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Umbilical Endometriosis

Nabonswindé Lamoussa Marie Ouédraogo, Safy Ilboudo, Abdoul Karim Ouattara, Aimé Sosthène Ouedraogo, Maurice Zida, Nayi Zongo, Dorcas Obiri-Yeboah, Edgard Ouangre, Jacques Simpore, Si Simon Traore
INTRODUCTION: Villar's nodule is an umbilical endometriosis without anterior or ongoing pelvic endometriosis. The primitive location of this nodule at the umbilical level is rare. Its etiopathogenesis remains unclear. PRESENTATION OF CASE: We report a case of umbilical endometriosis with unusual clinical expression in a woman in the reproductive years with no surgical history and no known history of endometriosis. Endometriosis manifested as progressive transformation of the normal umbilicus into several small nodules, with bleeding coinciding with the menstrual cycle...
November 1, 2018: International Journal of Surgery Case Reports
Huihui Sun, Dong Li, Ming Yuan, Qiuju Li, Ni Li, Guoyun Wang
Endometriosis is a common multifactorial gynecological disorder defined as the proliferation of endometrial tissue outside of the uterine cavity. Neuroangiogenesis (co-recruitment of nerves and blood vessels) is believed to play an integral part in the establishment and growth of endometriotic lesions. We hypothesized that exosomes derived from abnormal endometrium may serve as the second identifier of endometriosis and play an important role in the development of endometriosis by regulating neuroangiogenesis...
October 5, 2018: Biology of Reproduction
Yukai Liu, Jie Chen, Xiaoyong Zhu, Lingli Tang, Xuezhen Luo, Yingli Shi
Endometriosis is a common gynecological disease and the pathogenesis is not clearly understood. Previous studies have demonstrated via microarray techniques that microRNA (miR)‑449b was significantly downregulated both in ectopic and eutopic endometrium in patients with endometriosis. In the present study, the aberrant expression of miR‑449b was further confirmed by reverse transcription‑quantitative polymerase chain reaction. It was demonstrated that miR‑449b‑3p was downregulated in ectopic and eutopic tissues from women with endometriosis, and the same expression pattern was observed in endometrial stromal cells (ESCs) of eutopic endometrium from women with endometriosis and normal endometrium from women without endometriosis...
September 2018: Molecular Medicine Reports
Jhao-Lin Fu, Kuei-Yang Hsiao, Hsiu-Chi Lee, Wan-Ning Li, Ning Chang, Meng-Hsing Wu, Shaw-Jenq Tsai
STUDY QUESTION: How does hypoxia-mediated downregulation of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promote angiogenesis in endometriosis? SUMMARY ANSWER: Suppression of COUP-TFII by hypoxia stimulates angiogenesis through induction of angiogenin (ANG). WHAT IS KNOWN ALREADY: The level of COUP-TFII is downregulated in endometriotic tissues, and downregulation of COUP-TFII contributes to the development of endometriosis...
July 3, 2018: Human Reproduction
Rigved Gupta, Manoj Andley, Nikhil Talwar, Ajay Kumar
Desmoid-type fibromatosis (DF) or desmoid tumours are rare benign soft tissue tumours of musculo-aponeurotic origin, which have no malignant potential but are locally aggressive and can result in significant morbidity. They may be hereditary (in association with FAP, i.e. familial adenomatous polyposis syndrome resulting from APC gene mutation) or sporadic, with hereditary cases having a much higher risk of developing DF compared to sporadic ones. Desmoids are known to occur in previous surgical scars. However, previous laparoscopic port site/trocar site is an extremely uncommon site for sporadic desmoids, with only two cases of sporadic laparoscopic trocar site desmoids (occurring in absence of FAP) reported in world literature...
