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https://www.readbyqxmd.com/read/30341850/rhabdomyolysis-of-unknown-etiology-initial-suspicion-and-detection-on-99mtc-mdp-skeletal-scintigraphy
#1
Nandigam Santosh Kumar, Sandip Basu
The classical bone scan findings of Rhabdomyolysis is presented in this illustration. A 60 year old female patient with complaints of low backache and bilateral lower limbs weakness over 1 year was referred for whole body skeletal status evaluation. Whole body skeletal scintigraphy undertaken 3 hrs after I.V injection of 15 mci of 99mTc-MDP revealed bilaterally symmetrical diffuse skeletal muscle tracer activity in deltoid, lattisimus dorsi, diaphragm, paraspinal muscles, gluteus muscles and muscles of thigh...
January 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30325858/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-summary-of-the-working-group-on-drug-development-and-trials-in-chronic-pancreatitis-at-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#2
Christopher E Forsmark, Dana K Andersen, John T Farrar, Megan Golden, Aida Habtezion, Sohail Z Husain, Liang Li, Julia Mayerle, Stephen J Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav
The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325857/accelerating-the-drug-delivery-pipeline-for-acute-and-chronic-pancreatitis-summary-of-the-working-group-on-drug-development-and-trials-in-recurrent-acute-pancreatitis-at-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#3
Mark E Lowe, Marc T Goodman, Gregory A Coté, Marshall J Glesby, Mark Haupt, Nicholas J Schork, Vikesh K Singh, Dana K Andersen, Stephen J Pandol, Aliye Uc, David C Whitcomb
Recurrent acute pancreatitis (RAP) is a complex clinical syndrome with significant morbidity, unpredictable outcomes, and limited treatment options. The National Institute of Diabetes and Digestive and Kidney Disease sponsored a workshop on July 25, 2018, in Pittsburgh, Pennsylvania, to address research gaps impeding development of effective therapies for pancreatitis. The RAP working group identified challenges to clinical progress using existing definitions, risk assessment, diagnostic and severity criteria, disease trajectories, outcomes, and research methods...
November 2018: Pancreas
https://www.readbyqxmd.com/read/30325281/reporting-standards-for-chronic-pancreatitis-by-using-ct-mri-and-mr-cholangiopancreatography-the-consortium-for-the-study-of-chronic-pancreatitis-diabetes-and-pancreatic-cancer
#4
Temel Tirkes, Zarine K Shah, Naoki Takahashi, Joseph R Grajo, Stephanie T Chang, Sudhakar K Venkatesh, Darwin L Conwell, Evan L Fogel, Walter Park, Mark Topazian, Dhiraj Yadav, Anil K Dasyam
Chronic pancreatitis is an inflammatory condition of the pancreas with clinical manifestations ranging from abdominal pain, acute pancreatitis, exocrine and/or endocrine dysfunction, and pancreatic cancer. There is a need for longitudinal studies in well-phenotyped patients to ascertain the utility of cross-sectional imaging findings of chronic pancreatitis for diagnosis and assessment of disease severity. CT and MR cholangiopancreatography are the most common cross-sectional imaging studies performed for the evaluation of chronic pancreatitis...
October 16, 2018: Radiology
https://www.readbyqxmd.com/read/30324991/management-of-acute-pyelonephritis
#5
Imen Gorsane, Sana Barrah, Samia Barbouch, Hayet Kaaroud, Amel Harzallah, Taieb Ben Abdallah
INTRODUCTION: Acute pyelonephritis (APN) results from bacterial invasion of the renal parenchyma. The aim of this study was to investigate the epidemiological, clinico-biological, therapeutic and evolutionary APN and to identify the risk factors of this renal disease. METHODS: We conducted a retrospective and descriptive study, over a period of 37 years (1977-2014), including 43 patients with APN, hospitalized in our Department. RESULTS: There were 43 patients with mean age of 36...
January 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30319940/ameliorating-effect-of-alstonia-scholaris-l-bark-extract-on-histopathological-changes-following-viper-envenomation-in-animal-models
#6
Rituparna Ghosh, Koushik Mana, Sumana Sarkhel
Objectives: The primary symptoms associated with snake envenomation are both systemic and local. The local symptoms are characterized by pain, swelling, haemorrhage and myonecrosis at the site of bite. The present study investigates the ameliorating effect of the aqueous bark extract of A lstonia scholaris bark on viper venom induced histopathological and biochemical changes in liver and kidney of swiss albino mice models. Methods & materials: Swiss albino mice (20 ± 2)g were treated with sublethal doses(0...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/30318504/case-of-serotonin-syndrome-initially-presenting-as-diffuse-body-pain
#7
Michael H Guo, Reesa L Monir, Ashleigh Wright, Neal P Holland
BACKGROUND Serotonin syndrome is a common yet potentially life-threatening condition caused by increased serotonergic activity, usually from serotonergic pharmaceutical agents. Primary features of serotonin syndrome include mental status changes, autonomic hyperactivity, and neuromuscular abnormalities. However, the presentation of serotonin syndrome is often quite variable, leading to its under-diagnosis. CASE REPORT A 50-year-old female with chronic kidney disease on peritoneal dialysis presented to the Emergency Department with severe, diffuse body pain...
