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https://www.readbyqxmd.com/read/28810870/vector-borne-and-zoonotic-diseases-of-dogs-in-north-west-new-south-wales-and-the-northern-territory-australia
#1
Amanda J Shapiro, Graeme Brown, Jacqueline M Norris, Katrina L Bosward, Debbie J Marriot, Nandhakumar Balakrishnan, Edward B Breitschwerdt, Richard Malik
BACKGROUND: Vector-borne diseases of dogs in Australian Aboriginal communities are relatively unexplored. These dogs represent a unique group with variable ecto- and endo-parasitic burdens, nutritional stresses and a general lack of veterinary intervention. We investigated haemoprotozoal and bacterial pathogen prevalences in relation to erythrocyte and platelet numbers in dogs from North-West New South Wales (N-W NSW) and the Northern Territory (NT; Central Australia). METHODS: Real-time PCR (qPCR) amplification of Anaplasma platys, Babesia vogeli, Mycoplasma haemocanis, Candidatus Mycoplasma haematoparvum and Bartonella spp...
August 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28808159/chronic-brucella-infection-induces-selective-and-persistent-ifn-%C3%AE-dependent-alterations-of-marginal-zone-macrophages-in-the-spleen
#2
Arnaud Machelart, Abir Khadrawi, Aurore Demars, Kevin Willemart, Carl De Trez, Jean-Jacques Letesson, Eric Muraille
The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209(+) MZ macrophages (MZMs) and the CD169(+) marginal metallophilic macrophages (MMMs). Acute systemic infection strongly impacts MZ populations and the location of T and B lymphocytes. This phenomenon has been linked to reduced chemokine secretion by stromal cells. Brucella spp. are the causative agent of brucellosis, a widespread zoonotic disease. Here, we used B...
August 14, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28800594/species-identification-and-molecular-typing-of-human-brucella-isolates-from-kuwait
#3
Abu S Mustafa, Nazima Habibi, Amr Osman, Faraz Shaheed, Mohd W Khan
Brucellosis is a zoonotic disease of major concern in Kuwait and the Middle East. Human brucellosis can be caused by several Brucella species with varying degree of pathogenesis, and relapses are common after apparently successful therapy. The classical biochemical methods for identification of Brucella are time-consuming, cumbersome, and provide information limited to the species level only. In contrast, molecular methods are rapid and provide differentiation at intra-species level. In this study, four molecular methods [16S rRNA gene sequencing, real-time PCR, enterobacterial repetitive intergenic consensus (ERIC)-PCR and multilocus variable-number tandem-repeat analysis (MLVA)-8, MLVA-11 and MLVA-16 were evaluated for the identification and typing of 75 strains of Brucella isolated in Kuwait...
2017: PloS One
https://www.readbyqxmd.com/read/28798726/systems-biology-analysis-of-temporal-in-vivo-brucella-melitensis-and-bovine-transcriptomes-predicts-host-pathogen-protein-protein-interactions
#4
Carlos A Rossetti, Kenneth L Drake, Sara D Lawhon, Jairo S Nunes, Tamara Gull, Sangeeta Khare, Leslie G Adams
To date, fewer than 200 gene-products have been identified as Brucella virulence factors, and most were characterized individually without considering how they are temporally and coordinately expressed or secreted during the infection process. Here, we describe and analyze the in vivo temporal transcriptional profile of Brucella melitensis during the initial 4 h interaction with cattle. Pathway analysis revealed an activation of the "Two component system" providing evidence that the in vivo Brucella sense and actively regulate their metabolism through the transition to an intracellular lifestyle...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28797045/epidemiology-of-bovine-brucellosis-in-costa-rica-lessons-learned-from-failures-in-the-control-of-the-disease
#5
Gabriela Hernández-Mora, Nazareth Ruiz-Villalobos, Roberto Bonilla-Montoya, Juan-José Romero-Zúniga, Julio Jiménez-Arias, Rocío González-Barrientos, Elías Barquero-Calvo, Carlos Chacón-Díaz, Norman Rojas, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Edgardo Moreno
Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR were randomly sampled during 2012-2013. A non-random sample of 7907 herds (532199 bovines) of the six regions, arriving for diagnoses during 2014-2016 to the Costa Rican Animal Health Service was also studied. The prevalence estimated by Rose Bengal test (RBT) ranged from 10.5%-11.4%; alternatively, the prevalence estimated by testing the RBT positives in iELISA, ranged from 4...