June 2018: Indian Journal of Surgery
Paulo Vicente Dos Santos Filho, Marcelo Protásio Dos Santos, Samanta Castro, Valdinaldo Aragão DE Melo
OBJECTIVE: to report the characteristics, evolution and outcome of patients with primary umbilical endometriosis. METHODS: an observational and descriptive study of patients with primary umbilical endometriosis diagnosed between 2014 and 2017. The clinical variables evaluated were age, clinical picture, lesion characteristics, diagnostic methods, treatment and recurrence. RESULTS: six patients diagnosed with primary umbilical endometriosis aged 28 to 45 years were operated on during the study period...
June 21, 2018: Revista do Colégio Brasileiro de Cirurgiões
Denise Niza Benardete-Harari, José Manuel Muñoz-de Cote Frade, Jaime Antonio Hidalgo-Carrera, Alberto Felgueres-Hermida, Diego Meraz-Ávila
Background: Umbilical endometriosis or Villar’s nodule is uncommon. Incidence goes up to 0.5-1.2% of all patients with endometriosis. As far as 2012, only 109 cases of umbilical endometriosis have been reported worldwide, there is no incidence reports in Mexico. Clinically, it’s a solitary node, solid and well defined, colored red, blue or black and it’s ocassionally accompanied by bleeding and dysmenorrhea. The treatment can be medical or surgical and it consists of painkillers, and hormonal suppression using GnRH analogues, hormonal contraceptives, danazol or progesterone...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Alexandra K Rzepecki, Mathew R Birnbaum, Steven R Cohen
No abstract text is available yet for this article.
May 2018: Journal of Cutaneous Medicine and Surgery
Shoaib Z Junejo, Sandeep Singh Lubana, Sukhdip Singh Shina, Sandeep Singh Tuli
BACKGROUND Catamenial pneumothorax (CP) is a spontaneous pneumothorax commonly associated with menstrual periods. Endometrial tissues most commonly involve the pelvic region. However, after the pelvis, the lungs are most frequently involved. Thoracic endometriosis should always be suspected in young women presenting with CP. CASE REPORT A 30-year-old woman with history of endometriosis presented with chief complaint of umbilical pain. A computerized tomography (CT) scan of the abdomen and pelvis was performed, which showed an incidental finding of a large right-sided pneumothorax...
May 17, 2018: American Journal of Case Reports
Giovanni Genovese, Emanuela Passoni, Stefano Veraldi, Gianluca Nazzaro
Primary cutaneous endometriosis is a rare condition. It appears without a prior history of surgical procedure and the umbilicus is the most frequently involved area. Primary umbilical endometriosis, or Villar's nodule, usually presents as a painful nodule. Its differential diagnosis may be challenging. Although histopathological assessment represents the gold standard for diagnosis, cutaneous ultrasonography may be useful in guiding the surgical treatment. Ultrasonographic features of cutaneous endometriosis have not yet been fully explored in the literature...
March 2018: Anais Brasileiros de Dermatologia
Omar Sow, William Valentin, Diouf Cheikh, Barboza Denis, Faye Samba Thiapato, Diallo Ibrahima, Gueye Serigne Modou Kane
Endometriosis is defined as the implantation of endometrial tissue outside of the uterine cavity. It affects approximately 10% of women of childbearing age. Umbilical endometriosis is rare and its pathophysiology is poorly known. We report the case of a 42-year old nulliparous female patient with a 5-year history of myomectomy, presenting with cyclic pain associated with umbilical mass. The diagnosis of umbilical endometrioma was made and confirmed by the histological examination of the surgical specimen. Treatment was based on wide excision of the mass associated with pelvis exploration and umbilical plasty...
2018: Pan African Medical Journal
Fawaz Abomaray, Sebastian Gidlöf, Bartosz Bezubik, Mikael Engman, Cecilia Götherström
Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells. Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases. Therefore, the aim herein was to examine effects of allogeneic MSC on endometriosis-derived cells in vitro as a potential therapy for endometriosis. MSC from allogeneic adipose tissue (Ad-MSC) and stromal cells from endometrium (ESCendo ) and endometriotic ovarian cysts (ESCcyst ) from women with endometriosis were isolated...
