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Antibiotic allergy

Sandra E Kurtin, Jean A Ridgeway, Sara Tinsley
CASE STUDY A male patient aged 67 years with a 2-year history of refractory anemia and myelodysplastic syndromes (MDS) with del(5q) started lenalidomide (Revlimid) treatment as a participant in the MDS-001 trial (List et al., 2005). At the time of the study, this patient had been transfusion-dependent since 2001, and at study entry he had received a total of 12 units of red blood cells (RBCs). The patient started lenalidomide at 25 mg daily for 21 days of each 28-day cycle on April 2, 2002. (Please note that as a result of subsequent trials, the approved starting dose for lenalidomide in patients with del[5q] MDS is 10 mg...
November 2017: Journal of the Advanced Practitioner in Oncology
Juan J Díaz, Beatriz Espín, Oscar Segarra, Gloria Domínguez-Ortega, Javier Blasco-Alonso, Beatriz Cano, Ana Rayo, Ana Moreno
OBJECTIVE: To describe clinical, epidemiological and management characteristics of food protein-induced enterocolitis syndrome (FPIES) cases in Spain. PATIENTS AND METHODS: Multicenter observational retrospective study. FPIES cases diagnosed in specialized units in Spain over 12 months in 2017 (January to December) according to the recently published international diagnostic criteria were included. RESULTS: One hundred and twenty patients (53...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
So-Yoon Jo, Chan-Ho Lee, Woo-Jin Jung, Sung-Won Kim, Yoon-Ha Hwang
Purpose: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. Methods: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemia were retrospectively reviewed. The patients' medical records, including family history, weight, symptoms, treatment, complications, and laboratory test results for allergies and skin cultures, were examined...
September 16, 2018: Korean Journal of Pediatrics
Shichun Huang, Zhenggang Zhu, Li Cai, Zerong Zhu, Man Zhang, Quan Hu, Yuan Fang
Severe adverse events (AEs) following post-exposure rabies vaccination had been occasionally described in previous studies. Once AEs occurred, immediate medical treatment and appropriate change of vaccine and vaccination schedule were of significance. It was also important and challengeable to determine the relationship among adverse reactions, vaccines residues and laboratory tests for patients, to choose a proper vaccine in resumed vaccination, to avoid the reoccurrence of AEs and to ensure adequate immune response...
October 9, 2018: Human Vaccines & Immunotherapeutics
Mara De Amici, Fiorella Barocci, Silvia Caimmi, Luigi Nespoli, Amelia Licari, Giuseppe Giuliani, Gianluigi Marseglia
The basophil activation is emerging as a reliable and robust in vitro biomarker of in vivo allergy reactions. Basophil Activation Test (BAT), intended as in vitro stimulation of patient blood basophil with allergens, followed by flow cytometric detection and quantification of such activation, is nowadays a well-established assay in a growing number of routine diagnostic labs. The advancements in the standardization of BAT testing and first convincing clinical evidence are behind this spreading of the assay in clinical lab...
October 4, 2018: Minerva Pediatrica
Laura Trolle Saust, Lars Bjerrum, Volkert Siersma, Magnus Arpi, Malene Plejdrup Hansen
OBJECTIVE: To investigate areas in need of quality improvement within the diagnostic process and antibiotic treatment of acute respiratory tract infections (RTIs) in Danish general practice by using quality indicators (QIs). DESIGN AND SETTING: During a 4-week period in winter 2017, a prospective registration of patients diagnosed with RTIs was conducted in general practice in two regions of Denmark. SUBJECTS: Throughout the registration period each patient with symptoms of an RTI was registered...
October 8, 2018: Scandinavian Journal of Primary Health Care
Eunah Cheon, Harold W Horowitz
It is well-appreciated that patients with documented penicillin allergies often receive broader-spectrum antibiotics. This practice has been associated with increased antimicrobial resistance and cost. In recent years, considerable efforts have been made to spread awareness on the implications of self-reported penicillin allergies. The use of penicillin skin testing to evaluate for true allergies has been strongly recommended by major organizations for decades. However, testing remains underutilized. Current literature has suggested various models incorporating penicillin allergy screening and testing by different health-care practitioners (i...
