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Antibiotic allergy

Mahdieh Sadat Mohsenzadeh, Arash Mohammadinejad, Seyed Ahmad Mohajeri
The frequent, sometimes illegal, use of antibiotics for therapeutic and prophylactic purposes in dairy cattle management may cause residues in milk. Because of problems concerning bacterial resistance or allergies in consumers, monitoring of residues is required. In spite of the huge development of analytical instrumentation during recent years, sample preparation is still a bottleneck of the analytical process. In this regard, efforts have been directed towards improving selectivity during extraction and clean-up of samples...
August 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Katharine D Harper, Courtney Quinn, Joshua Eccles, Frederick Ramsey, Saqib Rehman
BACKGROUND: Recent literature has demonstrated that emergent administration of antibiotics is perhaps more critical than even emergent debridement. Most recent studies recommend patients receive antibiotics no later than 1 hour after injury to prevent infection. The objective of this study is to evaluate the time to antibiotic administration after patients with open fractures arrive to a trauma center depending on triaging team. METHODS: A retrospective study at a level 1 Trauma center from January 2013 to March 2015 where 117 patients with open fractures were evaluated...
2018: PloS One
Claire Daniels, Apryl Susi, Steve Min, Cade M Nylund
OBJECTIVES: Eosinophilic esophagitis (EoE) is an inflammatory, atopic disease of the esophagus without a clear etiology. Our objective was to identify exposures and conditions in early infancy associated with the development of EoE. METHODS: A case-control study was performed using the Military Health System Database. Subjects diagnosed with EoE from October 2008 to September 2015 were matched 1:2 on age and sex. Early infant risk factors from the first six months of life were investigated...
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
Amelia Pietropaolo, Patrick Jones, Mike Moors, Brian Birch, Bhaskar K Somani
PURPOSE OF REVIEW: Intravesical antibiotics (IVA) has been used for prophylaxis and treatment of recurrent urinary tract infections (rUTIs). However, there is a lack of comprehensive evidence and consensus on its use. We conducted a systematic review to collect all available data about the effectiveness of IVA in prevention and treatment of rUTIs and to give an overview on the outcomes to date. METHODS: A systematic review was carried out for all English language articles from inception to August 2017, according to the Cochrane and PRISMA standards using MEDLINE, Scopus, Biomed Central, EMBASE, CINAHL, and Web of Science with references cross-checked and individual urology journals hand-searched...
August 9, 2018: Current Urology Reports
Hyeon-Ho Park, Seok-Chun Ko, Gun-Woo Oh, Yu-Mi Jang, Young-Mog Kim, Won Sun Park, Il-Whan Choi, Won-Kyo Jung
Propionibacterium acnes plays a key role in the onset of inflammation leading to acne and in downregulation of the defense system against oxidative stress. Therefore, antibiotics such as macrolides, tetracyclines, azelaic acid, and erythromycin are used to reduce microbial proliferation and resulting inflammation. Nonetheless, antibiotic treatment has side effects including cytotoxicity, allergy, and diarrhea. Therefore, recent studies were focused on the development of alternative antimicrobial materials. We conjugated chitooligosaccharide (COS) with gallic acid (GA) by the hydrogen peroxide-mediated method and evaluated antioxidant and antimicrobial activities...
October 15, 2018: Carbohydrate Polymers
Marta Wanat, Sibyl Anthierens, Christopher C Butler, Judy M Wright, Naila Dracup, Sue H Pavitt, Jonathan A T Sandoe, Sarah Tonkin-Crine
About 10% of U.K. patients believe that they are allergic to penicillin and have a "penicillin allergy label" in their primary care health record. However, around 90% of these patients may be mislabelled. Removing incorrect penicillin allergy labels can help to reduce unnecessary broad-spectrum antibiotic use. A rapid review was undertaken of papers exploring patient and/or clinician views and experiences of penicillin allergy testing (PAT) services and the influences on antibiotic prescribing behaviour in the context of penicillin allergy...
