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Arterial hypertension in COPD

Krzysztof Bartus, Radoslaw Litwinowicz, Jerzy Sadowski, Wojciech Zajdel, Maciej Brzezinski, Magdalena Bartus, Paweł Kleczyński, Stanislaw Bartus, Dhanunjaya Lakkireddy, Boguslaw Kapelak
Introduction: Renal denervation (RD) can lead to a significant and sustained decrease in mean values of arterial blood pressure (BP). However, there is still a subset of patients without a significant BP drop after RD (non-responders). Aim: To compare characteristics of RD responders to RD non-responders and to identify the clinical predictors of BP reduction. Material and methods: Thirty-one patients with diagnosed resistant hypertension underwent RD...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Yan-Guang Li, Daniele Pastori, Alessio Farcomeni, Pil-Sung Yang, Eunsun Jang, Boyoung Joung, Yu-Tang Wang, Yu-Tao Guo, Gregory Y H Lip
BACKGROUND: The incidence of atrial fibrillation (AF) is increasing, conferring a major healthcare issue in Asia. No risk score for predicting incident AF has been specifically developed in Asian subjects. Our aim was to investigate risk factors for incident AF in Asian subjects and to combine them into a simple clinical risk score. METHODS: Risk factors for incident AF were analyzed in 471,446 subjects from the Chinese Yunnan Insurance Database (internal derivation cohort), and then combined into a simple clinical risk score...
October 4, 2018: Chest
Eva Bernardi, Carlotta Merlo, Annalisa Cogo
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischemic heart disease. Endothelial dysfunction may play a role in the onset of cardiovascular event. Previous studies showed an impaired endothelial function (measured by flow-mediated dilation, FMD) in COPD patients compared to healthy subjects. To the best of our knowledge no study has compared FMD in COPD and in cardiac (coronary artery disease, CAD) patients. We aimed to assess FMD in healthy subjects, COPD, CAD, and COPD + CAD...
October 3, 2018: Lung
Lucia Agoston-Coldea, Silvia Lupu, Teodora Mocan
In this prospective pilot study, we aimed to evaluate the ability of cardiac magnetic resonance imaging (CMR) parameters of right ventricular function and pulmonary artery stiffness to identify pulmonary hypertension (PH), predict major adverse cardiovascular events (MACEs) in patients with secondary PH due to chronic obstructive pulmonary disease (COPD), and to estimate a prospective sample size necessary for a reliable power of the study. Thirty consecutive patients with COPD and suspected secondary PH were assessed by clinical examination, the six minute walk test, echocardiography, right heart catheterization and CMR, and followed-up for a mean period of 16 months to identify MACEs (cardiac death, ventricular tachyarrhythmia, and heart failure)...
September 27, 2018: Scientific Reports
Giovanna Elisiana Carpagnano, Alessandro Radaeli, Donato Lacedonia, Michele Correale, Giuseppe Carpagnano, Antonio Palmiotti, Maria Pia Foschino Barbaro, Matteo Di Biase, Natale Brunetti, Giulia Scioscia, Mario Malerba
Background: Pulmonary hypertension (PH) is a progressive fatal disease thus, noninvasive prognostic tools are needed to follow these patients. The aim of our study was to evaluate fractional exhaled nitric oxide (FeNO) and exhaled breath temperature (EBT) values in patients with PH from different causes and to correlate them with respiratory functional data. Methods: Twenty-four PH patients underwent spirometry, carbon monoxide diffusion (DLCO) test, transthoracic echocardiography, right-heart catheterization, and FeNO and EBT measurements...
2018: BioMed Research International
Yu-Rui Jiao, Wei Wang, Peng-Cheng Lei, Hui-Ping Jia, Jie Dong, Yun-Qian Gou, Cheng-Long Chen, Jie Cao, Ya-Feng Wang, Yi-Kun Zhu
BACKGROUND: The influence of 5-HTT, BMPR2, EDN1, ENG, KCNA5 genes polymorphisms on susceptibility of pulmonary arterial hypertension remains uncertain. This meta-analysis is conducted for further study. METHODS: We conducted a literature search on PubMed and ISI web of science databases for searching relevant articles until November 2017. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. A total of 17 articles with 2631 PAH subjects and 5139 controls were included in the final meta-analysis...
September 12, 2018: Gene
Luke C Pilling, Janice L Atkins, George A Kuchel, Luigi Ferrucci, David Melzer
Higher Red Blood Cell Distribution Width (RDW or anisocytosis) predicts incident coronary artery disease (CAD) plus all-cause and cardiovascular mortality, but its predictive value for other common diseases in healthy volunteers is less clear. We aimed to determine the shorter and longer term associations between RDW and incident common conditions in participants free of baseline disease, followed for 9 years. We undertook a prospective analysis of RDW% using 240,477 healthy UK Biobank study volunteers aged 40-70 years at baseline, with outcomes ascertained during follow-up (≤9 years)...
