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H Pylori Cancer

Massimo Rugge, Robert M Genta, Matteo Fassan, Elisa Valentini, Irene Coati, Stefano Guzzinati, Edoardo Savarino, Manuel Zorzi, Fabio Farinati, Peter Malfertheiner
OBJECTIVES: Gastritis OLGA-staging ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This long-term follow-up study quantifies the GC risk associated with each OLGA stage. METHODS: Consecutive patients (7436) underwent esophagogastroscopy (T-0), with mapped gastric biopsies, OLGA staging, and H. pylori status assessment. Patients with neoplastic lesion (invasive or non-invasive) at the index endoscopy (and/or within 12 months) were excluded. All patients were followed-up (T-1) by combining different sources of clinical/pathological information (Regional Registries of: (i) esophagogastroduodenoscopies; (ii) pathology reports; (iii) cancer, (iv) mortality)...
October 17, 2018: American Journal of Gastroenterology
Seon Hee Lim, Nayoung Kim, Jin Won Kwon, Sung Eun Kim, Gwang Ho Baik, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Hyun Joo Song, Dae-Seong Myung, Suck Chei Choi, Hyun Jin Kim, Jeong Yoon Yim, Joo Sung Kim
The aims of this study were to demonstrate the trends in seropositivity and the eradication therapy rate for Helicobacter pylori (H. pylori) over an 18-year period in an asymptomatic Korean population and to explore the factors associated with H. pylori seropositivity and its eradication therapy. In total, 23,770 subjects (aged 17-97 years) from a health examination center participated in this cross-sectional study from January 2016 to June 2017. Questionnaires that included questions about the participants' H...
2018: PloS One
Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Wai Kay Seto, Ian C K Wong, Wai K Leung
Background: Although prior studies showed metformin could reduce gastric cancer (GC) risk in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and glycemic control. We aimed to investigate whether metformin reduced GC risk in H. pylori-eradicated diabetic patients and its association with glycemic control. Methods: This was a territory-wide cohort study using hospital registry database, recruiting all diabetic patients who were prescribed clarithromycin-based triple therapy for H...
October 16, 2018: Journal of the National Cancer Institute
Muhammad Junaid, Masaud Shah, Abbas Khan, Cheng-Dong Li, Muhammad Tahir Khan, Aman Chandra Kaushik, Arif Ali, Aamir Mehmood, Asma Sindhoo Nangraj, Sangdun Choi, Dong-Qing Wei
Helicobacter pylori (H. pylori) is one of the most extensively studied gram-negative bacteria due to its implication in gastric cancer. The oncogenicity of H. pylori is associated with cytotoxin-associated gene A (CagA), which is injected into epithelial cells lining the stomach. Both the C- and N-termini of CagA are involved in the interaction with several host proteins, thereby disrupting vital cellular functions, such as cell adhesion, cell cycle, intracellular signal transduction, and cytoskeletal structure...
October 17, 2018: Journal of Biomolecular Structure & Dynamics
Nidhi Chauhan, Alfred Chin Yen Tay, Barry J Marshall, Utkarsh Jain
BACKGROUND: Helicobacter pylori, gastric cancer-causing bacteria, survive in their gastric environment of more than 50% of the world population. The presence of H. pylori in the gastric vicinity promotes the development of various diseases including peptic ulcer and gastric carcinoma. H. pylori produce and secret Vacuolating cytotoxin A (VacA), a major toxin facilitating the bacteria against the host defense system. The toxin causes multiple effects in epithelial cells and immune cells, especially T cells, B cells, and Macrophages...
October 16, 2018: Helicobacter
Liping Liu, Yongxun Zhao, Guangrui Fan, Tiankui Shuai, Bin Li, Yumin Li
Helicobacter pylori (H. pylori) infection is the most important factor in the development of gastric cancer. Heparanase (HPA) is involved in tissue remodelling and cell migration, which leads to inflammation and tumour metastasis. The current study aimed was to explore whether a H. pylori infection leads to an increase in the level of HPA in gastric cancer and to investigate the specific mechanism underlying this association. Reverse transcription‑polymerase chain reaction and western blotting were used to detect HPA mRNA and protein expression, respectively, in MKN‑45 cells infected by H...
October 15, 2018: Molecular Medicine Reports
Zahra Ayati, Mohammad Sadegh Amiri, Mahin Ramezani, Elahe Delshad, Amirhossein Sahebkar, Seyed Ahmad Emami
BACKGROUND: The fruit of genus Rosa, known as "rose hip", is frequently used in different traditional medicines. Rose hips have long been used to treat kidney stones, gastroenteric ailments, hypertension and respiratory problems such as bronchitis, cough and cold. AIM: This review focused on the ethnopharmacological uses of rose hip as well as phytochemical and pharmacological aspects. RESULTS: Ethno-medical uses of rose hip have been recorded in many countries since a long time...
