Matthieu Legrand, Benedetta De Berardinis, Hanna K Gaggin, Laura Magrini, Arianna Belcher, Benedetta Zancla, Alexandra Femia, Mandy Simon, Shweta Motiwala, Rasika Sambhare, Salvatore Di Somma, Alexandre Mebazaa, Vishal S Vaidya, James L Januzzi
OBJECTIVE: The objective of the study was to assess urinary biomarkers of renal injury for their individual or collective ability to predict Worsening renal function (WRF) in patients with acutely decompensated heart failure (ADHF). METHODS: In a prospective, blinded international study, 87 emergency department (ED) patients with ADHF were evaluated with biomarkers of cardiac stretch (B type natriuretic peptide [BNP] and its amino terminal equivalent [NT-proBNP], ST2), biomarkers of renal function (creatinine, estimated glomerular filtration rate [eGFR]) and biomarkers of renal injury (plasma neutrophil gelatinase associated lipocalin [pNGAL], urine kidney injury molecule-1 [KIM-1], urine N-acetyl-beta-D-glucosaminidase [NAG], urine Cystatin C, urine fibrinogen)...
2014: PloS One