2018: PloS One
Isabelle Opitz, Silvia Ulrich
The exact prevalence of pulmonary hypertension (PH) and cor pulmonale (CP) in chronic obstructive pulmonary disease (COPD) is unknown, and varies considerably from 20-91%. Usually, mean pulmonary artery pressure (mPAP) does not exceed 30 mmHg, and PH is not severe. However, PH and CP are important predictors of mortality in COPD and contribute to disability in this disease. Many factors contribute to the development of PH in chronic lung disease, including reduction of the pulmonary vascular cross-sectional area due to parenchymal loss and accompanying hypoxia, effects of abnormal pulmonary mechanics due to hyperinflation, but also vascular remodeling processes...
August 2018: Journal of Thoracic Disease
J Nowak, B Hudzik, P Przybyłowski, J Niedziela, P Walczak, P Rozentryt, M Ochman, S Żegleń, J Wojarski, M Zembala, M Gąsior
BACKGROUND: Pulmonary hypertension (PH) is a common complication in end-stage lung disease (esLD). The aim of this study was to establish the best threshold values for mean, systolic, and diastolic artery pressure (mPAP, dPAP, and sPAP, respectively) to identify patients with esLD referred for lung transplantation and to predict 1-year prognosis. METHODS: Sixty-five patients were enrolled in the study (75% men) with a mean age of 53.3 ± 9.5 years; 31% had chronic obstructive pulmonary disease (COPD), 57% had idiopathic pulmonary fibrosis (IPF), and 12% had interstitial lung diseases (ILDs)...
September 2018: Transplantation Proceedings
N Y Grigoreva, M E Koroleva
OBJECTIVE: to compare hypotensive and pleiotropic effects of angiotensin II receptor blocker (ARB) azilsartan medoxomil (AM) and angiotensin converting enzyme inhibitor (ACEI) fosinopril in patients with concomitant arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: We included in this open study 49 patients with concomitant stage I-II AH and COPD. Initially all patients received hydrochlorothiazide (12.5 mg/day) and various ACEI but target blood pressure levels were not achieved, and these ACEI were withdrawn...
August 2018: Kardiologiia
Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
The aim of the study was to find out scientific evidence on the possible use of the combined angiotensin II receptor antagonist and neprilysin inhibitors (ARNI) in patients with right heart failure (RHF) in the course of chronic obstructive pulmonary disease (COPD). It has been proven that a lack of neprilysin or its reduced expression in hypoxia leads to exacerbation of pulmonary arterial remodelling (PAR) or pulmonary hypertension (PH) in the mechanism related to the platelet-derived growth factor (PDGF) resulting in the proliferation and migration of pulmonary artery smooth muscle cells and endothelial-to-mesenchymal transition...
August 15, 2018: Advances in Respiratory Medicine
Adam T Braithwaite, Helen M Marriott, Allan Lawrie
The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a widely expressed cytokine that can bind five different receptors. TRAIL has been of particular interest for its proposed ability to selectively induce apoptosis in tumour cells. However, it has also been found to regulate a wide variety of non-canonical cellular effects including survival, migration and proliferation via kinase signalling pathways. Lung diseases represent a wide range of conditions affecting multiple tissues. TRAIL has been implicated in several biological processes underlying lung diseases, including angiogenesis, inflammation, and immune regulation...
2018: Frontiers in Medicine
Mohammad A Hossain, Ami Amin, Anju Paul, Huzaif Qaisar, Monika Akula, Alireza Amirpour, Shreya Gor, Sofi Giglio, Jennifer Cheng, Roy Mathew, Tushar Vachharajani, Mohamed Bakr, Arif Asif
BACKGROUND: While obesity is a chronic condition that predisposes patients to other more serious disorders, the prevalence and the documentation of obesity as diagnosis has not been extensively studied in hospitalized patients. We conducted a retrospective chart review to investigate the prevalence and documentation of obesity as a diagnosis among patients admitted to our medical center. METHOD: IRB approval was obtained for this retrospective study. Body mass index (BMI) as per CDC, admission and discharge diagnosis of obesity and common comorbidities (hypertension, diabetes, hyperlipidemia, coronary artery disease, congestive heart disease, chronic kidney disease and chronic obstructive pulmonary disease) were recorded...
