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Multiple sclerosis related fatigue

Luis Carlos Nacul, Kathleen Mudie, Caroline C Kingdon, Taane G Clark, Eliana Mattos Lacerda
Background: The diagnosis of myalgic encephalomyelitis (ME/CFS) in research and clinical practice has largely relied on clinical history, which can be subjective in nature. Clinical signs are often subtle, overlap with other conditions, and are not formally included as part of diagnostic workup. The characterization of clinical signs and biomarkers is needed for better diagnosis and classification of patients and to monitor treatment response. Hand grip strength (HGS) has been used as an objective measure of muscle strength and fatigue, which is a primary symptom of ME/CFS...
2018: Frontiers in Neurology
James S Krause, Clara E Dismuke-Greer, Melinda Jarnecke, Chao Li, Karla S Reed, Phillip Rumrill
OBJECTIVE: To identify demographic, educational, and disease-related characteristics associated with the odds of employment and earnings among participants with multiple sclerosis (MS). DESIGN: Cross-sectional using self-report assessment obtained by mail or online SETTING: Medical University in the southeastern United States. PARTICIPANT: Participants with MS (n = 1059) were enrolled from a specialty hospital in the southeastern United States...
December 6, 2018: Archives of Physical Medicine and Rehabilitation
Anne Katrine Andreasen, Pernille Iversen, Lisbet Marstrand, Volkert Siersma, Hartwig Roman Siebner, Finn Sellebjerg
BACKGROUND: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course. METHODS: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC) and patients were further examined with a cognitive test battery, including Symbol Digit Modalities Test (SDMT), and 3 T MRI with subsequent quantitative analyses of 13 cortical regions of interest, deep grey matter and lesion volume...
December 4, 2018: Neurological Research
Fabio Basta, Domenico Paolo Emanuele Margiotta, Carmen Mazzuca, Veronica Batani, Giulio Dolcini, Patrizio Moras, Marta Vadacca, Antonella Afeltra
To assess clinical and psychosocial factors related to alexithymia in systemic sclerosis (SSc). We enrolled 40 consecutive SSc patients in a cross-sectional study evaluating alexithymia with Toronto Alexithymia scale (TAS-20). We measured Beck Depression inventory (BDI), Hamilton Anxiety rating scale (HAM-H), 36-Items Short-Form Healthy Survey (SF-36), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue, Visual Analog Scale (VAS) pain, Pittsburgh Sleep Quality Index (PSQI), Satisfaction with Appearance Scale (SWAP), and Mouth Handicap in Systemic Sclerosis (MHISS)...
November 29, 2018: Rheumatology International
Pamela Newland, Rebecca A Lorenz, Judith M Smith, Emily Dean, John Newland, Patricia Cavazos
AIMS AND OBJECTIVES: The aim of this study was to examine the relationships among multiple sclerosis (MS)-related symptoms, sleep hygiene behaviors, and sleep quality in adults with MS who self-report fatigue. BACKGROUND: Fatigue is a frequent, prevalent symptom among adults with MS. Few studies have examined the relationship among fatigue and other symptoms with sleep quality and sleep behaviors. DESIGN: This is a descriptive correlational study...
November 27, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Peter Rieckmann, Matthias Schwab, Dieter Pöhlau, Iris-Katharina Penner, Torsten Wagner, Elke Schel, Antonios Bayas
INTRODUCTION: Patient adherence is a key determinant of treatment success in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates patient self-injection of subcutaneous interferon β-1a (sc IFN β-1a) and allows quantitative measurement of adherence via its automated dosing log. We evaluated patient adherence and patient-reported cognitive and health-economic outcomes over 2 years in patients using RebiSmart® . METHODS: In this non-interventional, single-arm study, enrolled patients were 12-65 years of age, had relapsing-remitting MS or a single demyelinating event, and had been prescribed 44 or 22 μg sc IFN β-1a...
November 28, 2018: Advances in Therapy
Joanna Dymecka, Mariola Bidzan
The aim of this research was to assess the level of adaptation to multiple sclerosis ( Sclerosis multiplex ; MS) and health-related quality of life (HRQoL) of the study population as well as to determine the relationship between biomedical factors related to the course of multiple sclerosis, adaptation to the disease, and HRQoL. Analysis of medical records, clinical and psychological interviews, the Extended Disability Status Scale (EDSS), Guy's Neurological Disability Scale (GNDS), the Acceptance of Illness Scale (AIS), and the Multiple Sclerosis Impact Scale 29 (MSIS-29) were collected from 137 patients with MS...
