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Multiple sclerosis related fatigue

Sascha Köpke, Alessandra Solari, Anne Rahn, Fary Khan, Christoph Heesen, Andrea Giordano
BACKGROUND: People with multiple sclerosis (MS) are confronted with a number of important uncertainties concerning many aspects of the disease. These include diagnosis, prognosis, disease course, disease-modifying therapies, symptomatic therapies, and non-pharmacological interventions, among others. While people with MS demand adequate information to be able to actively participate in medical decision making and to self manage their disease, it has been shown that patients' disease-related knowledge is poor, therefore guidelines recommend clear and concise high-quality information at all stages of the disease...
October 14, 2018: Cochrane Database of Systematic Reviews
Brian M Sandroff, Lara A Pilutti, Robert W Motl
BACKGROUND: Aerobic exercise training may improve cognitive performance among persons with multiple sclerosis (MS). This is largely based on evidence that cardiorespiratory fitness (as a cross-sectional surrogate for aerobic exercise training) is associated with cognitive processing speed. There may be a set of "other" variables (i.e., psychological symptoms) that influences the association between cardiorespiratory fitness and cognitive processing speed in MS, and such factors should be accounted for when designing optimized exercise rehabilitation interventions...
October 2, 2018: Multiple Sclerosis and related Disorders
Manu Thakral, Andrea Z Lacroix, Ivan R Molton
BACKGROUND: Women with disabling conditions experience health disparities relative to nondisabled women, but few studies have compared women and men with disabling conditions. OBJECTIVES: To investigate gender differences in physical functioning and emotional health among individuals with long-term disabling conditions, that is, neuromuscular disease, multiple sclerosis, postpolio syndrome, or spinal cord injury. METHOD: From a mailed survey of 1,862 adults with long-term disabling conditions, we used the 12-item Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning to assess physical limitations in activities and Patient Health Questionnaire-9 (PHQ-9) for emotional health and severity of secondary conditions (rated 0-10)...
October 8, 2018: Rehabilitation Psychology
Samuel L Battalio, Mari Glette, Kevin N Alschuler, Mark P Jensen
OBJECTIVE: This longitudinal study examined the unique relationship between anxiety, symptoms (pain intensity, sleep disturbance, fatigue severity), and function domains (self-reported cognitive function, physical function, satisfaction with social roles) in individuals with chronic physical conditions, independent of depressive symptoms. METHOD: Three surveys were mailed on an approximately yearly basis to community-dwelling adults with one of four chronic physical conditions (spinal cord injury, multiple sclerosis, muscular dystrophy, postpoliomyelitis syndrome)...
October 8, 2018: Rehabilitation Psychology
Guillermo Borragán, Médhi Gilson, Anne Atas, Hichem Slama, Andreas Lysandropoulos, Melanie De Schepper, Philippe Peigneux
Patients with multiple sclerosis (MS) disease frequently experience fatigue as their most debilitating symptom. Fatigue in MS partially refers to a cognitive component, cognitive fatigue (CF), characterized by a faster and stronger than usual development of the subjective feeling of exhaustion that follows sustained cognitive demands. The feeling of CF might result from supplementary task-related brain activity following MS-related demyelination and neurodegeneration. Besides, CF in MS disease might also stem from disrupted sleep...
2018: Frontiers in Human Neuroscience
Rania S Nageeb, Noha A Hashim, Amal Fawzy
Background: Multiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients. Methods: This study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
A Carotenuto, T Costabile, M Moccia, F Falco, M R Scala, C V Russo, F Saccà, A De Rosa, R Lanzillo, V Brescia Morra
BACKGROUND: Both cognition and olfaction are impaired in multiple sclerosis (MS). However, little is known about the relationship between smell identification ability and measures of cognitive function in this disease. OBJECTIVE: To assess olfactory function in MS and to evaluate its relationship with cognitive and physical disability. METHODS: Fifty-five MS patients and 20 healthy controls (HCs) were tested. The University of Pennsylvania smell identification test (UPSIT) was administered to assess olfactory function...
