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https://www.readbyqxmd.com/read/29154728/neuromyelitis-optica-spectrum-disorders-and-pregnancy-interactions-and-management
#1
Eslam Shosha, Sean J Pittock, Eoin Flanagan, Brian G Weinshenker
Neuromyelitis optica spectrum disorders (NMOSD) predominantly affect women who are of childbearing age. Understanding the interactions between pregnancy and NMOSD is important for clinical management. Aquaporin-4 (AQP4), the most common target antigen in NMOSD, is expressed on placenta in early pregnancy. A variety of immune and cytokine changes in pregnancy may impact pregnancy outcomes in NMOSD patients. Relapses continue during pregnancy and increase in frequency postpartum. Preeclampsia and fetal loss are more frequent in NMOSD than in controls...
December 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29108637/expression-of-aquaporin-3-aqp3-in-placentas-from-pregnancies-complicated-by-preeclampsia
#2
Natalia Szpilbarg, Alicia E Damiano
Recently, we have reported that the blocking of AQP3 abrogates the apoptotic response of the trophoblast. Since trophoblast apoptosis is exacerbated in preeclampsia, we hypothesized that placental AQP3 is increased in these placentas in order to trigger the programmed cell death. Here, we examined mRNA levels, protein expression and localization of AQP3 in placentas from pregnancies complicated by preeclampsia and against what we expected, we found that AQP3 expression was significantly reduced, both at protein and mRNA levels, compared to normal placentas...
November 2017: Placenta
https://www.readbyqxmd.com/read/28764583/expression-and-significance-of-aquaporin-2-and-serum-hormones-in-placenta-of-patients-with-preeclampsia
#3
Yurong Zhao, Li Lin, Ailuan Lai
To evaluate the relationship between serum hormone or aquaporin-2 (AQP-2) and preeclampsia, patients with severe preeclampsia (A group), mild preeclampsia (B group), chronic hypertension (C group) and normal pregnant women (D group) were recruited and analysed. The AQP-2 level in placenta tissues was detected and the correlations of AQP-2 with serum hormone levels were analysed using linear correlation regression analysis. The differences of alpha foetal protein (AFP) and human chorionic gonadotropin (HCG) levels during mid-pregnancy, as well as the levels of AFP, HCG, unconjugated oestriol and progesterone during late pregnancy were significant among A, B, C and D groups (p < ...
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28382320/female-hormonal-exposures-and-neuromyelitis-optica-symptom-onset-in-a-multicenter-study
#4
Riley Bove, Liene Elsone, Enrique Alvarez, Nadja Borisow, Melissa M Cortez, Farrah J Mateen, Maureen A Mealy, Kerry Mutch, Sean Tobyne, Klemens Ruprecht, Guy Buckle, Michael Levy, Dean M Wingerchuk, Friedemann Paul, Anne H Cross, Brian Weinshenker, Anu Jacob, Eric C Klawiter, Tanuja Chitnis
OBJECTIVE: To study the association between hormonal exposures and disease onset in a cohort of women with neuromyelitis optica spectrum disorder (NMOSD). METHODS: Reproductive history and hormone use were assessed using a standardized reproductive survey administered to women with NMOSD (82% aquaporin-4 antibody positive) at 8 clinical centers. Using multivariable regression, we examined the association between reproductive exposures and age at first symptom onset (FS)...
May 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28274928/effects-of-childbirth-on-podocyturia-in-women-with-normotensive-uncomplicated-pregnancies
#5
COMPARATIVE STUDY
Itsuko Furuta, Tianyue Zhai, Takeshi Umazume, Satoshi Ishikawa, Kinuko Nakagawa, Takashi Kojima, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami
Changes in hemodynamics and blood pressure occur shortly before and after childbirth regardless of the mode of delivery. This study aimed to test the hypothesis that parturition induces a temporal increase in podocyturia monitored by podocyte-specific protein podocin mRNA expression levels (Pod-mRNA). A total of 105 urine specimens, consisting of 43 and 62 from 18 and 20 otherwise healthy women with vaginal delivery (VD) and elective cesarean delivery (ECS), respectively, were studied. Determination of urine protein and creatinine (Cr) concentrations and quantitative analyses of Pod-mRNA, nephrin mRNA (Nep-mRNA), synaptopodin mRNA (Syn-mRNA), and aquaporin 2 mRNA expression were performed using RT-PCR in pelleted urine samples...
