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https://www.readbyqxmd.com/read/29783033/coordination-of-symbiosis-and-cell-cycle-functions-in-sinorhizobium-meliloti
#1
REVIEW
Shuanghong Xue, Emanuele G Biondi
The symbiotic nitrogen fixing species Sinorhizobium meliloti represents a remarkable model system for the class Alphaproteobacteria, which includes genera such as Caulobacter, Agrobacterium and Brucella. It is capable of living free in the soil, and is also able to establish a complex symbiosis with leguminous plants, during which its cell cycle program is completely rewired presumably due, at least in part, to the action of peptides secreted by the plant. Here we will discuss how the cell cycle regulation works in S...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29781672/immunological-response-to-brucella-abortus-strain-19-vaccination-of-cattle-in-a-communal-area-in-south-africa
#2
Gregory J G Simpson, Tanguy Marcotty, Elodie Rouille, Abel Chilundo, Jean-Jacques Letteson, Jacques Godfroid
Brucellosis is of worldwide economic and public health importance. Heifer vaccination with live attenuated Brucella abortus strain 19 (S19) is the cornerstone of control in low- and middle-income countries. Antibody persistence induced by S19 is directly correlated with the number of colony-forming units (CFU) per dose. There are two vaccination methods: a 'high' dose (5-8 × 1010 CFU) subcutaneously injected or one or two 'low' doses (5 × 109 CFU) through the conjunctival route. This study aimed to evaluate serological reactions to the 'high' dose and possible implications of the serological findings on disease control...
March 29, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29777092/seroprevalence-of-brucellosis-in-butchers-veterinarians-and-slaughterhouse-workers-in-hamadan-western-iran
#3
Mojgan Mamani, Mohammad Mehdi Majzoobi, Fariba Keramat, Nesa Varmaghani, Abbas Moghimbeigi
BACKGROUND: Brucellosis is a zoonotic disease caused by Brucella species via infected domestic animals. In endemic areas, certain occupations such as veterinarians, butchers, and slaughterhouse workers are considered high risk regarding brucellosis. We evaluated the seroprevalence of brucellosis in high-risk occupations in Hamadan, West of Iran. STUDY DESIGN: a cross-sectional study. METHODS: Overall, 218 participants from 2014 to 2015 were enrolled...
February 10, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29774845/brucella-suis-infection-in-dog-fed-raw-meat-the-netherlands
#4
Marloes A M van Dijk, Marc Y Engelsma, Vanessa X N Visser, Marcel A H Spierenburg, Marjolijn E Holtslag, Peter T J Willemsen, Jaap A Wagenaar, Els M Broens, Hendrik I J Roest
A Brucella suis biovar 1 infection was diagnosed in a dog without typical exposure risks, but the dog had been fed a raw meat-based diet (hare carcasses imported from Argentina). Track and trace investigations revealed that the most likely source of infection was the dog's raw meat diet.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773631/draft-genome-sequence-of-staphylococcus-microti-dsm-22147-isolated-from-the-common-vole
#5
XinJun Hu, Yibing Shang, Jing Guo, Huping Zhang, Yalin Liang, Jifeng Sun, Feng Yue
Staphylococcus microti DSM 22147 was isolated from viscera of common voles ( Microtus arvalis Pallas) with generalized Brucella microti infection in the Czech Republic. To the best of our knowledge, the genome sequence of the species S. microti has not been previously studied. The complete genome sequence of strain DSM 22147 includes a genome of 2,381,859 bp (38.0% GC content) without any plasmids.
