keyword
https://read.qxmd.com/read/38614375/combination-immune-checkpoint-and-targeted-protein-kinase-inhibitors-for-the-treatment-of-renal-cell-carcinomas
#21
REVIEW
Robert Roskoski
Kidney cancers comprise about 3% of all new malignancies in the United States. Renal cell carcinomas (RCCs) are the most common type of renal malignancy making up about 85% of kidney cancer cases. Signs and symptoms of renal cell carcinomas can result from local tumor growth, paraneoplastic syndromes, or distant metastases. The classic triad of presentation with flank pain, hematuria, and a palpable abdominal mass occurs in fewer than 10% of patients. Most diagnoses result from incidental imaging findings (ultrasonography or abdominal CT imaging) performed for another reason...
April 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38613623/a-fatal-misdiagnosis-of-page-kidney-case-report
#22
JOURNAL ARTICLE
Gayan Kumarasinghe, Murugupillai Sivasubramanium, Kasun Bandara Ekanayake, Dhanushka Rambukwella, Bandarage Sanjaya
Page kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance...
April 13, 2024: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/38613212/renal-metastasis-arising-from-a-pulmonary-adenoid-cystic-carcinoma-a-rare-case-report-and-literature-review
#23
REVIEW
Guixin Ding, Tianqi Wang, Hongquan Liu, Qingsong Zou, Jitao Wu
Adenoid cystic carcinoma (ACC), a rare malignancy, typically originates in salivary glands and is rarely found in other locations. In this case report, we describe a 54-year-old male patient who was presented to the Urology Department of Yantai Yuhuangding hospital with right-sided waist pain. The patient underwent percutaneous ultrasound-guided biopsies of lesions in the kidney and lung, which were histologically confirmed as primary adenoid cystic carcinoma of the lung and metastatic renal adenoid cystic carcinoma, respectively...
2024: American Journal of Men's Health
https://read.qxmd.com/read/38608084/inappropriate-placement-of-urinary-catheters-into-the-ureter-a-case-report-and-literature-review
#24
JOURNAL ARTICLE
Jiun-Jia Li, Chin-Fong Au
OBJECTIVE: To emphasize preventive measures and outline management strategies for inadvertent ureteral cannulation. METHODS: We present a case report and conduct a literature review of 39 case reports on ureteral cannulation, examining a total of 48 patients. RESULTS: About 67% of the cases were female, and long-term catheterization was observed in 67% of the cases. Neurological conditions such as spinal cord injury (SCI), stroke, dementia, multiple sclerosis, and myasthenia gravis were the primary factors (48%) in ureteral cannulation...
April 12, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38607422/an-unusual-etiology-in-an-8-year-old-girl-with-chest-pain-and-elevated-troponin-i
#25
JOURNAL ARTICLE
Gulsah Ozdemir, Serpil Kaya Celebi, Seyma Kayalı
Acute post-streptococcal glomerulonephritis (APSGN) is the most common glomerulonephritis of childhood, and clinical presentation can vary widely. This case report presents an atypical manifestation of APSGN in an 8-year-old female patient with pleuritic chest pain and elevated troponin-I, despite lacking classical kidney symptoms. Imaging studies showed cardiomegaly and interstitial lung opacities. Further investigations revealed hematuria and proteinuria, and the diagnosis was confirmed through elevated antistreptolysin-O (ASO) titers and low complement 3 (C3) levels...
April 12, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38604400/perioperative-intravenous-dexamethasone-use-is-not-associated-with-periprosthetic-joint-infection-or-wound-healing-complications-following-shoulder-arthroplasty
#26
JOURNAL ARTICLE
Ryan D Freshman, Jacob L Kotlier, Cory K Mayfield, Amir Fathi, Aamir Ahmad, Christian Cruz, Joseph N Liu, Frank A Petrigliano
BACKGROUND: Perioperative intravenous (IV) dexamethasone is commonly used in lower extremity total joint arthroplasty to manage postoperative pain and nausea/vomiting, and recent studies have demonstrated that its use may lower rates of acute postoperative medical complications. However, there is limited information regarding the safety and efficacy of IV dexamethasone in patients undergoing total shoulder arthroplasty (TSA). Additionally, there is concern surrounding corticosteroid use prior to surgery as preoperative corticosteroid injections have been associated with adverse outcomes after TSA, including periprosthetic joint infection (PJI) and revision surgery...