October 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
J Azevedo, Â Gaspar, I Mota, F Benito-Garcia, M Alves-Correia, M Chambel, M Morais-Almeida
INTRODUCTION: Beta-lactams are the most frequently used antibiotics in pediatric age. Anaphylactic reactions may occur and need to be properly studied, but studies in children are scarce. OBJECTIVE: Characterization of case reports of anaphylaxis in children referred to an allergy department with suspected beta-lactams hypersensitivity. MATERIALS AND METHODS: Retrospective analysis of all children referred to our Drug Allergy Center with suspected beta-lactams hypersensitivity between January 2011 and December 2016...
September 21, 2018: Allergologia et Immunopathologia
N Franklin Adkinson, Louis M Mendelson, Charlotte Ressler, John C Keogh
OBJECTIVE: To review the history of the penicillin minor determinants and evaluate their relevance for current diagnosis. DATA SOURCES: Skin testing to detect immunoglobulin E (IgE) sensitivity to penicillins in patients with a history of penicillin allergy has been the subject of more than 55 years of published research involving tens of thousands of patients. STUDY SELECTIONS: Selection of data was based on its relevance to the objective of this article...
September 21, 2018: Annals of Allergy, Asthma & Immunology
Maria J Torres, N Franklin Adkinson, Jean-Christoph Caubet, David A Khan, Mona I Kidon, Louis Mendelson, Eva Rebelo Gomes, Ticha Rerkpattanapipat, Shuchen Zhang, Eric Macy
Available online September 20, 2018. The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at
September 20, 2018: Journal of Allergy and Clinical Immunology in Practice
V Kvedariene, B Sitkauskiene, L Tamasauskiene, O Rudzeviciene, V Kasiulevicius, G Nekrosyte, E R Gomes, P Demoly
INTRODUCTION AND OBJECTIVES: Drug hypersensitivity reactions (DHRs) are the adverse effects of drugs that, when taken at doses generally tolerated by normal subjects, clinically resemble allergy. We aimed to assess the prevalence of self-reported DHRs among Lithuanian children and adults and to identify possible risk factors. MATERIALS AND METHODS: A cross-sectional survey of a population visiting their general practitioners in Vilnius and Kaunas regions of Lithuania was performed...
September 20, 2018: Allergologia et Immunopathologia
Maša Vidič, Igor Bartenjev
Among several skin fillers developed in recent decades, hyaluronic acid (HA) fillers have become the material of choice. They are safe, long-lasting, not immunogenic, and cost effective, and they can be removed with hyaluronidase. Unfortunately, early and delayed complications can also occur following HA filler injection. Here we report the case of a hyaluronic filler-related complication in a 50-year-old female patient. The locations affected were the forehead, glabella, and nose. Three days after HA filler application in the upper lip, glabellar region, and nasal root, with no immediate diverse reaction at the time of application, an erythematous, livedoid rash with a well-defined border occurred at the site of the injection in the glabellar region, including the area from the nasal root to the scalp and left upper eyelid...
September 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Michaela Lucas, Annabelle Arnold, Aine Sommerfield, Michelle Trevenen, Laure Braconnier, Alina Schilling, Fuad Abass, Lliana Slevin, Brittany Knezevic, Christopher Blyth, Kevin Murray, Britta von Ungern-Sternberg, Kristina Rueter
BACKGROUND: Self-reported antibiotic allergies are common among hospitalized adults and children. However, there is a paucity of studies investigating the impact of an antibiotic allergy label in childhood. OBJECTIVE: To investigate the impact of antibiotic allergy labeling on clinical outcomes in children. METHODS: A retrospective study was conducted in a major pediatric tertiary hospital to capture inpatient admissions (N = 1672) in April 2014 and April 2015...
September 19, 2018: Journal of Allergy and Clinical Immunology in Practice
Dana Duricova, Eva Dvorakova, Ondrej Hradsky, Katarina Mitrova, Marianna Durilova, Jana Kozeluhova, Pavel Kohout, Kristyna Zarubova, Jiri Bronsky, Nora Hradska, Eva Bronska, Miroslava Adamcova, Nadezda Machkova, Veronika Hruba, Martin Bortlik, Martin Lukas, Karin Malickova, Milan Lukas
Background: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero exposure to anti-TNF-alpha due to mothers' inflammatory bowel disease (IBD) on long-term postnatal development of exposed children. Methods: We included consecutive children (≥12 months of age) born to mothers with IBD (2007-2016) treated with anti-TNF-alpha during pregnancy in 3 centers in the Czech Republic...
