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https://www.readbyqxmd.com/read/27909584/pyelonephritis-due-to-brucella-species-true-clinical-entity-or-ghost-disease
#1
N G Vallianou, E Geladari, K Trigkidis, E Kokkinakis
No abstract text is available yet for this article.
January 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/27907115/brucella-melitensis-16m-regulates-the-effect-of-air-domain-on-inflammatory-factors-autophagy-and-apoptosis-in-mouse-macrophage-through-the-ros-signaling-pathway
#2
Tiansen Li, Yafang Xu, Laizhen Liu, Meiling Huang, Zhen Wang, Zhixia Tong, Hui Zhang, Fei Guo, Chuangfu Chen
Brucellosis is a highly contagious zoonosis caused by Brucella. Brucella can invade and persist inside host cells, which results in chronic infection. We constructed AIR interference and overexpression lentiviruses to acquire AIR interference, overexpression, and rescue stable expression cell lines. We also established a Brucella melitensis 16M-infected macrophage model, which was treated with either the vehicle control or NAC (ROS scavenger N-acetylcysteine (NAC) for 0, 3, 6, 12, and 24 h. Confocal laser microscopy, transmission electron microscopy, fluorescence quantitative PCR, flow cytometry, ELISA, and Western blot were used to detect inflammation, cell autophagy and apoptosis-related protein expression levels, ROS levels, and the distribution of mitochondria...
2016: PloS One
https://www.readbyqxmd.com/read/27907105/epidemiology-of-brucellosis-and-genetic-diversity-of-brucella-abortus-in-kazakhstan
#3
Elena Shevtsova, Alexandr Shevtsov, Kasim Mukanov, Maxim Filipenko, Dinara Kamalova, Igor Sytnik, Marat Syzdykov, Andrey Kuznetsov, Assel Akhmetova, Mira Zharova, Talgat Karibaev, Pavel Tarlykov, Erlan Ramanculov
Brucellosis is a major zoonotic infection in Kazakhstan. However, there is limited data on its incidence in humans and animals, and the genetic diversity of prevalent strains is virtually unstudied. Additionally, there is no detailed overview of Kazakhstan brucellosis control and eradication programs. Here, we analyzed brucellosis epidemiological data, and assessed the effectiveness of eradication strategies employed over the past 70 years to counteract this infection. We also conducted multiple loci variable-number tandem repeat analysis (MLVA) of Brucella abortus strains found in Kazakhstan...
2016: PloS One
https://www.readbyqxmd.com/read/27900285/a-t4ss-effector-targets-host-cell-alpha-enolase-contributing-to-brucella-abortus-intracellular-lifestyle
#4
María I Marchesini, Susana M Morrone Seijo, Francisco F Guaimas, Diego J Comerci
Brucella abortus, the causative agent of bovine brucellosis, invades and replicates within cells inside a membrane-bound compartment known as the Brucella containing vacuole (BCV). After trafficking along the endocytic and secretory pathways, BCVs mature into endoplasmic reticulum-derived compartments permissive for bacterial replication. Brucella Type IV Secretion System (VirB) is a major virulence factor essential for the biogenesis of the replicative organelle. Upon infection, Brucella uses the VirB system to translocate effector proteins from the BCV into the host cell cytoplasm...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27899503/postreplication-roles-of-the-brucella-virb-type-iv-secretion-system-uncovered-via-conditional-expression-of-the-virb11-atpase
#5
Erin P Smith, Cheryl N Miller, Robert Child, Jennifer A Cundiff, Jean Celli
: Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the Brucella-containing vacuole (BCV). Initially of endosomal origin (eBCV), BCVs are remodeled into replication-permissive organelles (rBCV) derived from the host endoplasmic reticulum, a process that requires modulation of host secretory functions via delivery of effector proteins by the Brucella VirB type IV secretion system (T4SS)...