August 7, 2018: Journal of Clinical Medicine
Clovis Chabert, Saadi Khochbin, Sophie Rousseaux, Sylvie Veyrenc, Rebecca Furze, Nicholas Smithers, Rab K Prinjha, Uwe Schlattner, Christophe Pison, Hervé Dubouchaud
Pulmonary hypertension is a co-morbidity, which strongly participates in morbi-mortality in patients with chronic obstructive pulmonary disease (COPD). Recent findings showed that bromodomain-containing proteins, in charge of reading histone acetylation, could be involved in pulmonary arterial hypertension. Our aim was to study the effect of I-BET151, an inhibitor of bromodomain and extra-terminal domain (BET), on the right ventricle hypertrophy and pulmonary hypertension, induced by a combination of chronic hypoxia and pulmonary inflammation, as the two main stimuli encountered in COPD...
July 30, 2018: International Journal of Molecular Sciences
András Bikov, Alpár Horváth, Gábor Tomisa, Liza Bártfai, Zoltán Bártfai
PURPOSE: Comorbidities associated with chronic obstructive pulmonary disease (COPD) affect quality of life and increase mortality. Asthma-COPD overlap (ACO) may express a different profile of comorbidities compared to COPD alone. It is unclear how recent changes in GOLD recommendations affect the profile of comorbidities in COPD and ACO. METHODS: Eight hundred and thirty-four patients with COPD were recruited from 67 Hungarian secondary care outpatient clinics, 469 of them had ACO...
July 14, 2018: Lung
Xiaotong Guo, Yuchun Fan, Jieda Cui, Binwei Hao, Li Zhu, Xiao Sun, Jinxi He, Jiali Yang, Jianda Dong, Yanyang Wang, Xiaoming Liu, Juan Chen
BACKGROUND: Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms underpinning its pathogenesis however remain elusive. The dysregulated expression of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases and superoxide generation by pulmonary vasculatures have significant implications in the hypoxia-induced PH. METHODS: In this study, the involvement of NADPH oxidase subunit 4 (NOX4) in pulmonary arteriolar remodeling of PH in COPD was investigated by ascertaining the morphological alteration of pulmonary arteries and pulmonary blood flow using cardiac magnetic resonance imaging (cMRI), and the expression and correlation of NOX4 with pulmonary vascular remodeling and pulmonary functions in COPD lungs...
July 9, 2018: BMC Pulmonary Medicine
Kuang-Ming Liao, Yi-Chen Chen, Kuo-Chen Cheng, Jhi-Joung Wang, Chung-Han Ho
Objective: The objective of this study was to investigate the trends in COPD patients admitted to the intensive care unit (ICU) in Taiwan from 2003 to 2013. Patients and methods: A retrospective study was conducted to analyze the available data in the National Health Insurance Research Database compiled by the Taiwan Department of Health. We selected patients admitted to the ICU nationwide from 2003 to 2013. Patients older than 40 years with a diagnosis of COPD were enrolled...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Chien-Hua Chen, Cheng-Li Lin, Chung-Y Hsu, Chia-Hung Kao
PURPOSE: To assess the association between obstructive sleep apnea (OSA) and gallstones. METHODS: We identified 3827 patients aged ≥ 20 years with OSA between 2000 and 2010 from the Longitudinal Health Insurance Research Database 2000 (LHID2000) as the study cohort. The beneficiaries without OSA were randomly selected and propensity-matched with the study cohort in a 1:1 ratio according to age; sex; occupation; urbanization; comorbidities of hypothyroidism, hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, chronic obstructive pulmonary disease (COPD), obesity, inflammatory bowel disease, stroke, coronary artery disease (CAD), hepatitis B virus, and hepatitis C virus; and the index year...
July 7, 2018: Sleep & Breathing, Schlaf & Atmung
Kuruswamy Thurai Prasad, Inderpaul Singh Sehgal, Sahajal Dhooria, Navneet Singh, Ritesh Agarwal, Digambar Behera, Ashutosh Nath Aggarwal
Objective: Most countries worldwide have transplant registries for patients with end-stage lung diseases (ESLD) requiring lung transplantation. There is no such lung transplant registry in India. Herein, we describe the demographic profile and clinical outcomes among patients referred for lung transplantation at a tertiary care center in North India. Materials and Methods: This was a prospective, observational study of consecutive patients with chronic respiratory diseases who were referred for lung transplantation between July 2013 and December 2016...
July 2018: Lung India: Official Organ of Indian Chest Society
Sina Saffaran, Wenfei Wang, Anup Das, Walter Schmitt, Eva-Maria Becker-Pelster, Jonathan G Hardman, Gerrit Weimann, Declan G Bates
This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH) as a complication. Three virtual patients with COPD were configured in the simulator based on clinical data. In agreement with previous clinical studies, modeling systemic application of an sGC modulator results in reduced partial pressure of oxygen (PaO2 ) and increased partial pressure of carbon dioxide (PaCO2 ) in arterial blood, if a drug-induced reduction of pulmonary vascular resistance (PVR) equal to that observed experimentally is assumed...
August 2018: CPT: Pharmacometrics & Systems Pharmacology
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