2017: PloS One
https://www.readbyqxmd.com/read/28794225/the-divided-bacterial-genome-structure-function-and-evolution
#6
REVIEW
George C diCenzo, Turlough M Finan
Approximately 10% of bacterial genomes are split between two or more large DNA fragments, a genome architecture referred to as a multipartite genome. This multipartite organization is found in many important organisms, including plant symbionts, such as the nitrogen-fixing rhizobia, and plant, animal, and human pathogens, including the genera Brucella, Vibrio, and Burkholderia. The availability of many complete bacterial genome sequences means that we can now examine on a broad scale the characteristics of the different types of DNA molecules in a genome...
September 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28793352/brucellosis-in-mammals-of-costa-rica-an-epidemiological-survey
#7
Gabriela Hernández-Mora, Roberto Bonilla-Montoya, Osvaldo Barrantes-Granados, Andrea Esquivel-Suárez, Danilo Montero-Caballero, Rocío González-Barrientos, Zeanne Fallas-Monge, José David Palacios-Alfaro, Mario Baldi, Elena Campos, Grettel Chanto, Elías Barquero-Calvo, Carlos Chacón-Díaz, Esteban Chaves-Olarte, Caterina Guzmán Verri, Juan-José Romero-Zúñiga, Edgardo Moreno
Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the country. We have performed a brucellosis survey in these host mammal species, from 1999-2016. In addition, we have documented the number of human brucellosis reported cases, from 2003-2016. The brucellosis seroprevalence in goat and sheep herds was 0.98% and 0.7% respectively, with no Brucella isolation...
2017: PloS One
https://www.readbyqxmd.com/read/28780821/-an-analysis-of-influencing-factors-for-brucellosis-in-major-occupational-groups-in-bayannur-china
#8
M Z Cao, Y H Yang, Z T Chen, P Zhao, L L He
Objective: To investigate the current status of brucella infection in major occupational groups in Bayannur, China, and to analyze the risk factors for brucellosis. Methods: From January to March, 2015, a questionnaire survey and the serological testing were performed to investigate the current status of brucella infection in 649 workers in 13 slaughter and breeding plants in 7 counties in Bayannur, China. The items in the questionnaire survey included general information, related occupational information, living habits, medical history, and awareness of related knowledge...
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28774972/genome-sequences-of-brucella-melitensis-isolated-from-blood-samples-of-brucellosis-patients-in-malaysia
#9
Jama'ayah Mohamed Zahidi, Norazah Ahmad, Bee Yong Tay, Rohaidah Hashim, Evie Khoo, Nurizan Ahmad, Chung Yan Yee, Nur Qhaledaziea Dolhan
Human brucellosis is a neglected zoonotic disease and has widespread geographical distribution. Brucella melitensis has caused outbreaks and sporadic cases in Malaysia. Here, we present the whole-genome sequences of four B. melitensis strains isolated from brucellosis patients in Malaysia.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28770876/assessment-of-the-underlying-causes-of-the-immune-thrombocytopenia-ten-years-experience
#10
Mehmet Sinan Dal, Abdullah Karakus, Tuba Dal, Berrin Balik Aydin, Elif Hattapoglu, Mehmet Onder Ekmen, Turgay Ulas, Orhan Ayyildiz
OBJECTIVE: Immune thrombocytopenia (ITP) is an immune haematologic disorder causing platelet destruction mediated by anti-platelet antibodies. In this study we aimed to evaluate the clinical and laboratory variables of ITP patients in southeast of Turkey. METHODS: In this retrospective study 167 ITP patients between 2005 and 2015 were evaluated. All patients were screened for immunological parameters including ANA (antinuclear antibodies), anti dsDNA (anti-double-stranded-DNA), ACA(anti-cardiolipin) IgM and IgG, LA (lupus anticoagulants)...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28767704/b-abortus-rna-is-the-component-involved-in-the-down-modulation-of-mhc-i-expression-on-human-monocytes-via-tlr8-and-the-egfr-pathway
