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Kidney Pain

Jie-Sian Wang, Jen-Huai Chiang, Heng-Jung Hsu
Musculoskeletal pain is experienced by 5%-14% of the general adult population, and it is highly common among patients with chronic kidney disease (CKD). Therefore, the purpose of the study was to decide the prevalent rate of musculoskeletal pain in end-stage renal disease (ESRD) patients and to analyze this relationship between myalgia and ESRD using clinical features and determinants.A total of 93,013 patients who received ESRD diagnoses during 2000 and 2010 and were followed up until December 31, 2011, were identified from the Longitudinal Health Insurance Database 2000 (LHID2000) of the National Health Research Institutes (NHRI); non-ESRD controls were also selected from the LHID2000...
August 2018: Medicine (Baltimore)
Salah A Sheweita, Ainour A Almasmari, Sabah G El-Banna
Tramadol is an analgesic used to treat moderate to severe pain caused by cancer, osteoarthritis, and other musculoskeletal diseases. Cytochrome P450 system metabolizes tramadol and induces oxidative stress in different organs. Therefore, the present study aims at investigating the changes in the activities and the protein expressions of CYPs isozymes (2E1, 3A4, 2B1/2), antioxidants status, free radicals levels after pretreatment of rats with Curcumin and/or Gallic as single- and/or repeated-doses before administration of tramadol...
2018: PloS One
Mohd Noor Azreey Mukri, Wei-Yen Kong, Ruslinda Mustafar, Syahrul Sazliyana Shaharir, Shamsul Azhar Shah, Abdul Halim Abdul Gafor, Rozita Mohd, Rizna Abdul Cader, Lydia Kamaruzaman
Introduction: Hyperuricemia is associated with chronic kidney disease (CKD) progression and poor cardiovascular outcomes. We studied the effect of febuxostat on estimated glomerular filtration rate (eGFR), proteinuria and monitored the safety profile of the medication. Material and Methods: This is a prospective open-label, randomized study in CKD stage 3 and 4 patients with diabetic nephropathy and asymptomatic hyperuricemia. Patients were randomized into febuxostat 40 mg daily and no treatment group using block randomization method and were followed up for 6 months...
2018: EXCLI journal
Ashraf O Oweis, Sameeha A Al Shelleh, Najla Aldaoud, Osama Mohammed Alshari, Mousa A Al-Abbadi
BACKGROUND Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome in adults, which can be primary, or secondary to various causes. Unlike membranous nephropathy, FSGS is less likely to be associated with malignancy. Few cases have been reported of the occurrence of FSGS with hematological malignancies like multiple myeloma (MM). CASE REPORT A 48-year-old man presented with nephrotic syndrome and renal impairment and was diagnosed with primary FSGS after kidney biopsy, which showed a segmental scar with diffuse effacement of foot processes on electron microscopy...
August 13, 2018: American Journal of Case Reports
Xiu Hong Yang, Bao Long Zhang, Yan Hong Gu, Xiao Li Zhan, Li Li Guo, Hui Min Jin
OBJECTIVE: Sleep disorders, chronic pain, and fatigue have been long-standing torments in most patients with chronic kidney disease (CKD). In this review, we attempted to explore whether these nontraditional cardiovascular risk factors are associated with increased mortality in patients with CKD. METHOD: Electronic searches were performed in MEDLINE (PubMed, 1966-2018), EMBASE (1974-2018),, and the Cochrane Central Register of Controlled Trials databases...
August 9, 2018: Sleep Medicine
Mark H Pitcher, Michael Von Korff, M Catherine Bushnell, Linda Porter
The multidimensional nature of chronic pain is not reflected by definitions based solely on pain duration, resulting in high prevalence estimates limiting effective policy development. The newly proposed concept of High Impact Chronic Pain (HICP) incorporates both disability and pain duration to identify a more severely impacted portion of the chronic pain population, yet remains uncharacterized at the population level. As such, we used the 2011 National Health Interview Survey (NHIS; n=15,670) to (i) assess the likelihood of disability in the overall chronic pain population, (ii) to estimate the prevalence of HICP, and (iii) to characterize the disability, health status and health care use profile of this population in the United States...
