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https://www.readbyqxmd.com/read/29165317/the-effect-of-electrospun-polycaprolactone-scaffold-morphology-on-human-kidney-epithelial-cells
#1
Todd P Burton, Anthony Corcoran, Anthony Callanan
There is a pressing need for further advancement in tissue engineering of functional organs with a view to providing a more clinically relevant model for drug development and reduce the dependence on organ donation. Polymer-based scaffolds, such as polycaprolactone (PCL), have been highlighted as a potential avenue for tissue engineered kidneys, but there is little investigation down this stream. Focus within kidney tissue engineering has been on two-dimensional cell culture and decellularised tissue. Electrospun polymer scaffolds can be created with a variety of fibre diameters and have shown a great potential in many areas...
November 22, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28986213/characterization-of-nuclear-factor-of-activated-t-cells-c3-nfatc3-and-gene-expression-of-upstream-downstream-signaling-molecules-in-response-to-immunostimulants-in-pacific-red-snapper-cells
#2
Carlos Angulo, Erika Alamillo, Felipe Ascencio, Martha Reyes-Becerril
The nuclear factor of activated T cells (NFAT) proteins have crucial roles in the development and function of the immune system since they not only regulate activation of T cells but are also involved in the control of thymocyte development and T-cell differentiation. In this study, NFATc3 was characterized from the Pacific red snapper, Lutjanus peru. LpNFAtc3, which contains an open reading of 3300 bp frame coding for a protein of 1100 aa with a predicted molecular weight of 118.52 kDa. The predicted protein showed a conserved NFAT family structure with signature motifs and domains, sharing high identity (up to 76%) compared to other fish sequences...
October 3, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28825984/bioaccumulation-of-psychoactive-pharmaceuticals-in-fish-in-an-effluent-dominated-stream
#3
Katerina Grabicova, Roman Grabic, Ganna Fedorova, Jerker Fick, Daniel Cerveny, Jitka Kolarova, Jan Turek, Vladimir Zlabek, Tomas Randak
The treated effluent from sewage treatment plants (STP) is a major source of active pharmaceutical ingredients (APIs) that enter the aquatic environment. Bioaccumulation of 11 selected psychoactive pharmaceuticals (citalopram, clomipramine, haloperidol, hydroxyzine, levomepromazine, mianserin, mirtazapine, paroxetine, sertraline, tramadol and venlafaxine) was examined in Zivny Stream (tributary of the Blanice River, the Czech Republic), which is a small stream highly affected by effluent from the Prachatice STP...
November 1, 2017: Water Research
https://www.readbyqxmd.com/read/28751970/service-evaluation-of-the-implementation-of-a-digitally-enabled-care-pathway-for-the-recognition-and-management-of-acute-kidney-injury
#4
Alistair Connell, Hugh Montgomery, Stephen Morris, Claire Nightingale, Sarah Stanley, Mary Emerson, Gareth Jones, Omid Sadeghi-Alavijeh, Charles Merrick, Dominic King, Alan Karthikesalingam, Cian Hughes, Joseph Ledsam, Trevor Back, Geraint Rees, Rosalind Raine, Christopher Laing
Acute Kidney Injury (AKI), an abrupt deterioration in kidney function, is defined by changes in urine output or serum creatinine. AKI is common (affecting up to 20% of acute hospital admissions in the United Kingdom), associated with significant morbidity and mortality, and expensive (excess costs to the National Health Service in England alone may exceed £1 billion per year). NHS England has mandated the implementation of an automated algorithm to detect AKI based on changes in serum creatinine, and to alert clinicians...