October 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30317968/polymer-based-drug-delivery-systems-for-cancer
#8
Ru Wen, Afoma C Umeano, Pingping Chen, Ammad Ahmad Farooqi
The standard treatment for metastatic cancer is generally a combination of chemotherapy, surgery, and radiotherapy. Since there are few specific chemotherapeutics approved by the US Food and Drug Administration, systemic chemotherapy is widely employed in the hopes of destroying rapidly dividing cancer cells before doing irreversible damage to the human body. Because of the nature of traditional chemotherapeutics, systemic treatment is associated with various side effects, such as nausea, dysphoria, vomiting, and pain, and long-term, irreversible damage to major organs, such as the kidney and heart...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/30312166/effect-of-ocimum-basilicum-leaves-extract-on-acetaminophen-induced-nephrotoxicity-in-balb-c-mice
#9
Hajar F Karaali, Ragaee R Fahmi, Jamilah M Borjac
Background Acetaminophen (APAP) is one of the most widely used drugs to treat pain. Its overdose is lethal causing liver and kidney failure. Nephrotoxicity and hepatotoxicity are mostly due to the overproduction of reactive oxygen species. Ocimum basilicum, known as basil, is a commonly used medicinal plant due to its versatile role as antibacterial, antifungal, and anti-oxidative. We aim in this study to investigate the preventive and protective effect of basil leaves aqueous extract against APAP-induced hepatorenal toxicity in BALB/c mice...
October 12, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/30310642/spontaneous-resolution-of-a-spontaneous-steinstrasse-a-case-report
#10
Egemen Tezcan, Rebecca Burrell, Daniel J Bell, Stefanos Almpanis
A 63-year-old man presented with a 4-day history of right sided loin-to-groin pain. Computed tomography imaging revealed a 22 mm by 7 mm volume of contiguous ureteric calculi at the right vesicoureteric junction. Spontaneous steinstrasse was diagnosed with no recent history of extracorporeal shock wave lithotripsy (ESWL) or other urological intervention to the right kidney. Metabolic testing was negative. An initial plan was made for urgent primary ureteroscopy and lithotripsy, however, the patient spontaneously passed 20-25 calculi at home whilst awaiting his operation date...
October 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30305036/sickle-cell-disease-a-case-report-of-renal-amyloidosis
#11
Ann Bugeja, Paula Blanco, Edward G Clark, Manish M Sood
BACKGROUND: The development of proteinuria and reduced glomerular filtration rate is associated with higher mortality among patients with sickle cell disease (SCD). AA amyloidosis, also associated with increased mortality, in SCD is rare. We present a case of a woman with homozygous sickle cell disease with nephrotic syndrome and antibodies to double stranded DNA without clinical features of systemic lupus erythematosus. Kidney biopsy reveals AA amyloidosis and is the first report of concomitant AA amyloidosis with antibodies to double stranded DNA in SCD...
October 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30302093/a-very-rare-complication-of-hepatitis-a-infection-acute-myocarditis-a-case-report-with-literature-review
#12
Olivia Allen, Ahmed Edhi, Adam Hafeez, Alexandra Halalau
Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain-Barre syndrome, and pleural or pericardial effusion...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/30301607/reimaging-in-pediatric-blunt-spleen-and-liver-injury
#13
David M Notrica, Bethany L Sussman, Nilda M Garcia, Charles M Leys, R Todd Maxson, Amina Bhatia, Robert W Letton, Todd Ponsky, Karla A Lawson, James W Eubanks, Adam C Alder, Cynthia Greenwell, Daniel J Ostlie, David W Tuggle, Shawn D St Peter
BACKGROUND: APSA guidelines do not recommend routine reimaging for pediatric blunt liver or spleen injury (BLSI). This study characterizes the symptoms, reimaging, and outcomes associated with a selective reimaging strategy for pediatric BLSI patients. METHODS: A planned secondary analysis of reimaging in a 3-year multi-site prospective study of BLSI patients was completed. Inclusion required successful nonoperative management of CT confirmed BLSI without pancreas or kidney injury and follow up at 14 or 60 days...
September 16, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30298638/patient-reported-outcome-measures-and-their-utility-in-the-management-of-patients-with-advanced-chronic-kidney-disease
#14
K Ducharlet, V Sundarajan, J Philip, J Weil, N Barker N, R G Langham, J Burchell, H Gock
Symptom and quality of life (QOL) measures in patients with advanced chronic kidney disease (CKD) are recognised indicators of patient-centred care and represent important research, quality and clinical measures. This study examined relationships between symptom burden, QOL and functional status and associations of symptoms and mortality risk. A multisite longitudinal cohort analysis was undertaken in CKD stage 4/5 (no dialysis, ND) and dialysis patients. Patients completed symptom and QOL measures (Palliative Care Outcome Symptom Score (POS-S renal) [1], World Health Organisation QOL, WHOQOL-BREF) [2] and Karnofsky Performance scale [3]...
