martínez, Carles Pericay, Mireia Miquel, Félix Junquera, Rafael Campo, Xavier Calvet
Background: Helicobacter pylori infection causes long-term chronic active gastritis, a risk factor for the intestinal and diffuse forms of gastric cancer. Most gastric cancers develop in a stepwise progression from chronic active gastritis to precursor lesions of gastric cancer. The early detection of gastric cancer improves survival. Studies with recent evidence have proposed circulating-microRNAs as biomarkers of cancer. Objective: The purpose of this study was to explore the circulating-microRNA profile from H...
June 2018: United European Gastroenterology Journal
Lukmanul Hakkim, Seemaisamy Revathi, Govind Rajan, Gattu Sampath, Ramesh Kumar, Mohammed Al Buloshi, Sidgi Syed Anwar, Hamid Bakshi, Kayalvizhi Nagarajan
BACKGROUND: Colon cancer is the most aggressive form of cancers, that causes 0.5 million deaths per year around the globe. Targeting colon cancer by conventional therapeutic options elicits toxicity. Traditional medicines take lead to alleviate the existing clinical challenges. OBJECTIVE: To investigate anti bacterial activity against Helicobacter Pylori and in vitro anti colon cancer activity by Acacia nilotica extract (ACE) and its active constituent pyrogallol...
August 5, 2018: Anti-cancer Agents in Medicinal Chemistry
Mohadeseh Kosari-Monfared, Novin Nikbakhsh, Sadegh Fattahi, Elham Ghadami, Mohammad Ranaei, Hassan Taheri, Fatemeh Amjadi-Moheb, Gholam A Godazandeh, Shahryar Shafaei, Maryam Pilehchian-Langroudi, Ali A Samadani, Haleh Akhavan-Niaki
Gastric cancer is a life-threatening disease; resulting from interaction among genetic, epigenetic, and environmental factors. Aberrant dysregulation and methylation changes in Wnt/β-catenin signaling downstream elements are a prevalent phenomenon encountered in gastric tumorigenesis. Also, viral infections play a role in gastric cancer development. CTNNBIP1 (β-catenin interacting protein 1) gene is an antagonist of Wnt signaling which binds to the β-catenin molecules. The CTNNBIP1 function as tumor suppressor gene or oncogene in different types of cancer is controversial...
August 4, 2018: Journal of Cellular Physiology
Elvire Berthenet, Koji Yahara, Kaisa Thorell, Ben Pascoe, Guillaume Meric, Jane M Mikhail, Lars Engstrand, Helena Enroth, Alain Burette, Francis Megraud, Christine Varon, John C Atherton, Sinead Smith, Thomas S Wilkinson, Matthew D Hitchings, Daniel Falush, Samuel K Sheppard
BACKGROUND: Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gastric cancer. Epidemiological evidence shows that progression to cancer depends upon the host and pathogen factors, but questions remain about why cancer phenotypes develop in a minority of infected people. Here, we use comparative genomics approaches to understand how genetic variation amongst bacterial strains influences disease progression...
August 2, 2018: BMC Biology
Shrikant Babanrao Kokate, Pragyesh Dixit, Indrajit Poirah, Arjama Dhar Roy, Debashish Chakraborty, Niranjan Rout, Shivaram Prasad Singh, Hassan Ashktorab, Duane T Smoot, Asima Bhattacharyya
Helicobacter pylori is the strongest known risk-factor for gastric cancer. However, its role in gastric cancer metastasis remains unclear. Previously we have reported that H. pylori promotes gastric cancer invasiveness by stabilizing the E3 ubiquitin ligase Siah2 which is mediated by Siah2 acetylation at Lys 139 (K139 ) residue. Here we identify that cell adhesion-related proteins testin (TES) and filamin-C (FLN-C) interact with Siah2 and get proteasomally degraded. The efficiency of TES and FLN-C degradation is significantly potentiated by K139 -acetylated Siah2 (ac-K139 Siah2) in infected gastric cancer cells (GCCs)...
July 28, 2018: International Journal of Biochemistry & Cell Biology
Rachel Howard, Sameer Al Diffalha, Jose Pimiento, Jaime Mejia, Heiko Enderling, Anna Giuliano, Domenico Coppola
BACKGROUND/AIM: Gastric adenocarcinoma is the fourth most common cancer worldwide. While gastric cancer prevalence varies globally and incidence rates are decreasing in the West, many cases continue to be diagnosed at an advanced stage and the 5-year survival rate still falls below 30%. Early treatment of gastric cancer by endoscopic and/or surgical therapy may decrease mortality; yet reliable, universally applicable biomarkers for early detection of gastric cancer have still not been established...
August 2018: Anticancer Research
A Kowada
Gastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates. Helicobacter pylori (H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence...
July 30, 2018: Epidemiology and Infection
Yasuo Tsuchiya, Kumudesh Mishra, Vinay K Kapoor, Ruchira Vishwakarma, Anu Behari, Toshikazu Ikoma, Takao Asai, Kazuo Endoh, Kazutoshi Nakamura
Objective: Gallbladder cancer is the commonest gastrointestinal cancer in northern Indian women. Some studies have examined the association between Helicobacter pylori infection and gallbladder cancer risk, but findings have been inconsistent. We aimed to examine the association between H. pylori infection and gallbladder cancer in Indian people. Materials and Methods: We conducted a hospital-based case-control study including 100 gallbladder cancer patients with gallstones who were 32 to 79 years old (cases; 72 women and 28 men), and 100 cholelithiasis patients aged 14 to 75 years (controls; 65 women and 35 men)...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Duc Trong Quach, Den Van Ha, Toru Hiyama
Aim: To assess the endoscopic and clinicopathological features of early-onset gastric cancer (EOGC) in Vietnamese, a population with intermediate risk of gastric cancer. Patients and methods: Consecutive patients diagnosed with gastric adenocarcinoma were prospectively recruited. The demographic, clinical data in each patient were collected. The location and macroscopic type of all gastric lesions suspected to be malignant were reported according to the Japanese classification. The histologic tumor type of gastric cancer (GC) was classified according to the Lauren classification...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Stella Smith, Tolu Jolaiya, Muinah Fowora, Pia Palamides, Favour Ngoka, Moses Bamidele, Olufunmilayo Lesi, Charles Onyekwere, Rose Ugiagbe, Ifeanyi Agbo, Dennis Ndububa, Olusegun Adekanle, Abimbola Adedeji, Isaac Adeleye, Ute Harrison
Background: The aim of the study was to assess clinical and socio-demographic characteristics as well as prior drug usage as risk factors for Helicobacter pylori (H. pylori) infection in Nigeria. Methods: A total of 347 respondents were surveyed by assessing their clinical and socio-demographic characteristics in comparison with the non-invasive gold standard for H. pylori diagnosis, the urea breath test (UBT). Chi-square test and odds ratio analyses were conducted in order to assess if variables such as socio-demographic factors, drug intake, and history of ulcer/gastritis/ gastric cancer within the family significantly predicted test results...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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