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https://www.readbyqxmd.com/read/24576338/phase-1-results-of-safety-and-tolerability-in-a-rush-oral-immunotherapy-protocol-to-multiple-foods-using-omalizumab
#1
Philippe Bégin, Tina Dominguez, Shruti P Wilson, Liane Bacal, Anjuli Mehrotra, Bethany Kausch, Anthony Trela, Morvarid Tavassoli, Elisabeth Hoyte, Gerri O'Riordan, Alanna Blakemore, Scott Seki, Robert G Hamilton, Kari C Nadeau
BACKGROUND: Up to 30% of patients with food allergies have clinical reactivity to more than one food allergen. Although there is currently no cure, oral immunotherapy (OIT) is under investigation. Pilot data have shown that omalizumab may hasten the ability to tolerate over 4 g of food allergen protein. OBJECTIVE: To evaluate the safety and dose tolerability of a Phase 1 Single Site OIT protocol using omalizumab to allow for a faster and safe desensitization to multiple foods simultaneously...
2014: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/21164393/evidence-should-not-be-viewed-in-isolation
#2
Rui Moreno, Andrew Rhodes
After decades of negative multicenter, randomized, placebo-controlled, double-blind clinical trials in patients with critical illness, the last decade witnessed the publication of a series of studies demonstrating an improved outcome for a variety of interventions. These positive studies and interventions have subsequently been brought together into "bundles" of care. This rush to change clinicians' practice has often been with little regard for the context in which the evidence was generated and the problems created by the difference between efficacy and effectiveness...
October 2010: Critical Care Medicine
https://www.readbyqxmd.com/read/20578927/a-1-536-well-ultra-high-throughput-sirna-screen-to-identify-regulators-of-the-wnt-beta-catenin-pathway
#3
Namjin Chung, Shane Marine, Emily A Smith, Robert Liehr, S Todd Smith, Louis Locco, Edward Hudak, Anthony Kreamer, Alison Rush, Brian Roberts, Michael B Major, Randall T Moon, William Arthur, Michele Cleary, Berta Strulovici, Marc Ferrer
High-throughput siRNA screens are now widely used for identifying novel drug targets and mapping disease pathways. Despite their popularity, there remain challenges related to data variability, primarily due to measurement errors, biological variance, uneven transfection efficiency, the efficacy of siRNA sequences, or off-target effects, and consequent high false discovery rates. Data variability can be reduced if siRNA screens are performed in replicate. Running a large-scale siRNA screen in replicate is difficult, however, because of the technical challenges related to automating complicated steps of siRNA transfection, often with multiplexed assay readouts, and controlling environmental humidity during long incubation periods...
June 2010: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/16940746/basophil-interleukin-4-and-interleukin-13-production-is-suppressed-during-the-early-phase-of-rush-immunotherapy
#4
Halina Plewako, Katarzyna Wosińska, Monica Arvidsson, Janne Bjorkander, Per Stahl Skov, Lena Håkansson, Sabina Rak
BACKGROUND: Studies using rush immunotherapy (RIT) have shown that rapid protection can be achieved using protocols allowing a fast increment of allergen dose. We examined the early effects of RIT on basophil numbers and expression of CD203c, production of interleukin (IL)-4 and IL-13 and histamine release by basophils in the peripheral blood of patients treated with immunotherapy and controls. METHODS: Twelve patients treated with RIT and 4 untreated controls were included in the study...
2006: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/15521440/evaluation-of-a-focused-assessment-with-sonography-for-trauma-protocol-to-detect-free-abdominal-fluid-in-dogs-involved-in-motor-vehicle-accidents
#5
Søren R Boysen, Elizabeth A Rozanski, Amy S Tidwell, Jen L Holm, Scott P Shaw, John E Rush
OBJECTIVE: To establish a focused assessment with sonography for trauma (FAST) protocol in dogs, determine whether FAST can be performed by veterinary clinicians without extensive ultrasonographic experience, and assess the frequency of free fluid (as determined via FAST) in the abdominal cavity of dogs following motor vehicle accidents (MVAs). DESIGN: Prospective study. ANIMALS: 100 client-owned dogs evaluated within 24 hours of an MVA. PROCEDURE: Dogs were placed in lateral recumbency for the FAST examination...
October 15, 2004: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/11769300/screening-for-diabetes-mellitus-in-high-risk-patients-cost-yield-and-acceptability
#6
P J O'Connor, W A Rush, L M Cherney, N P Pronk
CONTEXT: Although universal screening for diabetes mellitus is generally not recommended, recent reports suggest that screening individuals with multiple diabetes risk factors may be worthwhile. Little is known about the cost, yield, or acceptability of this kind of screening. PRACTICE PATTERN EXAMINED: Screening of high-risk patients for diabetes mellitus using a two-step, glucose-based screening protocol: Patients were initially screened with a random glucose test; those with abnormal results received a follow-up fasting, 2-hour, 75-gram oral glucose tolerance test...
November 2001: Effective Clinical Practice: ECP
https://www.readbyqxmd.com/read/8911695/influence-of-bee-venom-immunotherapy-on-degranulation-and-leukotriene-generation-in-human-blood-basophils
#7
M Jutel, U R Müller, M Fricker, S Rihs, W J Pichler, C Dahinden
BACKGROUND: Rapid clinical tolerance can be induced over several hours by very fast bee venom immunotherapy (VIT) protocols. OBJECTIVE: To investigate the mechanisms underlying VIT we examined the changes of blood basophil responsiveness during VIT. METHODS: Seven bee venom allergic patients with a history of severe systemic reactions after a bee sting were investigated. A cumulative dose of 111.1 micrograms bee venom (BV) was administered sc over 3...
October 1996: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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