November 29, 2016: MBio
https://www.readbyqxmd.com/read/27893179/ctra-controls-cell-division-and-outer-membrane-composition-of-the-pathogen-brucella-abortus
#6
Nayla Francis, Katy Poncin, Antonella Fioravanti, Victoria Vassen, Kevin Willemart, Thi Anh Phuong Ong, Luca Rappez, Jean-Jacques Letesson, Emanuele G Biondi, Xavier De Bolle
Brucella abortus is a pathogen infecting cattle, able to survive, traffic and proliferate inside host cells. It belongs to the Alphaproteobacteria, a phylogenetic group comprising bacteria with free living, symbiotic and pathogenic lifestyles. An essential regulator of cell cycle progression named CtrA was described in the model bacterium Caulobacter crescentus. This regulator is conserved in many alphaproteobacteria, but the evolution of its regulon remains elusive. Here we identified promoters that are CtrA targets using ChIP-seq and we found that CtrA binds to promoters of genes involved in cell cycle progression, in addition to numerous genes encoding outer membrane components involved in export of membrane proteins and synthesis of lipopolysaccharide...
November 28, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27885593/campylobacter-jejuni-isolation-enumeration-from-environmental-samples
#7
Kelli L Hiett
Currently, there is no universally accepted standard media or method for the recovery of Campylobacter species. This is likely due to the ubiquity of the organism in nature, the complex sample matrices from which the organism is often recovered, as well as the fragile/viable-but nonculturable state the organism assumes in response to stress. The use of a sterile filter placed upon a nonselective Brucella Agar Blood Plate (BAB), followed by incubation at 37 °C in a hydrogen-containing atmosphere (Campycheck), is one method to recover stressed and emerging Campylobacter spp...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27871206/brucellosis-and-thrombosis-of-the-inferior-vena-cava
#8
Kristina Rüegger, Philip Tarr, Konstantinos Karatolios, Jörg Humburg, Rolf Hügli, Christina Jeanneret
We describe the case of a 23-year old woman with a newly diagnosed thrombosis of the inferior vena cava associated with a Brucella melitensis infection. We suggest possible mechanisms leading to brucellosis-associated venous thrombosis and review 14 previously reported cases.
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November 22, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27865263/molecular-assessment-of-the-transplacental-transmission-of-toxoplasma-gondii-neospora-caninum-brucella-canis-and-ehrlichia-canis-in-dogs
#9
Isis Indaiara Gonçalves Granjeiro Taques, Tatiane Rodrigues Barbosa, Andresa de Cássia Martini, Letícia Camara Pitchenin, Ísis Assis Braga, Andréia Lima Tomé de Melo, Luciano Nakazato, Valéria Dutra, Daniel Moura de Aguiar
Given the fact that numerous microbial species can be detected in pregnant female dogs, the objective of this study was to assess the transplacental transmission of Brucella canis, Ehrlichia canis, Neospora caninum and Toxoplasma gondii in stillborn puppies. This study involved 41 stillborn puppies, 78.6% of which were positive for T. gondii, 52.4% for N. caninum and 59.5% for B. canis. E. canis was not detected in any of the analyzed puppies. Pregnancy is an important physiological condition for the transmission of infectious agents to puppies and transplacental transmission may be epidemiologically relevant in the spread of these opportunistic agents...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27862467/combinatorial-control-of-adhesion-of-brucella-abortus-2308-to-host-cells-by-transcriptional-rewiring-of-the-trimeric-autotransporter-btae-gene
#10
Rodrigo Sieira, Magalí G Bialer, Mara S Roset, Verónica Ruiz-Ranwez, Tomás Langer, Gastón M Arocena, Estefanía Mancini, Angeles Zorreguieta
Regulatory network plasticity is a key attribute underlying changes in bacterial gene expression and a source of phenotypic diversity to interact with the surrounding environment. Here, we sought to study the transcriptional circuit of HutC, a regulator of both metabolic and virulence genes of the facultative intracellular pathogen Brucella. Using in silico and biochemical approaches, we identified a novel functional HutC-binding site upstream of btaE, a trimeric-autotransporter adhesin involved in the attachment of Brucella to host extracellular matrix components...
