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Multiple sclerosis related fatigue

Elisabet Guillamó, Álvaro Cobo-Calvo, Guillermo R Oviedo, Noémie Travier, Juan Álamo, Oscar A Niño-Mendez, Antonio Martínez-Yelamos, Sergio Martínez-Yelamos, Casimiro Javierre
Multiple sclerosis (MS) is a chronic neurological disease which affects young adults at a time of maximum personal, professional and social growth. Recent guidelines on physical activity have established that exercise is an essential component of the clinical management of people with MS with mild or moderate degree of disability. The main purpose of this study was to test the feasibility and the effects of two different 40-week structured physical exercise interventions (a supervised high intensity interval training plus home exercise program and a self-applied home-based exercise program) on clinical evolution, psychological wellbeing, quality of life, fatigue, cardiorespiratory fitness, strength and balance of people with MS...
September 2018: Journal of Sports Science & Medicine
Annette Baumgartner, Lars Frings, Florian Schiller, Oliver Stich, Michael Mix, Karl Egger, Gisa Schluh, Sebastian Rauer, Philipp T Meyer
OBJECTIVES: Although interferon-beta is an established drug for relapsing remitting multiple sclerosis (RRMS), its impact on neuronal activity is not well understood. METHODS: We investigated 15 patients with RRMS by [18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) to assess cerebral metabolic rate of glucose (CMRglc ) before interferon-beta therapy. Further, we performed clinical and neuropsychological investigations. In nine patients, these investigations were repeated after six months of therapy...
August 8, 2018: Acta Neurologica Scandinavica
Katrin Hanken, Carina Sander, Lara Qaiser, Hans-Peter Schlake, Andreas Kastrup, Michael Haupts, Paul Eling, Helmut Hildebrandt
Background: The causes of fatigue in multiple sclerosis (MS) and other inflammatory disorders are not well understood. One possible cause that might explain fatigue in inflammatory disorders appears to be the immunological process itself, triggering neural activity that is experienced as fatigue. Objectives: To investigate whether salivary IL-1ß concentration, associated with systemic inflammation, is related to subjective fatigue in MS. Methods: 116 MS patients (62 relapsing remitting MS, 54 secondary progressive MS) and 51 healthy controls participated in this study...
2018: Frontiers in Neurology
Laura Barin, Anke Salmen, Giulio Disanto, Haris Babačić, Pasquale Calabrese, Andrew Chan, Christian P Kamm, Jürg Kesselring, Jens Kuhle, Claudio Gobbi, Caroline Pot, Milo A Puhan, Viktor von Wyl
BACKGROUND: MS symptoms affect many functional domains. Knowing the specific impact of symptoms on health-related quality of life (HRQoL) is vital for successful disease and symptom management in MS. We aimed at investigating how specific MS symptoms contribute to the disease burden in individuals and from a population perspective. METHODS: We included 855 Swiss Multiple Sclerosis Registry participants with a relapsing-remitting form (RRMS) or a progressive form (PMS)...
July 21, 2018: Multiple Sclerosis and related Disorders
K Yarraguntla, N Seraji-Bozorgzad, S Lichtman-Mikol, S Razmjou, F Bao, S Sriwastava, C Santiago-Martinez, O Khan, E Bernitsas
BACKGROUND AND PURPOSE: Previous cross-sectional studies have reported the involvement of thalamus, pallidum, superior cerebellar peduncle, temporal cortex, and fronto-parietal white matter in multiple sclerosis (MS)-related fatigue. However, the longitudinal imaging correlates of fatigue severity variation in MS remain unclear. METHODS: Structural and diffusion tensor imaging (DTI) data were collected from 43 relapsing remitting MS (RRMS) patients with fatigue (Fatigue Severity Scale [FSS] range: 1-7)...
July 23, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Kevin N Alschuler, Anne Arewasikporn, Ian K Nelson, Ivan R Molton, Dawn M Ehde
PURPOSE/OBJECTIVE: Starting in middle adulthood, individuals living with multiple sclerosis (MS) are confronted with the simultaneous challenge of coping with advancing MS alongside age-related changes. Psychological resilience is thought to play an important role in promoting healthy aging and thus may be important in the context of aging with MS. This study aimed to evaluate whether Everyday Matters, a novel positive psychology program, had a positive effect on resilience and other related outcomes in adults with MS relative to a wait-list control group...