November 28, 2018: International Journal of Environmental Research and Public Health
Michelle H Cameron, Ylva Nilsagard
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) and the most widespread nontraumatic cause of disability in young adults around the world. MS occurs in people of all ages, races, and ethnicities. MS is characterized by clinical symptoms resulting from lesions in the brain, spinal cord, or optic nerves that can affect balance, gait, and fall risk. Lesions accumulate over time and occur in different areas of the CNS causing symptoms that include weakness, spasticity, and fatigue, as well as changes in sensation, coordination, vision, cognition, and bladder function...
2018: Handbook of Clinical Neurology
Susan Carroll, Trudie Chalder, Cheryl Hemingway, Isobel Heyman, Holly Bear, Louise Sweeney, Rona Moss-Morris
BACKGROUND: Fatigue is a disabling, poorly understood symptom in children and adolescents with multiple sclerosis (caMS), for which effective treatments are lacking. In paediatric Chronic Fatigue Syndrome (CFS), effective psychological interventions have been developed based on psychosocial factors associated with fatigue. This study aimed to identify potentially modifiable factors of fatigue in caMS by comparing caMS, adolescents with CFS, healthy adolescents and their parents on measures of fatigue, psychosocial factors, and neurocognitive functioning...
November 2, 2018: European Journal of Paediatric Neurology: EJPN
Maria Anagnostouli, Ioanna Babili, George Chrousos, Artemios Artemiadis, Christina Darviri
OBJECTIVES: Psychological stress is an important risk factor for multiple sclerosis (MS) onset, relapse, neurological symptoms and psychosocial adjustment to the disease. Mounting evidence suggests that stress management could halt the disease progression and improve patients' wellbeing. The aim of this study was to investigate the effectiveness of a novel cognitive-behavioral stress management technique (called Pythagorean Self-Awareness Intervention - PSAI) routinely used in our clinics in patients with MS...
November 19, 2018: Neurological Research
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized by chronic inflammation, demyelination, synaptopathy and neurodegeneration. Patients may exhibit sensory, motor, cognitive, emotional and behavioral symptoms throughout their disease process. Nowadays, the challenge is to find optimal treatment for MS symptoms, especially that available pharmacological interventions are faced by modest therapeutic outcomes and numerous side effects. Thus, finding alternative strategies might be of help in this context...
December 2018: Neurodegenerative Disease Management
Eli K Cehelyk, Denise Y Harvey, Meghan L Grubb, Rasha Jalel, Mohammad S El-Sibai, Clyde E Markowitz, Joseph R Berger, Roy H Hamilton, Salim Chahin
BACKGROUND: Fatigue and cognitive dysfunction are two common symptoms experienced by patients with multiple sclerosis (MS). The relationship between subjective and objective fatigue (fatigability) in MS is poorly understood. Cognitive control tasks might be more conducive to fatigability and more likely to show associations between subjective and objective cognitive fatigue in MS. OBJECTIVE: To study the association between objective fatigability, as induced by a cognitive control task called the Blocked Cyclic Naming Task (BCNT), subjective fatigue and baseline cognitive functioning in patients with MS...
October 27, 2018: Multiple Sclerosis and related Disorders
Arthur R Chaves, Elizabeth M Wallack, Liam P Kelly, Ryan W Pretty, Hailey D Wiseman, Alice Chen, Craig S Moore, Mark Stefanelli, Michelle Ploughman
OBJECTIVES: Investigate whether asymmetrical corticospinal excitability exists in Multiple Sclerosis (MS) and its association with MS symptoms. METHODS: Bilateral resting and active motor thresholds (RMT, AMT) were gathered using transcranial magnetic stimulation among 82 MS patients. Corticospinal excitability (CSE) asymmetry was expressed as the ratio between weaker and stronger sides' RMT and AMT. Stronger and weaker side was determined by pinch and grip strength...