October 10, 2018: Current Pharmaceutical Design
Yifei Li, Ran Xia, Bo Zhang, Chunsheng Li
Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. The autoimmune type is quite rare and affects people of all ethnicities. Globally, H. pylori infection is very common and is considered a class I carcinogen due to the large number of patients who subsequently develop gastric cancer...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Sandeep Kumar, Monisha Dhiman
Helicobacter pylori is a leading cause of gastric cancer worldwide, its type four secretary toxin CagA is cited to be primarily responsible for it. Other virulence factors such as urease, VacA, HopQ, BabA and SabA are responsible for bacterial survival in acidic environment, adherence and cellular damage but its molecular mechanism is not completely understood. A number of pathogens including bacteria, fungi and virus are involved in the regulation of cellular machinery of inflammasome. Inflammasomes are multimeric protein complexes formed after external stimuli such as PAMPs/DAMPs or salt crystals and activates cellular caspases causes inflammation via pro-inflammatory cytokines...
October 10, 2018: Microbial Pathogenesis
Kandasamy Saravanakumar, Suresh Mandava, Ramachandran Chellia, Elango Jeevithan, Ravi Shankar Babu Yelamanchi, Deepthi Mandava, Wu Wen-Hui, Jong Kook Lee, Deog-Hwan Oh, Kandasamy Kathiresan, Myeong-Hyeon Wang
The present study aimed to purify and identify the metabolites from T. atroviride using high-performance liquid chromatography (HPLC) and 1 H and 13 C nuclear magnetic resonance spectrometer (NMR) followed by analyzing their toxicological, antibacterial and anticancer properties. This work identified two metabolites - TM1 and TM2. TM1 was in two forms: (i) 1, 3-dione-5, 5-dimethylcyclohexane; and, (ii) 2-enone-3hydroxy -5,5-dimethylcylohex, while TM2 was 4H-1,3-dioxin-4-one-2,3,6-trimethyl. These metabolites did not exhibit any irritant or allergic reaction as revealed by HET- CAM test...
October 10, 2018: Microbial Pathogenesis
Zeyang Wang, Zhi Lv, Hanxi Ding, Qian Xu, Liping Sun, Jingjing Jing, Yuan Yuan
The study aimed to investigate the role of serum EBV-VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV-VCA IgG serologic testing using enzyme-linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV-VCA IgG was significantly associated with GC and its precursor, conferring a 1.55- and 1.36-fold increased risk of GC and AG, respectively (P = 0...
October 10, 2018: Cancer Medicine
Chang Yong Yun, Nayoung Kim, Jaebong Lee, Ju Yup Lee, Young Jae Hwang, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The operative link on gastric atrophy (OLGA) and operative link on gastric intestinal metaplasia (OLGIM) stages have been suggested for risk estimation of gastric cancer (GC). However, usefulness of OLGA/OLGIM systems in diffuse type of GC was not investigated so far. The aims of this study were to evaluate the OLGA/OLGIM systems in estimating the GC risk according to Lauren's classification and to investigate the interaction among the risk factors. MATERIALS AND METHODS: The OLGA/OLGIM stages were evaluated in 1398 (765 control and 633 GC patients) who were prospectively enrolled in the Seoul National University Bundang Hospital...
October 10, 2018: Helicobacter
Simbarashe Gift Mungazi, Onesai Blessing Chihaka, Godfrey I Muguti
Background: Helicobacter pylori infection is present in more than 50% of the world's population. The estimated life time risk of peptic ulcer disease is 20 percent and of gastric cancer is 1-2 percent. Materials and methods: A cross sectional study was done at two Central hospitals in Harare, Zimbabwe, with the objective being to estimate the prevalence of Helicobacter pylori infection in asymptomatic individuals. Other objectives were to determine the association of the Helicobacter pylori infection with potential risk factors...
November 2018: Annals of Medicine and Surgery
Taweesak Tongtawee, Theeraya Simawaranon, Wareeporn Wattanawongdon, Chavaboon Dechsukhum, Wilairat Leeanansaksiri
BACKGROUND/AIMS: Genetic polymorphisms in Toll-like receptors (TLRs) are important influence on gastric lesion development and Helicobacter pylori susceptibility. MATERIALS AND METHODS: TLR2 rs3804099 and rs3804100 and TLR4 rs10759932 were determined in a total of 400 patients. The association among genotypes and the risk of gastric lesion development and H. pylori susceptibility were evaluated by the odds ratios (ORs) and 95% confidence intervals (95% CIs) from logistic regression analyses...
