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Protein icu

Zhuxi Yu, Beiyuan Zhang, Ying Xu, Yingying Hao, Jian Tang, Wenkui Yu, Qin Gu
OBJECTIVE: To analyze the clinical characteristics of bloodstream infection in patients with immune function inhibition. METHODS: A retrospective analysis was conducted. 234 patients with bloodstream infection admitted to intensive care unit (ICU) of the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 1st in 2015 to December 31st in 2017 were enrolled. According to the immune function on the day of bloodstream infection, they were divided into normal immune function group [human leukocyte antigen DR (HLA-DR) > 30%, n = 144] and immunosuppression group (HLA-DR ≤ 30%, n = 90)...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Fei Xiao, Yin Wang, Haihuan Lin, Zexun Mo, Rui Chen, Dong Xie
OBJECTIVE: To investigate the predictive value of glycosylated serum protein (GSP) combined with glycemic variability (GV) in persistent inflammation immunosuppressive catabolic syndrome (PICS) in elderly septic patients. METHODS: A retrospective study was conducted. The septic patients aged ≥ 60 years old with 28 days hospitalized duration admitted to geriatric intensive care unit (ICU) of Guangzhou General Hospital of Guangzhou Military Command from January 2014 to December 2017 were enrolled...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Xin Chen, Wansheng Peng, Zhen Zhang, Qian Zhao, Yan Zhou, Li Chen, Jiahua Pan
OBJECTIVE: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100. METHODS: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Weina Guo, Chunmei Wang, Fangjie Huo, Hongqiang Li, Yanli Yan, Shumin Xu, Huihui Xu, Yusheng Li, Xiaoming Zhang, Jianwen Bai
OBJECTIVE: To evaluate the prognostic value of human antibacterial peptide LL-37 in elderly patients with sepsis. METHODS: Elderly sepsis patients over 65-year-old satisfied the diagnostic criteria for sepsis and septic shock admitted to intensive care unit of East Hospital of Tongji University from January 2016 to December 2017 were enrolled (elderly sepsis group). Aged community-acquired pneumonia (CAP) patients hospitalized during the same period were enrolled as a control group for pneumonia, and the aged health check-ups served as a healthy control group during the same period...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Onur Saydam, Ercan Türkmen, Oytun Portakal, Mustafa Arıcı, Rıza Doğan, Metin Demircin, İlhan Paşaoğlu, Mustafa Yılmaz
Background/aim: Cardiopulmonary bypass (CPB)-associated acute kidney injury (AKI) is a common situation and rapid diagnosis and risk classification are important in the prevention and management of AKI. Changes in serum creatinine (SCr) levels in the current consensus criteria do not allow clinicians to diagnose CPB-associated AKI until 48 h after surgery. Materials and methods: We conducted a prospective single center study involving 57 patients who underwent cardiac surgery with CBP to compare serum beta-trace protein (BTP), neutrophil gelatinase-associated lipocalin-2 (NGAL), and cystatin C (CysC) levels with SCr for early diagnosis of CPB associated AKI...
December 12, 2018: Turkish Journal of Medical Sciences
Tomoaki Yatabe, Moritoki Egi, Masahiko Sakaguchi, Takashi Ito, Nobuhiro Inagaki, Hiromi Kato, Jun Kaminohara, Amane Konishi, Michiko Takahashi, Hiroomi Tatsumi, Masaru Tobe, Ikue Nakashima, Naoki Nakamoto, Takeshi Nishimura, Masakazu Nitta, Masaji Nishimura
BACKGROUND: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. METHODS: The study population comprised 389 consecutive patients who received mechanical ventilation for at least 24 h and those admitted to the ICU for > 72 h in 13 hospitals...
December 12, 2018: Annals of Nutrition & Metabolism
Isabela Bernasconi José, Vânia Aparecida Leandro-Merhi, José Luis Braga de Aquino
BACKGROUND: Enteral nutritional therapy (ENT) is the best route for the nutrition of critically ill patients with improved impact on the clinical treatment of such patients. OBJECTIVE: To investigate the energy and protein supply of ENT in critically ill in-patients of an Intensive Care Unit (ICU). METHODS: Prospective longitudinal study conducted with 82 critically ill in-patients of an ICU, receiving ENT. Anthropometric variables, laboratory tests (albumin, CRP, CRP/albumin ratio), NUTRIC-score and Nutritional Risk Screening (NRS-2002), energy and protein goals, and the inadequacies and complications of ENT were assessed...