September 20, 2018: Inflammatory Bowel Diseases
Jun He, Feng Ning, Lei Tu, Jianjun Hu, Weijian Chen, Yaowang Zhao
The aim of the present case report was to investigate the clinical features, pathological examination and treatment of eosinophilic cystitis (EC) in children. Two cases of EC were reported and reviewed from January 2016 to March 2017. Case 1 (male; 6 years old) had intermittent hematuria, frequent urination, urgent urination, difficulty in urination and abdominal pain. Case 2 (male; 7 years old) had frequent urination, urgent urination, urinary pain, dysuria and suprapubic pain with no hematuria. One patient had a history of allergies and both patients underwent a cystoscope biopsy...
October 2018: Experimental and Therapeutic Medicine
Ümit Doğan, Sümeyra Ağca
AIM: To analyze the possible risk factors in the development of seasonal allergic conjunctivitis (SAC) through an evaluation of skin allergy tests and data obtained from questionnaires. METHODS: The study included a total of 75 SAC patients and 71 control subjects without SAC diagnosis who were admitted to the Abant Izzet Baysal University Medical Faculty Ophthalmology Clinic between March 2016 and December 2016. Skin prick tests were performed for all participants...
2018: International Journal of Ophthalmology
Mohammad Khosravi, Fatemeh Boroun, Mohammad Nemati
BACKGROUND: The hypersensitivity reaction to penicillin is a public health problem. Immunological responses to penicillin and other beta-lactam antibiotics can be classified into immediate and non-immediate responses. The immediate hypersensitivity is mediated by IgE; however, the non-immediate sensitivity is facilitated by other isotypes of antibody or T lymphocytes. OBJECTIVE: This research detected the non-IgE antibody value against penicillin in allergic and normal people...
September 7, 2018: Human Antibodies
J Barbarroja-Escudero, A Asúnsolo-Del-Barco, M J Sánchez-González, M Rodríguez-Rodríguez, M Alvarez-Mon
BACKGROUND AND OBJECTIVE: Edema of the uvula (EU) may appear in isolation or in association with other associated clinical manifestations such as urticaria, angioedema or anaphylaxis. EU may lead to upper airway obstruction, provoking obstructive respiratory distress and asphyxia. Objective: We sought to investigate the etiology of, and predisposing factors for, EU in a large population of patients referred to an outpatient clinic. METHODS: In this 3-year-follow-up cohort study, 171 patients presenting with EU were identified and classified as having isolated EU or non-isolated EU...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
Talal Alzahrani, Angelike P Liappis, Larry M Baddour, Pamela E Karasik
BACKGROUND: Cefazolin is used as standard preoperative prophylaxis for a variety of surgical procedures that involve the skin. In contrast, vancomycin is recommended for a minority of patients, specifically those with an IgE-mediated allergy to beta-lactams and considered in patients with known colonization with methicillin-resistant Staphylococcus aureus or at high risk for such. Vancomycin, however, has been overprescribed, has nephrotoxicity risk, and may be less effective due to its inferior coverage of methicillin-susceptible S...
September 17, 2018: Pacing and Clinical Electrophysiology: PACE
H Guvenir, E Dibek Misirlioglu, M Toyran, E Civelek, B Buyuktiryaki, T Ginis, C N Kocabas
BACKGROUND: Children may be referred to pediatric allergy clinics for reactions to multiple drugs. Multiple drug hypersensitivity (MDH) is defined as immunologically-mediated hypersensitivity to two or more chemically different drugs. OBJECTIVE: The aim of this study is to report the allergy work-up results of children who had a history of potential hypersensitivity reactions to two or more unrelated drugs. METHODS: This study was conducted in the Pediatric Allergy and Immunology department of our hospital...
September 12, 2018: Annals of Allergy, Asthma & Immunology
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