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influenza virus and muscle

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https://www.readbyqxmd.com/read/30425833/characterization-of-rhinovirus-c-from-a-4-year-old-boy-with-acute-onset-dilated-cardiomyopathy-in-jakarta-indonesia
#1
Ageng Wiyatno, E S Zul Febrianti, Aghnianditya Kresno Dewantari, Khin Saw Myint, Dodi Safari, Nikmah Salamia Idris
Introduction: Myocarditis, inflammation of the heart muscle, can be caused by infections, autoimmune disease or exposure to toxins. The major cause of myocarditis in the paediatric population is viral infection, including coxsackievirus B3, adenovirus, herpesvirus, parvovirus, influenza A and B, and hepatitis. Here, we report the detection of rhinovirus C in a boy with a clinical presentation of myocarditis, suggesting a possible causative role of this virus in this case. Case presentation: A previously well 4...
September 2018: JMM Case Reports
https://www.readbyqxmd.com/read/30240371/takotsubo-cardiomyopathy-triggered-by-influenza-b
#2
Waldemar Elikowski, Małgorzata Małek-Elikowska, Monika Lisiecka, Zofia Trypuć, Iwona Mozer-Lisewska
Influenza is associated with a high prevalence of cardiac complications, including myocarditis and exacerbation of ischemic heart disease or heart failure (HF). However, only four cases of stress-induced takotsubo cardiomyopathy (TC), all of them triggered by virus A influenza, have been reported so far. Another two TC cases after anti-influenza vaccination are also available in the literature. The authors describe a new case of TC, this time provoked by influenza B. An 89-year-old female with a history of hypertension and chronic obstructive pulmonary disease (COPD) was admitted due to a fever (39oC), muscle aches and cough...
August 29, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/30110182/impact-of-cigarette-smoke-exposure-on-lung-fibroblastic-response-after-influenza-pneumonia
#3
Sei Won Lee, Lokesh Sharma, Young Ae Kang, Sang-Hun Kim, Sreelakshmi Chandrasekharan, Ashley Losier, Virginia Brady, Santos Bermejo, Nathaniel Andrews, Chang-Min Yoon, Wei Liu, Jung-Yeon Lee, Min-Jong Kang, Charles S Dela Cruz
Influenza viruses can result in significant lung injury with significant morbidity and mortality. In this study, we evaluated the impact of cigarette smoke (CS) exposure on the pulmonary fibroblastic response after influenza infection. We employed a murine model in which animals were exposed to cigarette smoke or room air and subsequently infected with H1N1 influenza virus. Inflammatory and fibrotic responses were measured at different time points post influenza infection. Primary fibroblasts were isolated from lung of mice and their characteristics were evaluated...
August 15, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30101152/bioengineered-viral-platform-for-intramuscular-passive-vaccine-delivery-to-human-skeletal-muscle
#4
Nicole K Paulk, Katja Pekrun, Gregory W Charville, Katie Maguire-Nguyen, Michael N Wosczyna, Jianpeng Xu, Yue Zhang, Leszek Lisowski, Bryan Yoo, Jose G Vilches-Moure, Gordon K Lee, Joseph B Shrager, Thomas A Rando, Mark A Kay
Skeletal muscle is ideal for passive vaccine administration as it is easily accessible by intramuscular injection. Recombinant adeno-associated virus (rAAV) vectors are in consideration for passive vaccination clinical trials for HIV and influenza. However, greater human skeletal muscle transduction is needed for therapeutic efficacy than is possible with existing serotypes. To bioengineer capsids with therapeutic levels of transduction, we utilized a directed evolution approach to screen libraries of shuffled AAV capsids in pools of surgically resected human skeletal muscle cells from five patients...
September 21, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30090764/nipah-virus-epidemic-in-southern-india-and-emphasizing-one-health-approach-to-ensure-global-health-security
#5
EDITORIAL
Vijay K Chattu, Raman Kumar, Soosanna Kumary, Fnu Kajal, Joseph K David
Nipah virus (NiV) encephalitis first reported in "Sungai Nipah" in Malaysia in 1999 has emerged as a global public health threat in the Southeast Asia region. From 1998 to 2018, more than 630 cases of NiV human infections were reported. NiV is transmitted by zoonotic (from bats to humans, or from bats to pigs, and then to humans) as well as human-to-human routes. Deforestation and urbanization of some areas have contributed to greater overlap between human and bat habitats resulting in NiV outbreaks...