September 22, 2018: Multiple Sclerosis and related Disorders
Anna M Barbarulo, Giacomo Lus, Elisabetta Signoriello, Luigi Trojano, Dario Grossi, Mariateresa Esposito, Teresa Costabile, Roberta Lanzillo, Francesco Saccà, Vincenzo Brescia Morra, Giovannina Conchiglia
Background: Few studies examined the effects of combined motor and cognitive rehabilitation in patients with multiple sclerosis (MS). The present prospective, multicenter, observational study aimed to determine the efficacy of an integrated cognitive and neuromotor rehabilitation program versus a traditional neuromotor training on walking, balance, cognition and emotional functioning in MS patients. Methods: Sixty three MS patients were selected and assigned either to the Integrated Treatment Group (ITG; n = 32), receiving neuropsychological treatment (performed by ERICA software and paper-pencil tasks) complemented by conventional neuromotor rehabilitation, or to the Motor Treatment Group ( n = 31) receiving neuromotor rehabilitation only...
2018: Frontiers in Behavioral Neuroscience
Christine K Cowan, Jane M Pierson, Sandra G Leggat
PURPOSE: To explore participants' personal perspectives: on psychosocial aspects of living with multiple sclerosis (MS) following inpatient rehabilitation; and on experiences of the rehabilitation hospital stay and discharge to home. METHODS: One-on-one, semi-structured in-depth interviews, were conducted with 15 people with various forms of MS, post discharge from a rehabilitation hospital. Thematic analysis of the data was undertaken. RESULTS: The emergent themes were: Fatigue, Independence and Dependence, Loss, Provision of Care, and Perceptions of Care...
September 27, 2018: Disability and Rehabilitation
Dusanka Janezic, Lorentz Jantschi, Sorana D Bolboaca
Several studies report the effects of excessive use of sugars and sweeteners in the diet. These include obesity, cardiac diseases, diabetes, and even lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus. On the other hand, each sugar and sweetener has a distinct metabolic assimilation process, and its chemical structure plays an important role in this process. Several scientific papers present the biological effects of the sugars and sweeteners in relation to their chemical structure...
September 26, 2018: Current Medicinal Chemistry
Vanitha A Jagannath, Graziella Filippini, Carlo Di Pietrantonj, G V Asokan, Edward W Robak, Liz Whamond, Sarah A Robinson
BACKGROUND: This review is an update of a previously published review, "Vitamin D for the management of multiple sclerosis" (published in the Cochrane Library; 2010, Issue 12). Multiple sclerosis (MS) is characterised by inflammation, demyelination, axonal or neuronal loss, and astrocytic gliosis in the central nervous system (CNS), which can result in varying levels of disability. Some studies have provided evidence showing an association of MS with low levels of vitamin D and benefit derived from its supplementation...
September 24, 2018: Cochrane Database of Systematic Reviews
Sue-Jin Lin, Irene Vavasour, Brenda Kosaka, David K B Li, Anthony Traboulsee, Alex MacKay, Martin J McKeown
Graphical network characteristics and nonstationary functional connectivity features, both derived from resting-state functional magnetic resonance imaging (rsfMRI) data, have been associated with cognitive performance in healthy subjects. How these features jointly relate to cognition in diseased states has not been investigated. In this study, 46 relapsing-remitting multiple sclerosis subjects underwent rsfMRI scans and a focused cognitive battery. With a sliding window approach, we examined six dynamic network features that indicated how connectivity changed over time as well as six measures derived from graph theory to reflect static network characteristics...
September 21, 2018: Human Brain Mapping
Ola Mioduszewski, Heather MacLean, Patricia A Poulin, Andra M Smith, Lisa A S Walker
Multiple sclerosis (MS) is a chronic, progressive, autoimmune, neurodegenerative disorder that can interfere with physical and psychological functioning, negatively affecting health-related quality of life (HRQoL). Fostering mindfulness may mitigate the negative consequences of MS on HRQoL. The relationship between mindfulness, mood and MS-related quality of life was investigated. In total, 52 individuals with MS completed questionnaires to examine the relationship between trait mindfulness and wellness. Higher levels of trait mindfulness were associated with better HRQoL, lower depression and anxiety, lower fatigue impact and fewer perceived cognitive deficits...
September 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Scott Otallah, Brenda Banwell
PURPOSE OF REVIEW: Diagnostic criteria for pediatric-onset multiple sclerosis (POMS) and related demyelinating disorders have been updated, neuroimaging studies have revealed new insights, biological assays identify patients with specific antibodies that influence both diagnosis and treatment, clinical trials are informing on treatment efficacy and safety, and longitudinal studies of neurological, cognitive and quality of life outcomes are informing on the impact of these diseases. We provide updates to assist providers caring for these children...
