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Antibiotic allergy

Isil Eser Simsek, Mujde Tuba Cogurlu, Metin Aydogan
BACKGROUND: Most children diagnosed with β-lactam allergy based only on history are not truly allergic, and mislabeling leads to use of less effective and more costly alternative broader-spectrum antibiotics, significantly increasing drug resistance. OBJECTIVE: To determine the frequency and risk factors of confirmed allergy in patients with β-lactam allergy reported by parents or their doctors and evaluate cross-reactivity between β-lactams in children with confirmed allergy...
December 5, 2018: International Archives of Allergy and Immunology
Paolo Cotogni, Cristina Barbero, Mauro Rinaldi
AIM: To investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery. METHODS: In this prospective study, patients undergoing cardiac surgery received a single dose of 1000 mg of vancomycin. Multiple arterial samples were drawn during surgery. Exclusion criteria were hepatic dysfunction; renal dysfunction; ongoing infectious diseases; solid or hematologic tumors; severe insulin-dependent diabetes; body mass index of < 17 or > 40 kg/m2 ; pregnancy or lactation; antibiotic, corticosteroid, or other immunosuppressive therapy; vancomycin or nonsteroidal anti-inflammatory drug therapy in the previous 2 wk; chemotherapy or radiation therapy in the previous 6 mo; allergy to vancomycin or cefazolin; drug abuse; cardiac surgery in the previous 6 mo; previous or scheduled organ transplantation; preoperative stay in the intensive care unit for more than 24 h; emergency procedure or lack of adequate preparation for surgery; and participation in another trial...
November 26, 2018: World Journal of Cardiology
Marlene Richter Jensen, Elisabeth Arndal, Christian Von Buchwald
The aim of this review is to evaluate current guidelines for diagnosis, treatment and follow-up of patients with chronic rhinosinusitis. We discuss: 1) diagnostic criteria, 2) the use of supplementary tools like visual analogue scale, Sino-Nasal Outcome Test and Sniffin' Sticks, 3) the use of tests like allergy, serum IgE and biopsy and 4) comorbidity in relation to the unified airways concept. Furthermore, we evaluate: 1) initial treatment with topical steroids and nasal irrigation, 2) additional treatment options including surgery, systemic steroids and antibiotics and 3) treatment risks...
November 19, 2018: Ugeskrift for Laeger
Richard J Silverwood, Charlotte E Rutter, Edwin A Mitchell, M Innes Asher, Luis Garcia Marcos, David P Strachan, Neil Pearce
BACKGROUND: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors for asthma symptoms in combination, at both the individual and the school level, to explore the potential role of reverse causation due to selective avoidance or confounding by indication. OBJECTIVE: To explore the role of reverse causation in risk factors of asthma symptoms...
December 3, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Minghui Li, Kevin Lu, David J Amrol, Joshua R Mann, James W Hardin, Jing Yuan, Christina L Cox, Bryan L Love
BACKGROUND: Food allergy is a significant public health concern in the United States, especially in the pediatric population. It places substantial clinical and economic burdens on the healthcare system. Exposure to antibiotics in early childhood is thought to increase the risk of subsequent food allergy. OBJECTIVE: The objective of the study was to examine the impact of exposure to antibiotics early in life on time to development of food allergy. METHODS: We conducted a population-based matched cohort study using Medicaid data from 28 states...
November 20, 2018: Journal of Allergy and Clinical Immunology in Practice
Keith A Sacco, Benjamin P Cochran, Kevin Epps, Mark Parkulo, Alexei Gonzalez-Estrada
BACKGROUND: Penicillin allergy is the most commonly reported drug allergy in hospitalized patients, resulting in increased second-line antibiotic use, nosocomial infections, and healthcare utilization. Given that the vast majority of patients are not truly allergic, a safe strategy that empowers the admitting physician is needed. OBJECTIVE: To assess the impact on antibiotic prescribing practices for hospitalized patients with penicillin allergy using a validated intervention...
November 19, 2018: Annals of Allergy, Asthma & Immunology
Michael Hogan, Mary Barna Bridgeman, Gee Hee Min, Deepali Dixit, Patrick J Bridgeman, Navaneeth Narayanan
Purpose: To evaluate the use of aztreonam as an active empiric therapy against subsequent culture of Pseudomonas aeruginosa (P. aeruginosa) . Methods: This was a retrospective cohort study conducted among patients who received either aztreonam or an antipseudomonal beta-lactam (BL) as an empiric therapy with subsequent culture with P. aeruginosa . All patients with at least one positive culture for P. aeruginosa between January 2014 and August 2016 were included in this analysis...
