keyword
https://read.qxmd.com/read/38465335/brucella-infection-combined-with-nocardia-infection-a-case-report-and-literature-review
#21
Yan Feng, Chun-Lei Zuo, Jia-Xin Shi
Human brucellosis is an infectious disease caused by Brucella and is often misdiagnosed for atypical manifestations including fever of unknown origin, headache, weakness, among else. Nocardiosis is a zoonotic disease caused by the genus Nocardia, which usually spreads through the respiratory tract, skin, and digestive tract. Limited research has documented cases of co-infection involving both Brucella and Nocardia pathogens in patients. A 55-year-old male was admitted to our hospital with intermittent high-grade fever...
2024: Open Life Sciences
https://read.qxmd.com/read/38464511/-brucella-abortus-triggers-the-differential-expression-of-immunomodulatory-lncrnas-in-infected-murine-macrophages
#22
JOURNAL ARTICLE
Manuel Flores-Concha, Leonardo A Gómez, Rodrigo Soto-Shara, Raúl E Molina, Roberto F Coloma-Rivero, David A Montero, Ítalo Ferrari, Ángel Oñate
INTRODUCTION: The lncRNAs (long non-coding RNAs) are the most diverse group of non-coding RNAs and are involved in most biological processes including the immune response. While some of them have been recognized for their influence on the regulation of inflammatory activity, little is known in the context of infection by Brucella abortus , a pathogen that presents significant challenges due to its ability to manipulate and evade the host immune system. This study focuses on characterize the expression profile of LincRNA-cox2, Lethe, lincRNA-EPS, Malat1 and Gas5 during infection of macrophages by B...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38464217/comparison-of-ccrm-dependent-methylation-in-caulobacter-crescentus-and-brucella-abortus-by-nanopore-sequencing
#23
Maxwell Campbell, Ian Scott Barton, R Martin Roop, Peter Chien
UNLABELLED: Bacteria rely on DNA methylation for restriction-modification systems and epigenetic control of gene expression. Here, we use direct detection of methylated bases by nanopore sequencing to monitor global DNA methylation in Alphaproteobacteria, where use of this technique has not yet been reported. One representative of this order, Caulobacter crescentus , relies on DNA methylation to control cell cycle progression, but it is unclear whether other members of this order, such as Brucella abortus , depend on the same systems...
March 2, 2024: bioRxiv
https://read.qxmd.com/read/38459818/rescue-and-rehabilitation-of-maned-wolf-chrysocyon-brachyurus-in-paraguay-case-description
#24
Joerg Richard Vetter Hiebert, José Gaspar Petters Cabrera, Santhiago Benítez Del Puerto, Roger González Vatteone, Marlene Florentín Morel, Diego Augusto Dacak Aguilera, César Esteban Brítez Valinotti, Raquel Ramírez Diarte, Lilian Maria González González, Carlos Coronel Díaz, Paola Osorio, Walter Cardozo, Fátima Bracho, Claudia Raquel Soto, Nilsa Melissa Domínguez Barreto, Antonio Alejandro Sciabarrasi
The maned wolf, Chrysocyon brachyurus, is the largest South American canid, with a natural distribution that stretches across Peru, Bolivia, Brazil, Argentina, Paraguay and Uruguay. The present study reports the case of a rescued specimen of maned wolf that underwent a rehabilitation process in Paraguay, starting in October 2020 with its rescue, and finalising in May 2021 with the reintroduction. Herein, we document findings regarding the general management, biometrics, feeding and environmental enrichment; chemical immobilisation and monitoring; haematology, blood biochemistry and specific serology-relevant pathogens; skin examination and bone marrow cytology; orthopaedic, ophthalmological and dental evaluation; abdominal and cardiac ultrasonography; radiology and copro-parasitology...
March 2024: Veterinary Medicine and Science
https://read.qxmd.com/read/38459616/human-exposures-to-brucella-canis-from-a-pregnant-dog-during-an-international-flight-public-health-risks-diagnostic-challenges-and-future-considerations
#25
JOURNAL ARTICLE
Cara Williams, Samantha Swisher, Nicholas Miller, Toby Pinn-Woodcock, Connie Austin, Shih-Hsuan Hsiao, Angela M Arenas-Gamboa, Rebekah Tiller, Tyler Thacker, Sara Taetzsch, Rebecca Franklin-Guild, Laurel Cutter, Christine Quance, Chien-Che Hung, Carol W Maddox, Mark Ernst, Cassandra Guarino, Saraswathi Lanka, Daniel G Garcia-Gonzalez, Staci Slager, Zenia Sunavala, Clive Brown, Maria Negron, Emily G Pieracci
AIMS: This report documents the exposure of passengers and crew of a commercial international flight to the zoonotic pathogen Brucella canis after an infected dog aborted in the passenger cabin of the aircraft. This case demonstrates the challenges associated with brucellosis screening and the risks that airline personnel, airport employees and travellers face when animals with unrecognized zoonotic infections are transported. METHODS/RESULTS: The public health investigation of this case was conducted by the Centers for Disease Control, the Illinois Department of Health and the Illinois Department of Agriculture, in collaboration with a local veterinary clinic and several academic and federal diagnostic laboratories...