October 8, 2018: Nephrology
https://www.readbyqxmd.com/read/30290633/neck-xanthogranuloma-mimicking-malignancy-in-a-patient-with-diabetes-mellitus-a-case-report-and-literature-review
#15
Tzu-Pai Chen, Wan-Ling Yi, Chiang-Shin Liu, Yu-Hsuan Lin
RATIONALE: Xanthogranulomatous inflammation (XGI) is a rare inflammatory process, which mostly affects the kidney and gallbladder. It usually simulates an aggressive neoplastic process. Occurrences in the neck are extremely rare and would usually be associated with a preexisting cyst or glandular tissues. PATIENT CONCERNS: A 49-year-old diabetic patient presented with a right painful neck mass for a week. The pretreatment computed tomography (CT) imaging with contrast demonstrated a huge ill-defined heterogeneous-enhanced lesion abutting surrounding musculatures and great vessels...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30286646/the-diagnostic-yield-of-computed-tomography-in-the-management-of-acute-flank-pain-and-the-emergency-intervention-rate-for-a-proven-acute-ureteric-stone
#16
S Keoghane, T Austin, J Coode-Bate, S Deverill, T Drake, J Sanpera-Iglesias, T Johnston
INTRODUCTION: The diagnostic and management pathways for patients presenting with acute flank pain are complex. Although computed tomography (CT) of the kidneys, ureters and bladder (KUB) is the gold standard investigation for urolithiasis, the multitude of differential diagnoses must also be considered in the context of long-term risk from ionising radiation. This study investigated the integrated role and diagnostic yield of non-contrast CT in cases of acute flank pain. METHODS: A retrospective cohort study was undertaken of 1,442 consecutive patients investigated with CT KUB between March 2013 and February 2015...
October 5, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/30286626/acupuncture-application-in-chronic-kidney-disease-and-its-potential-mechanisms
#17
Wei Xiong, Fang-Fang He, Ren-Yu You, Jing Xiong, Yu-Mei Wang, Chun Zhang, Xian-Fang Meng, Hua Su
Chronic kidney disease (CKD) is an increasing major public health problem worldwide. The number of CKD patients on hemodialysis is growing rapidly as well. Acupuncture technique is one of the traditional Chinese medicine methods and has been used in a variety of diseases. Nowadays, the clinical application of acupuncture technique for CKD patients has become the focus for its effectiveness and security. In this paper, we will review the therapeutic effects and mechanisms of different acupuncture techniques for CKD patients...
2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/30285879/robotic-renal-cyst-decortication-with-calyceal-diverticulectomy-in-a-toddler-technical-practicalities-a-case-report
#18
Yi-Chun Wang, Jia-Dong Xia, Qi-Jie Zhang, Chen Chen, Jian-Xin Xue, Jie Yang, Chao Qin, Ning-Hong Song, Zeng-Jun Wang
BACKGROUND: Incidence of simultaneous renal cyst with calyceal diverticula in contralateral kidney is rare in children. A minimally invasive procedure in different sittings is often recommended. CASE PRESENTATION: A Chinese 15-month-old boy presented to the Urology department of a tertiary care center with right flank pain. He was subjected to magnetic resonance urography and was diagnosed as having right renal cyst and contralateral calyceal diverticula. He underwent robotic cyst decortication and calyceal diverticulectomy using da Vinci robot...
October 2, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30285830/late-presentation-mr-imaging-features-and-surgical-treatment-of-herlyn-werner-wunderlich-syndrome-classification-2-2-a-case-report
#19
Hidayatullah Hamidi, Nilab Haidary
BACKGROUND: Herlyn-Werner-Wunderlich syndrome is a very rare congenital genitourinary anomaly characterized by uterus didelphys, blind hemivagina and ipsilateral renal agenesis. CASE PRESENTATION: Authors present a case of Herlyn-Werner-Wunderlich syndrome in a 19-year-old unmarried woman who presented with pelvic pain and pelvic mass. MR imaging revealed the typical features of didelphys uterus, obstructed right hemivagina and ipsilateral renal agenesis. The patient subsequently underwent surgery...
October 3, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/30281895/urolithiasis-in-anomalous-kidneys-witnessing-the-changing-trends-in-the-endourological-management
#20
Abhishek G Singh, Ankush Jairath, S B Sudharshan, Gopal Tak, Arvind P Ganpule, Mohankumar Vijayakumar, Ravindra B Sabnis, Mahesh R Desai
OBJECTIVES: To present single center experience of urolithiasis management in anomalous kidneys, highlighting the need for algorithm-based approach in deciding the modality to be used in treatment planning. PATIENTS AND METHODS: We retrospectively reviewed data of all the patients who presented to our anomalous renal unit with urolithiasis from January 1990 to July 2014. Perioperative features of all the patients along with management was studied. RESULTS: Percutaneous nephrolithotomy (PCNL) was the most common surgical modality used followed by flexible ureteroscopy...
October 3, 2018: BJU International
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