2018: Infection and Drug Resistance
Christopher Martin Sauer, David Sasson, Kenneth E Paik, Ned McCague, Leo Anthony Celi, Iván Sánchez Fernández, Ben M W Illigens
BACKGROUND: Tuberculosis is a major cause of morbidity and mortality in the developing world. Drug resistance, which is predicted to rise in many countries worldwide, threatens tuberculosis treatment and control. OBJECTIVE: To identify features associated with treatment failure and to predict which patients are at highest risk of treatment failure. METHODS: On a multi-country dataset managed by the National Institute of Allergy and Infectious Diseases we applied various machine learning techniques to identify factors statistically associated with treatment failure and to predict treatment failure based on baseline demographic and clinical characteristics alone...
2018: PloS One
M M Li, L Q Guo, S S Li, Q Zhang, D D Zhao, B Y Zhang, S N Dang, H Yan
Objective: To analyze the relationship between medication taken during pregnancy and congenital heart disease of the newborns. Methods: A large cross-sectional survey was conducted between August and November 2013. A questionnaire survey was conducted among the childbearing aged women, selected through multistage stratified random sampling in Shaanxi from 2010 to 2013. All of the childbearing aged women under study were in pregnancy and with definite pregnancy outcomes. Multivariable Poisson regression was conducted for data analyses...
October 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Oscar Salomó-Coll, Naroa Lozano-Carrascal, Aida Lázaro-Abdulkarim, Federico Hernández-Alfaro, Jordi Gargallo-Albiol, Marta Satorres-Nieto
PURPOSE: The aim of this clinical study was to determinate if patients allergic to penicillin present a higher incidence of dental implant failure compared with nonallergic patients. MATERIALS AND METHODS: This cross-sectional clinical study analyzed patients rehabilitated with endosseous dental implants between September 2011 and July 2015, at the University Dental Clinic, School of Dentistry, International University of Catalonia (UIC). Prophylactic antibiotic therapy was prescribed for all patients: a single dose of 2 g of amoxicillin taken orally 1 hour before implant surgery for non-penicillin-allergic patients, and 600 mg of clindamycin taken orally 1 hour before the implant surgery for penicillin-allergic patients...
November 2018: International Journal of Oral & Maxillofacial Implants
Hicham Mansour, Mireille Feghali, Nadine Saleh, Mona Zeitouny
Objectives: Explore antibiotic use, assess conformity with evidence-practice guidelines, and describe knowledge and attitudinal factors among Lebanese dentists. Methods: National cross-sectional telephonic survey, using a standardized questionnaire addressing demographic, educational and professional data, usual antibiotics prophylactic and curative prescription pattern and influential factors, knowledge concerning antibiotics use in selected patient-populations, and attitude regarding antimicrobial resistance...
July 2018: Pharmacy Practice
Rozlyn C T Boutin, Zach Dwyer, Kyle Farmer, Chris Rudyk, Mark R Forbes, Shawn Hayley
Background: Accumulating evidence suggests that the gut microbiota shapes developmental processes within the immune system. Early life antibiotic use is one factor which may contribute to immune dysfunction and the recent surge in allergies by virtue of its effects on gut microbiota. Objective and methods: As a first step towards determining whether a relationship exists between perinatal antibiotic induced changes in the gut microbiota and the later development of a peanut allergy, we exposed newborn mice to either the broad-spectrum antibiotic vancomycin or to a vehicle for 6 weeks and then used a novel murine model of peanut allergy...
2018: Allergy, Asthma, and Clinical Immunology
A C Prins-van Ginkel, P C J Bruijning-Verhagen, A H Wijga, M L Bots, U Gehring, W van der Hoek, G H Koppelman, L van Rossem, C S P M Uiterwaal, H A Smit, M A B van der Sande
Atherosclerotic changes can be measured as changes in common carotid intima media thickness (CIMT). It is hypothesised that repeated infection-associated inflammatory responses in childhood contribute to the atherosclerotic process. We set out to determine whether the frequency of infectious diseases in childhood is associated with CIMT in adolescence. The study is part of the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) population-based birth cohort. At age 16 years, common CIMT was measured...
