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Streptococcus group B

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https://www.readbyqxmd.com/read/29045606/clinical-and-laboratory-features-of-group-b-streptococcus-meningitis-in-infants-and-newborns-study-of-848-cases-in-france-from-2001-2014
#1
Anne-Sophie Romain, Robert Cohen, Céline Plainvert, Caroline Joubrel, Stéphane Béchet, Amélie Perret, Asmaa Tazi, Claire Poyart, Corinne Levy
Background: Group B Streptococcus (GBS) disease is the leading cause of neonatal bacterial meningitis despite women receiving an intravenous antibiotic prophylaxis (IAP) during labor. We aimed to describe GBS meningitis in children less than 1 year old in France during 2001-2014. Methods: Clinical and biological data of GBS meningitis gathered by ACTIV/GPIP and the French National Reference Center for Streptococci were analyzed. The cases were classified by age: 0 to 6 days old (early-onset disease [EOD]), newborns and infants 7 to 89 days old (late-onset disease [LOD]: LOD1, 7-26 days; LOD2, 27-89 days to 3 months) and infants 3 months to 1 year old (infant disease [ID])...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29042860/toll-like-receptor-8-is-a-major-sensor-of-group-b-streptococcus-but-not-escherichia-coli-in-human-primary-monocytes-and-macrophages
#2
Birgitta Ehrnström, Kai Sandvold Beckwith, Mariia Yurchenko, Siv Helen Moen, June Frengen Kojen, Germana Lentini, Giuseppe Teti, Jan Kristian Damås, Terje Espevik, Jørgen Stenvik
TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphylococcus aureus and is antagonized by TLR2. The relative importance of TLR8 for the sensing of various bacterial species is however still unclear. We here compared the role of TLR8 and IRF5 for the sensing of Group B Streptococcus (GBS), S...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29040443/a-dysbiosis-index-to-assess-microbial-changes-in-fecal-samples-of-dogs-with-chronic-inflammatory-enteropathy
#3
M K AlShawaqfeh, B Wajid, Y Minamoto, M Markel, J A Lidbury, J M Steiner, E Serpedin, J S Suchodolski
Recent studies have identified various bacterial groups that are altered in dogs with chronic inflammatory enteropathies (CE) compared to healthy dogs. The study aim was to use quantitative PCR (qPCR) assays to confirm these findings in a larger number of dogs, and to build a mathematical algorithm to report these microbiota changes as a dysbiosis index (DI). Fecal DNA from 95 healthy dogs and 106 dogs with histologically confirmed CE was analyzed. Samples were grouped into a training set and a validation set...
October 11, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29037552/the-impact-of-prenatal-group-b-streptococcus-screening-as-a-national-health-policy-in-taiwan
#4
Fung-Wei Chang, Chun-I Lee, Hueng-Chuen Fan, Her-Young Su, Yung-Liang Liu, Cheng-Yu Chen
OBJECTIVE: There was no national data on group B streptococcus (GBS) infections in Taiwan. Until 2012, when prenatal GBS screening was introduced to obstetric practices as a national health policy aimed at reducing neonatal GBS infections. The purpose of this study was to examine the impact of this national health policy on the incidence of maternal GBS colonization and neonatal GBS infection rate. Relatedly, the clinical characteristics of neonatal GBS infection were investigated to determine the correlations between the incidence of maternal GBS colonization and the neonatal GBS infection rate...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29036682/perinatal-risk-factors-for-neonatal-early-onset-group-b-streptococcal-sepsis-after-initiation-of-risk-based-maternal-intrapartum-antibiotic-prophylaxis-a-case-control-study
#5
Sridhar Santhanam, Sumita Arun, Grace Rebekah, Nithya J Ponmudi, Jolly Chandran, Ruby Jose, Atanu Kumar Jana
Objectives: To identify the perinatal risk factors for early-onset Group B Streptococcus (EOGBS) sepsis in neonates after inception of a risk-based maternal intrapartum antibiotic prophylaxis strategy in 2004. Design: Case control study. Methods: All newborn with early onset GBS sepsis (born between 2004 and 2013) were deemed to be "cases" and controls were selected in a 1:4 ratio. Results: More than three per vaginal (PV) examinations [odds ratio (OR) 8...
September 23, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29034376/exploring-the-pregnant-guinea-pig-as-a-model-for-group-b-streptococcus-intrauterine-infection
#6
Maria I Harrell, Kellie Burnside, Christopher Whidbey, Jay Vornhagen, Kristina M Adams Waldorf, Lakshmi Rajagopal
Infection of the amniotic cavity remains a major cause of preterm birth, stillbirth, fetal injury and early onset, fulminant infections in newborns. Currently, there are no effective therapies to prevent in utero infection and consequent co-morbidities. This is in part due to the lack of feasible and appropriate animal models to understand mechanisms that lead to in utero infections. Use of mouse and rat models do not fully recapitulate human pregnancy, while pregnant nonhuman primate models are limited by ethical considerations, technical constraints, and cost...