March 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/30031688/tissue-acylcarnitine-status-in-a-mouse-model-of-mitochondrial-%C3%AE-oxidation-deficiency-during-metabolic-decompensation-due-to-influenza-virus-infection
#6
Tatiana N Tarasenko, Kristina Cusmano-Ozog, Peter J McGuire
Despite judicious monitoring and care, patients with fatty acid oxidation disorders may experience metabolic decompensation due to infection which may result in rhabdomyolysis, cardiomyopathy, hypoglycemia and liver dysfunction and failure. Since clinical studies on metabolic decompensation are dangerous, we employed a preclinical model of metabolic decompensation due to infection. By infecting mice with mouse adapted influenza and using a pair-feeding strategy in a mouse model of long-chain fatty acid oxidation (Acadvl-/- ), our goals were to isolate the effects of infection on tissue acylcarnitines and determine how they relate to their plasma counterparts...
June 23, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29963988/clinical-and-epidemiological-aspects-of-microcephaly-in-the-state-of-piau%C3%A3-northeastern-brazil-2015-2016
#7
Isabel Marlúcia Lopes Moreira de Almeida, Carmen Viana Ramos, Danielle Carvalho Rodrigues, Amanda Carvalho de Sousa, Maria de Lourdes Cristina Alcântara Paz Carvalho do Nascimento, Marcos Vilhena Bittencourt da Silva, Francisca Miriane Araújo Batista, Jéssica Pereira Dos Santos, Roselane Sampaio de Oliveira, Filipe Augusto de Freitas Soares, Samanta Cristina das Chagas Xavier, Filipe Anibal Carvalho-Costa
OBJECTIVES: To describe aspects of the microcephaly epidemic in the state of Piauí. METHODS: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n=100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n=63) were used as a comparison group. RESULTS: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital...
June 29, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29764680/the-parasite-derived-rov-asp-1-is-an-effective-antigen-sparing-cd4-t-cell-dependent-adjuvant-for-the-trivalent-inactivated-influenza-vaccine-and-functions-in-the-absence-of-myd88-pathway
#8
Sonia Jain, Parakkal Jovvian George, Wanyan Deng, Joseph Koussa, Kaela Parkhouse, Scott E Hensley, Jiu Jiang, Jie Lu, Zhuyun Liu, Junfei Wei, Bin Zhan, Maria Elena Bottazzi, Hao Shen, Sara Lustigman
Vaccination remains the most cost-effective biomedical approach for controlling influenza disease. In times of pandemics, however, these vaccines cannot be produced in sufficient quantities for worldwide use by the current manufacturing capacities and practices. What is needed is the development of adjuvanted vaccines capable of inducing an adequate or better immune response at a decreased antigen dose. Previously we showed that the protein adjuvant rOv-ASP-1 augments influenza-specific antibody titers and survival after virus challenge in both young adult and old-age mice when administered with the trivalent inactivated influenza vaccine (IIV3)...
June 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29617814/a-respiratory-syncytial-virus-vaccine-based-on-the-small-hydrophobic-protein-ectodomain-presented-with-a-novel-lipid-based-formulation-is-highly-immunogenic-and-safe-in-adults-a-first-in-humans-study
#9
Joanne M Langley, Lisa D MacDonald, Genevieve M Weir, Donna MacKinnon-Cameron, Lingyun Ye, Shelly McNeil, Bert Schepens, Xavier Saelens, Marianne M Stanford, Scott A Halperin
Background: Respiratory syncytial virus infection can cause lower respiratory tract infection in older adults comparable to influenza, but no vaccines are available. Methods: This was a randomized, observer-blinded, first-in-humans study of a novel synthetic RSV antigen based on the ectodomain of the small hydrophobic glycoprotein (SHe) of RSV subgroup A, formulated with either the lipid and oil-based vaccine platform DepoVax (DPX-RSV[A]) or alum (RSV[A]-Alum), in healthy, 50-64-year-old individuals...