2017: F1000Research
https://www.readbyqxmd.com/read/28632265/3d-printed-conformal-microfluidics-for-isolation-and-profiling-of-biomarkers-from-whole-organs
#5
Manjot Singh, Yuxin Tong, Kelly Webster, Ellen Cesewski, Alexander P Haring, Sahil Laheri, Bill Carswell, Timothy J O'Brien, Charles H Aardema, Ryan S Senger, John L Robertson, Blake N Johnson
The ability to interface microfluidic devices with native complex biological architectures, such as whole organs, has the potential to shift the paradigm for the study and analysis of biological tissue. Here, we show 3D printing can be used to fabricate bio-inspired conformal microfluidic devices that directly interface with the surface of whole organs. Structured-light scanning techniques enabled the 3D topographical matching of microfluidic device geometry to porcine kidney anatomy. Our studies show molecular species are spontaneously transferred from the organ cortex to the conformal microfluidic device in the presence of fluid flow through the organ-conforming microchannel...
July 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28443914/probing-the-pharmacokinetics-of-cucurbit-7-8-and-10-uril-and-a-dinuclear-ruthenium-antimicrobial-complex-encapsulated-in-cucurbit-10-uril
#6
Fangfei Li, Anil K Gorle, Marie Ranson, Kara L Vine, Robert Kinobe, Marshall Feterl, Jeffrey M Warner, F Richard Keene, J Grant Collins, Anthony I Day
The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK studies are the next step in determining the pharmacological applicability in their drug delivery potential. The results for the first PK and bio-distribution of drug-free (14)C-Q[7] are described for administration via intravenous (i.v.) and intraperitoneal (i.p.) dosing. A study of oral administration of drug-free (14)C-Q[8] has also been undertaken to determine the time course for the gastrointestinal tract (GIT), absorption and subsequent bio-distribution...
May 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28330498/identification-of-cattle-buffaloes-and-rodents-as-reservoir-animals-of-leptospira-in-the-district-of-gampaha-sri-lanka
#7
D T H Denipitiya, N V Chandrasekharan, W Abeyewickreme, R A Hartskeerl, M D Hapugoda
BACKGROUND: Leptospirosis is an important emerging infectious disease in Sri Lanka. Rats are the most important reservoir of Leptospira but domestic and wild mammals may also act as important maintenance or accidental hosts. In Sri Lanka, knowledge of reservoir animals of leptospires is poor. The objective of this study was to identify potential reservoir animals of Leptospira in the District of Gampaha, Sri Lanka. FINDINGS: Blood and kidney samples were collected from 38 rodents and mid-stream urine samples were randomly collected from 45 cattle and five buffaloes in the District of Gampaha...
March 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28271103/a-liquid-thermal-gradient-refractive-index-lens-and-using-it-to-trap-single-living-cell-in-flowing-environments
#8
H L Liu, Y Shi, L Liang, L Li, S S Guo, L Yin, Y Yang
A gradient refractive index (GRIN) lens has a great potential for on-chip imaging and detection systems because of its flat surface with reduced defects. This paper reports a liquid thermal GRIN lens prepared using heat conduction between only one liquid, and uses it as a tunable optical tweezer for single living cell trapping in a flowing environment. This liquid GRIN lens consists of a trapezoidal region in the upper layer which is used to establish a GRIN profile by the heat conduction between three streams of benzyl alcohol with different temperatures, and subsequently a rhombus region in the lower layer with compensation liquids to form a steady square-law parabolic refractive index profile only in transverse direction...
March 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28130181/differential-response-of-bone-and-kidney-to-acei-in-db-db-mice-a-potential-effect-of-captopril-on-accelerating-bone-loss
#9
Yan Zhang, Xiao-Li Li, Nan-Nan Sha, Bing Shu, Yong-Jian Zhao, Xin-Luan Wang, Hui-Hui Xiao, Qi Shi, Man-Sau Wong, Yong-Jun Wang
The components of renin-angiotensin system (RAS) are expressed in the kidney and bone. Kidney disease and bone injury are common complications associated with diabetes. This study aimed to investigate the effects of an angiotensin-converting enzyme inhibitor, captopril, on the kidney and bone of db/db mice. The db/db mice were orally administered by gavage with captopril for 8weeks with db/+ mice as the non-diabetic control. Serum and urine biochemistries were determined by standard colorimetric methods or ELISA...