September 2017: J Infect Dis Med
https://www.readbyqxmd.com/read/29032514/surface-roughness-and-bacterial-adhesion-on-root-dentin-treated-with-diode-laser-and-conventional-desensitizing-agents
#7
Maiza S Cury, Camilla B Silva, Ruchele D Nogueira, Michelle G D Campos, Regina G Palma-Dibb, Vinicius R Geraldo-Martins
The treatments for dentin hypersensitivity (DH) may change the surface roughness of the root dentin, which can lead to biofilm accumulation, increasing the risk of root caries. The aim was to compare the surface roughness of root dentin after different treatments of DH and the biofilm formation on those surfaces. After initial surface roughness (Sa) assessment, 50 bovine root fragments received the following treatments (n = 10): G 1-no treatment; G2-5% sodium fluoride varnish; G3-professional application of a desensitizing dentifrice; G4-toothbrushing with a desensitizing dentifrice; and G5-diode laser application (908 nm; 1...
October 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29029763/serotype-virulence-profile-antimicrobial-resistance-and-macrolide-resistance-determinants-in-streptococcus-agalactiae-isolates-in-pregnant-women-and-neonates-in-catalonia-spain
#8
Yuly López, Elena Parra, Virginio Cepas, Isabel Sanfeliú, Teresa Juncosa, Antonia Andreu, Mariona Xercavins, Josefa Pérez, Sergi Sanz, Andrea Vergara, Jordi Bosch, Sara Maria Soto
INTRODUCTION: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed...
October 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29029143/genome-wide-analysis-of-genetic-risk-factors-for-rheumatic-heart-disease-in-aboriginal-australians-provides-support-for-pathogenic-molecular-mimicry
#9
Lesley-Ann Gray, Heather A D'Antoine, Steven Y C Tong, Melita McKinnon, Dawn Bessarab, Ngaire Brown, Bo Reményi, Andrew Steer, Genevieve Syn, Jenefer M Blackwell, Michael Inouye, Jonathan R Carapetis
Background: Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells. Methods: Genome-wide genetic analysis was undertaken in 1263 Aboriginal Australians (398 RHD cases; 865 controls). Single nucleotide polymorphisms (SNPs) were genotyped using Illumina HumanCoreExome BeadChips. Direct typing and imputation was used to fine-map the human leukocyte antigen (HLA) region...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029127/antibody-kinetics-and-response-to-routine-vaccinations-in-infants-born-to-women-who-received-an-investigational-trivalent-group-b-streptococcus-polysaccharide-crm197-conjugate-vaccine-during-pregnancy
#10
Shabir A Madhi, Anthonet Koen, Clare L Cutland, Lisa Jose, Niresha Govender, Frederick Wittke, Morounfolu Olugbosi, Ajoke Sobanjo-Ter Meulen, Sherryl Baker, Peter M Dull, Vas Narasimhan, Karen Slobod
Background: Maternal vaccination against group B Streptococcus (GBS) might provide protection against invasive GBS disease in infants. We investigated the kinetics of transplacentally transferred GBS serotype-specific capsular antibodies in the infants and their immune response to diphtheria toxoid and pneumococcal vaccination. Methods: This phase 1b/2, observer-blind, single-center study (NCT01193920) enrolled infants born to women previously randomized (1:1:1:1) to receive either GBS vaccine at dosages of 0...
September 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29021957/whole-genome-shotgun-sequencing-of-indian-strains-of-streptococcus-agalactiae
#11
Balaji Veeraraghavan, Naveen Kumar Devanga Ragupathi, Sridhar Santhanam, Valsan Philip Verghese, Francis Yesurajan Inbanathan, Charles Livingston
Group B streptococcus is known as a leading cause of neonatal infections in developing countries. The present study describes the whole genome shotgun sequences of four Group B Streptococcus (GBS) isolates. Molecular data on clonality is lacking for GBS in India. The present genome report will add important information on the scarce genome data of GBS and will help in deriving comparative genome studies of GBS isolates at global level. This Whole Genome Shotgun project has been deposited at DDBJ/ENA/GenBank under the accession numbers NHPL00000000 - NHPO00000000...
December 2017: Genomics Data
https://www.readbyqxmd.com/read/29020160/immune-cross-opsonization-within-emm-clusters-following-group-a-streptococcus-skin-infection-broadening-the-scope-of-type-specific-immunity
#12
Hannah R Frost, Delphine Laho, Martina L Sanderson-Smith, Paul Licciardi, Susan Donath, Nigel Curtis, Joseph Kado, James B Dale, Andrew C Steer, Pierre R Smeesters
Background: Group A Streptococcus (GAS) skin infections are particularly prevalent in developing nations. The GAS M protein, by which strains are differentiated into >220 different emm types, is immunogenic and elicits protective antibodies. A major obstacle for vaccine development has been the traditional understanding that immunity following infection is restricted to a single emm type. However, recent evidence has led to the hypothesis of immune cross-reactivity between emm types...
