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Pulmonary hypertension WHO-G-2

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https://www.readbyqxmd.com/read/30213693/impact-of-micronutrient-deficiency-malnutrition-in-systemic-sclerosis-cohort-study-and-literature-review
#1
REVIEW
Romain Dupont, Mélanie Longué, Anne Galinier, Christel Cinq Frais, Cécile Ingueneau, Léonardo Astudillo, Philippe Arlet, Daniel Adoue, Laurent Alric, Grégoire Prévot, Bastien Cabarrou, Laurent Sailler, Grégory Pugnet
OBJECTIVES: The purpose of our study was to determine the prevalence and risk factors associated with malnutrition, and selenium (Se) and vitamin C (vitC) deficiencies in systemic sclerosis (SSc) patients. METHODS: We included adult SSc patients fulfilling the 2013 ACR/EULAR criteria from the Toulouse University Hospital cohort who underwent a micronutrient workup (including vitC, Se or thiamine levels) between 2011 and 2016. RESULTS: 82 patients were included, mostly women (76%), with a median age of 60 years...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30114222/self-reported-functional-status-predicts-post-operative-outcomes-in-non-cardiac-surgery-patients-with-pulmonary-hypertension
#2
Aalap C Shah, Kevin Ma, David Faraoni, Daniel C S Oh, G Alec Rooke, Gail A Van Norman
BACKGROUND: Pulmonary hypertension (PHTN) is associated with increased post-procedure morbidity and mortality. Pre-procedure echocardiography (ECHO) is a widely used tool for evaluation of these patients, but its accuracy in predicting post-procedure outcomes is unproven. Self-reported exercise tolerance has not been evaluated for operative risk stratification of PHTN patients. OBJECTIVE: We analyzed whether self-reported exercise tolerance predicts outcomes (hospital length-of-stay [LOS], mortality and morbidity) in PHTN patients (WHO Class I-V) undergoing anesthesia and surgery...
2018: PloS One
https://www.readbyqxmd.com/read/30110046/effects-of-coexistence-hypertension-and-type-ii-diabetes-on-heart-rate-variability-and-cardiorespiratory-fitness
#3
Daniela Bassi, Ramona Cabiddu, Renata G Mendes, Natália Tossini, Vivian M Arakelian, Flávia C R Caruso, José C Bonjorno Júnior, Ross Arena, Audrey Borghi-Silva
BACKGROUND: Type 2 diabetes Mellitus (T2DM) is associated with cardiac autonomic dysfunction, which is an independent predictor of mortality in chronic diseases. However, whether the coexistence of systemic arterial hypertension (HTN) with DMT2 alters cardiac autonomic modulation remains unknown. OBJECTIVE: To evaluate the influence of HTN on cardiac autonomic modulation and cardiorespiratory fitness in subjects with DMT2. METHODS: 60 patients of both genders were evaluated and allocated to two groups: DMT2 patients (n = 32; 51 ± 7...
July 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/30109814/therapeutic-hypothermia-for-moderate-and-severe-hypoxic-ischaemic-encephalopathy-in-newborns-using-low-cost-devices-ice-packs-and-phase-changing-material
#4
Y N Prashantha, P N Suman Rao, Saudamini Nesargi, B S Chandrakala, Kalyan Chakravarthy Balla, A Shashidhar
BACKGROUND: Different methods have been used for therapeutic hypothermia for neonates with moderate-to-severe hypoxic ischaemic encephalopathy (HIE). As standard cooling devices are expensive, there is a need to establish the safety and efficacy of low-cost devices such as ice packs (IP) and phase changing material (PCM). AIM: To assess the efficacy and safety of therapeutic hypothermia (TH) and the clinico-laboratory profile of neonates who underwent cooling with IP or PCM...
August 15, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/30093545/right-ventricle-to-pulmonary-artery-coupling-in-patients-undergoing-transcatheter-aortic-valve-implantation
#5
Ibrahim Sultan, Arturo Cardounel, Islam Abdelkarim, Arman Kilic, Andrew D Althouse, Michael S Sharbaugh, Aman Gupta, Jeff Xu, Miho Fukui, Marc A Simon, John T Schindler, Joon S Lee, Thomas G Gleason, João L Cavalcante
OBJECTIVES: To evaluate the prognostic value of the ratio between tricuspid annular plane systolic excursion (TAPSE)-pulmonary artery systolic pressure (PASP) as a determinant of right ventricular to pulmonary artery (RV-PA) coupling in patients undergoing transcatheter aortic valve replacement (TAVI). BACKGROUND: RV function and pulmonary hypertension (PH) are both prognostically important in patients receiving TAVI. RV-PA coupling has been shown to be prognostic important in patients with heart failure but not previously evaluated in TAVI patients...