July 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29473978/distinction-between-rhinovirus-induced-acute-asthma-and-asthma-augmented-influenza-infection
#10
G V Guibas, M Tsolia, I Christodoulou, F Stripeli, Z Sakkou, N G Papadopoulos
BACKGROUND: Rhinovirus (RV) is an established trigger of asthma attacks, whereas such a link is less consistent for influenza virus (IFV). OBJECTIVE: In the context of precision medicine, we hypothesized that IFV infection may cause a condition essentially different from RV, and we investigated this by evaluating clinical characteristics of RV/IFV-positive and -negative children with respiratory symptoms and/or fever. METHODS: One thousand two hundred and seven children, 6 months to 13 years old, hospitalized for flu-like illness were recruited in this cross-sectional study...
May 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29416543/neutralizing-antibodies-induced-by-gene-based-hydrodynamic-injection-have-a-therapeutic-effect-in-lethal-influenza-infection
#11
Tatsuya Yamazaki, Maria Nagashima, Daisuke Ninomiya, Akira Ainai, Akira Fujimoto, Isao Ichimonji, Hidekazu Takagi, Naoko Morita, Kenta Murotani, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of vectored immune-prophylaxis against influenza virus infection. We generated a plasmid encoding neutralizing IgG monoclonal antibodies (mAbs) against A/PR/8/34 influenza virus (IAV) hemagglutinin (HA). We then performed electroporation of the plasmid encoding neutralizing mAbs (EP) in mice muscles and succeeded in inducing the expression of neutralizing antibodies in mouse serum...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29260019/influenza-a-h3n2-induced-rhabdomyolysis-complicating-anterior-compartment-syndrome-serial-changes-in-muscle-mri-t2-fat-suppression-imaging
#12
Tadanori Hamano, Akiko Matsunaga, Osamu Yamamura, Masako Nakamura, Yasutaka Kawamura, Itsuro Higuchi, Masaru Kuriyama, Yasunari Nakamoto
Background: Rhabdomyolysis with influenza infection is rarely reported in adults. We report here influenza A induced rhabdomyolysis and anterior compartment syndrome (ACS). Case report: This case report describes a 43-year-old woman exhibiting influenza A induced rhabdomyolysis. High levels of creatine kinase (97,000 IU/L) and high titer of anti-influenza A virus antibody (H3N2) (320 ×) with negative anti-influenza B virus antibody were observed. T2 fat suppression muscle MRI imaging showed high-intensity signals in rectus femoris, vastus lateralis, adductor magnus, and semimembranosus (SM) muscles...
June 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29188128/influenza-a-virus-infection-damages-zebrafish-skeletal-muscle-and-exacerbates-disease-in-zebrafish-modeling-duchenne-muscular-dystrophy
#13
Michelle Goody, Denise Jurczyszak, Carol Kim, Clarissa Henry
INTRODUCTION: Both genetic and infectious diseases can result in skeletal muscle degeneration, inflammation, pain, and/or weakness. Duchenne muscular dystrophy (DMD) is the most common congenital muscle disease. DMD causes progressive muscle wasting due to mutations in Dystrophin. Influenza A and B viruses are frequently associated with muscle complications, especially in children. Infections activate an immune response and immunosuppressant drugs reduce DMD symptoms. These data suggest that the immune system may contribute to muscle pathology...
October 25, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29166978/molecular-detection-of-influenza-a-h1n1-pdm09-viruses-with-m-genes-from-human-pandemic-strains-among-nigerian-pigs-2013-2015-implications-and-associated-risk-factors
#14
O A Adeola, B O Olugasa, B O Emikpe
In the post-pandemic period, influenza A(H1N1)pdm09 virus has been detected in swine populations in different parts of the world. This study was conducted to determine the presence and spatial patterns of this human pandemic virus among Nigerian pigs and identify associated risk factors. Using a two-stage stratified random sampling method, nasal swab specimens were obtained from pigs in Ibadan, Nigeria during the 2013-2014 and 2014-2015 influenza seasons, and the virus was detected by reverse transcriptase-polymerase chain reaction (RT-PCR)...
