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https://www.readbyqxmd.com/read/28934239/characterisation-of-north-american-brucella-isolates-from-marine-mammals
#1
Adrian M Whatmore, Claire Dawson, Jakub Muchowski, Lorraine L Perrett, Emma Stubberfield, Mark Koylass, Geoffrey Foster, Nicholas J Davison, Christine Quance, Inga F Sidor, Cara L Field, Judy St Leger
Extension of known ecological niches of Brucella has included the description of two novel species from marine mammals. Brucella pinnipedialis is associated predominantly with seals, while two major Brucella ceti clades, most commonly associated with porpoises or dolphins respectively, have been identified. To date there has been limited characterisation of Brucella isolates obtained from marine mammals outside Northern European waters, including North American waters. To address this gap, and extend knowledge of the global population structure and host associations of these Brucella species, 61 isolates from marine mammals inhabiting North American waters were subject to molecular and phenotypic characterisation enabling comparison with existing European isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28930081/exposure-of-harbour-seals-phoca-vitulina-to-brucella-in-declining-populations-across-scotland
#2
Joanna L Kershaw, Emma J Stubberfield, Geoffrey Foster, Andrew Brownlow, Ailsa J Hall, Lorraine L Perrett
Since 2000 there has been a major decline in the abundance of Scottish harbour seals Phoca vitulina. The causes of the decline remain uncertain. The aim of this study was to establish the extent to which the seals in the regions of greatest decline have been exposed to Brucella, a bacterial pathogen that causes reproductive failure in terrestrial mammalian hosts. Tissues from dead seals collected between 1992 and 2013 were cultured for Brucella (n = 150). Serum samples collected from live capture-released seals (n = 343) between 1997 and 2012 were tested for Brucella antibodies using the Rose Bengal plate agglutination test (RBT) and a competitive enzyme-linked immunosorbent assay (cELISA)...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28930080/seroprevalence-of-brucella-antibodies-in-harbor-seals-in-alaska-usa-with-age-regional-and-reproductive-comparisons
#3
A Hoover-Miller, J L Dunn, C L Field, G Blundell, S Atkinson
Populations of harbor seal Phoca vitulina in the Gulf of Alaska have dramatically declined during the past 4 decades. Numbers of seals in Glacier Bay, in southeast Alaska, USA, have also declined despite extensive protection. Causes of the declines and slow recovery are poorly understood. Brucellosis is a zoonotic disease that adversely affects reproduction in many domestic species. We measured the seroprevalence of Brucella antibodies in 554 harbor seals in 3 Alaska locations: Prince William Sound (PWS), Glacier Bay (GB), and Tracy Arm Fords Terror (TAFT) Wilderness Area...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28929962/-determination-of-in-vitro-susceptibilities-of-brucella-spp-strains-against-11-different-antibacterial-gents-isolated-from-blood-cultures
#4
Recep Keşli, Hüseyin Bilgin, Halim Yılmaz
Brucellosis is a worldwide zoonotic disease and still continuous to be a major public health problem. In this study, it was aimed to identify the Brucella strains to the species level isolated from blood cultures, and to determine the rate of antimicrobial susceptibility against eleven antibacterial agents. A total of 106 Brucella spp. strains were included in the study, which were isolated from blood cultures in University of Health Sciences, Konya Training and Research Hospital, Medical Microbiology Laboratory between January 2011 and June 2013...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28926008/the-economic-efficiency-and-equity-of-government-policies-on-brucellosis-comparative-insights-from-albania-and-the-united-states-of-america
#5
D Peck, M Bruce
Brucellosis is a zoonotic bacterial disease that causes recurring febrile illness in humans, as well as reproductive failure and reduced milk production in livestock. The cost of brucellosis is equal to the sum of lost productivity of humans and animals, as well as private and public expenditures on brucellosis surveillance, prevention, control and treatment. In Albania, Brucella abortus and B. melitensis affect humans, cattle and small ruminants. In the United States, B. abortus affects cattle and wild ungulates in the Greater Yellowstone Area...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28924723/sixteen-chinese-pediatric-brucellosis-patients-onset-of-fever-in-non-epidemic-areas-and-8-developed-with-osteoarticular-involvement
#6
Xinning Wang, Yuchun Yan, Fengqi Wu, Gaixiu Su, Shengnan Li, Xinyu Yuan, Jianming Lai, Zhixuan Zhou
The purpose of this study is to summarize the manifestations, diagnosis, differential diagnosis, and treatment of childhood brucellosis in non-epidemic areas of China. A retrospective review of 16 admitted children patients with brucella's disease who were diagnosed of brucellosis during the period from 2011 to 2016 was performed. Diagnostic criteria, clinical presentations, and outcomes were recorded. The most common symptom was fever. Osteoarticular involvement was found in 50% of the patients. They were infected by contacting with infected animals or consuming of unpasteurized milk or meat of sheep or goats, also...