March 8, 2024: Zoonoses and Public Health
https://read.qxmd.com/read/38459363/biodegradation-of-polyethylene-terephthalate-pet-by-brucella-intermedia-iitr130-and-its-proposed-metabolic-pathway
#26
JOURNAL ARTICLE
Pallavi Srivastava, Joel Saji, Natesan Manickam
Accumulation of polyethylene terephthalate (PET) polyester in ecosystems across the globe is a major pollution of concern. Microbial degradation recently generated novel insights into the biodegradation of varieties of plastics. In this study, a PET degrading bacterium Brucella intermedia IITR130 was isolated from a contaminated lake ecosystem at Pallikaranai, Chennai, India. Incubation of the bacterium along with the PET sheet (0.1 mm thickness) for 60 days resulted in 26.06% degradation, indicating a half-life of 137...
March 9, 2024: Biodegradation
https://read.qxmd.com/read/38456084/diversity-and-functional-characteristics-of-culturable-bacterial-endosymbionts-from-cassava-whitefly-biotype-asia-ii-5-bemisia-tabaci
#27
JOURNAL ARTICLE
Venkatesh Kumar, Jeyarani Subramanian, Murugan Marimuthu, Mohankumar Subbarayalu, Venkatachalam Ramasamy, Karthikeyan Gandhi, Manikandan Ariyan
UNLABELLED: Whitefly Bemisia tabaci , a carrier of cassava mosaic disease (CMD), poses a significant threat to cassava crops. Investigating culturable bacteria and their impact on whiteflies is crucial due to their vital role in whitefly fitness and survival. The whitefly biotype associated with cassava and transmitting CMD in India has been identified as Asia II 5 through partial mitochondrial cytochrome oxidase I gene sequencing. In this study, bacteria associated with adult B. tabaci feeding on cassava were extracted using seven different media...
April 2024: 3 Biotech
https://read.qxmd.com/read/38456025/an-unusual-case-of-brucella-melitensis-related-wound-infection
#28
Ozge Alkan Bilik, Fatma Meral Ince, Nida Ozcan, Zeynep Ayaydin
BACKGROUND: Brucellosis is an anthropo-zoonotic infectious disease caused by various Brucella species. It is usually transmitted through contact with infected animals or consumption of contaminated animal products. Brucellosis most commonly affects the musculoskeletal and reticuloendothelial system with additional involvement observed in gastrointestinal system, urinary tract, reproductive system, central nervous system, and cardiovascular system. Skin involvement is extremely rare in brucellosis...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38453565/effects-of-vaccination-with-brucella-melitensis-strains-rev-1-%C3%AE-erycd-and-rev-1-on-the-reproductive-system-of-young-male-goats
#29
JOURNAL ARTICLE
Isauro Alejandro López Vásquez, Erika Gabriela Palomares Resendiz, José Luis Gutiérrez Hernández, Germán Isauro Garrido Fariña, Jorge Luis Tórtora Pérez, José de Jesús Olmos Espejel, Rigoberto Hernández Castro, Félix Sangari, Francisco Suárez Güemes, Efrén Díaz Aparicio
The present study evaluates the effects of vaccination with Brucella melitensis strains Rev 1 ΔeryCD and Rev 1 on the reproductive system of male goats. Three groups, each of them consisting of 15 six-month-old brucellosis-free male goats, were studied. The first group was vaccinated with the Rev 1 ΔeryCD strain, the second group received Rev 1 and the third group was inoculated with sterile physiological saline solution. The dose of both strains was of 1×109 CFU/ml. Over the course of the five months of this study, three males from each group were euthanized every month...