January 24, 2017: Bone
https://www.readbyqxmd.com/read/27821351/cytochrome-p450-1a-mrna-in-the-guppy-phalloceros-caudimaculatus-and-response-to-beta-naphthoflavone-and-environmental-samples
#10
Roger Stacke Ferreira, Cíntia da Cruz Chivittz, Guilherme Senna Dos Santos, Juliano Zanette
The cytochrome P450 1A (CYP1A) mRNA is induced by environmental contaminants such as PAHs, PCBs and dioxins. The present study cloned the CYP1A transcript from the guppy Phalloceros caudimaculatus, which represents a potential fish for toxicological studies in South America. The newly identified CYP1A encodes a protein with 521 amino acids that shared 96-70% identity with other fishes. The characterization of organ- and time-dependent induction of CYP1A using RT-qPCR was evaluated after waterborne exposure to beta-naphthoflavone (BNF; 1μM)...
December 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27770648/accumulation-of-lead-pb-in-brown-trout-salmo-trutta-from-a-lake-downstream-a-former-shooting-range
#11
Espen Mariussen, Lene Sørlie Heier, Hans Christian Teien, Marit Nandrup Pettersen, Tor Fredrik Holth, Brit Salbu, Bjørn Olav Rosseland
An environmental survey was performed in Lake Kyrtjønn, a small lake within an abandoned shooting range in the south of Norway. In Lake Kyrtjønn the total water concentrations of Pb (14µg/L), Cu (6.1µg/L) and Sb (1.3µg/L) were elevated compared to the nearby reference Lake Stitjønn, where the total concentrations of Pb, Cu and Sb were 0.76, 1.8 and 0.12µg/L, respectively. Brown trout (Salmo trutta) from Lake Kyrtjønn had very high levels of Pb in bone (104mg/kg w.w.), kidney (161mg/kg w.w.) and the gills (137mg/kg d...
January 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27615355/characterization-of-a-fetal-liver-cell-population-endowed-with-long-term-multiorgan-endothelial-reconstitution-potential
#12
Ana Cañete, Valentine Comaills, Isabel Prados, Ana María Castro, Seddik Hammad, Patricia Ybot-Gonzalez, Ernesto Bockamp, Jan G Hengstler, Bertie Gottgens, María José Sánchez
Stable reconstitution of vascular endothelial beds upon transplantation of progenitor cells represents an important challenge due to the paucity and generally limited integration/expansion potential of most identified vascular related cell subsets. We previously showed that mouse fetal liver (FL) hemato/vascular cells from day 12 of gestation (E12), expressing the Stem Cell Leukaemia (SCL) gene enhancer transgene (SCL-PLAP(+) cells), had robust endothelial engraftment potential when transferred to the blood stream of newborns or adult conditioned recipients, compared to the scarce vascular contribution of adult bone marrow cells...
February 2017: Stem Cells
https://www.readbyqxmd.com/read/27577501/electronic-medical-record-based-predictive-model-for-acute-kidney-injury-in-an-acute-care-hospital
#13
Olga Laszczyńska, Milton Severo, Ana Azevedo
Patients with acute kidney injury (AKI) are at risk for increased morbidity and mortality. Lack of specific treatment has meant that efforts have focused on early diagnosis and timely treatment. Advanced algorithms for clinical assistance including AKI prediction models have potential to provide accurate risk estimates. In this project, we aim to provide a clinical decision supporting system (CDSS) based on a self-learning predictive model for AKI in patients of an acute care hospital. Data of all in-patient episodes in adults admitted will be analysed using "data mining" techniques to build a prediction model...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27243144/excess-hb-egf-which-promotes-vegf-signaling-leads-to-hydrocephalus
#14
Joon W Shim, Johanna Sandlund, Mustafa Q Hameed, Bonnie Blazer-Yost, Feng C Zhou, Michael Klagsbrun, Joseph R Madsen
Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence rostral migratory stream in rodents. Cell migratory defects have been identified in animal models of hydrocephalus; however, the relationship between HB-EGF and hydrocephalus is unclear. We show that mice overexpressing human HB-EGF with β-galactosidase reporter exhibit an elevated VEGF, localization of β-galactosidase outside the subventricular zone (SVZ), subarachnoid hemorrhage, and ventriculomegaly...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27001248/improved-dialytic-removal-of-protein-bound-uraemic-toxins-with-use-of-albumin-binding-competitors-an-in-vitro-human-whole-blood-study
#15
Xia Tao, Stephan Thijssen, Peter Kotanko, Chih-Hu Ho, Michael Henrie, Eric Stroup, Garry Handelman
Protein-bound uraemic toxins (PBUTs) cause various deleterious effects in end-stage kidney disease patients, because their removal by conventional haemodialysis (HD) is severely limited by their low free fraction in plasma. Here we provide an experimental validation of the concept that the HD dialytic removal of PBUTs can be significantly increased by extracorporeal infusion of PBUT binding competitors. The binding properties of indoxyl sulfate (IS), indole-3-acetic acid (IAA) and hippuric acid (HIPA) and their binding competitors, ibuprofen (IBU), furosemide (FUR) and tryptophan (TRP) were studied in uraemic plasma...