#11
M Ayelén Milillo, Lis N Velásquez, Aldana Trotta, M Victoria Delpino, Fábio V Marinho, Luciana Balboa, Mónica Vermeulen, Sonia L Espindola, Nahuel Rodriguez-Rodrigues, Gabriela C Fernández, Sergio Costa Oliveira, Guillermo H Giambartolomei, Paula Barrionuevo
Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modulating cytotoxic CD8+ T cell responses. MHC-I down-modulation depends on bacterial viability and results from the capacity of B. abortus to retain the MHC-I molecules within the Golgi apparatus. Furthermore, we recently demonstrated that epidermal growth factor receptor (EGFR) pathway is involved in this phenomenon and that this is an early event during infection...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28766326/a-review-of-brucellosis-in-iran-epidemiology-risk-factors-diagnosis-control-and-prevention
#12
Maryam Golshani, Saeid Buozari
Brucellosis caused by species of Brucella is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination, which harbors significant disadvantages. Considering the identification of many immunogenic proteins in Brucella, several studies have recently been performed to evaluate the vaccine potency of such antigens as a new subunit vaccine candidate...
August 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28766037/did-rev-1-small-ruminants-vaccination-helped-improve-cattle-brucellosis-prevalence-status-in-algeria
#13
Moustafa Kardjadj
In 2006, the Algerian authorities started the Rev-1 vaccination of sheep and goats; consequently, there was a significant improvement of small ruminant brucellosis sanitary status. In this paper, we attempt to study the effect of Rev-1 small ruminants' vaccination on cattle brucellosis prevalence in Algeria. Our results showed an overall cattle herd seroprevalence of 12% (9 positive herds of 75). The risk factor analysis using a logistic regression model indicated that the presence of small ruminants along with cattle in the herd (mixed herds) decreased the odds for brucellosis seropositivity by 1...
August 1, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28757013/a-haplotype-at-intron-8-of-ptprt-gene-is-associated-with-resistance-to-brucella-infection-in-argentinian-creole-goats
#14
Ursula A Rossi, Flavia C Hasenauer, Maria E Caffaro, Roberto Neumann, Antonio Salatin, Mario A Poli, Carlos A Rossetti
Brucellosis is the leading zoonosis on a worldwide scale and constitutes a major public health threat in many regions of the world. Several molecular markers associated with natural resistance to intracellular bacterial infection have been identified. Recently seven single-nucleotide polymorphisms (SNPs) located in the PTPRT gene were associated with resistance to Mycobacterium bovis infection in cattle. Here, we perform a case-control study to test if polymorphisms at PTPRT intron 8 might influence the resistance or susceptibility to Brucella infection in goats...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28750539/octupolar-metastructures-for-a-highly-sensitive-rapid-and-reproducible-phage-based-detection-of-bacterial-pathogens-by-surface-enhanced-raman-scattering
#15
Massimo Rippa, Riccardo Castagna, Marianna Pannico, Pellegrino Musto, Giorgia Borriello, Rubina Paradiso, Giorgio Galiero, Sergio Bolletti Censi, Jun Zhou, Joseph Zyss, Lucia Petti
The development of fast and ultrasensitive methods to detect bacterial pathogens at low concentrations is of high relevance for human and animal health care and diagnostics. In this context, surface-enhanced Raman scattering (SERS) offers the promise of a simplified, rapid, and high-sensitive detection of biomolecular interactions with several advantages over previous assay methodologies. In this work, we have conceived reproducible SERS nanosensors based on tailored multilayer octupolar nanostructures which can combine high enhancement factor and remarkable molecular selectivity...