August 7, 2018: Journal of Pain: Official Journal of the American Pain Society
Rhian L Clissold, Jon Fulford, Michelle Hudson, Beverley M Shields, Timothy J McDonald, Sian Ellard, Andrew T Hattersley, Coralie Bingham
Background: Heterozygous mutations in the HNF1B gene are the most common monogenic cause of developmental kidney disease. Extrarenal phenotypes frequently occur, including diabetes mellitus and pancreatic hypoplasia; the latter is associated with subclinical exocrine dysfunction. We measured faecal elastase-1 in patients with HNF1B-associated disease regardless of diabetes status and assessed the degree of symptoms associated with pancreatic exocrine deficiency. Methods: Faecal elastase-1 was measured in 29 patients with a known HNF1B mutation...
August 2018: Clinical Kidney Journal
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
Karel Decaestecker, Benjamin Van Parys, Jeroen Van Besien, Nicolas Doumerc, Liesbeth Desender, Caren Randon, Frederic De Ryck, Thomas Tailly, Matthias Beysens, Carl Van Haute, Diederik Ponette, Kathia De Man, Piet Hoebeke, Frank Vermassen
BACKGROUND: Kidney autotransplantation (KAT) is the ultimate way to salvage kidneys with complex renovascular, ureteral, or malignant pathologies that are not amenable to in situ reconstruction. A minimally invasive approach could broaden its adoption. OBJECTIVE: To describe operative technique, perioperative complications, and early functional outcomes of robot-assisted kidney autotransplantation (RAKAT). DESIGN, SETTING, AND PARTICIPANTS: Retrospective review of prospectively collected data regarding consecutive patients undergoing RAKAT between March 2017 and February 2018 at two university hospitals...
August 6, 2018: European Urology Focus
Ibrahim Almassri, Mohamed Sekkarie
In mid-March 2015, a mother and her teenage daughter and son from Syria presented to a Syrian American Medical Society (SAMS) refugee clinic in the Beqaa Valley in Lebanon with the chief complaints of hair loss together with weakness and numbness of their lower extremities. They reported that on March 1, a military foe of their relative had given him several boxes of Middle Eastern cookies which were consumed by over 20 members of their families and neighbors. Soon after the consumption, most members of the households developed symptoms including abdominal pain, nausea, vomiting, and constipation...
July 2018: Avicenna Journal of Medicine
Maximilian Gericke, Dirk Hartmann
HISTORY:  The 43-year-old patient was admitted because of vomiting and abdominal pain. He had a history of depression and multiple discus prolapses. He reported the consumption of three beers per day. FINDINGS:  The patient presented diffuse abdominal pain. The serume-kreatine was elevated (205 µmol/l), there was a leucocytosis (18,4^3/µl) and a mild elvation of y-GT (2,3µkat/l). Stool culture was negative. An abdominal ultrasound and a gastroscopy did not show groundbreaking findings...
August 2018: Deutsche Medizinische Wochenschrift
Claudio Bianchini Massoni, Matteo Azzarone, Danilo Barbarisi, Paolo Perini, Antonio Freyrie
A 90-year-old male developed acute onset of abdominal and lumbar pain due to the rupture of an 11-cm abdominal aortic aneurysm. A congenital fused pelvic kidney perfused by three renal arteries arising from iliac axes was detected. In an emergent setting, an aorto-uni-iliac endograft was deployed through right femoral surgical access with occlusion of the upper right renal artery. An occluder device was placed in the common iliac artery above the renal artery through left femoral access. A femorofemoral crossover bypass completed the procedure...
February 2018: Aorta (Stamford, Conn.)
Manju Lata Verma, Uma Singh, Indrani Ghosh, Pushpa Lata Sankhwar
A 14-year-old girl presented with increasing cyclical pain, scanty menses, pelvic mass and absence of the left kidney. With both radiological and clinical examinations (examination under anaesthesia), diagnosis of bicornuate uterus with single cervix could be made while on laparotomy, and it turned out to be uterine didelphys, with one cervix obscured by blind hemivagina with haematometra and haematocolpos in the left horn, for which hemihysterectomy was done. Post procedure the patient was relieved of cyclical pain and is menstruating properly...