August 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30053566/clinical-risk-factors-and-postoperative-complications-associated-with-unplanned-hospital-readmissions-after-cranial-neurosurgery
#6
Christian Lopez Ramos, Michael G Brandel, Robert C Rennert, Arvin R Wali, Jeffrey A Steinberg, David R Santiago-Dieppa, Brittany N Burton, Jeffrey S Pannell, Scott E Olson, Alexander A Khalessi
BACKGROUND: Hospital readmission is a key surgical quality metric associated with financial penalties and greater healthcare costs. We examined the clinical risk factors and postoperative complications associated with 30-day unplanned hospital readmissions after cranial neurosurgery. METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Program database from 2011 to 2016 for adult patients who had undergone a cranial neurosurgical procedure...
July 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29977892/incremental-shuttle-walking-test-distance-is-reduced-in-patients-with-pulmonary-hypertension-in-world-health-organisation-functional-class-i
#7
Catherine G Billings, Robert Lewis, Iain J Armstrong, Judith A Hurdman, Ian A Smith, Matthew Austin, Charlie A Elliot, Athanasios Charalampopoulos, Ian Sabroe, Allan Lawrie, A A Roger Thompson, Robin Condliffe, David G Kiely
Background: There is increasing interest in screening for and diagnosing pulmonary hypertension earlier in the course of disease. However, there is limited data on cardiopulmonary abnormalities in patients with pulmonary hypertension newly diagnosed in World Health Organization Function Class (WHO FC) I. Methods: Data were retrieved from the ASPIRE registry (Assessing the Spectrum of Pulmonary hypertension Identified at a REferral center) for consecutive treatment naïve patients diagnosed with pulmonary hypertension by cardiac catheterization between 2001 and 2010 who underwent incremental shuttle walk exercise testing...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29885688/pulmonary-hypertension-registry-of-kerala-india-pro-kerala-clinical-characteristics-and-practice-patterns
#8
S Harikrishnan, G Sanjay, M Ashishkumar, Jaideep Menon, Gopalan Nair Rajesh, Raman Krishna Kumar, A George Koshy, Thankachan V Attacheril, Raju George, Eapen Punnoose, S M Ashraf, S R Arun, Mohammed Cholakkal, Panniyammakal Jeemon
BACKGROUND: Epidemiological data on pulmonary hypertension (PH) are scarce from developing countries including India. METHODS: We established a multi-center registry of PH, the PRO-KERALA registry, in Kerala, India. Fifty hospitals enrolled consecutive adult (>18 years) patients for one year. Echocardiographic criteria (right ventricular systolic pressure - RVSP > 50 mmHg) or invasively obtained mean pulmonary artery pressure > 25 mmHg was the criteria for entry...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29807868/safety-of-laparoscopic-sleeve-gastrectomy-and-roux-en-y-gastric-bypass-in-elderly-patients-analysis-of-the-mbsaqip
#9
Michał R Janik, Rami R Mustafa, Tomasz G Rogula, Adel Alhaj Saleh, Mujjahid Abbas, Leena Khaitan
BACKGROUND: An increase in the prevalence of obesity and longer life expectancy has resulted in an increased number of candidates over the age of 60 who are pursuing a bariatric procedure. OBJECTIVE: The aim of this study was to assess the safety of laparoscopic Roux-Y gastric bypass (LRYGB) compared to laparoscopic sleeve gastrectomy (LSG) in patients aged 60 years or older. SETTING: University Hospital, United States METHODS: Preoperative characteristics and 30-day outcomes from the MBSAQIP 2015 were selected for all patients aged 60 years or older who underwent a LSG or LRYGB...
September 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29800952/association-of-early-inhaled-nitric-oxide-with-the-survival-of-preterm-neonates-with-pulmonary-hypoplasia
#10
Kevin R Ellsworth, Marc A Ellsworth, Amy L Weaver, Kristin C Mara, Reese H Clark, William A Carey
Importance: Pulmonary hypoplasia affects a very small percentage of preterm neonates, but its presence is associated with high rates of mortality. Objective: To determine whether treatment with inhaled nitric oxide during the first week of life was associated with improved in-hospital survival in a cohort of extremely preterm neonates with pulmonary hypoplasia. Design, Setting, and Participants: This cohort study used data from the Pediatrix Medical Group's Clinical Data Warehouse, a data set containing information from more than 350 neonatal intensive care units in 35 US states and Puerto Rico...