May 17, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29769511/an-elderly-lady-with-neurobrucellosis-and-multiple-co-morbid-conditions
#6
M N Islam
Neurobrucellosis is a rare (1.7-7.0% of prevalence) neurological complication of brucellosis which has neither a typical clinical picture nor specific cerebrospinal fluid (CSF) findings and mimics other neurological disorders leading to clinical diagnostic dilemmas. This study describes one elderly patient of neurobrucellosis with fever, irrelevant behavior, sweating, fatigue, drowsiness, neck stiffness inability to speak and reduced activity for about 10 days hailing from Beanibazar, Sylhet, Bangladesh admitted in Mount Adora Hospital, Sylhet, Bangladesh on 16th October 2016...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29761597/the-mycobacterium-tuberculosis-complex-has-a-pathway-for-the-biosynthesis-of-4-formamido-4-6-dideoxy-d-glucose
#7
Haley A Brown, Evgeny Vinogradov, Michel Gilbert, Hazel M Holden
Recent studies have demonstrated that the O-antigens of some pathogenic bacteria such as Brucella abortus, Francisella tularensis, and Campylobacter jejuni contain quite unusual N-formylated sugars (3-formamido-3,6-dideoxy-d-glucose or 4-formamido-4,6-dideoxy-d-glucose). Typically, four enzymes are required for the formation of such sugars: a thymidylyltransferase, a 4,6-dehydratase, a pyridoxal 5'-phosphate or PLP-dependent aminotransferase, and an N-formyltransferase. To date, there have been no published reports of N-formylated sugars associated with Mycobacterium tuberculosis...
May 15, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29755726/-trueperella-pyogenes-and-brucella-abortus-coinfection-in-a-dog-and-a-cat-on-a-dairy-farm-in-egypt-with-recurrent-cases-of-mastitis-and-abortion
#8
Gamal Wareth, Mohamed El-Diasty, Falk Melzer, Jayaseelan Murugaiyan, Amir Abdulmawjood, Lisa D Sprague, Heinrich Neubauer
Trueperella pyogenes was isolated from a dog and a cat with a mixed infection with Brucella abortus . Both lived on a dairy cattle farm with a history of regular cases of abortion and mastitis. Identification of the bacteria was done by means of MALDI-TOF MS, loop-mediated isothermal amplification (LAMP) based on cpn 60, partial 16S rRNA sequencing, and growth on Loeffler Serum Medium. Isolation of Trueperella pyogenes on the dairy farm highlights its neglected role in reproduction failure and draws attention to its effects in the dairy industry in Egypt...
2018: Veterinary Medicine International
https://www.readbyqxmd.com/read/29752779/sequencing-and-phylogenetic-characterization-of-brucella-canis-isolates-ohio-2016
#9
L Wang, J Cui, M B Misner, Y Zhang
Brucella canis is one of zoonotic pathogens causing infection in human. In this study, we isolated and sequenced 38 B. canis strains from 11 cases. Core genome multilocus sequence typing analysis classified all B. canis isolates into two genogroups, GI and GII. All 38 isolates cluster together forming a 2016 Ohio cluster, in which they form five subclusters reflecting their geographical differences. Unlike GI, the isolates of the GII are from diverse geographical locations including Asia, America, Africa, and Europe and form Asia and South America clusters...
May 11, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29751649/serosurvey-for-infectious-agents-associated-with-subfertility-and-abortion-in-dairy-cattle-in-trinidad-and-tobago-west-indies
#10
Michael J Morris, Jamie Sookhoo, Lemar Blake, Arianne Brown Jordan, Justine John, Sheliza Ali, Gervaise Sarjusingh, Janelle St Aime, Edward H Amoroso, Christopher A L Oura
Despite frequent reports of subfertility and abortion in dairy cattle in Trinidad and Tobago (T&T), little is known about the potential infectious and non-infectious causes. This study set out to investigate possible infectious causes of reproductive problems by measuring the seroprevalence of four of the most significant reproductive pathogens in dairy cattle worldwide: Brucella abortus (B. abortus) ; Neospora caninum ( N. caninum ), Bovine Viral Diarrhoea virus (BVDV), and Infectious Bovine Rhinotracheitis virus (IBRV)...