July 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016319/clinical-epidemiology-of-septic-arthritis-caused-by-burkholderia-pseudomallei-and-other-bacterial-pathogens-in-northeast-thailand
#13
Prapit Teparrukkul, Jiraphorn Nilsakul, Susanna Dunachie, Direk Limmathurotsakul
Septic arthritis is a medical emergency, and if not treated appropriately, it can be associated with high morbidity and mortality. Melioidosis, a serious infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is highly endemic in South and Southeast Asia and northern Australia. We reviewed the medical charts of adult patients admitted with bacterial septic arthritis at Sunpasitthiprasong Hospital, Ubon Ratchathani, northeast Thailand from January 2012 to December 2014. Bacterial septic arthritis was defined as one or more hot swollen joints with isolation of a pathogenic organism from an affected joint or from blood...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991323/-neonatal-infection-and-universal-screening-for-streptococcus-agalactiae-group-b-%C3%AE-hemolytic-streptococcus-in-the-pregnant-woman-technical-recommendation
#14
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28988964/epidemiology-of-bacteremia-in-febrile-infants-aged-60-days-and-younger
#15
Elizabeth C Powell, Prashant V Mahajan, Genie Roosevelt, John D Hoyle, Rajender Gattu, Andrea T Cruz, Alexander J Rogers, Shireen M Atabaki, David M Jaffe, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
STUDY OBJECTIVE: To describe the current epidemiology of bacteremia in febrile infants 60 days of age and younger in the Pediatric Emergency Care Applied Research Network (PECARN). METHODS: We conducted a planned secondary analysis of a prospective observational study of febrile infants 60 days of age and younger presenting to any of 26 PECARN emergency departments (2008 to 2013) who had blood cultures obtained. We excluded infants with significant comorbidities or critically ill appearance...
October 6, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28969684/group-b-streptococcus-gbs-is-an-important-pathogen-in-human-disease-but-what-about-in-cystic-fibrosis
#16
Kate Skolnik, Austin Nguyen, Christina S Thornton, Barbara Waddell, Tyler Williamson, Harvey R Rabin, Michael D Parkins
BACKGROUND: Group B Streptococcus (GBS) is a common commensal capable of causing severe invasive infections. Most GBS infections occur in neonates (often as pneumonia). GBS can also cause infection in adults with diabetes and other immunological impairments but rarely leads to pneumonia in adults. GBS has occasionally been found in the sputum of Cystic Fibrosis (CF) patients, an inherited condition known for progressive lung disease. However, the epidemiology and clinical significance of GBS in CF are not understood...
October 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28969130/group-b-streptococcus-an-unusual-cause-for-urinary-tract-infection
#17
Bichitrananda Swain, Anindita Rakshit, Kundan Kumar Sahu, Nalinee Sahoo, Sarita Otta
No abstract text is available yet for this article.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28968016/-molecular-characterization-of-non-vaccine-streptococcus-pneumoniae-serotypes-11a-15-b-c-and-23a-recovered-from-invasive-isolates-in-colombia
#18
Paola Andrea Palacios, Carolina Duarte, Olga Sanabria, Jaime Moreno
INTRODUCTION: A total of 192 invasive Streptococcus pneumoniae isolates, from serotypes 11A, 15B/C and 23A (not included in the conjugated vaccines), were collected in Colombia between 1994 and 2014 as part of the activities of the Network surveillance system for the causative agents of pneumonia and meningitis (SIREVA II). OBJECTIVE: To determine the molecular characteristics of invasive S. pneumoniae isolates from serotypes 11A, 15B/C and 23A in Colombia from 1994 to 2014...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28964304/the-effect-of-pneumococcal-conjugate-vaccines-on-incidence-and-microbiology-associated-with-complicated-acute-otitis-media
#19
B B Laursen, C S Danstrup, S Hoffmann, N Nørskov-Lauritsen, A L B Christensen, T Ovesen
OBJECTIVES: The objectives of this study were to investigate the incidence of complicated acute otitis media (cAOM) as well as the associated microbiology before and after introduction of the 7- and 13-valent pneumococcal conjugate vaccines (PCV-7 and -13), respectively. CAOM comprises "heavy" AOM (AOM demanding hospitalization), mastodismus (M) and acute mastoiditis (AM). METHODS: A retrospective cohort study of the incidence and microbiology associated with cAOM during the non-PCV era, the PCV-7 and 13 eras, respectively...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28961888/multiclonal-emergence-of-levofloxacin-resistant-group-b-streptococcus-taiwan
#20
Chi-Jung Wu, Jui-Fen Lai, I-Wen Huang, Li-Yun Hsieh, Hui-Ying Wang, Yih-Ru Shiau, Tsai-Ling Lauderdale
Objectives: This study investigated the trend in antimicrobial resistance among group B Streptococcus (GBS) from a national surveillance programme in Taiwan and delineated characteristics of and factors associated with levofloxacin-resistant isolates. Methods: Clinical isolates of all sample types and patient groups were collected from multiple hospitals biennially between 2002 and 2012. Susceptibilities to different antibiotics were determined by broth microdilution...
September 6, 2017: Journal of Antimicrobial Chemotherapy
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