July 2018: Arquivos de Gastroenterologia
Y-M Li, Y Jiang, S-D Feng, Z-H Lin
OBJECTIVE: Infection can be caused by severe burnt, trauma and hypoxia, further causing systemic inflammatory syndrome or sepsis. The sepsis occurs in about 2% of all hospitalizations and ranges from 6% to 30% in intensive care unit (ICU) in developed countries This study aimed to investigate the effects of normal lymph fluid on sepsis complicated with pulmonary injury. MATERIALS AND METHODS: Wistar rats were prepared for sepsis complicated with acute pulmonary model via cecal ligation and puncture, and received normal lymph fluid injection 60 min later...
November 2018: European Review for Medical and Pharmacological Sciences
H-G Ding, H-F Zhou, M-Y Diao, Y Xu, Q-M Pan, X-H Shen
OBJECTIVE: Histidine-Rich Glycoprotein (HRG) has been reported to be associated with idiopathic pulmonary fibrosis, cancer, and sepsis as a novel biomarker. However, there is limited evidence regarding its value in diagnosing or prognosis evaluating of ventilator-associated pneumonia (VAP). PATIENTS AND METHODS: A total of 186 patients intubated in ICU and 65 healthy volunteers were enrolled in this study. Patients were divided into VAP group (n = 116), non-VAP group (n = 70) and control group (n = 65)...
November 2018: European Review for Medical and Pharmacological Sciences
Ana Navas, Ricard Ferrer, Maria Luisa Martínez, Gemma Gomà, Gisela Gili, Jordi Masip, David Suárez, Antonio Artigas
BACKGROUND: Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and biological response to hemoperfusion in patients with septic shock and acute kidney injury. METHODS: This prospective case-control study in the medical-surgical intensive care unit of a university hospital included consecutive adults patients with septic shock and suspected gram-negative bacteria infection with elevated plasma endotoxin activity (EAA > 0...
December 7, 2018: Annals of Intensive Care
Alexia Chauzy, Abdelouaid Nadji, Jean-Christophe Combes, Nadine Defrance, Belaid Bouhemad, William Couet, Pascal Chavanet
Background: Owing to its antibacterial properties, ceftaroline could be attractive for prevention or treatment of bacterial post-neurosurgical meningitis/ventriculitis. However, few data are available concerning its meningeal concentrations. Objectives: To investigate ceftaroline CSF pharmacokinetics in ICU patients with an external ventricular drain (EVD). Methods: Patients received a single 600 mg dose of ceftaroline as a 1 h intravenous infusion...
December 6, 2018: Journal of Antimicrobial Chemotherapy
Nikolay V Volozhantsev, Angelina A Kislichkina, Anastasia I Lev, Ekaterina V Solovieva, Vera P Myakinina, Tatiana N Mukhina, Alexandr G Bogun, Nadezhda K Fursova
We report here the genome sequences of 10 Klebsiella pneumoniae strains of capsular type K2 isolated in Russia from patients in an infectious clinical hospital and neurosurgical intensive care unit. The draft genome sizes range from 5.34 to 5.87 Mb and include 5,448 to 6,137 protein-coding sequences.
October 2018: Microbiology resource announcements
Dino Moretti, Melisa D Ré, Nicolás S Rocchetti, Daniel Horacio Bagilet, Claudio Jesus Settecase, Martin Gonzalo Buncuga, Marta Quaglino
INTRODUCTION: the Nutrition Risk in Critically Ill (NUTRIC) score does not include a variable that objectively estimates protein hypercatabolism (PHC), one of the main metabolic changes experienced by critical patients. OBJECTIVE: to evaluate the correlation of the NUTRIC score with PHC in critically ventilated patients. MATERIALS AND METHODS: prospective, observational study. Mixed ICU. It included ventilated patients ≥ 18 years old, without anuria or chronic renal failure...
