keyword
MENU ▼
Read by QxMD icon Read
search

Pregnant colonization

keyword
https://www.readbyqxmd.com/read/29117332/estimates-of-the-burden-of-group-b-streptococcal-disease-worldwide-for-pregnant-women-stillbirths-and-children
#1
Anna C Seale, Fiorella Bianchi-Jassir, Neal J Russell, Maya Kohli-Lynch, Cally J Tann, Jenny Hall, Lola Madrid, Hannah Blencowe, Simon Cousens, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie J Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Joy E Lawn
Background: We aimed to provide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal infection/stillbirth, and infants. Intrapartum antibiotic prophylaxis is the current mainstay of prevention, reducing early-onset infant disease in high-income contexts. Maternal GBS vaccines are in development. Methods: For 2015 live births, we used a compartmental model to estimate (1) exposure to maternal GBS colonization, (2) cases of infant invasive GBS disease, (3) deaths, and (4) disabilities...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117327/maternal-colonization-with-group-b-streptococcus-and-serotype-distribution-worldwide-systematic-review-and-meta-analyses
#2
Neal J Russell, Anna C Seale, Megan O'Driscoll, Catherine O'Sullivan, Fiorella Bianchi-Jassir, Juan Gonzalez-Guarin, Joy E Lawn, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Samir K Saha, Margaret Ip
Background: Maternal rectovaginal colonization with group B Streptococcus (GBS) is the most common pathway for GBS disease in mother, fetus, and newborn. This article, the second in a series estimating the burden of GBS, aims to determine the prevalence and serotype distribution of GBS colonizing pregnant women worldwide. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus), organized Chinese language searches, and sought unpublished data from investigator groups...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117325/risk-of-early-onset-neonatal-group-b-streptococcal-disease-with-maternal-colonization-worldwide-systematic-review-and-meta-analyses
#3
Neal J Russell, Anna C Seale, Catherine O'Sullivan, Kirsty Le Doare, Paul T Heath, Joy E Lawn, Linda Bartlett, Clare Cutland, Michael Gravett, Margaret Ip, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Carol J Baker
Background: Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0-6) born to pregnant women who are rectovaginally colonized with group B Streptococcus (GBS), but the risk of EOGBS from vertical transmission has not been systematically reviewed. This article, the seventh in a series on the burden of GBS disease, aims to estimate this risk and how it varies with coverage of intrapartum antibiotic prophylaxis (IAP), used to reduce the incidence of EOGBS. Methods: We conducted systematic reviews (Pubmed/Medline, Embase, Latin American and Caribbean Health Sciences Literature (LILACS), World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups on maternal GBS colonization and neonatal outcomes...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117323/group-b-streptococcal-disease-worldwide-for-pregnant-women-stillbirths-and-children-why-what-and-how-to-undertake-estimates
#4
Joy E Lawn, Fiorella Bianchi-Jassir, Neal J Russell, Maya Kohli-Lynch, Cally J Tann, Jennifer Hall, Lola Madrid, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Anna C Seale
Improving maternal, newborn, and child health is central to Sustainable Development Goal targets for 2030, requiring acceleration especially to prevent 5.6 million deaths around the time of birth. Infections contribute to this burden, but etiological data are limited. Group B Streptococcus (GBS) is an important perinatal pathogen, although previously focus has been primarily on liveborn children, especially early-onset disease. In this first of an 11-article supplement, we discuss the following: (1) Why estimate the worldwide burden of GBS disease? (2) What outcomes of GBS in pregnancy should be included? (3) What data and epidemiological parameters are required? (4) What methods and models can be used to transparently estimate this burden of GBS? (5) What are the challenges with available data? and (6) How can estimates address data gaps to better inform GBS interventions including maternal immunization? We review all available GBS data worldwide, including maternal GBS colonization, risk of neonatal disease (with/without intrapartum antibiotic prophylaxis), maternal GBS disease, neonatal/infant GBS disease, and subsequent impairment, plus GBS-associated stillbirth, preterm birth, and neonatal encephalopathy...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29104563/promotion-of-early-gut-colonization-by-probiotic-intervention-on-microbiota-diversity-in-pregnant-sows
#5