June 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28258575/aquaporins-in-fetal-development
#6
REVIEW
Nora Martínez, Alicia E Damiano
Water homeostasis during fetal development is of crucial physiologic importance. The successful formation and development of the placenta is critical to maintain normal fetal growth and homeostasis. The expression of several aquaporins (AQPs ) was found from blastocyst stages to term placenta and fetal membranes. Therefore, AQPs are proposed to play important roles in normal pregnancy, fetal growth, and homeostasis of amniotic fluid volume, and water handling in other organs. However, the functional importance of AQPs in fetal development remains to be elucidated...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28199196/danshen-extract-regulates-the-expression-of-aquaporin-3-in-human-amniotic-epithelial-cells
#7
Wenwen Zhang, Yiwen Zhang, Xiaoli Hu, Huihui Cheng, Ying Hua, Xueqiong Zhu
Danshen extract has been used in the treatment of oligohydramnios, however, the mechanism of its action has not been elucidated. Previously, we demonstrated that down-regulation of AQP3 in fetal membranes may contribute to the development of oligohydramnios. In this study, we investigated the effects of Danshen extract on AQP3 expression in human amniotic epithelial cells from term pregnancies with oligohydramnios or those with those with (those with) normovolemic amniotic fluid. Human amniotic epithelial cells from the oligohydramnios group expressed a lower level of AQP3 mRNA and protein than those with normovolemia...
March 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28188955/increased-podocyturia-in-pregnant-women-compared-to-non-pregnant-women
#8
Itsuko Furuta, Tianyue Zhai, Takeshi Umazume, Satoshi Ishikawa, Kinuko Nakagawa, Rina Akaishi, Takahiro Yamada, Mamoru Morikawa, Hisanori Minakami
AIM: Hyperfiltration is a cause of podocyturia and occurs physiologically in the kidney of pregnant women. Podocyturia is increased in preeclamptic pregnancies, but it is unclear whether there is also any increase in uncomplicated pregnancies. This study was performed to examine whether podocyturia and urine aquaporin 2 mRNA expression are increased in healthy pregnant women (PW) compared to healthy non-pregnant women (NPW). METHODS: Eleven urines obtained from 11 NPW and longitudinal 76 urines from 40 PW with uncomplicated pregnancies (median number [range] of urine samples/person, 2 [1 - 3]) were studied...
February 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28017203/pregnancy-in-neuromyelitis-optica-spectrum-disorder-a-multicenter-study-from-south-china
#9
MULTICENTER STUDY
Yanlu Huang, Yuge Wang, Yifan Zhou, Qiao Huang, Xiaobo Sun, Chen Chen, Ling Fang, Youming Long, Hui Yang, Honghao Wang, Caixia Li, Zhengqi Lu, Xueqiang Hu, Allan G Kermode, Wei Qiu
OBJECTIVE: This study aimed to assess the effect of pregnancy on the course of neuromyelitis optica spectrum disorder (NMOSD), and the effect of this disease on pregnancy outcomes. METHODS: Consecutive patients with NMOSD were recruited between September 2015 and April 2016 at an outpatient clinic from four referral institutes in South China. Demographic, clinical, and pregnancy data were retrieved by questionnaires to analyze the association between NMOSD and pregnancy, as well as the potential risk factors for relapse...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27800085/-a-treatment-of-neuromyelitis-optica-devic-s-disease-during-pregnancy
#10
REVIEW
Moussa Toudou Daouda, Norlin Samuel Obenda, Hamid Assadeck, Diankanagbe Camara, Fatimata Hassane Djibo
Neuromyelitis optica (Devic's disease) is an inflammatory demyelinating disease of the central nervous system that mainly affects spinal cord, optic nerve and brain regions with high aquaporin 4 antigen expression. This is a severe autoimmune disease caused by autoantibodies directed against aquaporin 4 and associated with high morbidity and mortality. Unlike other inflammatory conditions such as multiple sclerosis or rheumatoid polyarthritis, pregnancy does not seem to influence the activity of neuromyelitis optica, hence the need for a thorough treatment during pregnancy...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27761482/immunology-of-neuromyelitis-optica-during-pregnancy
