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Streaming potential kidney

Espen Mariussen, Lene Sørlie Heier, Hans Christian Teien, Marit Nandrup Pettersen, Tor Fredrik Holth, Brit Salbu, Bjørn Olav Rosseland
An environmental survey was performed in Lake Kyrtjønn, a small lake within an abandoned shooting range in the south of Norway. In Lake Kyrtjønn the total water concentrations of Pb (14µg/L), Cu (6.1µg/L) and Sb (1.3µg/L) were elevated compared to the nearby reference Lake Stitjønn, where the total concentrations of Pb, Cu and Sb were 0.76, 1.8 and 0.12µg/L, respectively. Brown trout (Salmo trutta) from Lake Kyrtjønn had very high levels of Pb in bone (104mg/kg w.w.), kidney (161mg/kg w.w.) and the gills (137mg/kg d...
October 19, 2016: Ecotoxicology and Environmental Safety
Ana Cañete, Valentine Comaills, Isabel Prados, Ana María Castro, Seddik Hammad, Patricia Ybot-Gonzalez, Ernesto Bockamp, Jan G Hengstler, Bertie Gottgens, María José Sánchez
Stable reconstitution of vascular endothelial beds upon transplantation of progenitor cells represents an important challenge due to the paucity and generally limited integration/expansion potential of most identified vascular related cell subsets. We previously showed that mouse fetal liver (FL) hemato/vascular cells from day 12 of gestation (E12), expressing the Stem Cell Leukaemia (SCL) gene enhancer transgene (SCL-PLAP(+) cells), had robust endothelial engraftment potential when transferred to the blood stream of newborns or adult conditioned recipients, compared to the scarce vascular contribution of adult bone marrow (BM) cells...
September 12, 2016: Stem Cells
Olga Laszczyńska, Milton Severo, Ana Azevedo
Patients with acute kidney injury (AKI) are at risk for increased morbidity and mortality. Lack of specific treatment has meant that efforts have focused on early diagnosis and timely treatment. Advanced algorithms for clinical assistance including AKI prediction models have potential to provide accurate risk estimates. In this project, we aim to provide a clinical decision supporting system (CDSS) based on a self-learning predictive model for AKI in patients of an acute care hospital. Data of all in-patient episodes in adults admitted will be analysed using "data mining" techniques to build a prediction model...
2016: Studies in Health Technology and Informatics
Joon W Shim, Johanna Sandlund, Mustafa Q Hameed, Bonnie Blazer-Yost, Feng C Zhou, Michael Klagsbrun, Joseph R Madsen
Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence rostral migratory stream in rodents. Cell migratory defects have been identified in animal models of hydrocephalus; however, the relationship between HB-EGF and hydrocephalus is unclear. We show that mice overexpressing human HB-EGF with β-galactosidase reporter exhibit an elevated VEGF, localization of β-galactosidase outside the subventricular zone (SVZ), subarachnoid hemorrhage, and ventriculomegaly...
2016: Scientific Reports
Xia Tao, Stephan Thijssen, Peter Kotanko, Chih-Hu Ho, Michael Henrie, Eric Stroup, Garry Handelman
Protein-bound uraemic toxins (PBUTs) cause various deleterious effects in end-stage kidney disease patients, because their removal by conventional haemodialysis (HD) is severely limited by their low free fraction in plasma. Here we provide an experimental validation of the concept that the HD dialytic removal of PBUTs can be significantly increased by extracorporeal infusion of PBUT binding competitors. The binding properties of indoxyl sulfate (IS), indole-3-acetic acid (IAA) and hippuric acid (HIPA) and their binding competitors, ibuprofen (IBU), furosemide (FUR) and tryptophan (TRP) were studied in uraemic plasma...
2016: Scientific Reports
Kuan-Hsing Chen, Hsiang-Hao Hsu, Huang-Yu Yang, Ya-Chung Tian, Yi-Ching Ko, Chih-Wei Yang, Cheng-Chieh Hung
Renal fibrosis results from an excessive accumulation of extracellular matrix that occurs in most types of chronic kidney disease. Among the many fibrogenic factors that regulate renal fibrotic processes, transforming growth factor-β1 (TGF-β1) and inflammation after injury play critical roles. Spleen tyrosine kinase (Syk) is important for signaling processes implicated in autoimmune, inflammatory, and allergic diseases. We examined the effects of Syk inhibition on renal fibrosis in vivo and on TGF-β1-induced renal fibroblast activation in vitro...