December 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29074428/identification-and-function-analysis-of-canine-stimulator-of-interferon-gene-sting
#15
Yuxiang Zhang, Mengyan Zhu, Gairu Li, Jie Liu, Xiaofeng Zhai, Ruyi Wang, Junyan Zhang, Gang Xing, Jinyan Gu, Liping Yan, Jing Lei, Haifeng Sun, Zhiyu Shi, Fei Liu, Boli Hu, Shuo Su, Jiyong Zhou
Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. In this study, we identified and cloned canine STING gene. Full-length STING encodes a 375 amino acid product that shares the highest similarity with feline STING. Highest levels of mRNA of canine STING were detected in the spleen and lungs while the lowest levels in the heart and muscle. Analysis of its cellular localization showed that STING is localizes to the endoplasmic reticulum...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28941132/infectious-dose-dependent-accumulation-of-live-highly-pathogenic-avian-influenza-h5n1-virus-in-chicken-skeletal-muscle-implications-for-public-health
#16
G Vasudevan, P R Vanamayya, S Nagarajan, K Rajukumar, S Suba, G Venketash, C Tosh, R Sood, R H Nissly, S V Kuchipudi
Highly pathogenic avian influenza viruses (HPAIV) of H5N1 subtype are a major global threat to poultry and public health. Export of poultry products, such as chicken and duck meat, is a known source for the cross-boundary spread of HPAI H5N1 viruses. Humans get infected with HPAI H5N1 viruses either by close contact with infected poultry or through consumption of fresh/undercooked poultry meat. Skeletal muscle is the largest soft tissue in chicken that has been shown to contain virus during systemic HPAIV infection and supports productive virus infection...
February 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28625993/survival-of-highly-pathogenic-avian-influenza-h5n1-virus-in-tissues-derived-from-experimentally-infected-chickens
#17
Yu Yamamoto, Kikuyasu Nakamura, Masaji Mase
Eurasian lineage highly pathogenic avian influenza (HPAI) H5N1 virus has been a severe threat to the poultry industry since its emergence in 1996. The carcass or tissues derived from infected birds may present the risk of the virus spreading to humans, animals, and the surrounding environment. In this study, we investigated the survival of the virus in feather, muscle, and liver tissues collected from six chickens ( Gallus gallus ) experimentally infected with HPAI H5N1 virus. The tissues were stored at +4°C or +20°C, and viral isolation was performed at different times for 360 days...
August 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27833453/benign-acute-childhood-myositis-complicating-influenza-b-infection-in-a-boy-with-idiopathic-nephrotic-syndrome
#18
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Pańczyk-Tomaszewska
INTRODUCTION: Benign acute childhood myositis (BACM) is an acute complication of an infection characterized by calf pain, limitation of lower limb mobility, an increase in serum creatine kinase, and a self-limiting course. No reports of BACM in children with idiopathic nephrotic syndrome (INS) can be found in the literature. CASE REPORT: A 5-year-old boy with steroid-sensitive INS presented with fever, leg pain, and problems with walking. Physical examination showed pharyngeal erythema, preserved movements in all joints, and weakness of leg muscles...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27610732/highly-pathogenic-eurasian-h5n8-avian-influenza-outbreaks-in-two-commercial-poultry-flocks-in-california
#19
Simone Stoute, Richard Chin, Beate Crossley, C Gabriel Sentíes-Cué, Arthur Bickford, Mary Pantin-Jackwood, Richard Breitmeyer, Annette Jones, Silvia Carnaccini, H L Shivaprasad
In January 2015, a highly pathogenic Eurasian lineage H5N8 avian influenza (AI) virus (AIV) was detected in a commercial meat turkey flock in Stanislaus County, CA. Approximately 3 wk later, a similar case was diagnosed in commercial brown layers from a different company located in Kings County, CA. Five 14-wk-old turkey hens were submitted to the California Animal Health and Food Safety Laboratory System (CAHFS), Turlock, and eleven 12-wk-old chickens were submitted to CAHFS, Tulare laboratory due to an acute increase in flock mortality...
September 2016: Avian Diseases
https://www.readbyqxmd.com/read/27545762/exercise-prior-to-influenza-vaccination-for-limiting-influenza-incidence-and-its-related-complications-in-adults
#20
REVIEW
Antonio Jose Grande, Hamish Reid, Emma E Thomas, David Nunan, Charles Foster
BACKGROUND: Influenza is an infectious virus affecting both humans and animals. In humans, symptoms present as fever, cough, sore throat, runny nose, headache, muscle and joint pain, and malaise. The epidemiological profile of influenza is influenced by multiple factors, including transmissibility of the virus and the susceptibility of the population. Annually, influenza is estimated to infect 5% to 10% of adults, with higher rates in winter seasons in countries with seasonal variation...
August 22, 2016: Cochrane Database of Systematic Reviews
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