March 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26948651/inhibition-of-spleen-tyrosine-kinase-syk-suppresses-renal-fibrosis-through-anti-inflammatory-effects-and-down-regulation-of-the-mapk-p38-pathway
#16
Kuan-Hsing Chen, Hsiang-Hao Hsu, Huang-Yu Yang, Ya-Chung Tian, Yi-Ching Ko, Chih-Wei Yang, Cheng-Chieh Hung
Renal fibrosis results from an excessive accumulation of extracellular matrix that occurs in most types of chronic kidney disease. Among the many fibrogenic factors that regulate renal fibrotic processes, transforming growth factor-β1 (TGF-β1) and inflammation after injury play critical roles. Spleen tyrosine kinase (Syk) is important for signaling processes implicated in autoimmune, inflammatory, and allergic diseases. We examined the effects of Syk inhibition on renal fibrosis in vivo and on TGF-β1-induced renal fibroblast activation in vitro...
May 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/26707189/isolinderalactone-enhances-the-inhibition-of-socs3-on-stat3-activity-by-decreasing-mir-30c-in-breast-cancer
#17
Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Kuo
Development of an efficient treatment for triple-negative breast cancer is an urgent issues. Compounds from plant extracts are a potential source of novel cancer treatment. Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity. In the present study, isolinderalactone induced apoptosis in MDA-MB-231 cells which is a kind of triple-negative breast cancer cell line through induction of an intrinsic mitochondria-mediated and caspase-independent cell death...
March 2016: Oncology Reports
https://www.readbyqxmd.com/read/26287527/potential-biomarkers-for-radiation-induced-renal-toxicity-following-177lu-octreotate-administration-in-mice
#18
Emil Schüler, Maria Larsson, Toshima Z Parris, Martin E Johansson, Khalil Helou, Eva Forssell-Aronsson
UNLABELLED: The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreotate administration in normal mice, and to identify biomarkers for radiation induced renal toxicity...
2015: PloS One
https://www.readbyqxmd.com/read/26241118/multiparametric-ultrasound-mpus-imaging-terminology-describing-the-many-aspects-of-ultrasonography
#19
COMPARATIVE STUDY
P S Sidhu
No abstract text is available yet for this article.
August 2015: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/25851285/renal-impairment-an-impediment-to-heart-transplantation
#20
REVIEW
Cédric Rafat, Alexandre Hertig, Eric Rondeau
Chronic kidney disease and chronic heart failure are now recognized as closely intertwined entities. The noxious interactions between the heart and kidney systems as part of the so-called cardiorenal syndrome is a matter of great concern for heart transplant candidates. Not only is chronic kidney disease a commonly associated comorbidity, but its detrimental effect on the outcome of heart transplantation is now well established. In the more advanced stages of kidney disease, it may even deter physicians from carrying out heart transplantation in potential candidates...
March 2015: Iranian Journal of Kidney Diseases
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