Katarina Veljović, Miroslav Dinić, Jovanka Lukić, Sanja Mihajlović, Maja Tolinački, Milica Živković, Jelena Begović, Igor Mrvaljević, Nataša Golić, Amarela Terzić-Vidojević
The aim of this work was to design a novel mixed probiotic culture for piglets and to evaluate its beneficial effect on the piglets' gut health. The possible mechanisms of probiotic activity, such as adhesion, competitive pathogen exclusion and influence on gut microbiota diversity were determined. Mixed probiotic starter culture is composed of three thermophilic lactic acid bacteria (LAB) strains: Lactobacillus helveticus BGRA43, Lactobacillus fermentum BGHI14 and Streptococcus thermophilus BGVLJ1-44. The strains BGVLJ1-44 and BGRA43 showed good technological properties (fast milk curdling, strong proteolytic activity)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29082442/intrapartum-group-b-streptococcus-screening-in-the-labor-ward-by-xpert%C3%A2-gbs-real-time-pcr
#6
C Plainvert, F El Alaoui, A Tazi, C Joubrel, O Anselem, M Ballon, A Frigo, C Branger, L Mandelbrot, F Goffinet, C Poyart
Group B Streptococcus (GBS) is the leading cause of neonatal infections in industrialized countries. Intrapartum antibiotic prophylaxis (IAP) given to colonized parturients is a key step for the prevention of neonatal early-onset infection. We compared the performances of Xpert® GBS polymerase chain reaction (PCR) (Cepheid, Sunnyvale, CA, USA) as a point-of-care system in labor wards to standard culture for intrapartum GBS detection. Pregnant women with a GBS-positive antenatal screening were prospectively included...
October 29, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29046297/renal-and-colonic-potassium-transporters-in-the-pregnant-rat
#7
Crystal A West, Paul A Welling, David A West, Richard A Coleman, Kit-Yan Cheng, Chao Chen, Thomas D DuBose, Jill W Verlander, Chris Baylis, Michelle L Gumz
Gestational potassium retention, most of which occurs during late pregnancy, is essential for fetal development. The purpose of this study was to examine mechanisms underlying changes in potassium handling by the kidney and colon in pregnancy. We found that potassium intake and renal excretion increased in late pregnancy while fecal potassium excretion remained unchanged and that pregnant rats exhibited net potassium retention. By qPCR we found markedly increased H+/K+-ATPase type2 (HKA2) mRNA expression in cortex and OM of late pregnant vs virgin...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29037552/the-impact-of-prenatal-group-b-streptococcus-screening-as-a-national-health-policy-in-taiwan
#8
Fung-Wei Chang, Chun-I Lee, Hueng-Chuen Fan, Her-Young Su, Yung-Liang Liu, Cheng-Yu Chen
OBJECTIVE: There was no national data on group B streptococcus (GBS) infections in Taiwan. Until 2012, when prenatal GBS screening was introduced to obstetric practices as a national health policy aimed at reducing neonatal GBS infections. The purpose of this study was to examine the impact of this national health policy on the incidence of maternal GBS colonization and neonatal GBS infection rate. Relatedly, the clinical characteristics of neonatal GBS infection were investigated to determine the correlations between the incidence of maternal GBS colonization and the neonatal GBS infection rate...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29029763/serotype-virulence-profile-antimicrobial-resistance-and-macrolide-resistance-determinants-in-streptococcus-agalactiae-isolates-in-pregnant-women-and-neonates-in-catalonia-spain
#9
Yuly López, Elena Parra, Virginio Cepas, Isabel Sanfeliú, Teresa Juncosa, Antonia Andreu, Mariona Xercavins, Josefa Pérez, Sergi Sanz, Andrea Vergara, Jordi Bosch, Sara Maria Soto
INTRODUCTION: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed...
October 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29028813/evaluation-of-shedding-tissue-burdens-and-humoral-immune-response-in-goats-after-experimental-challenge-with-the-virulent-brucella-melitensis-strain-16m-and-the-reduced-virulence-vaccine-strain-rev-1
#10
Jennifer L Higgins, Mercedes Gonzalez-Juarrero, Richard A Bowen
Brucella melitensis is the causative agent of brucellosis in small ruminants and is of considerable economic and public health importance in many countries worldwide. The control of disease in humans depends on the control of disease in livestock; however, few counties with endemic B. melitensis infection have been able to successfully eradicate this pathogen. This underscores the need for further research on the pathogenesis of both virulent and vaccine strains of B. melitensis in the small ruminant host. The aim of the present study was to characterize clinical effects, tissue colonization, shedding, and humoral immune response following B...