October 9, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Julia Butt, Matthew G Varga, William J Blot, Lauren Teras, Kala Visvanathan, Loïc Le Marchand, Christopher Haiman, Yu Chen, Ying Bao, Howard D Sesso, Sylvia Wassertheil-Smoller, Gloria Y F Ho, Lesley E Tinker, Richard M Peek, John D Potter, Timothy L Cover, Laura H Hendrix, Li-Ching Huang, Terry Hyslop, Caroline Um, Francine Grodstein, Mingyang Song, Anne Zeleniuch-Jacquotte, Sonja Berndt, Allan Hildesheim, Tim Waterboer, Michael Pawlita, Meira Epplein
BACKGROUND & AIMS: Previous studies reported an association of the bacteria Helicobacter pylori, the primary cause of gastric cancer, and risk of colorectal cancer (CRC). However, these findings have been inconsistent, appear to vary with population characteristics, and may be specific for virulence factor VacA. To more thoroughly evaluate the potential association of H pylori antibodies with CRC risk, we assembled a large consortium of cohorts representing diverse populations in the United States...
October 5, 2018: Gastroenterology
José B Sáenz, Nancy Vargas, Jason C Mills
BACKGROUND AND AIMS: In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relationship between H pylori and these metaplastic changes is unclear. We investigated whether H pylori localizes to regions of SPEM. METHODS: We developed an in situ adherence assay in which we incubated H pylori with free-floating tissue sections from the gastric corpora of mice; we assessed H pylori distribution along the gastric unit by immunofluorescence...
October 1, 2018: Gastroenterology
Chizu Tanikawa, Yoichiro Kamatani, Osamu Toyoshima, Hiromi Sakamoto, Hidemi Ito, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Nobuo Fuse, Takako Takai-Igarashi, Atsushi Shimizu, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Mariko Naito, Asahi Hishida, Kenji Wakai, Norihiro Furusyo, Yoshinori Murakami, Yusuke Nakamura, Issei Imoto, Johji Inazawa, Isao Oze, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Hiroshi Hirose, Teruhiko Yoshida, Keitaro Matsuo, Kubo Michiaki, Koichi Matsuda
Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, here, we performed a large-scale GWAS using 6,171 cases and 27,178 controls followed by three replication analyses. The analysis using a total of 11,507 cases and 38,904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3...
October 3, 2018: Cancer Science
Madhawa Neranjan Gunathilake, Jeonghee Lee, Aelee Jang, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Although physical activity (PA) is beneficial for prolonging lifespan, evidence for the protective role of PA against the development of gastric cancer (GC) is not yet well established. This study assessed the association between PA and GC risk in patients with and without Helicobacter pylori (H. pylori) infection in a Korean population. In total, 415 GC patients and 830 controls were enrolled at the National Cancer Center, Korea. The International Physical Activity Questionnaire-Short Form was used to collect PA data...
October 2, 2018: Cancers
Alice Blosse, Philippe Lehours, Keith T Wilson, Alain P Gobert
Helicobacter pylori infection induces a chronic gastric inflammation which can lead to gastric ulcers and cancer. The mucosal immune response to H. pylori is first initiated by the activation of gastric epithelial cells that respond to numerous bacterial factors, such as the cytotoxin-associated gene A or the lipopolysaccharide intermediate heptose-1,7-bisphosphate. The response of these cells is orchestrated by different receptors including the intracellular nucleotide-binding oligomerization domain-containing protein 1 or the extracellular epidermal growth factor receptor...
September 2018: Helicobacter
Ana Ferro, Samantha Morais, Claudio Pelucchi, Nuria Aragonés, Manolis Kogevinas, Lizbeth López-Carrillo, Reza Malekzadeh, Shoichiro Tsugane, Gerson S Hamada, Akihisa Hidaka, Raúl U Hernández-Ramírez, Malaquias López-Cervantes, David Zaridze, Dmitry Maximovitch, Farhad Pourfarzi, Zuo-Feng Zhang, Guo-Pei Yu, Mohammadreza Pakseresht, Weimin Ye, Amelie Plymoth, Marcis Leja, Evita Gasenko, Mohammad H Derakhshan, Eva Negri, Carlo La Vecchia, Bárbara Peleteiro, Nuno Lunet
Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case-control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis...
September 27, 2018: European Journal of Cancer Prevention
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