July 2, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29533148/anthropometric-evaluation-and-functional-assessment-of-patients-with-pulmonary-hypertension-and-its-relationship-with-pulmonary-circulation-parameters-and-functional-performance
#11
Priscila B Zanella, Camila C Àvila, Carolina G de Souza
OBJECTIVE: The objective of this study was to investigate the anthropometric and functional status in patients with pulmonary hypertension (PH) and its relationship with pulmonary circulation parameters and functional performance. METHODS: The study is cross-sectional with 34 subjects, who were evaluated in terms of anthropometric measurements, physical performance, pulmonary circulation, and regular physical activity. RESULTS: Subjects had a mean age of 47...
July 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29528272/angiogenic-and-inflammatory-biomarkers-for-screening-and-follow-up-in-patients-with-pulmonary-arterial-hypertension
#12
D Kylhammar, R Hesselstrand, S Nielsen, C Scheele, G Rådegran
OBJECTIVE: To identify circulating angiogenic and inflammatory biomarkers with potential in screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc), and in early diagnosis and determination of treatment response in PAH. METHOD: Plasma samples were taken at the time of PAH diagnosis and at treatment follow-up after a median (interquartile range) of 4 months (3-9.8 months) in idiopathic (n = 9) and SSc-associated PAH (n = 11). In patients with SSc-associated PAH, plasma samples had also been gathered a median of 2 years (0...
July 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29518195/atrial-fibrillation-progression-and-outcome-in-patients-with-young-onset-atrial-fibrillation
#13
Ruben R De With, Ernaldo G Marcos, Isabelle C Van Gelder, Michiel Rienstra
Aims: Clinicians increasingly encounter patients with young-onset atrial fibrillation (AF). Aim is to study clinical profile, AF progression, and outcome of patients with young-onset AF. Methods and results: A total of 468 patients with paroxysmal or persistent AF starting <60 years of age were included. Clinical profile, AF progression, defined as development of permanent AF, and cardiovascular events were prospectively collected. Onset of AF was at 46 ± 10 years, 354 (76%) were men, 329 (70%) had paroxysmal AF, 50 (11%) had AF without risk factors or comorbidities, and 118 (25%) had familial AF...
March 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29509767/the-current-and-potential-health-benefits-of-the-national-health-service-health-check-cardiovascular-disease-prevention-programme-in-england-a-microsimulation-study
#14
Oliver T Mytton, Christopher Jackson, Arno Steinacher, Anna Goodman, Claudia Langenberg, Simon Griffin, Nick Wareham, James Woodcock
BACKGROUND: The National Health Service (NHS) Health Check programme was introduced in 2009 in England to systematically assess all adults in midlife for cardiovascular disease risk factors. However, its current benefit and impact on health inequalities are unknown. It is also unclear whether feasible changes in how it is delivered could result in increased benefits. It is one of the first such programmes in the world. We sought to estimate the health benefits and effect on inequalities of the current NHS Health Check programme and the impact of making feasible changes to its implementation...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29473101/cardiac-function-assessments-in-left-bochdalek-s-hernia-clinical-relevance
#15
Arvind Sehgal, Kenneth Tan, Peter Ferguson
The objectives of this study were to characterize peri-operative echocardiographic (ECHO) assessments of right ventricular (RV) function and pulmonary hypertension (PH) and ascertain correlation with clinical outcomes in infants with left Bochdalek's hernia (LBH). This retrospective study in a quaternary neonatal intensive care unit involved electronic database search for infants with LBH during January 2009 to July 2017. Demographics, outcomes, and ECHO parameters were accessed from archived databases. Thirty-one infants with mean gestational age and birthweight (BW) 38...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29452997/long-term-outcomes-of-total-anomalous-pulmonary-venous-drainage-repair-in-neonates-and-infants
#16
Matthew S Yong, Nima Yaftian, Sophie Griffiths, Johann Brink, Terry Robertson, Luigi D'Orsogna, Robert G Weintraub, Yves d'Udekem, Christian P Brizard, Igor E Konstantinov