May 2016: International Journal of Biochemistry & Cell Biology
Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Kuo
Development of an efficient treatment for triple-negative breast cancer is an urgent issues. Compounds from plant extracts are a potential source of novel cancer treatment. Isolinderalactone, a kind of sesquiterpenoids compound, was purified from the root of Lindera strychnifolia and Neolitsea daibuensis and shows anti-inflammatory and anticancer capacity. In the present study, isolinderalactone induced apoptosis in MDA-MB-231 cells which is a kind of triple-negative breast cancer cell line through induction of an intrinsic mitochondria-mediated and caspase-independent cell death...
March 2016: Oncology Reports
Emil Schüler, Maria Larsson, Toshima Z Parris, Martin E Johansson, Khalil Helou, Eva Forssell-Aronsson
UNLABELLED: The kidneys are one of the main dose-limiting organs in peptide receptor radionuclide therapy and due to large inter-individual variations in renal toxicity, biomarkers are urgently needed in order to optimize therapy and reduce renal tissue damage. The aim of this study was to investigate the transcriptional, functional, and morphological effects on renal tissue after 177Lu-octreotate administration in normal mice, and to identify biomarkers for radiation induced renal toxicity...
2015: PloS One
P S Sidhu
No abstract text is available yet for this article.
August 2015: Ultraschall in der Medizin
Cédric Rafat, Alexandre Hertig, Eric Rondeau
Chronic kidney disease and chronic heart failure are now recognized as closely intertwined entities. The noxious interactions between the heart and kidney systems as part of the so-called cardiorenal syndrome is a matter of great concern for heart transplant candidates. Not only is chronic kidney disease a commonly associated comorbidity, but its detrimental effect on the outcome of heart transplantation is now well established. In the more advanced stages of kidney disease, it may even deter physicians from carrying out heart transplantation in potential candidates...
March 2015: Iranian Journal of Kidney Diseases
Mourad Elhabiri, Sabah Abada, Mohamadou Sy, Aline Nonat, Philippe Choquet, David Esteban-Gómez, Claudio Cassino, Carlos Platas-Iglesias, Mauro Botta, Loïc J Charbonnière
A series composed of a tetra-, a tris- and a bisphosphonated ligand based on a pyridine scaffold (L(4) , L(3) and L(2) , respectively) was studied within the frame of lanthanide (Ln) coordination. The stability constants of the complexes formed with lanthanide cations (Ln=La, Nd, Eu, Gd, Tb, Er and Lu) were determined by potentiometry in aqueous solutions (25.0 °C, 0.1 M NaClO4 ), showing that the tetraphosphonated complexes are among the most stable Ln(III) complexes reported in the literature. The complexation of L(4) was further studied by different titration experiments using mass spectrometry and various spectroscopic techniques including UV/Vis absorption, and steady state and time-resolved luminescence (Ln=Eu and Tb)...
April 20, 2015: Chemistry: a European Journal
Kuan-Hsing Chen, Hsiang-Hao Hsu, Cheng-Chia Lee, Tzu-Hai Yen, Yi-Ching Ko, Chih-Wei Yang, Cheng-Chieh Hung
Activation of interstitial myofibroblasts and excessive production of extracellular matrix proteins are common pathways that contribute to chronic kidney disease. In a number of tissues, AMP-activated kinase (AMPK) activation has been shown to inhibit fibrosis. Here, we examined the inhibitory effect of the AMPK activator, 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR), on renal fibrosis in vivo and TGF-β1-induced renal fibroblasts activation in vitro. A unilateral ureteral obstruction (UUO) model was induced in male BALB/c mice...
2014: PloS One
Patrizia Burra, Kryssia I Rodríguez-Castro, Francesco Marchini, Luciana Bonfante, Lucrezia Furian, Alberto Ferrarese, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Marco Senzolo
Liver disease secondary to chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients with end-stage renal disease (ESRD) on renal replacement therapy and after kidney transplantation (KT). Hemodialytic treatment (HD) for ESRD constitutes a risk factor for bloodborne infections because of prolonged vascular access and the potential for exposure to infected patients and contaminated equipment. Evaluation of HCV-positive/ESRD and HCV-positive/KT patients is warranted to determine the stage of disease and the appropriateness of antiviral therapy, despite such treatment is challenging especially due to tolerability issues...