November 12, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27857610/predictors-of-specific-anti-brucella-antibodies-among-humans-in-agro-pastoral-communities-in-sengerema-district-mwanza-tanzania-the-need-for-public-awareness
#11
Elifuraha B Mngumi, Mariam M Mirambo, Sospeter Wilson, Stephen E Mshana
BACKGROUND: Human brucellosis remains to be a neglected zoonotic disease among agro-pastoral communities where livestock rearing is one of the main economic activities. This study was conducted in different agro-pastoral communities in Sengerema district, Mwanza, Tanzania, to determine seroprevalence and predictors of anti-Brucella antibodies, information that may influence public awareness on the risk factors and strategies to improve the diagnosis of brucellosis in developing countries...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27853717/amiata-donkey-milk-chain-animal-health-evaluation-and-milk-quality
#12
Giuseppe Ragona, Franco Corrias, Martina Benedetti, Maria Paladini, Federica Salari, Lolanda Altomonte, Mina Martini
This study presents an investigation of Amiata donkey health and quality of milk for human consumption. Thirty-one lactating dairy jennies were examined. The following samples were collected: faecal samples from the rectum of animals for parasitological examination; cervical swabs for the detection of bacteria causing reproductive disorders; and blood samples for serological diagnosis of main zoonotic (Brucella spp., Leptospira spp.) and donkey abortion agents (Brucella spp., Leptospira spp., Salmonella abortus equi, Equine viral arterithis virus, Equine herpesvirus type 1)...
June 3, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27853716/contamination-of-bovine-sheep-and-goat-meat-with-brucella-spp
#13
Francesco Casalinuovo, Lucia Ciambrone, Antonio Cacia, Paola Rippa
A study was conducted in order to evaluate the contamination by Brucella spp. of meat from animals slaughtered because they had resulted positive for brucellosis at some time during their life. After slaughter and before delivery to market outlets, swab samples were taken from 307 carcasses of infected animals: 40 cattle, 60 sheep and 207 goats. The swabs were subsequently analysed by means of polymerase chain reaction (PCR) tests. In addition, bacteriological tests were carried out on the lymph nodes and internal organs of the same animals...
June 3, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27847417/seroprevalence-of-brucellosis-among-cattle-slaughtered-in-three-municipal-abattoirs-of-gombe-state-northeastern-nigeria
#14
Saleh Mohammed Jajere, Naphtali Nayamanda Atsanda, Asinamai Athliamai Bitrus, Tasiu Mallam Hamisu, Ajurojo Oluwaseun Ayo
AIM: A cross-sectional study was conducted to determine the seroprevalence of bovine brucellosis among cattle slaughtered at three municipal abattoirs of Gombe State, Nigeria. MATERIALS AND METHODS: A total of 200 blood samples collected from slaughtered cattle of different breeds (Sokoto Gudali - 50, White Fulani - 102, Red bororo - 34, and Crossbreeds - 14), sex (males - 19 and females - 181), and from different locations (Billiri - 30, Yamaltu Deba - 50, and Gombe - 120) were screened for brucellosis using rose bengal plate test (RBPT), serum agglutination test (SAT), and microtiter agglutination test (MAT)...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27846274/meta-analysis-and-advancement-of-brucellosis-vaccinology
#15
Tatiane F Carvalho, João Paulo A Haddad, Tatiane A Paixão, Renato L Santos
BACKGROUND/OBJECTIVES: In spite of all the research effort for developing new vaccines against brucellosis, it remains unclear whether these new vaccine technologies will in fact become widely used. The goal of this study was to perform a meta-analysis to identify parameters that influence vaccine efficacy as well as a descriptive analysis on how the field of Brucella vaccinology is advancing concerning type of vaccine, improvement of protection on animal models over time, and factors that may affect protection in the mouse model...