July 19, 2018: Rehabilitation Psychology
S Coe, E Axelsson, V Murphy, M Santos, J Collett, M Clegg, H Izadi, J M Harrison, E Buckingham, H Dawes
CONTEXT: Current research suggests that dark cocoa may reduce fatigue; however, the effect on fatigue in people with MS (pwMS) has never been established. The objective of this feasibility study was to explore the acute effect of high flavonoid cocoa on measures of fatigue and glycaemic response. METHODS: This was a randomised crossover participant blind exploratory study in 12 participants (2 male and 10 female) with MS-related fatigue (>4 on the Fatigue Severity Scale; FSS)...
October 2017: Clinical Nutrition ESPEN
Fuchun Lin, Robert Zivadinov, Jesper Hagemeier, Bianca Weinstock-Guttman, Caila Vaughn, Sirin Gandhi, Dejan Jakimovski, Hanneke E Hulst, Ralph Hb Benedict, Niels Bergsland, Tom Fuchs, Michael G Dwyer
BACKGROUND: The thalamus, affected early in multiple sclerosis (MS), is a heterogeneous composition of functionally distinct nuclei and is associated with fatigue, cognition, and other outcomes. However, most previous functional imaging studies considered the thalamus only as a whole. OBJECTIVE: To investigate MS-related abnormalities in nuclei-specific thalamic functional connectivity (FC) and their associations with fatigue and cognitive outcomes. METHODS: Resting-state functional magnetic resonance imaging (fMRI) was analyzed in 64 MS patients and 26 healthy controls (HC)...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Eva Hyncicova, Adam Kalina, Martin Vyhnalek, Tomas Nikolai, Lukas Martinkovic, Jiri Lisy, Jakub Hort, Eva Meluzinova, Jan Laczó
BACKGROUND: Neuropsychiatric symptoms and reduced health-related quality of life (HRQoL) are frequent in multiple sclerosis, where are associated with structural brain changes, but have been less studied in clinically isolated syndrome (CIS). OBJECTIVE: To characterize HRQoL, neuropsychiatric symptoms (depressive symptoms, anxiety, apathy and fatigue), their interrelations and associations with structural brain changes in CIS. METHODS: Patients with CIS (n = 67) and demographically matched healthy controls (n = 46) underwent neurological and psychological examinations including assessment of HRQoL, neuropsychiatric symptoms and cognitive functioning, and MRI brain scan with global, regional and lesion load volume measurement...
2018: PloS One
Derrick Robertson, Angela Aungst, Ryan Collier, Jhulianna Vivar, Natalie Moreo, Lise Casady, Tuan Vu
Purpose: Sexual dysfunction is a common but often overlooked secondary symptom of multiple sclerosis (MS) and can be associated with a decreased health-related quality of life (HRQoL). Natalizumab is a disease-modifying therapy approved for the treatment of relapsing forms of MS. In addition to its efficacy, those using natalizumab have shown improvement in HRQoL parameters, including fatigue and cognition. The idea that improvement in fatigue may also correlate with improvement in sexual dysfunction is the impetus for this study...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Alon Kalron, Roy Aloni, Uri Givon, Shay Menascu
BACKGROUND: There is a consensus that physical activity is imperative for people with MS (PwMS). However, regardless of the benefits, many PwMS do not participate in any meaningful physical activity. AIM: To examine the relationship between leisure-time physical activity with clinical characteristics and common symptoms in PwMS. METHODS: The sample included 190 PwMS (107 women), mean age 40.8 (S.D = 13.1) and mean disease duration of 6...
June 30, 2018: Gait & Posture
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is a neurological disease of the central nervous system characterized by inflammation, demyelination and neurodegeneration. Throughout the disease process, patients may complain of a panel of sensory, motor, cognitive and behavioral symptoms. Fatigue is a debilitating manifestation of central nervous system diseases with physical, cognitive and psychosocial dimensions. In MS, fatigue could be very frequent concerning up to 90% of patients and may have a drastic impact on their quality of life...
June 15, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
E Ann Yeh, Nicole Chiang, Bindia Darshan, Nadine Nejati, Stephanie A Grover, Carolyn E Schwartz, Ruth Slater, Marcia Finlayson
Rates of medication nonadherence in youth with multiple sclerosis (MS) range from 10% to 60%. Qualitative studies of adherence can provide insight into children's own perspectives about barriers and facilitators to their adherence and inform future interventions. This qualitative longitudinal descriptive study included children with MS ( n = 28) participating in a randomized controlled trial focused on medication adherence ( : NCT02234713). Following established methods, three independent reviewers coded transcripts of motivational interviewing (MI) sessions (three interviews per subject, performed monthly over a 3-month period) for relevant themes...