May 11, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29747573/global-evolution-and-phylogeography-of-brucella-melitensis-strains
#11
Sergey V Pisarenko, Dmitry A Kovalev, Anna S Volynkina, Dmitry G Ponomarenko, Diana V Rusanova, Nina V Zharinova, Anna A Khachaturova, Lyudmila E Tokareva, Irina G Khvoynova, Alexander N Kulichenko
BACKGROUND: Brucellosis is a bacterial zoonotic disease. Annually in the world more than 500,000 new cases of brucellosis in humans are registered. In this study, we propose an evolutionary model of the historical distribution of B. melitensis based on the full-genomic SNP analysis of 98 strains. RESULTS: We performed an analysis of the SNP of the complete genomes of 98 B. melitensis strains isolated in different geographical regions of the world to obtain relevant information on the population structure, genetic diversity and the evolution history of the species...
May 10, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29746469/cost-benefit-analysis-of-intervention-policies-for-prevention-and-control-of-brucellosis-in-india
#12
Balbir B Singh, Polychronis Kostoulas, Jatinder P S Gill, Navneet K Dhand
BACKGROUND: Brucellosis is endemic in the bovine population in India and causes a loss of US$ 3·4 billion to the livestock industry besides having a significant human health impact. METHODS: We developed a stochastic simulation model to estimate the impact of three alternative vaccination strategies on the prevalence of Brucella infection in the bovine populations in India for the next two decades: (a) annual mass vaccination only for the replacement calves and (b) vaccination of both the adult and young population at the beginning of the program followed by an annual vaccination of the replacement calves and, (c) annual mass vaccination of replacements for a decade followed by a decade of a test and slaughter strategy...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29745323/research-progress-on-brucellosis
#13
Yuming Deng, Xinyue Liu, Kaifang Duan, Qisheng Peng
Brucellosis is a debilitating febrile illness caused by an intracellular Brucella. The disease distributed in humans and animals widely, especially in developing countries. Ten species are included in the genus Brucella nowadays; four species of them are pathogenic to humans, which making brucellosis a zoonosis with more than 500,000 new cases reported annually. For human brucellosis, the most pathogenic specie is B. melitensis followed by B. suis, while B. abortus is the mildest type of brucellosis. The infection mechanism of Brucella is complicated and mostly relies on its virulence factors...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29742157/an-optimal-set-of-features-for-predicting-type-iv-secretion-system-effector-proteins-for-a-subset-of-species-based-on-a-multi-level-feature-selection-approach
#14
Zhila Esna Ashari, Nairanjana Dasgupta, Kelly A Brayton, Shira L Broschat
Type IV secretion systems (T4SS) are multi-protein complexes in a number of bacterial pathogens that can translocate proteins and DNA to the host. Most T4SSs function in conjugation and translocate DNA; however, approximately 13% function to secrete proteins, delivering effector proteins into the cytosol of eukaryotic host cells. Upon entry, these effectors manipulate the host cell's machinery for their own benefit, which can result in serious illness or death of the host. For this reason recognition of T4SS effectors has become an important subject...
2018: PloS One
https://www.readbyqxmd.com/read/29740101/tissue-distribution-and-cell-tropism-of-brucella-canis-in-naturally-infected-canine-foetuses-and-neonates
#15
Tayse Domingues de Souza, Tatiane Furtado de Carvalho, Juliana Pinto da Silva Mol, João Vítor Menezes Lopes, Monique Ferreira Silva, Tatiane Alves da Paixão, Renato Lima Santos
Brucella canis infection is an underdiagnosed zoonotic disease. Knowledge about perinatal brucellosis in dogs is extremely limited, although foetuses and neonates are under risk of infection due to vertical transmission. In this study, immunohistochemistry was used to determine tissue distribution and cell tropism of B. canis in canine foetuses and neonates. Diagnosis of B. canis in tissues of naturally infected pups was based on PCR and sequencing of amplicons, bacterial isolation, and immunohistochemistry, whose specificity was confirmed by laser capture microdissection...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736150/diagnostic-potential-of-brucella-melitensis-rev1-native-omp28-precursor-in-human-brucellosis