July 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28749771/seroprevalence-of-brucellosis-among-patients-attending-a-district-hospital-in-rwanda
#16
James Gafirita, George Kiiza, Angelique Murekatete, Leonard L Ndahayo, John Tuyisenge, Vedaste Mashengesho, Rudoviko Ruhirwa, Theogene Nyandwi, Brenda Asiimwe-Kateera, Vedaste Ndahindwa, Kato J Njunwa
Studies on human brucellosis in Rwanda are scarce, and the incidence is likely to be higher than official estimates. In a recent study using Rose Bengal Test (RBT) on women who had aborted or had still births in Huye district, 25% were Brucella seroprevalent. Thus, purpose of the present study was to investigate the Brucella seroprevalence in patients presenting with the key signs and symptoms of brucellosis. Cross-sectional study was done in Nyagatare District in the Eastern Province of Rwanda. A total of 198 patients were recruited from Nyagatare District Hospital, blood samples were collected, and sera analyzed with RBT...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28738473/-hoof-genotyping-characteristics-of-brucella-melitensis-strains-isolated-in-ulanqab-of-inner-mongolia-autonomous-region
#17
Z G Liu, M Wang, R H Liu, X J Shang, B Y Cui
Objective: To investigate the HOOF genotyping characteristics of 83 Brucella (B.) melitensis strains isolated in Ulanqab of Inner Mongolia Autonomous Region from 2012 to 2015. Methods: A total of 83 B. melitensis strains were detected by convention identification and AMOS-PCR, then HOOF protocol with eight VNTR locus were used for the genotyping of the strains, and the allelic diversity of each VNTR locus and the discriminatory power of VNTR typing of HOOF were assessed by Hunter-Gaston Discriminatory index...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28737147/brucella-causing-liver-abscess-in-a-child-with-selective-iga-deficiency
#18
Devdeep Mukherjee, Priyankar Pal, Ritabrata Kundu
BACKGROUND: Brucella has been known to cause pyrexia of unknown origin. CASE CHARACTERISTICS: 9-year-old boy with fever and abdominal pain; multiple abscesses within the liver on ultrasonography. OBSERVATIONS: IgM Antibodies against Brucella were raised in his serum sample, and Brucella serum agglutination test was positive. Immunological work-up suggested selective IgA deficiency. Reduction in size following treatment with trimethoprim-sulphamethoxazole, amikacin and doxycycline...
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28734711/-bifidobacterium-scardovii-isolated-from-2-consecutive-urine-samples
#19
Daiana Guevara Nuñez, Adriana N De Paulis, Eugenia Bertona, Miguel Ángel Gutiérrez, Carlos A Vay, Juan P Suárez, Silvia C Predari
Bifidobacterium scardovii species consists of facultative anaerobic gram-positive rods whose growth is stimulated by CO2 and anaerobiosis. Exceptionally it has been associated with infections in humans. An elderly male patient with a urinary tract infection due to B. scardovii and Enterococcus faecalis is presented here; both microorganisms were isolated from two consecutive urine samples. The bacillus did not grow on standard media, but on chocolate agar incubated in CO2 and on supplemented Brucella agar in an anaerobic atmosphere, incubated for 72h at 35°C...
July 19, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28719613/visual-detection-of-brucella-in-bovine-biological-samples-using-dna-activated-gold-nanoparticles
#20
Dheeraj Pal, Nongthombam Boby, Satish Kumar, Gurpreet Kaur, Syed Atif Ali, Julien Reboud, Sameer Shrivastava, Praveen K Gupta, Jonathan M Cooper, Pallab Chaudhuri
Brucellosis is a bacterial disease, which, although affecting cattle primarily, has been associated with human infections, making its detection an important challenge. The existing gold standard diagnosis relies on the culture of bacteria which is a lengthy and costly process, taking up to 45 days. New technologies based on molecular diagnosis have been proposed, either through dip-stick, immunological assays, which have limited specificity, or using nucleic acid tests, which enable to identify the pathogen, but are impractical for use in the field, where most of the reservoir cases are located...
2017: PloS One
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