2018: Stem Cells International
Lei Yan, Shenon Sethi, Pincas Bitterman, Vijaya Reddy, Paolo Gattuso
BACKGROUND: Umbilical lesions are rare, and can be benign or malignant. This retrospective study was conducted to assess the epidemiological, clinical, and histologic characteristics of umbilical masses. METHODS: Cases of umbilical masses from January 1994 to August 2016 were retrieved from our institution's pathology databases, and their clinicopathological features were reviewed. RESULTS: There were a total of 99 cases of umbilical masses, 78 women (78...
August 2018: International Journal of Surgical Pathology
Dpa Van den Nouland, M Kaur
Primary umbilical endometriosis is a rare phenomenon accounting for 0,4-1,0% of extragenital endometriosis. Despite the fact that it mostly presents as a typical cyclic umbilical discharge coincidental with a palpable mass, the diagnosis is often delayed due to its low prevalence, as was seen in the presented case. The exact pathogenesis is still unclear. The golden standard for diagnosis is histopathological examination, but diagnostic tools like ultrasound, MRI or CT scan can be helpful. The differential diagnosis includes a wide range of disorders...
June 2017: Facts, Views & Vision in ObGyn
Nicole R Laferriere, Christopher G Yheulon
Umbilical hernias are rather common in the General Surgery clinic; however, endometriosis of an umbilical hernia is rare. It is especially unusual to have endometriosis of an umbilical hernia spontaneously occur compared to occurring at a site of a prior surgery. We present a case of spontaneous endometriosis of an umbilical hernia without prior surgery to her umbilicus. She had not presented with the usual symptoms of endometriosis and it was not considered as a diagnosis prior to surgery. Umbilical endometriosis is rare but usually occurs after prior laparoscopic surgery...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
Ayida A Al-Khalili, Robin Billick
No abstract text is available yet for this article.
August 2017: Sultan Qaboos University Medical Journal
Jacob Juel, Sine Holst-Albrechtsen, Daiva Erantaite
Umbilical endometriosis is rare, representing only 0.5-1% of all cases of extragenital endometriosis. In infertile women, endometriosis may be as prevalent as 50%. Numerous differential diagnoses are present, hence the clinical diagnosis of umbilical tumours is intricate. In a 33-year-old woman, an umbilical tumour presented 12 months prior to referral. On referral, no cyclic bleeding was noticed, although intermittent bleeding and soreness of the element were present. Dysmenorrhoea, dyspareunia, intermittent pelvic pain, and three years of infertility were noted...
October 9, 2017: Ugeskrift for Laeger
Seung-Hee Loh, Bark-Lynn Lew, Woo-Young Sim
Cutaneous endometriosis is defined by the presence of endometrial glands and/or stroma in skin and represents less than 1% of all ectopic endometrium. Cutaneous endometriosis is classified as primary and secondary. Primary cutaneous endometriosis appears without a prior surgical history and secondary cutaneous endometriosis mostly occurs at surgical scar tissue after abdominal operations. The most widely accepted pathogenesis of secondary endometriosis is the iatrogenic implantation of endometrial cells after surgery, such as laparoscopic procedures...
October 2017: Annals of Dermatology
Samantha S Mooney, Lenore Ellett
No abstract text is available yet for this article.
August 2, 2017: ANZ Journal of Surgery
H-S Kourouma, E-J Ecra, A-S Allou, M Kouyaté, Y-I Kouassi, M Kaloga, K-A Kouassi, K Kassi, K Kouamé, C Ahogo, I-P Gbery, A Sangaré
BACKGROUND: Most umbilical tumors are diagnosed as benign tumors, umbilical metastases of abdominal and pelvic tumors, or Sister Marie Joseph nodule. Herein, we report a case of cutaneous umbilical endometriosis mistaken for a keloid. PATIENTS AND METHODS: A young black woman aged 26 consulted for a painful umbilical tumefaction. She had noted the appearance of a nodule of the umbilicus 10 months ago with bleeding during her menstrual periods. Skin examination revealed a firm and painful umbilical nodule 2...
October 2017: Annales de Dermatologie et de Vénéréologie
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