September 2014: Transplant International: Official Journal of the European Society for Organ Transplantation
Nihal Martis, Sylvie Leroy, Véronique Blanc
Antimicrobial resistance to Pseudomonas aeruginosa is on the rise. In the absence of new anti-pseudomonal drugs, clinicians have had to resort to older antimicrobials such as colistin for the treatment of multi-drug resistant (MDR) strains. This polymyxin compound acts on the outer membrane of the bacteria resulting in its permeability and cell-death. Its bactericidal action is concentration-dependant. This antibiotic is mainly used as salvage therapy in the treatment of often life-threatening infections due to MDR P...
July 2014: Journal of Infection
Ana Luisa Miranda-Vilela, Kelly Reis Yamamoto, Kely Lopes Caiado Miranda, Breno Noronha Matos, Marcos Célio de Almeida, João Paulo Figueiró Longo, José de Souza Filho, Juliana Menezes Soares Fernandes, Patrícia Pommé Confessori Sartoratto, Zulmira Guerrero Marques Lacava
Dextran-functionalized maghemite fluid (DexMF) has been tested to treat Ehrlich-solid-tumor-bearing mice, evidencing its potential use in mediating magnetohyperthermia in breast cancer treatment. However, although magnetic nanoparticles tend to accumulate in tumor tissues, part of the nanomaterial can reach the blood stream, and then the organism. The aim of this study was to investigate the acute systemic effects of the intratumoral injection of DexMF mediating magnetohyperthermia in the treatment of an advanced clinical Ehrlich-solid-tumor, assessed through histopathological analyses of liver, kidneys, heart and spleen, comet assay, micronucleus test, hemogram, and serum levels of bilirubin, aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transferase, alkaline phosphatase, creatinine, and urea...
April 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
S M Cormier, T W Neiheisel, P Wernsing, R N Racine, R Reimschuessel
: Recent evidence has shown that fish have the ability to develop new nephrons following renal injury. This study evaluated the usefulness of quantifying developing nephrons in mature fish as an ecotoxicological assessment tool. Histological sections of kidney were prepared from Atlantic tomcod and brown bullhead specimens collected from reference and contaminated streams. The numbers of developing nephrons and basophilic cell clusters from which the nephrons arise per section area were determined by image analysis...
June 1995: Ecotoxicology
Richard H McKee, David Steup, Ceinwen Schreiner, Paula Podhasky, Linda A Malley, Linda Roberts
Gasoline blending stocks (naphthas) are comprised of normal, iso- and cycloparaffins and aromatic hydrocarbons with carbon numbers ranging from C4 to C12. Heavy straight run naphtha (HSRN, CAS number 64741-41-9) was selected for toxicity screening because substances of this type contain relatively high levels (28%) of cycloparaffins by comparison to other naphtha streams and the data complement toxicity information on other gasoline blending streams. Rats were exposed by inhalation to wholly vaporized material at levels of approximately 100, 500, or 3000 parts per million (ppm) daily to screen the potential for systemic toxicity, neurotoxicity, reproductive toxicity, and developmental effects to postnatal day 4...
January 2014: International Journal of Toxicology
Marcus Johannes Moeller
No abstract text is available yet for this article.
April 2, 2013: Biophysical Journal
G Fichi, G Cardeti, C Cocumelli, N Vendramin, A Toffan, C Eleni, N Siemoni, R Fischetti, F Susini
Sixteen specimens of female crucian carp, Carassius carassius (L.), during the breeding season, were investigated for post-mortem and full diagnostic examination during a mortality outbreak in a tributary stream of the Arno River in Tuscany in 2011. Necropsy highlighted the presence of a swollen anus and widespread haemorrhages in the body, fins, gills and eyes. Haemorrhages in internal organs and spleen granulomas were also observed. Bacteria isolated from the brain, kidney and spleen of affected fish were identified as A...
October 2013: Journal of Fish Diseases
Frank Iversen, Chuanxu Yang, Frederik Dagnæs-Hansen, David H Schaffert, Jørgen Kjems, Shan Gao
Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain length affects siRNA pharmacokinetics and biodistribution. The PEG chains were conjugated to chemically stabilized siRNA at the 5' terminal end of the passenger strand using click chemistry. The siRNA conjugate remained functionally active and showed significantly prolonged circulation in the blood stream after intravenous injection...
2013: Theranostics
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