November 8, 2018: Epidemiology and Infection
Clifford A Reilly, Grant Backer, Danielle Basta, Natalie B V Riblet, Pamela M Hofley, Megan C Gallagher
Background: The majority of patients for elective surgery and with a history of penicillin allergy are placed on alternative prophylactic antibiotic therapies, which have been associated with the emergence of multidrug-resistant pathogens and increased morbidity and mortality rates. However, self-reporting of penicillin allergy alone may overestimate the prevalence of penicillin allergy in the population. Objective: To assess the effects of preoperative antibiotic allergy testing protocols in reducing the use of non-beta-lactam antibiotics...
November 1, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
International consensus on the treatment of pediatric otitis media with effusion and current status of treatment in China Summary Otitis media with effusion (OME) is a non-suppurative inflammatory disease of the middle ear characterized by middle ear effusion and hearing loss, which is common in children.The main impact of OME in children is hearing loss and cooccurring recurrent acute otitis media, which would affect speech language development. Thus OME should be highly vigilant and prompt treatment is necessary...
November 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Ainslie Lavers, Wai Siong Yip, Bruce Sunderland, Richard Parsons, Sarah Mackenzie, Jason Seet, Petra Czarniak
Background: Surgical site infections (SSIs) are a common complication following breast surgery procedures, despite being considered a clean surgery. The prevalence of SSIs can be minimised with the appropriate use of antibiotic prophylaxis as outlined in the Australian Therapeutic Guidelines (eTG). The aims of this study were to evaluate adherence to the eTG for antibiotic prophylaxis in breast surgery procedures at a Western Australian teaching hospital following an update of the guidelines in 2014 and examine the impact of prophylactic antibiotics on SSI incidence and length of hospital stay...
2018: PeerJ
Iker Falces-Romero, Irene Hernández-Martín, Ana Fiandor, Alicia Rico-Nieto
No abstract text is available yet for this article.
October 22, 2018: Enfermedades Infecciosas y Microbiología Clínica
Anna Strzępa, Francis M Lobo, Monika Majewska-Szczepanik, Marian Szczepanik
The newborn infant emerges from an almost sterile environment into a world of bacteria. Bacteria colonize the infant's skin, lungs, and, of most importance, the gut. The process of bacterial colonization is coordinated, and each body niche acquires a unique composition of bacteria. In the gut, most bacteria belong to the Firmicutes and Bacteroidetes phyla, while Actinobacteria and Proteobacteria are far less abundant. Some of these bacteria possess strong immunoregulatory properties. Bacterial colonization is essential to skew the newborn's immune response away from the allergy-favoring Type-2 response towards a Type-1 immune response, which is essential for pathogen elimination...
December 2018: International Immunopharmacology
M Dinleyici, G K Yildirim, O Aydemir, T B Kaya, Y Bildirici, K B Carman
OBJECTIVE: It is important to identify undesirable toxins and metabolites present in human milk that may be passed on to nursing infants. Such residues may derive from the antibiotics that are widely used to treat infectious diseases in both humans and food-producing animals. To the best of our knowledge, there are no reports in the literature on human milk antibiotic residue levels. PATIENT AND METHODS: As a part of the Human Milk Artificial Pollutants (HUMAP) study, we aimed to evaluate human milk antibiotic residues among mothers with 7 to 90-day-old babies...
October 2018: European Review for Medical and Pharmacological Sciences
Sandra E Kurtin, Jean A Ridgeway, Sara Tinsley
CASE STUDY A male patient aged 67 years with a 2-year history of refractory anemia and myelodysplastic syndromes (MDS) with del(5q) started lenalidomide (Revlimid) treatment as a participant in the MDS-001 trial (List et al., 2005). At the time of the study, this patient had been transfusion-dependent since 2001, and at study entry he had received a total of 12 units of red blood cells (RBCs). The patient started lenalidomide at 25 mg daily for 21 days of each 28-day cycle on April 2, 2002. (Please note that as a result of subsequent trials, the approved starting dose for lenalidomide in patients with del[5q] MDS is 10 mg...
November 2017: Journal of the Advanced Practitioner in Oncology
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