August 6, 2018: Antibiotics
Tenielle Watkins, Sandra M Aguero, Michael Jaecks
Failure to appropriately document patient medical information, such as allergies, is an important cause of medication errors. Lack of allergy details in the electronic medical record (EMR) may prolong the pharmacist order verification process. A retrospective chart review was conducted in October 2017, to evaluate the impact of incomplete allergy details on time to antibiotic order resolution at the Einstein Medical Center Philadelphia. Details were present on 71% of orders. The difference in median time to order resolution, for orders with versus without details, was ⁻21 min (95% CI (confidence interval), ⁻39 to ⁻2...
August 3, 2018: Pharmacy (Basel, Switzerland)
Daniel Asfaw Erku, Sisay Yifru Aberra
Background: Although prohibited by law and legal regulatory frameworks, non-prescribed sale of antibiotics in community medicine retail outlets (CMROs) remains a serious problem in Ethiopia. The aim of this study was to document the extent of and motivations behind non-prescribed sale of antibiotics among CMROs in Gondar town, Ethiopia. Methods: A 2 phase mixed-methods study (a simulated patient visit followed by an in-depth interview) was conducted among CMROs in Gondar town, Ethiopia...
2018: Antimicrobial Resistance and Infection Control
Rebecca R Saff, Yu Li, Nikita Santhanakrishnan, Carlos A Camargo, Kimberly G Blumenthal, Li Zhou, Aleena Banerji
BACKGROUND: The study of allergic drug reactions has been limited due to challenges in identifying and confirming cases. OBJECTIVE: To determine the utility of ICD-9-CM codes for identifying inpatient allergic drug reactions and compare findings to prior data in the emergency department. METHODS: By reviewing medical records of inpatients with ICD-9-CM codes and E codes suggestive of allergic drug reactions at a large urban academic medical center, we determined codes that yielded the most drug allergy cases and identified culprit drugs...
July 31, 2018: Journal of Allergy and Clinical Immunology in Practice
Jason A Trubiano, M Lindsay Grayson, Elizabeth J Phillips, Andrew J Stewardson, Karin A Thursky, Monica A Slavin
No abstract text is available yet for this article.
July 27, 2018: Journal of Antimicrobial Chemotherapy
Oscar Alonso-Ezpeleta, Milagros Martín-Jiménez, Benjamín Martín-Biedma, José López-López, Leopoldo Forner-Navarro, Jenifer Martín-González, Paloma Montero-Miralles, María Del Carmen Jiménez-Sánchez, Eugenio Velasco-Ortega, Juan J Segura-Egea
Background: The incidence of endodontic infections is high. The contribution of Endodontics to the global problem of antibiotic resistance could be significant. The ESE, together with the World Health Organization, are promoting the World Antibiotic Awareness Week (13-19 November 2017) to promote the appropriate use of systemic antibiotics in Endodontics. The objective of this study was to determine the prescription pattern of antibiotics in the treatment of endodontic infections of Spanish dentists attending specialization programs in Endodontics...
July 2018: Journal of Clinical and Experimental Dentistry
Xiaotong Li, Sydney Thai, Wenchao Lu, Shusen Sun, Huilin Tang, Suodi Zhai, Tiansheng Wang
Background Traditional Chinese medicine (TCM) is one of the major triggers for drug-induced anaphylaxis (DIA). Objective We aimed to use the Beijing pharmacovigilance database (BPD) to analyze TCM-induced DIAs in Beijing, China. Setting Drug allergy case reports from the BPD provided by the Beijing Center for Adverse Drug Reaction Monitoring. Method Drug allergy cases from January 2004 to December 2014 were adjudicated. DIA triggered by TCMs were analyzed and compared with those triggered by non-TCM drugs by calculating the reported risk ratio (RRR)...
July 26, 2018: International Journal of Clinical Pharmacy
Paolo Marraccini, Patrizia Pignatti, Andrea D Apos Alcamo, Rossana Salimbeni, Dario Consonni
BACKGROUND: The diagnosis of drug hypersensitivity reactions (DHRs) is based both on clinical history and in vivo tests, such as specific IgE and cutaneous tests, when available. OBJECTIVES: The aim of this work was to evaluate the basophil activation test (BAT) as a supplementary tool for drug challenges and drug allergy diagnosis. METHOD: We evaluated 204 outpatients reporting DHRs. Available serum-specific IgE drugs were determined and cutaneous tests were performed when appropriate...
