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https://www.readbyqxmd.com/read/30337925/gskj4-protects-mice-against-early-sepsis-via-reducing-proinflammatory-factors-and-up-regulating-mir-146a
#1
Yuchen Pan, Jiali Wang, Yaxian Xue, Jiaojiao Zhao, Dan Li, Shaolong Zhang, Kuanyu Li, Yayi Hou, Hongye Fan
Sepsis, defined as life-threatening organ dysfunction, is one of the most common causes of mortality in intensive care units with limited therapeutic options. However, the mechanism underlying the regulation of epigenetics on sepsis remains largely undefined. Here we showed that JMJD3, the histone lysine demethylase, played a critical role in the epigenetic regulation of innate immunity during early sepsis. Pharmacological inhibition of JMJD3 by GSKJ4 protected mice against early septic death and reduced pro-inflammatory cytokine interleukin-1β (IL-1β) production as well as IL-6, tumor necrosis factor-α (TNF-α), and monocyte chemotactic protein-1 (MCP-1) expression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30336524/serum-high-sensitivity-c-reactive-protein-improves-sensitivity-of-curb-65-in-predicting-icu-admission-and-mortality-in-community-acquired-pneumonia-patients
#2
Yan L Ge, Cong H Liu, Jing Xu, Zi Y Cui, Wei C Guo, Hui L Li, Ai S Fu, Hong Y Wang, Hai F Zhang, Xiao Y Zhu
BACKGROUND: The CURB-65 scoring system is a simple tool in assessment and prognosis prediction for communityacquired pneumonia (CAP) patients. However, the variations in performance of CURB-65 in young and elderly patients, underestimation or overestimation of the severity, and mortality have often been reported. The aim of this study was to investigate the usefulness of serum high-sensitivity C reactive protein (hs-CRP) combined with CURB-65 in predicting ICU admission and 30-day mortality in CAP patients...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30328046/accuracy-of-valproic-acid-concentration-correction-based-on-serum-albumin
#3
Aulbrey Drisaldi, Erin Weeda, Ron Neyens, Nicholas Orvin, Leonardo Bonilha, Zeke Campbell, Nicole Bohm
BACKGROUND: Patient-specific factors can alter the pharmacokinetic disposition of valproic acid. Specifically, the free fraction of valproic acid can increase substantially in patients with hypoalbuminemia or as serum drug concentrations rise due to saturable protein binding. Direct measurement of free serum drug concentrations allows for accurate assessment of drug levels, but the assay may not be readily available in all institutions. The effect of hypoalbuminemia on free fraction has been quantified and serves as the basis of an equation used to "correct" measured total valproic acid concentrations...
October 16, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30326483/significance-of-hyperbaric-oxygenation-in-the-treatment-of-fournier-s-gangrene-a-comparative-study
#4
Petra Anheuser, Sandra Mühlstädt, Jennifer Kranz, Laila Schneidewind, Joachim Steffens, Paolo Fornara
INTRODUCTION: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene. PATIENTS AND METHODS: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017...
October 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30326195/two-indole-2-carboxamide-derivatives-attenuate-lps-induced-acute-lung-injury-by-inhibiting-inflammatory-response
#5
Wei Dai, Xiangting Ge, Tingting Xu, Chun Lu, Wangfeng Zhou, Dandan Sun, Yuqiang Gong, Yuanrong Dai
Acute lung injury (ALI) is the leading cause of mortality in intensive care unit. Currently, there is no effective pharmacological treatment for ALI. In our previous study, we reported that Lg25 and Lg26, two indole-2-carboxamide derivatives, inhibited the LPS-induced inflammatory cytokines in vitro and attenuated LPS-induced sepsis in vivo. In the present study, we confirmed data from previous studies that LPS significantly induced pulmonary edema, pathological changes in lung tissue, increased protein concentration and number of inflammatory cells in bronchoalveolar lavage fluids (BALF), increased inflammatory cytokine TNF-α expression in serum and BALF, pro-inflammatory genes expression and macrophages infiltration in lung tissue...
October 16, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30324775/acute-infection-in-ventilated-patients-in-the-intensive-care-unit-association-between-resting-energy-expenditure-and-c-reactive-protein
#6
David Dahan, Gali Epstein Shochet, Ester Fizitsky, Miriam Almagor, David Shitrit
BACKGROUND: Sepsis is a common cause of hospitalization, particularly in intensive care units (ICUs), and is a major cause of morbidity and mortality. Diagnosis is often difficult due to the absence of characteristic clinical signs (e.g., fever and leukocytosis); therefore, additional markers, in addition to C-reactive protein (CRP) and white blood cell (WBC) count, are needed. OBJECTIVES: To prospectively link resting energy expenditure (REE) with CRP, WBC count, and sequential organ failure assessment (SOFA) scores in ICU patients...