2017: PloS One
https://www.readbyqxmd.com/read/29023541/improved-influenza-viral-vector-based-brucella-abortus-vaccine-induces-robust-b-and-t-cell-responses-and-protection-against-brucella-melitensis-infection-in-pregnant-sheep-and-goats
#11
Aigerim Mailybayeva, Bolat Yespembetov, Sholpan Ryskeldinova, Nadezhda Zinina, Abylai Sansyzbay, Gourapura J Renukaradhya, Nikolai Petrovsky, Kaissar Tabynov
We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella Omp16 and L7/L12 proteins (Flu-BA). Our success in the Flu-BA vaccine trial in cattle and results of a pilot study in non-pregnant small ruminants prompted us in the current study to test its efficacy against B. melitensis infection in pregnant sheep and goats. In this study, we improved the Flu-BA vaccine formulation and immunization method to achieve maximum efficacy and safety...
2017: PloS One
https://www.readbyqxmd.com/read/28954525/clinical-relevance-of-gastrointestinal-microbiota-during-pregnancy-a-primer-for-nurses
#12
Seon-Yoon Chung, Jacques Ravel, Mary Regan
Emerging evidence about the human microbiome, a collective term for all the microorganisms living in and on the human body, consistently demonstrates the critical influence it has on host physiology and disease risk. The microbiota in the gastrointestinal (GI) tract has the most significant and far-reaching effect on human physiology. The maternal GI microbiota can decrease the risk of adverse pregnancy outcomes by modulating energy extraction, glucose metabolism, vitamin production, and host immunity essential for optimal maternal and neonatal health...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28951085/cost-effectiveness-of-a-potential-group-b-streptococcal-vaccine-for-pregnant-women-in-the-united-states
#13
Sun-Young Kim, Chi Nguyen, Louise B Russell, Sara Tomczyk, Fatimah Abdul-Hakeem, Stephanie J Schrag, Jennifer R Verani, Anushua Sinha
BACKGROUND: In the U.S., intrapartum antibiotic prophylaxis (IAP) for pregnant women colonized with group B streptococcus (GBS) has reduced GBS disease in the first week of life (early-onset/EOGBS). Nonetheless, GBS remains a leading cause of neonatal sepsis, including 1000 late-onset (LOGBS) cases annually. A maternal vaccine under development could prevent EOGBS and LOGBS. METHODS: Using a decision-analytic model, we compared the public health impact, costs, and cost-effectiveness of five strategies to prevent GBS disease in infants: (1) no prevention; (2) currently recommended screening/IAP; (3) maternal GBS immunization; (4) maternal immunization with IAP when indicated for unimmunized women; (5) maternal immunization plus screening/IAP for all women...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28939305/prevalence-of-vulvovaginal-candidiasis-in-pregnancy-at-three-health-centers-in-burkina-faso
#14
I Sangaré, C Sirima, S Bamba, A Zida, M Cissé, W W Bazié, S Sanou, B Dao, H Menan, R T Guiguemdé
INTRODUCTION: Pregnant women are more susceptible to vaginal colonization and infection by yeast. The role of Candida colonization in the occurrence of preterm birth is well established. The knowledge of local epidemiology and identification of risk factors for preterm birth is important for the prevention and management strategies. The purpose of the study was to determine the prevalence of Candida sp. in vaginal swabs of pregnant women. METHODS: Pregnant women attending routine antenatal visits in three primary health centres in Bobo-Dioulasso (Burkina Faso) were enrolled into a cross-sectional study carried out from February to April 2015...