2016: PloS One
https://www.readbyqxmd.com/read/27836044/risk-assessment-and-management-of-brucellosis-in-the-southern-greater-yellowstone-area-ii-cost-benefit-analysis-of-reducing-elk-brucellosis-prevalence
#16
Kari Boroff, Mandy Kauffman, Dannele Peck, Eric Maichak, Brandon Scurlock, Brant Schumaker
Recent cases of bovine brucellosis (Brucella abortus) in cattle (Bos taurus) and domestic bison (Bison bison) of the southern Greater Yellowstone Area (SGYA) have been traced back to free-ranging elk (Cervus elaphus). Several management activities have been implemented to reduce brucellosis seroprevalence in elk, including test-and-slaughter, low-density feeding at elk winter feedgrounds, and elk vaccination. It is unclear which of these activities are most cost-effective at reducing the risk of elk transmitting brucellosis to cattle...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27824952/low-seroprevalence-of-brucellosis-in-humans-and-small-ruminants-in-the-gambia
#17
Eveline A Germeraad, Lenny Hogerwerf, Tisbeh Faye-Joof, Bart Goossens, Wim van der Hoek, Momodou Jeng, Modou Lamin, Ismaila L Manneh, Davis Nwakanma, Hendrik I J Roest, Arss Secka, Arjan Stegeman, Rita Wegmüller, Marianne A B van der Sande, Ousman Secka
BACKGROUND: Brucellosis is a worldwide zoonosis with significant impact on rural livelihoods and a potentially underestimated contributor to febrile illnesses. The aim of this study was to estimate the seroprevalence of brucellosis in humans and small ruminants in The Gambia. METHODS: The study was carried out in rural and urban areas. In 12 rural villages in Kiang West district, sera were collected from humans (n = 599) and small ruminants (n = 623) from the same compounds...
2016: PloS One
https://www.readbyqxmd.com/read/27824867/microrna-expression-patterns-of-cd8-t-cells-in-acute-and-chronic-brucellosis
#18
Ferah Budak, S Haldun Bal, Gulcin Tezcan, Furkan Guvenc, E Halis Akalin, Guher Goral, Gunnur Deniz, H Barbaros Oral
Although our knowledge about Brucella virulence factors and the host response increase rapidly, the mechanisms of immune evasion by the pathogen and causes of chronic disease are still unknown. Here, we aimed to investigate the immunological factors which belong to CD8+ T cells and their roles in the transition of brucellosis from acute to chronic infection. Using miRNA microarray, more than 2000 miRNAs were screened in CD8+ T cells of patients with acute or chronic brucellosis and healthy controls that were sorted from peripheral blood with flow cytometry and validated through qRT-PCR...
2016: PloS One
https://www.readbyqxmd.com/read/27816477/molecular-epidemiology-of-brucella-abortus-isolated-from-cattle-in-brazil-2009-2013
#19
Mayra Silva Oliveira, Elaine Maria Seles Dorneles, Paulo Martins Filho Soares, Antônio Augusto Fonseca, Lívia Orzil, Patrícia Gomes de Souza, Andrey Pereira Lage
The aims of the present study were to genotype Brucella abortus strains isolated from cattle in Brazil between 2009 and 2013, and to analyze their distribution to support the Programa Nacional de Controle e Erradicação de Brucelose e Tuberculose (PNCEBT) (National Brucellosis and Tuberculosis Control and Eradication Program). One hundred forty B. abortus strains isolated from cattle in Brazil between 2009 and 2013 were genotyped using a set of 18 variable number of tandem repeats (VNTR) (MLVA16+HOOF-Print 3 and 4)...
November 2, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27811842/inhibition-of-mhc-i-by-brucella-abortus-is-an-early-event-during-infection-and-involves-egfr-pathway
#20
Lis N Velásquez, M Ayelén Milillo, M Victoria Delpino, Aldana Trotta, M Florencia Mercogliano, Roberto G Pozner, Roxana Schillaci, Patricia V Elizalde, Guillermo H Giambartolomei, Paula Barrionuevo
Brucella abortus is able to persist inside the host despite the development of potent CD8(+) T cell responses. We have recently reported the ability of B. abortus to inhibit the IFN-γ-induced MHC-I cell surface expression on human monocytes. This phenomenon was due to the B. abortus-mediated retention of MHC-I molecules within the Golgi apparatus and was dependent on bacterial viability. However, the implications of bacterial virulence or replicative capacity and the signaling pathways remained unknown. Here, we demonstrated that the B...
November 4, 2016: Immunology and Cell Biology
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