April 9, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38600620/central-nervous-system-medication-use-around-hospitalization
#27
JOURNAL ARTICLE
Juliessa M Pavon, Richard J Sloane, Cathleen S Colón-Emeric, Carl F Pieper, Kenneth Schmader, David Gallagher, Susan N Hastings
BACKGROUND: Central nervous system (CNS) medication use is common among older adults, yet the impact of hospitalizations on use remains unclear. This study details CNS medication use, discontinuations, and user profiles during hospitalization periods. METHODS: Retrospective cohort study using electronic health records on patients ≥65 years, from three hospitals (2018-2020), and prescribed a CNS medication around hospitalization (90 days prior to 90 days after)...
April 10, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38596896/comprehensive-management-of-challenging-recurrent-aortoiliac-and-lower-extremity-occlusive-disease-with-simultaneous-modified-covered-endovascular-reconstruction-of-the-aortic-bifurcation-inferior-mesenteric-artery-snorkel-and-lower-extremity-bypass
#28
JOURNAL ARTICLE
Wei Li, Dixon Santana, Cooper Phillips
OBJECTIVES: Despite recent advancements in endovascular technology and proven durability of open surgeries, managing extensive aortoiliac occlusive disease (AIOD) with concurrent severe lower extremity (LE) arterial occlusion remains a formidable challenge. This paper introduces a comprehensive approach to addressing recurrent AIOD and LE occlusive diseases by employing modified-CERAB, inferior mesenteric artery (IMA) snorkel, and LE bypass in a challenging case. METHODS: A 56-year-old male patient presented with subacute bilateral lower extremity rest pain with dry gangrene in the left great toe and a complex medical history...
April 10, 2024: Vascular
https://read.qxmd.com/read/38595876/the-prevalence-of-nephrolithiasis-and-associated-risk-factors-among-the-population-of-the-riyadh-province-saudi-arabia
#29
JOURNAL ARTICLE
Abdullah M Alshubaili, Abdulaziz F Alotaibi, Khalid A Alsaleh, Abdulaziz I Almogarri, Abdullah A Alanizi, Saif S Alsaif, Ahmad S Alghamdi, Nasser M Alnazari, Amwaj Almalki
Background and objective Kidney stones, also referred to as nephrolithiasis or renal calculi, is a condition where crystal depositions are formed within the kidney and ideally excreted from the body via the urethra with no pain; however, larger calculi may cause significant pain and require further medical assistance. The vast majority of patients who develop renal calculi form calcium stones, which are either a composition of calcium oxalate or calcium phosphate. Other types include uric acid, struvite, and cysteine...
March 2024: Curēus
https://read.qxmd.com/read/38595259/-a-case-of-covid-19-associated-ischemic-colitis
#30
JOURNAL ARTICLE
Xin Liu, Xueying Shi, Jun Li
Ischemic colitis is a disease in which local tissue in the intestinal wall dies to varying degrees due to insufficient blood supply to the colon. Risk factors include cardiovascular disease, diabetes, chronic kidney disease, chronic obstructive pulmonary disease, etc . Typical clinical manifestations of the disease are abdominal pain and hematochezia. The most common locations are the watershed areas of splenic flexure and rectosigmoid junction. The lesions are segmental and clearly demarcated from normal mucosa under endoscopy...
April 18, 2024: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/38594600/hemodynamics-in-nutcracker-syndrome-implications-for-diagnosis
#31
JOURNAL ARTICLE
Hui Tang, Xianchao Yu, Qun Chen, Yuexing Zhu, Shikun Zhang, Lu Tang, Yinghong Zhao, Gang Hua, Jinqiu Hu
BACKGROUND: Nutcracker syndrome is a disease characterized by complex symptoms, making its diagnosis challenging and often delayed, often resulting in a painful experience for the patients. OBJECTIVE: This study aimed to investigate the pathogenesis of nutcracker syndrome through the perspective of hemodynamics by simulating blood flow with varying compression degrees of the left renal vein. METHODS: 3D patient-specific vascular models of the abdominal aorta, superior mesenteric artery and left renal vein were constructed based on CT images of patients suspected of having nutcracker syndrome...