October 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/30321485/cholesteryl-ester-transfer-protein-influences-high-density-lipoprotein-levels-and-survival-in-sepsis
#7
Mark Trinder, Kelly R Genga, HyeJin Julia Kong, Lisanne L Blauw, Cody Lo, Xuan Li, Mihai Cirstea, Yanan Wang, Patrick C N Rensen, James A Russell, Keith R Walley, John H Boyd, Liam R Brunham
RATIONALE: High-density lipoprotein cholesterol (HDL-C) levels decline during sepsis, and lower levels are associated with worse survival. However, the genetic mechanisms underlying changes in HDL-C during sepsis, and whether the relationship with survival is causative, is largely unknown. OBJECTIVES: We hypothesized that variation in genes involved in HDL metabolism would contribute to changes in HDL-C levels and clinical outcomes during sepsis. METHODS: We performed targeted re-sequencing of HDL-related genes in 200 patients admitted to an emergency department with sepsis (Early Infection cohort)...
October 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30320052/strategies-of-increased-protein-intake-in-elbw-infants-fed-by-human-milk-lead-to-long-term-benefits
#8
Elisa Mariani, Augusto Biasini, Lucia Marvulli, Silvia Martini, Arianna Aceti, Giacomo Faldella, Luigi Corvaglia, Alessandra Sansavini, Silvia Savini, Francesca Agostini, Marcello Stella, Erica Neri
Objective: The aim of this observational study was to evaluate the effects of two different protein intake regimes on feeding tolerance, in-hospital growth, anthropometric data and psychomotor outcome up to 24 months corrected age (CA) in extremely low birth-weight (ELBW; birth weight <1000 g) infants. Methods: During the period 2008-2013, 52 ELBW infants admitted at birth to two Neonatal Intensive Care Units of Emilia Romagna (Italy) were fed according to different protocols of protein fortification of human milk: an estimated protein intakes at maximum fortification levels of 3...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/30318663/weight-improvement-with-the-use-of-protein-and-energy-enriched-nutritional-formula-in-infants-with-a-prolonged-picu-stay
#9
R D Eveleens, D K Dungen, S C A T Verbruggen, J M Hulst, K F M Joosten
BACKGROUND: Reaching an optimal nutritional intake is challenging in critically ill infants. One possible way to minimise nutritional deficits is the use of protein and energy-enriched (PE)-formulas. We aimed to describe weight achievement and gastrointestinal symptoms in infants admitted to the paediatric intensive care unit (PICU) while receiving PE-formula for a prolonged period. METHODS: Records from infants admitted to a multidisciplinary PICU and using PE-formula were analysed retrospectively...
October 14, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/30308469/c-reactive-protein-and-procalcitonin-profile-in-ventilator-associated-lower-respiratory-infections
#10
Luis Coelho, Ligia Rabello, Jorge Salluh, Ignacio Martin-Loeches, Alejandro Rodriguez, Saad Nseir, José Andrade Gomes, Pedro Povoa
PURPOSE: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. METHODS: Pre-planned analysis of the prospective multinational TAVeM database, performed on 2960 patients receiving mechanical ventilation for >48 h, including 689 patients with VA-LRTI...
October 2, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/30307281/effects-of-intravenous-fluid-overload-on-caloric-and-protein-deficit-in-critically-ill-patients
#11
Diana Borges Dock-Nascimiento, João Manoel Silva, Suzana Souza Arantes, José Eduardo De Aguilar-Nascimento
INTRODUCTION: intravenous fluid overload may lead to dysmotility that may impair early enteral nutrition delivery in critically ill patients. OBJECTIVES: this study aimed to compare the volume of intravenous fluids (IF) with the occurrence of caloric and protein deficits in Intensive Care Unit (ICU) patients. METHODS: this cohort study included critically ill patients with mechanical ventilation and receiving early enteral nutrition (target: 25-30 kcal/kg/day and 1...
October 5, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30305832/expression-changes-of-autophagy-related-proteins-in-aki-patients-treated-with-crrt-and-their-effects-on-prognosis-of-adult-and-elderly-patients
#12
Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao, Yu Wu
Background: Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, multiple organ dysfunction, and failure. The mortality of acute renal injury is the highest among the complications, which is a serious threat to the safety of patients and affects the quality of life. This study aimed to observe the changes in autophagy-related protein expressions in patients with acute kidney injury (AKI) after continuous renal replacement therapy (CRRT) and their impacts on prognosis...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30304901/genotype-phenotype-correlations-in-pediatric-patients-with-myotonic-dystrophy-type-1
#13
Hyeong Jung Kim, Ji-Hoon Na, Young-Mock Lee
Purpose: Myotonic dystrophy (also known as dystrophia myotonica; DM) is an autosomal dominant disorder with two genetically distinct forms. DM Type 1 (DM1) is the more common form, and is caused by abnormal expansion of CTG repeat in the DM protein kinase (DMPK) gene. Our study aimed to determine whether age of onset is correlated with CTG-repeat length in a pediatric patient population having DM1. Methods: We retrospectively identified 30 pediatric patients with DM1 that underwent DMPK testing, 17 of which had sufficient clinical data...