June 1, 2018: Qualitative Health Research
Jing Chen, Bruce Taylor, Andrew J Palmer, Andrea Kirk-Brown, Pieter van Dijk, Steve Simpson, Leigh Blizzard, Ingrid van der Mei
BACKGROUND: Little is known about the work productivity loss in multiple sclerosis (MS). OBJECTIVES: To quantify the MS-related work productivity loss and to compare factors associated with labour force participation and work productivity loss. METHODS: Participants were from the Australian MS Longitudinal Study. MS-related work productivity loss included absenteeism (time missed from work) and presenteeism (reduced productivity while working)...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
M León Ruiz, M Sospedra, S Arce Arce, J Tejeiro-Martínez, J Benito-León
INTRODUCTION: A growing number of studies have evaluated the effects of transcranial magnetic stimulation (TMS) for the symptomatic treatment of multiple sclerosis (MS). METHODS: We performed a PubMed search for articles, recent books, and recommendations from the most relevant clinical practice guidelines and scientific societies regarding the use of TMS as symptomatic treatment in MS. CONCLUSIONS: Excitatory electromagnetic pulses applied to the affected cerebral hemisphere allow us to optimise functional brain activity, including the transmission of nerve impulses through the demyelinated corticospinal pathway...
June 10, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Kaitlynne Leclaire, Audrey Cecil, Allison LaRussa, Fiona Stuart, Christopher C Hemond, Brian C Healy, Tanuja Chitnis, Howard Weiner, Jeff Huffman, Bonnie I Glanz
Background: Positive psychology uses targeted activities to increase the frequency and intensity of positive emotional experiences. Positive psychology interventions that increase positive constructs may facilitate adjustment and improve well-being in patients with multiple sclerosis (MS). The primary goal of this study was to assess the feasibility and acceptability of a 5-week group positive psychology intervention for patients with MS. In addition, we examined the utility of the group intervention to increase positive psychological constructs and health-related quality of life (HRQOL)...
May 2018: International Journal of MS Care
L B Strober
BACKGROUND: Reductions in quality of life (QOL) exist among individuals with multiple sclerosis (MS). OBJECTIVE: The present investigation aimed to adopt a biopsychosocial model in examining QOL in the early stages of MS. METHODS: Individuals with MS (34 with average to low QOL and 35 with high QOL) were compared on measures of disease symptoms, psychological functioning, personality, self-efficacy, locus of control (LOC), social support, and coping to determine the most salient predictors of QOL...
May 31, 2018: Disability and Health Journal
Somasundaram Aadhimoolam Chinnadurai, Divya Gandhirajan, Vijaya Pamidimukala, Bhanu Kesavamurthy, Srinivasan Avathvadi Venkatesan
OBJECTIVES: We aimed to determine whether there was a relationship between objective measures of sleep measured by polysomnography and measures of physical and cognitive fatigue in patients with Multiple Sclerosis (MS). METHODS: People with MS of age 18-50 years of any subtype attending the OPD satisfying the revised 2010 McDonald criteria were recruited. Modified Fatigue Impact Scale (MFIS) and the Fatigue Severity Scale (FSS) were used to assess physical fatigue...
May 23, 2018: Multiple Sclerosis and related Disorders
Murray W Enns, Charles N Bernstein, Kristine Kroeker, Lesley Graff, John R Walker, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, John D Fisk, Ruth Ann Marrie
Impairment in work function is a frequent outcome in patients with chronic conditions such as immune-mediated inflammatory diseases (IMID), depression and anxiety disorders. The personal and economic costs of work impairment in these disorders are immense. Symptoms of pain, fatigue, depression and anxiety are potentially remediable forms of distress that may contribute to work impairment in chronic health conditions such as IMID. The present study evaluated the association between pain [Medical Outcomes Study Pain Effects Scale], fatigue [Daily Fatigue Impact Scale], depression and anxiety [Hospital Anxiety and Depression Scale] and work impairment [Work Productivity and Activity Impairment Scale] in four patient populations: multiple sclerosis (n = 255), inflammatory bowel disease (n = 248, rheumatoid arthritis (n = 154) and a depression and anxiety group (n = 307), using quantile regression, controlling for the effects of sociodemographic factors, physical disability, and cognitive deficits...
2018: PloS One
Terry Wahls, Maria O Scott, Zaidoon Alshare, Linda Rubenstein, Warren Darling, Lucas Carr, Karen Smith, Catherine A Chenard, Nicholas LaRocca, Linda Snetselaar
BACKGROUND: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS) and contributes to diminishing quality of life. Although currently available interventions have had limited success in relieving MS-related fatigue, clinically significant reductions in perceived fatigue severity have been reported in a multimodal intervention pilot study that included a Paleolithic diet in addition to stress reduction, exercise, and electrical muscle stimulation. An optimal dietary approach to reducing MS-related fatigue has not been identified...
June 4, 2018: Trials
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