November 6, 2018: Behavioural Brain Research
B Pedraz, G Sammer
Multiple sclerosis is an inflammatory disease, which still today affects the Northern-hemisphere population, generating a socioeconomically burden. One of the most unfavorable symptoms in this chronic disorder is fatigue. In this review, we favor and sustain a main alteration of the hypothalamus-pituitary-axis complex and its physiopathologic consequences, mostly related to glutamate and corticoid levels. We try to sustain our hypothesis in what is already reported, corroborating that the inflammatory cells release mainly glutamate, a neuro-toxic substance which leads to a demyelinating effect and as a main result fatigue as a symptom...
November 16, 2018: Revista de Neurologia
Julie Pétrin, Max Fiander, Prenitha Mercy Ignatius Arokia Doss, E Ann Yeh
Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and O'Malley. Four databases were searched for pediatric MS and modifiable lifestyle factors using index terms and keywords, from inception to May 2018. All quantitative and qualitative primary articles were included and limited to English and full text. Of the 7202 articles identified and screened, 25 full-text articles were relevant to our objective and were included...
October 26, 2018: Children
Tara A Nazareth, Andrew R Rava, Jackie L Polyakov, Edward N Banfe, Royce W Waltrip Ii, Kristine B Zerkowski, Leslie B Herbert
BACKGROUND: Underestimation of relapse in multiple sclerosis (MS) is detrimental to the patient as well as to their relationship with their MS healthcare professional (HCP). OBJECTIVE: To obtain direct insight into relapse prevalence, symptoms, and HCP engagement from patients with MS who responded to the Multiple Sclerosis in America (MSIA) 2017 survey. METHODS: Information on patient demographics, health insurance coverage, symptoms, disability, relapses, and related HCP interactions were captured...
September 7, 2018: Multiple Sclerosis and related Disorders
Olivia Svolgaard, Kasper Winther Andersen, Christian Bauer, Kristoffer Hougaard Madsen, Morten Blinkenberg, Finn Selleberg, Hartwig Roman Siebner
Fatigue is a common and highly disabling symptom of multiple sclerosis. Patients experience an effort-independent general subjective feeling of fatigue as well as excessive fatigability when engaging in physical or mental activity. Previous research using functional magnetic resonance imaging (fMRI) has revealed heterogeneous findings, but some evidence implicates the motor system. To identify brain correlates of fatigue, 44 mildly impaired patients with relapsing-remitting multiple sclerosis and 25 age- and gender-matched healthy controls underwent functional magnetic resonance imaging at 3 Tesla, while they performed alternating blocks of rest and a non-fatiguing precision grip task...
2018: PloS One
Katherine B Knox, Lynne Clay, Kiersten Stuart-Kobitz, Darren Nickel
PURPOSE: People with multiple sclerosis (MS) rank walking among the most challenging aspects of their condition. A greater understanding of people's perspectives concerning their walking may help to prioritize walking outcomes and strategies for optimizing walking. The purpose was to explore perceptions of walking in people with MS and to describe their reactions after observing themselves walk on video. MATERIALS AND METHODS: An interpretive thematic analysis study using face-to-face, semi-structured interviews was conducted with 14 people who self-identified a change in their walking due to MS...
October 22, 2018: Disability and Rehabilitation
Sascha Köpke, Alessandra Solari, Anne Rahn, Fary Khan, Christoph Heesen, Andrea Giordano
BACKGROUND: People with multiple sclerosis (MS) are confronted with a number of important uncertainties concerning many aspects of the disease. These include diagnosis, prognosis, disease course, disease-modifying therapies, symptomatic therapies, and non-pharmacological interventions, among others. While people with MS demand adequate information to be able to actively participate in medical decision making and to self manage their disease, it has been shown that patients' disease-related knowledge is poor, therefore guidelines recommend clear and concise high-quality information at all stages of the disease...
October 14, 2018: Cochrane Database of Systematic Reviews
Brian M Sandroff, Lara A Pilutti, Robert W Motl
BACKGROUND: Aerobic exercise training may improve cognitive performance among persons with multiple sclerosis (MS). This is largely based on evidence that cardiorespiratory fitness (as a cross-sectional surrogate for aerobic exercise training) is associated with cognitive processing speed. There may be a set of "other" variables (i.e., psychological symptoms) that influences the association between cardiorespiratory fitness and cognitive processing speed in MS, and such factors should be accounted for when designing optimized exercise rehabilitation interventions...
October 2, 2018: Multiple Sclerosis and related Disorders
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