BACKGROUND: Outcomes of operations for total anomalous pulmonary venous drainage (TAPVD) have improved. However, operations in the neonatal period and the development of postoperative pulmonary venous obstruction are associated with a high mortality rate. METHODS: A retrospective review was conducted for all neonates and infants (n = 214) who underwent operations for isolated TAPVD (1973 to 2014). RESULTS: Median age was 18 days (1 day to 1 year)...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29281101/sildenafil-for-improving-outcomes-in-patients-with-corrected-valvular-heart-disease-and-persistent-pulmonary-hypertension-a-multicenter-double-blind-randomized-clinical-trial
#17
Javier Bermejo, Raquel Yotti, Rocío García-Orta, Pedro L Sánchez-Fernández, Mario Castaño, Javier Segovia-Cubero, Pilar Escribano-Subías, José Alberto San Román, Xavier Borrás, Angel Alonso-Gómez, Javier Botas, María G Crespo-Leiro, Sonia Velasco, Antoni Bayés-Genís, Amador López, Roberto Muñoz-Aguilera, Eduardo de Teresa, José R González-Juanatey, Arturo Evangelista, Teresa Mombiela, Ana González-Mansilla, Jaime Elízaga, Javier Martín-Moreiras, José M González-Santos, Eduardo Moreno-Escobar, Francisco Fernández-Avilés
Aims: We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD). Methods and results: The sildenafil for improving outcomes after valvular correction (SIOVAC) study was a multricentric, randomized, parallel, and placebo-controlled trial that enrolled stable adults with mean pulmonary artery pressure ≥ 30 mmHg who had undergone a successful valve replacement or repair procedure at least 1 year before inclusion...
April 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29262488/-estimation-of-the-impact-of-risk-factors-control-on-non-communicable-diseases-mortality-life-expectancy-and-the-labor-force-lost-in-china-in-2030
#18
X Y Zeng, Y C Li, J M Liu, Y N Liu, S W Liu, J L Qi, M G Zhou
Objective: To estimate the impact of risk factors control on non-communicable diseases (NCDs) mortality, life expectancy and the numbers of labor force lost in China in 2030. Methods: We used the results of China from Global Burden of Disease Study 2013, according to the correlation between death of NCDs and exposure of risk factors and the comparative risk assessment theory, to calculate population attributable fraction (PAF) and disaggregate deaths of NCDs into parts attributable and un-attributable. We used proportional change model to project risk factors exposure and un-attributable deaths of NCDs in 2030, then to get deaths of NCDs in 2030...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29258394/quality-of-anticoagulation-with-warfarin-at-a-tertiary-hospital-in-botswana
#19
Julius C Mwita, Joel M Francis, Anthony A Oyekunle, Marea Gaenamong, Monkgogi Goepamang, Mgaywa G M D Magafu
Warfarin treatment requires regular and proper monitoring to avoid overanticoagulation and at the same time to prevent thromboembolic complications. This study assessed the quality of warfarin anticoagulation at Princess Marina Hospital in Botswana. This cross-sectional study consecutively enrolled patients who were on warfarin for at least 3 months in the outpatient medical clinic. The level of anticoagulation was determined by the time in therapeutic range (TTR) using the Rosendaal method that calculates the percentage of days when the international normalized ratio is in the therapeutic range (2...
May 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29248236/bipolar-androgen-therapy-in-men-with-metastatic-castration-resistant-prostate-cancer-after-progression-on-enzalutamide-an-open-label-phase-2-multicohort-study
#20
Benjamin A Teply, Hao Wang, Brandon Luber, Rana Sullivan, Irina Rifkind, Ashley Bruns, Avery Spitz, Morgan DeCarli, Victoria Sinibaldi, Caroline F Pratz, Changxue Lu, John L Silberstein, Jun Luo, Michael T Schweizer, Charles G Drake, Michael A Carducci, Channing J Paller, Emmanuel S Antonarakis, Mario A Eisenberger, Samuel R Denmeade
BACKGROUND: Prostate cancer that progresses after enzalutamide treatment is poorly responsive to further antiandrogen therapy, and paradoxically, rapid cycling between high and low serum testosterone concentrations (bipolar androgen therapy [BAT]) in this setting might induce tumour responses. We aimed to evaluate BAT in patients with metastatic castration-resistant prostate cancer that progressed after enzalutamide. METHODS: We did this single-centre, open-label, phase 2, multicohort study in the USA...
January 2018: Lancet Oncology
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