September 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28924631/new-features-in-the-lipid-a-structure-of-brucella-suis-and-brucella-abortus-lipopolysaccharide
#7
Adriana C Casabuono, Cecilia Czibener, Mariela G Del Giudice, Ezequiel Valguarnera, Juan E Ugalde, Alicia S Couto
Brucellaceae are Gram-negative bacteria that cause brucellosis, one of the most distributed worldwide zoonosis, transmitted to humans by contact with either infected animals or their products. The lipopolysaccharide exposed on the cell surface has been intensively studied and is considered a major virulence factor of Brucella. In the last years, structural studies allowed the determination of new structures in the core oligosaccharide and the O-antigen of this lipopolysaccharide. In this work, we have reinvestigated the lipid A structure isolated from B...
September 18, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28919691/molecular-etiopathology-of-naturally-occurring-reproductive-diseases-in-female-goats
#8
V Beena, R V S Pawaiya, K Gururaj, D D Singh, A K Mishra, N K Gangwar, V K Gupta, R Singh, A K Sharma, M Karikalan, Ashok Kumar
AIM: The aim of the present study was to investigate the molecular etiopathology of occurrence of reproductive diseases in female goats. Reproductive diseases in goats account for major economic losses to goat farmers in terms of valuable loss of offspring and animal productivity. MATERIALS AND METHODS: A total of 660 female genitalia were examined for pathological conditions (macroscopic and microscopic lesions). The etiopathological study was carried out for the presence of pathogenic organisms such as Brucella, Chlamydia, and Campylobacter in the uterus and ovary...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919584/reduced-ifn-%C3%AE-production-in-chronic-brucellosis-patients
#9
Ehsanollah Ghaznavi Rad, Khadijeh Khosravi, Nader Zarinfar, Ghasem Mosayebi
BACKGROUND: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. OBJECTIVE: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. METHODS: In this cross-sectional study, 22 individuals with acute brucellosis, 21 individuals with chronic brucellosis, and 21 healthy individuals with the same genetic background were recruited from October 2015 to April 2016...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919551/identification-of-potential-antigens-from-non-classically-secreted-proteins-and-designing-novel-multitope-peptide-vaccine-candidate-against-brucella-melitensis-through-reverse-vaccinology-and-immunoinformatics-approach
#10
Udayakumar S Vishnu, Jagadesan Sankarasubramanian, Paramasamy Gunasekaran, Jeyaprakash Rajendhran
Brucella melitensis is an intracellular pathogen resides in the professional and non-professional phagocytes of the host, causing zoonotic disease brucellosis. The stealthy nature of the Brucella makes it's highly pathogenic, and it is hard to eliminate the bacteria completely from the infected host. Hitherto, no licensed vaccines are available for human brucellosis. In this study, we identified potential antigens for vaccine development from non-classically secreted proteins through reverse vaccinology approach...
September 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28916316/the-brucella-melitensis-m5-90%C3%AE-manb-live-vaccine-candidate-is-safer-than-m5-90-and-confers-protection-against-wild-type-challenge-in-balb-c-mice
#11
Junbo Zhang, Shuanghong Yin, Dewu Yi, Hong Zhang, Zhiqiang Li, Fei Guo, Chuangfu Chen, Weihuan Fang, Jiafu Wang
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. Although effective, the current Brucella vaccines (strain M5-90 or others) have several drawbacks. The first is their residual virulence for animals and humans and the second is their inability to differentiate natural infection from that caused by vaccination. In the present study, Brucella melitensis M5-90 manB mutant (M5-90ΔmanB) was generated to overcome these drawbacks. M5-90ΔmanB showed significantly reduced survival in macrophages and mice, and induced strong protective immunity in BALB/c mice...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28916314/immunization-with-recombinant-gntr-plasmid-confers-protection-against-brucella-challenge-in-balb-c-mice
#12
Zhiqiang Li, Shuli Wang, Hui Zhang, Li Xi, Jinliang Zhang, Xiaogen Zhang, Jincheng Han, Junbo Zhang
It is essential to improve animal vaccine for brucellosis since conventional vaccines are residual virulent and poor protective effect, limit their applications. To solve these problems, the recombinant DNA vaccines were appeared, which could improve protective immunity and were attenuated to animals. In current research, the recombinant DNA vaccine (pVGntR) based on transcriptional regulator GntR of Brucella abortus (B. abortus) was constructed. The results show that pVGntR is significantly more protective than the conventional RB51 vaccine...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28912327/whole-genome-sequence-of-the-first-sequence-type-27-brucella-ceti-strain-isolated-from-european-waters
#13
Sanja Duvnjak, Silvio Špičić, Darja Kušar, Bojan Papić, Irena Reil, Maja Zdelar-Tuk, Željko Pavlinec, Martina Đuras, Tomislav Gomerčić, Rene S Hendriksen, Željko Cvetnić
Brucella spp. that cause marine brucellosis are becoming more important, as the disease appears to be more widespread than originally thought. Here, we report a whole and annotated genome sequence of Brucella ceti CRO350, a sequence type 27 strain isolated from a bottlenose dolphin carcass found in the Croatian part of the northern Adriatic Sea.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28904852/seroprevalence-of-brucellosis-in-human-immunodeficiency-virus-infected-patients-in-hamadan-iran