#16
Ismail Koyuncu, Abdurrahman Kocyigit, Ahmet Ozer, Sahabettin Selek, Adnan Kirmit, Hasan Karsen
Serologic tests for brucellosis aim to detect antibodies produced against membranous lipopolysaccharide of bacteria. Diagnostic use of this method is limited due to false positiveness. This study evaluates an alternative antigen to lipopolysaccharides (LPS), outer membrane 28-precursor-protein, of Brucella melitensis Rev1 for its diagnostic value. Omp28 precursor of B. melitensis Rev1 was cloned, expressed, and purified. 6-His and sumo epitope tags were used to tag the protein at N-termini. Omp28 gene was amplified based on the ORF sequence and cloned into a pETSUMO vector...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29735518/-brucella-peptide-cross-reactive-mhc-i-presentation-activates-siinfekl-specific-tcr-expressing-t-cells
#17
Jerome S Harms, Mike Khan, Cherisse Hall, Gary A Splitter, E Jane Homan, Robert D Bremel, Judith A Smith
Brucella spp are intracellular pathogenic bacteria remarkable in their ability to escape immune surveillance and therefore inflict a state of chronic disease within the host. To enable further immune response studies, Brucella were engineered to express the well characterized chicken ovalbumin (OVA). Surprisingly, we found that CD8 T cells bearing T cell receptors (TCR) nominally specific for the OVA peptide SIINFEKL (OT-1) reacted to parental Brucella -infected targets as well as OVA-expressing Brucella variants in cytotoxicity assays...
May 7, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29733367/learning-from-the-master-targets-and-functions-of-the-ctra-response-regulator-in-brucella-abortus-and-other-alpha-proteobacteria
#18
Katy Poncin, Sébastien Gillet, Xavier De Bolle
The α-proteobacteria are a fascinating group of free-living, symbiotic and pathogenic organisms, including the Brucella genus, which is responsible for a worldwide zoonosis. One common feature of α-proteobacteria is the presence of a conserved response regulator called CtrA, first described in the model bacterium Caulobacter crescentus, where it controls gene expression at different stages of the cell cycle. Here, we focus on Brucella abortus and other intracellular α-proteobacteria in order to better assess the potential role of CtrA in the infectious context...
May 3, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29732324/retrospective-study-on-the-hygienic-quality-of-fresh-ricotta-cheeses-produced-in-sicily-italy
#19
Maria Luisa Scatassa, Isabella Mancuso, Sonia Sciortino, Giusi Macaluso, Marisa Palmeri, Luigi Arcuri, Massimo Todaro, Cinzia Cardamone
The present work was carried out to investigate the microbiological profile of Sicilian ewes' ricotta cheeses during fifteen years of investigations (2002-2016). The samples were collected between those conferred to the Istituto Zooprofilattico Sperimentale della Sicilia (IZSSi) Adelmo Mirri , Palermo (Italy), by the competent authority during official control, by food business operator in HACCP systems and in research projects. Enterobacteriaceae, Escherichia coli and coagulase - positive staphylococci (CPS) were found only in some samples...
March 31, 2018: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29732320/activation-of-host-ire1%C3%AE-dependent-signaling-axis-contributes-the-intracellular-parasitism-of-brucella-melitensis
#20
Aseem Pandey, Furong Lin, Ana L Cabello, Luciana F da Costa, Xuehuan Feng, Hui-Qiang Feng, Ming-Zhe Zhang, Takao Iwawaki, Allison Rice-Ficht, Thomas A Ficht, Paul de Figueiredo, Qing-Ming Qin
Brucella spp. are intracellular vacuolar pathogens that causes brucellosis, a worldwide zoonosis of profound importance. We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1α (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitensis and Brucella abortus intracellular replication. However, the mechanism by which host IRE1α regulates the pathogen intracellular lifestyle remains elusive. In this study, by employing a diverse array of molecular approaches, including biochemical analyses, fluorescence microscopy imaging, and infection assays using primary cells derived from Ern1 (encoding IRE1) conditional knockout mice, we address this gap in our understanding by demonstrating that a novel IRE1α to ULK1, an important component for autophagy initiation, signaling axis confers susceptibility to Brucella intracellular parasitism...
2018: Frontiers in Cellular and Infection Microbiology
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