Jooyoung Kim, Yifan Yuan, Karen Agaronyan, Amy Zhao, Victoria D Wang, Gayatri Gupta, Heran Essayas, Ayelet Kaminski, John McGovern, Sheeline Yu, Samuel Woo, Chris J Lee, Tayebeh Saleh, Buqu Hu, Ying Sun, Genta Ishikawa, William Bain, John Evankovich, Erica L Herzog, Charles S Dela Cruz, Changwan Ryu, Lokesh Sharma
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood. In this study, we utilized mice that are deficient in toll-like receptor-9 (TLR9), which binds to unmethylated CpG DNA sequences such as those present in bacterial and mitochondrial DNA...
March 6, 2024: bioRxiv