March 6, 2024: Revista Argentina de Microbiología
https://read.qxmd.com/read/38443949/detection-of-selected-pathogens-in-reproductive-tissues-of-wild-boars-in-the-campania-region-southern-italy
#30
JOURNAL ARTICLE
Gianmarco Ferrara, Nadia Piscopo, Ugo Pagnini, Luigi Esposito, Serena Montagnaro
Monitoring disease among wildlife is critical to preserving health in both domestic animals and wildlife, and it becomes much more critical when the diseases cause significant economic damage to the livestock industry or threaten public health. Given the continuous increase in populations and its role as a reservoir for several infections, wild boar (Sus scrofa) requires special attention regarding disease surveillance and monitoring. In this study, we investigated the molecular prevalence of selected pathogens in the wild boar population of Campania, southern Italy...
March 5, 2024: Acta Veterinaria Scandinavica
https://read.qxmd.com/read/38426745/corrigendum-the-outbreak-of-seasonal-goat-s-brucellosis-in-the-swat-ecosystem-of-khyber-pakhtunkhwa
#31
JOURNAL ARTICLE
Nabilla Qayum, Muhammad N Uddin, Wajid Khan, Habib Un Nabi, Taj- Ud- Din, Muhammad Suleman, Hanif Ur Rahman, Iftikhar Ali, Ahmed M Hassan, Rafa Almeer, Farman Ullah
No abstract available.
February 29, 2024: Onderstepoort Journal of Veterinary Research
https://read.qxmd.com/read/38423297/evaluation-of-maldi-tof-mass-spectrometry-coupled-with-clinprotools-as-a-rapid-tool-for-toxin-producing-clostridioides-difficile
#32
JOURNAL ARTICLE
Asami Nakayama, Yoshitomo Morinaga, Ryota Izuno, Keita Morikane, Katsunori Yanagihara
INTRODUCTION: The performance of MALDI-TOF MS combined with analysis platform for identification of toxin-producing Clostridiodes difficile is yet to be known. METHODS: Between August 2018 and September 2020, 61 isolates from stool specimens of patients with C. difficile-associated diarrhea were analyzed using the MALDI Biotyper system. A C. difficile toxin-producer detection model was developed using ClinProTools. The model was validated using 28 known strains that differed from the isolates used to develop the model...
February 27, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38422032/periprosthetic-hip-infections-caused-by-brucella-a-rare-case-report-and-literature-review
#33
JOURNAL ARTICLE
Jun Wei Feng, Peng Hao, Jiang Hu, Xia Deng, Yue Wang
Periprosthetic hip infection caused by Brucella abortus is rare and only a few cases have been reported. This current case report presents a case of a man in his early 50s who developed periprosthetic hip infection 2 years after right hip arthroplasty. There was no fever or pain, the usual cardinal signs of infection, except for a sinus tract at the previous surgical incision. Laboratory and arthrocentesis culture examinations (done twice) confirmed infection with B. abortus . Accordingly, a two-stage revision surgery was performed accompanied by antibiotic treatment with doxycycline and rifampicin after each stage...
February 2024: Journal of International Medical Research
https://read.qxmd.com/read/38420443/brucellosis-an-unusual-presentation-as-isolated-septic-mono-arthritis-of-the-knee-joint-a-case-report
#34
Muad Abdi Hassan, Fatima Noor, Aram Salehi, Bassem Al Hariri
Brucellosis is a zoonotic infection that is widely spread across the world. It is becoming more common in Middle Eastern countries such as Qatar, Saudi Arabia, and the Mediterranean region. Despite this, we need to remain vigilant as it is still prevalent in many parts of the world. The most common presentation is musculoskeletal, but it can also present as septic arthritis in the sacroiliac, hip, or knee joints. Brucella melitensis was only found in one extended culture of synovial fluid. Treatment involved a combination of antimicrobial therapy using gentamycin, doxycycline, and rifampin...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38419498/a-subunit-vaccine-based-on-brucella-melitensis-rbp26-induces-th1-immune-responses-and-m1-macrophage-activation
#35
JOURNAL ARTICLE
Jia Wen, Zihua Li, Yongxue Lv, Shuqin Ding, Yazhou Zhu, Jihui Yang, Jing Tang, Mingxing Zhu, Yinqi Zhao, Wei Zhao
Brucellosis is a global zoonotic infection caused by Brucella bacteria, which poses a significant burden on society. While transmission prevention is currently the most effective method, the absence of a licenced vaccine for humans necessitates the urgent development of a safe and effective vaccine. Recombinant protein-based subunit vaccines are considered promising options, and in this study, the Brucella BP26 protein is expressed using prokaryotic expression systems. The immune responses are evaluated using the well-established adjuvant CpG-ODN...