August 4, 2018: BMJ Case Reports
Kalyan Sharma, Sudhir Kumar Yadav, Bimbadhar Valluru, Ling Liu
RATIONALE: Clear cell sarcoma of tendon and aponeurosis (CCSTA) or soft parts is a rare malignant melanin producing tumor entity that is derived from the neural crest cells originating from soft tissues displaying melanocytic differentiation. Diagnosis of CCSTA is difficult as it is dependent on age, size, location, necrosis, calcifications, cystic degeneration, and local to distant metastatic deposits. These tumors have very poor prognosis with a survival rate of 5-10 years because of local recurrence, early to late metastasis to lymph nodes, lungs, bones, and liver...
August 2018: Medicine (Baltimore)
David Carter, Bill Papps, Nicholas R Brook
Background: Hemorrhage from an angiomyolipoma (AML) of the kidney can be life threatening and arterial embolization is the primary treatment. Embolization is less invasive than surgery, is well tolerated, and major complications are rare. We describe a case of disseminated intravascular coagulation (DIC) after embolization of a bleeding renal AML in a 44-year-old man with massive bilateral AMLs. This report aims to highlight the possibility that acute DIC could be a major complication of embolization itself and so should be considered and screened for because, if present, it requires early and aggressive management...
2018: Journal of Endourology Case Reports
Niloy Ghosh, Jeremiah H Moon, Jonathan A Henderson, Robert P Kauffman
An 18-year-old virginal woman was referred to the reproductive endocrinology clinic with primary amenorrhoea and secondary sexual development in the absence of pelvic pain. Additionally, she had significant congenital sensorineural hearing loss, autism, bipolar disorder and class III obesity. On physical examination, secondary sexual development was confirmed (Tanner 5 breasts and Tanner 4 pubic hair). She refused further pelvic examination following prior attempts by the referring physicians. Serum leutinizing hormone (LH), follicle sitmulating hormone (FSH)...
July 30, 2018: BMJ Case Reports
Eric Gourley, Gilda Digman, Marlo Nicolas, Dharam Kaushik
An older male patient with a history of tachycardia treated with atenolol presented to an outside hospital on 22 February 2017 with acute right flank pain. He had a CT scan which revealed a large right renal mass with acute haemorrhage. He was initially managed with interventional radiology guided embolism on 25 February 2017 due to the ongoing bleeding and haemodynamic instability. He was then transferred to our institution. He underwent right radical nephrectomy on 13 March 2017. His pathology revealed a 12...
July 30, 2018: BMJ Case Reports
Piotr Bryniarski, Paweł Rajwa, Marcin Życzkowski, Piotr Taborowski, Zbigniew Kaletka, Andrzej Paradysz
BACKGROUND: Totally tubeless percutaneous nephrolithotomy (ttPCNL) becomes increasingly frequently utilized in the treatment of kidney stones. This procedure emerged as an answer for patients' needs to minimize hospitalization time, pain intensity and discomfort due to nephrostomy tube. However, ttPCNL may be less safe for patients, as without nephrostomy tube bleeding from renal vessels is potentially more severe. OBJECTIVES: The purpose of our study was to retrospectively evaluate the safety parameters of ttPCNL collected in a prospective manner...
July 30, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Tahira Younis, Azhar Rasul, Faiza Jabeen, Ghulam Hussain, Javaria Altaf, Laila Jafri, Rehana Rani, Muhammad Rashid Khan, Iqra Sarfraz, Muhammad Ali
Roots, bark, stem/twigs, and leaves of Fraxinus xanthoxyloides are being used regionally for the cure of malaria, jaundice, internal injuries, pneumonia, pain, rheumatism and also in fracture of bones. Our objective was to assess the methanolic leaves extract of F. xanthoxyloides for its antioxidant capability against oxidative stress induced by carbon tetrachloride (CCl4 ) in the kidney of Sprague-Dawley rats. Duration of this experiment was 30 days and doses were given on alternative days. Urine of rats was assessed for kidney function and renal tissues for antioxidant enzymes activity, biochemical markers, comet assay and histopathology...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Emmy Luu, Kevin B Ita, Matthew J Morra, Inna E Popova
It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. This project will examine the effect of microneedle rollers on the transport of DH and PE across pig ear skin...
July 30, 2018: Current Drug Delivery
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