September 18, 2018: Current Neurology and Neuroscience Reports
Magdalena Krbot Skorić, Luka Crnošija, Ivan Adamec, Barbara Barun, Tereza Gabelić, Tomislav Smoljo, Ivan Stanić, Tin Pavičić, Ivan Pavlović, Jelena Drulović, Tatjana Pekmezović, Mario Habek
OBJECTIVES: To investigate a possible association between autonomic dysfunction and fatigue in people with multiple sclerosis. METHODS: In 70 people with multiple sclerosis early in the disease course (51 females, mean age 33.8 ± 9.1), quantitative sudomotor axon reflex tests, cardiovascular reflex tests (heart rate and blood pressure responses to the Valsalva maneuver and heart rate response to deep breathing), and the tilt table test were performed. Participants completed the Composite Autonomic Symptom Score 31, the Modified Fatigue Impact Scale, and the Epworth Sleepiness Scale, as well as the Beck Depression Inventory...
September 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Shahnaz Shahrbanian, Pierre Duquette, Nancy E Mayo
Background: Identifying the predictors of pain is important for both health professionals and researchers, because pain has repeatedly been found to be a strong predictor of activity limitations and participation restrictions. The objective of this study was to determine the predictors of pain presence and severity in a large, well-designed sample of community dwelling individuals with multiple sclerosis (MS). Methods: This was a cross-sectional study. A center-stratified random sample including 188 persons with MS were recruited from three major MS clinics in the Greater Montreal, Canada...
2018: Caspian Journal of Internal Medicine
Sascha Gill, Jonathan Santo, Mervin Blair, Sarah A Morrow
Depression and anxiety are common among persons with multiple sclerosis (MS), and both negatively affect functional status. However, studies rarely account for overlap in depressive and anxiety symptoms on functional outcomes among people with MS. The authors aimed to examine the differential impact of depression and anxiety, measured by the Anxiety and Depression subscales of the Hospital Anxiety and Depression Scale (HADS-A and HADS-D), on functional outcomes among people with MS. Using a retrospective chart review of 128 people with MS, the authors used exploratory structural equation modeling to examine the relation of HADS-A and HADS-D to functional outcomes, namely employment status, fatigue (with the Fatigue Severity Scale), disability (with the Expanded Disability Status Scale [EDSS]), and cognition (with the Symbol Digit Modalities Test [SDMT])...
September 6, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
Lyan J M Blikman, Jetty van Meeteren, Dimitris Rizopoulos, Vincent de Groot, Heleen Beckerman, Henk J Stam, Johannes B J Bussmann
BACKGROUND: Fatigue affects 80% of persons with multiple sclerosis and is associated with daily physical functioning. Both fatigue and physical behaviour are multidimensional concepts. OBJECTIVE: To study the association between the dimensions of physical behaviour and multiple sclerosis-related fatigue. METHODS: Cross-sectional analysis of 212 persons with multiple sclerosis. Participants were severely fatigued, with a Fatigue Severity Scale median (interquartile range): 5...
September 28, 2018: Journal of Rehabilitation Medicine
Moussa A Chalah, Ulrich Palm, Jean-Pascal Lefaucheur, Alain Créange, Samar S Ayache
BACKGROUND: Depression and anxiety stand among the most frequent and debilitating complaints in multiple sclerosis (MS) patients. Understanding their neurophysiological correlates might improve their management. To date, no single study has addressed this issue. METHOD: Patients completed the Hospital Anxiety and Depression Scale (HADS). Transcranial magnetic stimulation (TMS) was performed to obtain the following corticospinal excitability measures: resting motor threshold, short interval intracortical inhibition and facilitation, cortical silent period and interhemispheric inhibition...
August 30, 2018: Brain Research
Uwe Martin Pommerich, John Brincks, Marie Ernst Christensen
BACKGROUND: Fatigue is considered the most common symptom of persons with multiple sclerosis MS (pwMS), occurring in up to 90% of the patients at some point with two-thirds of pwMS experience fatigue as their most disturbing symptom. Pharmacological treatment options for MS-related fatigue show only limited and contradicting results. Consequently, many pwMS search for alternative options to control the symptom. A considerable interest in dietary interventions as a means of MS symptom management has advanced in the MS community...
August 21, 2018: Multiple Sclerosis and related Disorders
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