April 9, 2024: Journal of Nephrology
https://read.qxmd.com/read/38592088/significantly-elevated-ca-19-9-after-covid-19-vaccination-and-literature-review-of-non-cancerous-cases-with-ca-19-9-1000-u-ml
#32
Jakub Ciesielka, Krzysztof Jakimów, Natalia Tekiela, Laura Peisert, Anna Kwaśniewska, Dariusz Kata, Jerzy Chudek
BACKGROUND: CA 19-9 is a commonly assessed tumor marker, considered characteristic of pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers; however, the positive predictive value of CA 19.9 is too low, and the usage of CA 19.9 as a screening tool in the healthy population remains controversial. METHODS: The presented case illustrates a reversed diagnosis of highly elevated serum CA 19-9 levels in a 54-year-old female complaining of pain in the epigastric region, shortly after COVID-19 vaccination...
February 23, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38590946/effectiveness-and-safety-of-immune-response-to-sars%C3%A2-cov%C3%A2-2-vaccine-in-patients-with-chronic-kidney-disease-and-dialysis-a-systematic-review-and-meta%C3%A2-analysis
#33
JOURNAL ARTICLE
Kejia Li, Yang Xia, Hua Ye, Xian Sun, Bairu Shi, Jiajun Wu
The coronavirus disease 2019 (COVID-19) vaccination is the most effective way to prevent COVID-19. However, for chronic kidney disease patients on long-term dialysis, there is a lack of evidence regarding the efficacy and safety of the immune response to the vaccine. The present meta-analysis explores the efficacy and safety of COVID-19 vaccine in the immune response of patients with chronic kidney disease (CKD) undergoing dialysis. PubMed, Web of Science, Science Direct, and Cochrane Library databases were systematically searched from January 1, 2020, to December 31, 2022...
May 2024: Biomedical Reports
https://read.qxmd.com/read/38587872/2024-isfm-and-aafp-consensus-guidelines-on-the-long-term-use-of-nsaids-in-cats
#34
JOURNAL ARTICLE
Samantha Taylor, Margaret Gruen, Kate KuKanich, B Duncan X Lascelles, Beatriz P Monteiro, Llibertat Real Sampietro, Sheilah Robertson, Paulo V Steagall
PRACTICAL RELEVANCE: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and are effective for the management of pain in cats. These Guidelines will support veterinarians in decision-making around prescribing NSAIDs in situations of chronic pain, to minimise adverse effects and optimise pain management. Information is provided on mechanism of action, indications for use, screening prior to prescription, use in the presence of comorbidities, monitoring of efficacy, and avoidance and management of adverse effects...
April 2024: Journal of Feline Medicine and Surgery
https://read.qxmd.com/read/38586459/associations-of-comorbid-depression-with-cardiovascular-renal-events-and-all-cause-mortality-accounting-for-patient-reported-outcomes-in-individuals-with-type-2-diabetes-a-6-year-prospective-analysis-of-the-hong-kong-diabetes-register
#35
JOURNAL ARTICLE
Yiu-Lam Yeung, Ka-Long Lee, Eric Sh Lau, Tsun-Fung Yung, Aimin Yang, Hongjiang Wu, Kelly Tc Wong, Alice Ps Kong, Elaine Yk Chow, Ronald Cw Ma, Theresa Yeung, Kit-Man Loo, Risa Ozaki, Andrea Oy Luk, Juliana Nm Lui, Juliana Cn Chan
BACKGROUND: Psychosocial status and patient reported outcomes (PRO) [depression and health-related quality-of-life (HRQoL)] are major health determinants. We investigated the association between depression and clinical outcomes in Chinese patients with type 2 diabetes (T2D), adjusted for PRO. METHODS: Using prospective data from Hong Kong Diabetes Register (2013-2019), we estimated the hazard-ratio (HR, 95%CI) of depression (validated Patient Health Questionnaire 9 (PHQ-9) score≥7) with incident cardiovascular disease (CVD), ischemic heart disease (IHD), chronic kidney disease (CKD: eGFR<60 ml/min/1...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38581942/a-case-report-of-chromophobe-renal-cell-carcinoma-with-renal-subcapsular-hematoma
#36
Yuehui Yin, Shanfang Tang
INTRODUCTION AND IMPORTANCE: Chromophobe renal cell carcinoma (CHRCC) is a rare subtype of renal cancer, accompanied by subcapsular renal hematoma (SRH) without a history of traumatic or hemorrhagic disease, which is clinically rare. The reason for CHRCC with SRH may be caused by tumor rupture or vascular rupture. In the early stage, it is often asymptomatic and can be easily overlooked and misdiagnosed, leading to delayed treatment and serious consequences. CASE PRESENTATION: A 39-year-old female patient was admitted to the emergency department due to sudden dull pain and discomfort in the lower back...