#14
Fariba Keramat, Mohammad Mehdi Majzobi, Jalal Poorolajal, Zohreh Zarei Ghane, Maryam Adabi
OBJECTIVES: Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in Hamadan Province in the west of Iran. METHODS: A total of 157 HIV-infected patients were screened through standard serological tests, including Wright's test, Coombs' Wright test, and 2-mercaptoethanol Brucella agglutination test (2ME test), blood cultures in Castaneda media, and CD4 counting...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28904791/brucellosis-in-livestock-and-wildlife-zoonotic-diseases-without-pandemic-potential-in-need-of-innovative-one-health-approaches
#15
Jacques Godfroid
Human brucellosis remains the commonest zoonotic disease worldwide with more than 500 000 new cases annually. Understanding the biology of Brucella infections and the transmission patterns at the wildlife/livestock/human interface is of paramount importance before implementing any brucellosis control or eradication program in animals, even more so should interventions be justified within One Health. In addition to calling for transdisciplinary collaboration, One Health formally aims to conserve the environment and to promote the well-being of animals...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28899413/evolution-and-genome-specialization-of-brucella-suis-biovar-2-iberian-lineages
#16
Ana Cristina Ferreira, Rogério Tenreiro, Maria Inácia Corrêa de Sá, Ricardo Dias
BACKGROUND: Swine brucellosis caused by B. suis biovar 2 is an emergent disease in domestic pigs in Europe. The emergence of this pathogen has been linked to the increase of extensive pig farms and the high density of infected wild boars (Sus scrofa). In Portugal and Spain, the majority of strains share specific molecular characteristics, which allowed establishing an Iberian clonal lineage. However, several strains isolated from wild boars in the North-East region of Spain are similar to strains isolated in different Central European countries...
September 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28888882/genome-wide-sequence-transposon-insertion-sites-and-analyze-the-essential-genes-of-brucella-melitensis
#17
Yanyan De, Congyue Dong, Yanyang Cao, Xiaolei Wang, Xiaowen Yang, Ning Wang, Cunrui Zhang, Zhen Wang, Yanli Lyu, Qingmin Wu
A transposon mutant library of B. melitensis NI including 32,640 transposon mutants was established. By sequencing the transposon insertion sites, 10,832 mutants were successfully defined for their insertion sites. Analysis of the mutants with defined transposon insertion sites (DTIS) indicated that the insertions were well spread through the two genomes. In addition, 948 genes with no detectable transposon insertions were taken as the candidate for identification of essential genes. In comparison with the Bacterial Database of Essential Genes and by using comparative genomics analysis, 183 potential essential genes of B...
September 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28888634/development-of-improved-enzyme-based-and-lateral-flow-immunoassays-for-rapid-and-accurate-serodiagnosis-of-canine-brucellosis
#18
María E Cortina, Analía Novak, Luciano J Melli, Sebastián Elena, Natalia Corbera, Juan E Romero, Ana M Nicola, Juan E Ugalde, Diego J Comerci, Andrés E Ciocchini
Brucellosis is a widespread zoonotic disease caused by Brucella spp. Brucella canis is the etiological agent of canine brucellosis, a disease that can lead to sterility in bitches and dogs causing important economic losses in breeding kennels. Early and accurate diagnosis of canine brucellosis is central to control the disease and lower the risk of transmission to humans. Here, we develop and validate enzyme and lateral flow immunoassays for improved serodiagnosis of canine brucellosis using as antigen the B...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28886746/prevalence-of-antibodies-to-brucella-species-in-commercial-raw-bovine-milk-in-southwestern-uganda
#19
Monicah Kamwine, Patrick Orikiriza, Kabanda Taseera, Jacob Stanley Iramiot, Patrick Ojuka, Steven Ikiriza, Jeninah Atwebembeire, Duncan Otieno, Silver Tweshengyereze, Juliet Mwanga-Amumpaire, Joel Bazira, Yap Boum
OBJECTIVES: The purpose and objective of this research was to explore the prevalence of antibodies against Brucella species in raw milk samples collected in Southwestern Uganda, one of the biggest milk producing regions in the Country. We hypothesized that there is a high level of antibodies in milk samples from this region. This builds more evidence to other studies in the region on the level contamination of raw milk. RESULTS: A total of 185 raw milk samples, collected from dairy farms and factories in southwestern region, were tested for antibodies to Brucella spp...
September 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28882137/methodology-for-the-assessment-of-brucellosis-management-practices-and-its-vaccination-campaign-example-in-two-argentine-districts
#20
M N Aznar, M Arregui, M F Humblet, L E Samartino, C Saegerman
BACKGROUND: In Argentina, vaccination with Brucella abortus Strain 19 vaccine is mandatory. The objective of the study was to develop and test a method for evaluating, in an innovative way, some farmers' and veterinarians' management practices in relation to brucellosis and to assess the vaccination campaign and coverage. The work took place in Brandsen and Navarro districts. Four questionnaires were designed (for officials from Local Sanitary Entities, vaccinators, vet practitioners and farmers)...
September 7, 2017: BMC Veterinary Research
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