October 17, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Zahra Gholamnezhad, Zahra Fatehi Hassanabad
Objectives: Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein kinase C (PKC) pathways in isolated kidney of Lipopolysaccharide-treated (LPS) rats were investigated in this study. Materials and Methods: Vascular responsiveness to phenylephrine and acetylcholine in the presence and absence of a potent PKC inhibitor (chelerythrine) and nonspecific NO inhibitor (L-NAME) as well as responses to acetylcholine and sodium nitroprusside (SNP) were examined...
October 2018: Iranian Journal of Basic Medical Sciences
Eyüp Murat Yılmaz, Altay Kandemir
BACKGROUND: Acute pancreatitis (AP) is one of the major pathologies among gastrointestinal system diseases. The aim of this study was to determine the relationship between the red cell distribution width (RDW) value and the C-reactive protein (CRP)/ albumin ratio in patients with AP. METHODS: In this retrospective study, AP cases were enrolled and divided into 2 groups according to the Ranson criteria as moderate or severe pancreatitis. The RDW and CRP/albumin values, length of hospitalization and stay in the intensive care unit (ICU), and the complications experienced were compared between these 2 groups...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Vijay Kumar
Sepsis is a major health problem all over the world. Despite its existence since the time of Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units. The most current US FDA-approved drug called recombinant human activated protein C or Drotrecogin-α is also failed in clinical trials and showed similar effects as placebo. The epidemiological data and studies have indicated sepsis as a major socioeconomic burden all over the world...
December 1, 2018: Inflammation
Lanqiu Zhang, Chongyang Qiu, Lei Yang, Zhen Zhang, Qi Zhang, Botao Wang, Ximo Wang
AIMS: GPR18, a G protein-coupled receptor (GPCR), is involved in bacterial clearance and survival in microbial sepsis. In this study, we examine GPR18 expression on polymorphonuclear neutrophils (PMNs) of patients with sepsis and to determine the potential association with disease severity and outcomes. MAIN METHODS: We enrolled 81 patients admitted at the intensive care unit (ICU) with the diagnosis of sepsis. PMNs GPR18 expression was measured by flow cytometry at admission...
November 29, 2018: Life Sciences
Maya N Elías, Cindy L Munro, Zhan Liang, Karel Calero, Ming Ji
BACKGROUND: Older adults in the intensive care unit (ICU) often experience sleep disturbances, which may stem from life-threatening illness, the ICU environment, medications/sedation, or psychological stress. Two complementary endocrinological responses occur as a result of compromised sleep and consequently could exacerbate ICU-acquired weakness: a decrease in anabolic hormones leading to decreased protein synthesis and an increase in catabolic hormones leading to increased protein degradation...
January 2019: Dimensions of Critical Care Nursing: DCCN
Gülsüm Kadıoğlu Şimşek, Evrim Alyamaç Dizdar, Sema Arayıcı, Fuat Emre Canpolat, Fatma Nur Sarı, Nurdan Uraş, Serife Suna Oguz
BACKGROUND: This study aimed to compare the effects of adjustable fortification (AF), targeted fortification (TF), and standard fortification (SF) methods on the early growth of very low birth weight infants. MATERIALS AND METHODS: Sixty infants <32 weeks of gestational age and weighing <1,500 g were selected. These infants were exclusively fed with breast milk and were randomized into three fortification groups: SF, AF, and TF. SF consists of adding a fixed amount of fortifier to maternal milk...
November 28, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Wei-Tsun Kao, Yung-Hao Tseng, Yuh-Jyh Jong, Tai-Heng Chen
BACKGROUND: No previous studies have explored emergency medical care for children with chronic neuromuscular disorders (NMDs). We aimed to determine the major reasons for the emergency room (ER) readmission of pediatric patients with NMDs and suggest changes to the care plan to decrease readmissions. METHODS: Children with chronic NMDs (aged <18 years) who visited a medical center-based ER between January 2005 and January 2015 were included. The following data were extracted from the patient's ER records: presentations; demographic data, including sex and age; NMD diagnosis; triage classification; emergency examination; initial management and outcomes...
October 2, 2018: Pediatrics and Neonatology
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