September 20, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28936424/acid-stress-response-mechanisms-of-group-b-streptococci
#15
REVIEW
Sarah Shabayek, Barbara Spellerberg
Group B streptococcus (GBS) is a leading cause of neonatal mortality and morbidity in the United States and Europe. It is part of the vaginal microbiota in up to 30% of pregnant women and can be passed on to the newborn through perinatal transmission. GBS has the ability to survive in multiple different host niches. The pathophysiology of this bacterium reveals an outstanding ability to withstand varying pH fluctuations of the surrounding environments inside the human host. GBS host pathogen interations include colonization of the acidic vaginal mucosa, invasion of the neutral human blood or amniotic fluid, breaching of the blood brain barrier as well as survival within the acidic phagolysosomal compartment of macrophages...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28934751/first-trimester-vaginal-ureaplasma-biovar-colonization-and-preterm-birth-results-of-a-prospective-multicenter-study
#16
Judith Rittenschober-Böhm, Thomas Waldhoer, Stefan M Schulz, Birgit Stihsen, Birgit Pimpel, Katharina Goeral, Erich Hafner, Gerhard Sliutz, David C Kasper, Armin Witt, Angelika Berger
BACKGROUND: While there is a proven association of upper genital tract Ureaplasma infection during pregnancy with adverse pregnancy outcome, the effect of vaginal Ureaplasma colonization on preterm delivery has been controversially debated. OBJECTIVES: We hypothesized that women with isolation of vaginal U. parvum but not U. urealyticum are at increased risk for spontaneous preterm birth (SPB) compared to women with negative results. METHODS: A vaginal swab taken between 12 and 14 weeks of gestation was analyzed for the presence of Ureaplasma biovars by PCR in 4,330 pregnant women...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28934088/accuracy-of-a-rapid-intrapartum-group%C3%A2-b-streptococcus-test-a-new-immunochromatographic-assay
#17
A Delabaere, S Curinier, S Ughetto, L Gibold, R Bonnet, A Rossi, D Gallot
OBJECTIVES: To decrease the incidence of early-onset group B streptococcal (GBS) disease, a culture-based screening of all pregnant women at 35-37 weeks is recommended. This gold standard test requires 24-72hours culture. This delay precludes its use for intrapartum screening. This study assesses a new immunoassay, the DIMA test, for identifying GBS-positive patients in the labor ward. MATERIALS AND METHODS: This was a prospective observational study of 195 pregnant women presenting with full-term labor at a single site in France between June and August 2012...
May 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/28919196/inca-c-plasmids-conferring-high-azithromycin-resistance-in-vibrio-cholera
#18
Ruibai Wang, Haican Liu, Xiuqin Zhao, Jie Li, Kanglin Wan
Azithromycin (AZM) is a clinically important antibiotic to Vibrio cholerae especially for inhibiting colonization of V. cholerae in intestine and the treatment of severe cholera in children and pregnant women. One IncA/C plasmid was isolated from both of the high MIC AZM resistant V cholerae strains of the two mainly pathogenic serogroups, O1 and O139. In the 172 predicted ORFs, 16 genes were related to antibiotic resistance in which 5 were well-defined genes associated with macrolide resistance. The 5 macrolide resistant genes disturbed in two clusters, mphR-mrx-mph(K) and mel-mph2, flanking by insertion sequence (IS) and involving two kinds of mechanisms...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28915910/colonization-of-the-bovine-uterus-by-candida-kefyr
#19
Cecilia Christensen Karstrup, Bent Aalbæk, Kirstine Klitgaard, Tim Kåre Jensen, Hanne Gervi Pedersen, Jørgen Steen Agerholm
BACKGROUND: While fungal infections of the bovine uterus are well-known diseases in pregnant cattle, very limited knowledge exists on the presence and significance of fungi in the uterus of non-pregnant cows. Presence of fungi in the uterine lumen of postpartum (pp) cows has been reported, but little attention has been paid to this as most studies of the bovine pp uterus have focused on bacteria. CASE PRESENTATION: Microscopy of uterine lavage cytology slides of three cows from one herd revealed the presence of numerous yeast-like organisms, which were located either free in the fluid or within macrophages...
September 16, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28913714/high-transient-colonization-by-pneumocystis-jirovecii-between-mothers-and-newborn
#20
Cristian Vera, Yudy A Aguilar, Lázaro A Vélez, Zulma Vanessa Rueda
The aim of the study was to explore the frequency and dynamics of acquisition and colonization of Pneumocystis jirovecii among neonates, as well as the epidemiological and genotypic characteristics in mother-child binomial. In a prospective enrolled cohort of women in their third trimester of pregnancy, nasopharyngeal swabs (NPS) and clinical and epidemiological data were collected at four different times: 17 days, 2nd, 4th, and 6th month of life of the newborn. P. jirovecii was detected by nested-PCR for the mtLSU-rRNA gene in each NPS; the genotypes were determined amplifying four genes...
December 2017: European Journal of Pediatrics
keyword
keyword
16275
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"