July 25, 2018: International Archives of Allergy and Immunology
Santi M Mandal, Sounik Manna, Sneha Mondal, Ananta K Ghosh, Ranadhir Chakraborty
While antibiotics remain as a major therapy against life threatening pathogenic infections, they often lead to side effects like rashes, gastrointestinal and central nervous system reactions to serious allergies or organ damage. These adverse effects alongside the emergence of multi-antibiotic resistant bacteria and the decline in the development of new antibiotics, have posed a serious impediment for effective antibiotic therapy. A paradigm shift in attitudes has led us to think about the possibility of controlling infections with the indigenous antimicrobial peptides synthesized by human beings...
August 13, 2018: Biological Chemistry
Maria J Torres, Tahia D Fernández
Drug hypersensitivity is a worldwide health problem that has gained importance in the last years due to the increased number of patients labelled as drug allergic, especially to antibiotics, and to the onset of allergy to new drugs such as biologicals and chemotherapy. The 8th Drug Hypersensitivity Meeting (DHM), organized by the European Academy of Allergy and Clinical Immunology (EAACI), took place in Amsterdam in 2018. DHM8 brought together international experts from different disciplines, including allergists, dermatologists, pharmacologists, immunologists, biologists, chemists, toxicologists, etc...
July 25, 2018: Allergy
Ravinder Nagpal, Yuichiro Yamashiro
Our gut microbiome plays a fundamental role in our health and disease. The microbial colonization of human gut begins immediately at birth and is an indispensable natural process that modulates our physiology and immunity. Recent studies are elegantly revealing how and when these microbes colonize the gut and what elements could potentially influence this natural phenomenon. The vertical mother-to-baby transmission of microbes is a crucial factor for normal development and maturation of newborn's immune, metabolic as well as neurological health...
2018: Annals of Nutrition & Metabolism
S Marin, L Campins, M Miarons, L Pérez-Cordón, C Reina-Aguilar, M Solsona
WHAT IS KNOWN AND OBJECTIVE: Beta-lactam antibiotic (BLA) therapy is frequently needed to treat infective endocarditis (IE). Hypersensitive reactions to BLA restrict BLA therapy in allergic patients. In the current case, we aim to describe the utility of desensitization (DS) in this context. Although the evidence is limited, DS is recommended. CASE DESCRIPTION: This case report deals with a 79-year-old woman with a clinical suspicion of allergy to BLA and a methicillin-sensitive Staphylococcus aureus (MSSA) IE...
July 21, 2018: Journal of Clinical Pharmacy and Therapeutics
Sarah E White, Stephen D Woolley
This is a case of Actinomyces europaeus in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature describing nonpenicillin treatment options. A 69-year-old woman presented acutely with a breast abscess which was managed with incision and drainage and antibiotic therapy to good response. 21 days after presentation, Actinomyces were grown from the culture of pus, so the patient was recalled and more rigorous treatment and follow-up were initiated...
2018: Case Reports in Infectious Diseases
Rosa García Rodríguez, Lucia Moreno Lozano, Alba Extremera Ortega, Jesús Borja Segade, Pedro Galindo Bonilla, Elisa Gómez Torrijos
BACKGROUND: Beta-lactam antibiotics are the most common trigger of reactions in children with most of them being nonimmediate (85.5%), but proven allergy after the allergological work-up is between 7% -10%. There is no agreement on how to perform the provocation tests in these type of hypersensitivity reactions. OBJECTIVE: To determine whether or not repeated doses of the beta-lactams are required to reproduce a nonimmediate reaction in children. METHODS: This is a retrospective observational study...
July 13, 2018: Journal of Allergy and Clinical Immunology in Practice
C L Downey, J Croft, H Buckley, R Randell, J M Brown, D G Jayne
Background: Despite medical advances, major surgery remains high risk. Up to 44% of patients experience postoperative complications, which can have huge impacts for patients and the healthcare system. Early recognition of postoperative complications is crucial in reducing morbidity and preventing long-term disability. The current standard of care is intermittent manual vital signs monitoring, but new wearable remote monitors offer the benefits of continuous vital signs monitoring without limiting the patient's mobility...
2018: Pilot and Feasibility Studies
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