September 23, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30301824/inflammation-and-psychopathology-in-children-following-picu-admission-an-exploratory-study
#14
Giorgia Caspani, Georgina Corbet Burcher, M Elena Garralda, Mehrengise Cooper, Christine M Pierce, Lorraine C Als, Simon Nadel
BACKGROUND: Survivors of critical illness in childhood commonly display subsequent psychiatric symptoms including emotional and behavioural difficulties, and manifestations of post-traumatic stress disorder (PTSD). Anomalies in inflammatory profiles are an established finding in these childhood psychiatric conditions. OBJECTIVE: This exploratory study aimed to investigate whether abnormal peripheral blood inflammatory markers measured during paediatric intensive care unit (PICU) admission were associated with psychiatric symptoms after discharge...
October 9, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/30297724/clinical-usefulness-of-c-reactive-protein-to-albumin-ratio-in-predicting-30-day-mortality-in-critically-ill-patients-a-retrospective-analysis
#15
Tak Kyu Oh, In-Ae Song, Jae Ho Lee
This study aimed to examine the prognostic value of C-reactive protein (CRP)/albumin (ALB) ratio among patients who were admitted to the intensive care unit (ICU) in predicting 30-day mortality rate. This retrospective cohort study was conducted by examining the medical records of adult patients who were admitted to the ICU at Seoul National University Bundang Hospital between 1 January 2012 and 31 December 2016. Data from 6,972 individuals were included in the final analysis, and 547 of these individuals (7...
October 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30297655/the-c-reactive-protein-albumin-ratio-as-a-predictor-of-mortality-in-critically-ill-patients
#16
Ji Eun Park, Kyung Soo Chung, Joo Han Song, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang, Ah Young Leem
The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin ratio and 28-day mortality and predict the accuracy of CRP/albumin ratio for 28-day mortality in medical intensive care unit (ICU) patients. This was a retrospective cohort study of 875 patients. We evaluated the prognostic value of CRP/albumin ratio to predict mortality at 28 days after ICU admission, using Cox proportional hazard model and Kaplan-Meier survival analysis...
October 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30294930/admission-25-hydroxyvitamin-d-levels-are-associated-with-functional-status-at-time-of-discharge-from-intensive-care-unit-in-critically-ill-surgical-patients
#17
Karolina Brook, Tiffany M N Otero, D Dante Yeh, Cecilia Canales, Donna Belcher, Sadeq A Quraishi
BACKGROUND: Vitamin D status is associated with length of stay (LOS) and discharge destination in critically ill patients. To further understand this relationship, we investigated whether admission 25-hydroxyvitaminD (25OHD) levels are associated with discharge functional status in the intensive care unit (ICU). METHODS: In this retrospective study, data from 2 surgical ICUs at a large teaching hospital were analyzed. 25OHD levels were measured within 24 hours of ICU admission and Functional Status Score for the ICU (FSS-ICU) was calculated within 24 hours of ICU discharge for all patients...
October 7, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30290852/an-early-increase-in-endothelial-protein-c-receptor-is-associated-with-excess-mortality-in-pneumococcal-pneumonia-with-septic-shock-in-the-icu
#18
Agnès Chapelet, Yohann Foucher, Nathalie Gérard, Christophe Rousseau, Olivier Zambon, Cédric Bretonnière, Jean-Paul Mira, Béatrice Charreau, Christophe Guitton
BACKGROUND: This study investigated changes in plasma level of soluble endothelial protein C receptor (sEPCR) in association with outcome in patients with septic shock. We explored sEPCR for early sepsis prognosis assessment and constructed a scoring system based on clinical and biological data, in order to discriminate between surviving at hospital discharge and non-surviving patients. METHODS: Clinical data and samples were extracted from the prospective "STREPTOGENE" cohort...
October 5, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30288260/acute-kidney-injury-in-children-with-nephrotic-syndrome-a-single-center-study
#19
Manjuri Sharma, Arunima Mahanta, Anup Kumar Barman, P J Mahanta
Background: Children with nephrotic syndrome (NS) are at risk for the development of acute kidney injury (AKI) through a variety of mechanisms.The frequency of NS hospitalizations complicated by AKI has almost doubled in the last decade. Children with AKI have longer hospital length of stay and increased need for intensive care unit admission. The main objectives of this study were to determine the incidence, clinical characteristics, risk factors and short-term outcome of AKI in children hospitalized with NS...
October 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30286558/the-beneficial-effects-of-%C3%AE-lipoic-acid-in-critically-ill-patients-a-prospective-randomized-double-blind-placebo-controlled-trial
#20
Najmeh Hejazi, Zohreh Mazloom, Farid Zand, Abbas Rezaianzadeh, Reza Nikandish
BACKGROUND: Critical illness is associated with oxidative stress and insulin resistance. These conditions affect the clinical outcomes in intensive care unit (ICU). The aim of this study was to determine whether intervention with α-lipoic acid (ALA) influences the oxidative stress, insulin resistance, and clinical outcomes in critically ill patients. METHOD: In this randomized double-blind placebo-controlled trial, 80 critically ill patients who were expected to stay at least seven days in the ICU and required enteral feeding were randomly allocated to two equal groups to receive either ALA (900 mg) or placebo daily for 10 days...
June 2018: Asian Journal of Anesthesiology
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