February 29, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38418509/structure-function-analysis-of-the-cyclic-%C3%AE-1-2-glucan-synthase-from-agrobacterium-tumefaciens
#36
JOURNAL ARTICLE
Jaroslaw Sedzicki, Dongchun Ni, Frank Lehmann, Henning Stahlberg, Christoph Dehio
The synthesis of complex sugars is a key aspect of microbial biology. Cyclic β-1,2-glucan (CβG) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). CβG is produced by the cyclic glucan synthase (Cgs), a multi-domain membrane protein. So far, its structure as well as the mechanism underlining the synthesis have not been clarified. Here we use cryo-electron microscopy (cryo-EM) and functional approaches to study Cgs from A...
February 28, 2024: Nature Communications
https://read.qxmd.com/read/38404575/guanylate-binding-protein-5-is-involved-in-inflammasome-activation-by-bacterial-dna-but-only-the-cooperation-of-multiple-gbps-accounts-for-control-of-brucella-abortus-infection
#37
JOURNAL ARTICLE
Fabio V Marinho, Camila Brito, Ana Carolina V S C de Araujo, Sergio C Oliveira
INTRODUCTION: Guanylate-binding proteins (GBPs) are produced in response to pro-inflammatory signals, mainly interferons. The most studied cluster of GBPs in mice is on chromosome 3. It comprises the genes for GBP1-to-3, GBP5 and GBP7. In humans, all GBPs are present in a single cluster on chromosome 1. Brucella abortus is a Gram-negative bacterium known to cause brucellosis, a debilitating disease that affects both humans and animals. Our group demonstrated previously that GBPs present on murine chromosome 3 (GBPchr3) is important to disrupt Brucella-containing vacuole and GBP5 itself is important to Brucella intracellular LPS recognition...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38402187/molecular-epidemiological-characteristics-of-osteoarthritis-associated-brucella-melitensis-in-china-evidence-from-whole-genome-sequencing-based-analysis
#38
JOURNAL ARTICLE
Lei Zhu, Chi Zhang, Chen Liang, Li Peng, Huanyu Yan, Xiuwen Liang, Youjia Xu
BACKGROUND: Brucellosis, developing complications including arthritis, spondylitis, sacroiliitis, and osteomyelitis, is one of the most common zoonotic diseases in the current world which causes economic losses to the livestock industry and is a great public health concern. Brucella melitensis are the main pathogen of brucellosis epidemics in China, most of which are located in northern China. However, there is limited knowledge about the epidemiology of osteoarthritis-associated brucellosis...
February 24, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38401756/application-of-metagenomic-next-generation-sequencing-in-suspected-spinal-infectious-diseases
#39
JOURNAL ARTICLE
Cheng Li, Nian-Su Xiao, Bao-Yi Ke, Sen Li, Yang Lin
OBJECTIVE: This study aimed to explore the clinical efficacy of metagenomic next-generation sequencing (mNGS) in diagnosing and treating suspected spinal infectious diseases. METHODS: Between October 2022 to December 2023, a retrospective analysis was performed on patient records within the Department of Spinal Surgery at Guilin People's Hospital. The analysis included comprehensive data on patients with presumed spinal infectious diseases, incorporating results from mNGS tests conducted externally, conventional pathogen detection results, laboratory examination results, and imaging findings...
February 22, 2024: World Neurosurgery
https://read.qxmd.com/read/38392917/exposure-to-brucella-species-coxiella-burnetii-and-trichinella-species-in-recently-imported-camels-from-sudan-to-egypt-possible-threats-to-animal-and-human-health
#40
JOURNAL ARTICLE
Ragab M Fereig, Amira M Mazeed, Ashraf A Abd El Tawab, Mohamed El-Diasty, Ahmed Elsayed, Raafat M Shaapan, Abdelbaset E Abdelbaset, Caroline F Frey, Bader S Alawfi, Sarah A Altwaim, Azzah S Alharbi, Gamal Wareth
Brucellosis and coxiellosis/Q fever are bacterial infections caused by Brucella species and Coxiella burnetii , respectively; camels are highly susceptible to both pathogens. Trichinellosis is a parasitic infection caused by various Trichinella nematode species. Reportedly, camels are susceptible to experimental infection with Trichinella spp., but information on this potential host species is scarce. All three infections are of zoonotic nature and thus of great public health concern. The current study aimed to determine antibodies against the three pathogens in recently imported camels (n = 491) from Sudan at the two main ports for the entrance of camels into southern Egypt using commercial indirect ELISAs...
February 16, 2024: Pathogens
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