April 4, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38581588/comparative-analysis-of-renal-calculi-treatment-via-different-extracorporeal-shock-wave-lithotripsy-eswl-pathways
#37
JOURNAL ARTICLE
Shuai Yuan, Ramaiyan Velmurugan, S Prasanna Bharathi
OBJECTIVE: To compare the efficacy and safety of Extracorporeal Shock Wave Lithotripsy (ESWL) for treating renal calculi under different shock wave pathways. METHODS: This study involved a prospective analysis of clinical data obtained from 264 eligible patients with renal stones treated at the Urology Department of Shanxi Bethune Hospital between January 2021 and June 2023. Among these patients, 125 underwent ESWL via the dorsal shock wave pathway (Group A), while 139 patients underwent ESWL via the ipsilateral clavicular midline shock wave pathway (Group B)...
April 6, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38579700/identification-of-dominant-leptospira-serogroups-among-leptospirosis-cases-and-their-clinical-outcomes-a-prospective-hospital-based-study-in-mangaluru-india
#38
JOURNAL ARTICLE
Gillaine Vail Pinto, Kuppusamy Senthilkumar, Praveen Rai, Shama Prakash Kabekkodu, Indrani Karunasagar, Ballamoole Krishna Kumar
Leptospirosis is a reemerging zoonotic disease of worldwide significance, endemic to the southern region of India, with clinical manifestations similar to other febrile illnesses; hence, it is often misdiagnosed and underreported. Inadequate information about the disease burden and the regional circulating serogroups contributes to its neglected disease status. This study aimed to identify the infecting Leptospira serogroup in the coastal region of Mangaluru and study the clinical symptoms and outcome among leptospirosis patients...
April 2, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38579043/microwave-ablation-for-diffuse-adenomyosis-leading-to-multiple-complications-after-hysterectomy-a-case-report-and-literature-review
#39
JOURNAL ARTICLE
Xiuchun Yang, Wenhui Zhao, Shujuan Chen, Jinhong Yang
RATIONALE: Hysterectomy after microwave ablation (MWA) is more difficult than conventional surgery which increases the probability of postoperative complications due to MWA's collateral thermal damage to nearby intestines. Here we report a case of multiple postoperative complications after hysterectomy following MWA. PATIENT CONCERNS: A 44-year-old female was admitted due to progressive abdominal pain during menstruation for 30 years and no relief 1 year after MWA...
April 5, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38578155/determination-of-vitamin-c-in-raw-fruit-and-vegetable-homogenates-dietary-exposure-and-health-effects-of-excess-intake-in-adults-and-children
#40
JOURNAL ARTICLE
Vincent N Okafor, Daniel O Omokpariola, Daniel E Enenche
OBJECTIVE: The aim of the study was to determine Vitamin C content in some fruits and vegetables (FAV) including apple, banana, orange, pineapple, watermelon, carrot and cucumber, sold in the local markets in Awka, Anambra State, Nigeria as well as Vitamin C content in two-component and three-component homogenates FAV. The work was also designed to investigate the dietary exposure and health effects of excess vitamin C intake in adults and children. MATERIAL AND METHODS: Vitamin C as total ascorbic acid (AA) after reduction of dehydroascorbic acid was analyzed using both titrimetric and spectrophotometric methods...
2024: Roczniki Państwowego Zakładu Higieny
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