#11
REVIEW
Vahid Davoudi, Kiandokht Keyhanian, Riley M Bove, Tanuja Chitnis
Anti-aquaporin-4 (AQP4) autoantibody plays a key role in the pathogenesis of neuromyelitis optica (NMO). Studies have shown increased relapse rates in patients with NMO during pregnancy and postpartum. High estrogen levels during pregnancy can increase activation-induced cytidine deaminase expression, which is responsible for immunoglobulin production. Additionally, sex hormones may influence antibody glycosylation, with effects on antibody function. Estrogen decreases apoptosis of self-reactive B cells, through upregulation of antiapoptotic molecules...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27556454/the-effects-of-female-sexual-hormones-on-the-expression-of-aquaporin-5-in-the-late-pregnant-rat-uterus
#12
Adrienn Csányi, Judit Bóta, George Falkay, Robert Gáspár, Eszter Ducza
Thirteen mammalian aquaporin (AQP) water channels are known, and few of them play a role in the mammalian reproductive system. In our earlier study, the predominance of AQP5 in the late-pregnant rat uterus was proven. Our current aim was to investigate the effect of estrogen- and gestagen-related compounds on the expression of the AQP5 channel in the late-pregnant rat uterus. Furthermore, we examined the effect of hormonally-induced preterm delivery on the expression of AQP5 in the uterus. We treated pregnant Sprague-Dawley rats subcutaneously with 17β-estradiol, clomiphene citrate, tamoxifen citrate, progesterone, levonorgestrel, and medroxyprogesterone acetate...
August 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27226190/modulatory-effects-of-steroid-hormones-oxytocin-arachidonic-acid-forskolin-and-cyclic-amp-on-the-expression-of-aquaporin-1-and-aquaporin-5-in-the-porcine-uterus-during-placentation
#13
A Skowronska, P Mlotkowska, S Okrasa, S Nielsen, M T Skowronski
Aquaporins (AQPs) are proteins forming trans-membrane channels responsible for water transport. AQP1 and AQP5 are present in structures of the female reproductive system. In the uterus, these AQPs are involved in water movement between the intraluminal, interstitial and capillary compartments and their uterine expression is essential throughout the pregnancy, including its early stages. Thus, the study aimed to assess the influence of P4 (progesterone), E2 (estradiol), OT (oxytocin), AA (arachidonic acid), cAMP and FSK (forskolin) on the AQP1 and AQP5 mRNA and protein expression in the uterine tissue of gilts on Days 30 - 32 of gestation (the placentation period), following short (3 h) and long (24 h) incubations...
April 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27082037/increased-expression-of-aquaporin-9-in-trophoblast-from-gestational-diabetic-patients
#14
T Vilariño-García, A Pérez-Pérez, V Dietrich, M Fernández-Sánchez, P Guadix, J L Dueñas, C L Varone, A E Damiano, V Sánchez-Margalet
Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing the incidence of complications in both mother and fetus. The macrosomia that occurs in these fetuses may be related with some changes in nutrient transport mechanism in placenta. The presence of aquaporin 9, an aquaglyceroporin, has previously been demonstrated in placenta. We raised the question whether aquaporin 9 expression may be upregulated in placenta from gestational diabetes, thus providing a faster transport of glycerol and water through placenta...
August 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/26908840/expressions-of-aquaporin-family-in-human-luteinized-granulosa-cells-and-their-correlations-with-ivf-outcomes
#15
Hee Jun Lee, Byung Chul Jee, Seul Ki Kim, Hoon Kim, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
STUDY QUESTION: Are mRNAs for specific aquaporins (AQPs) expressed in human luteinized granulosa cells (GCs) and are their expression levels correlated with in vitro fertilization (IVF) outcomes? SUMMARY ANSWER: The mRNAs of AQP1-7, 9, 11, and 12 were expressed in human luteinized GCs; the level of AQP1 mRNA was negatively associated with retrieved oocyte number and the level of AQP7 mRNA was positively associated with fertilization rate. WHAT IS KNOWN ALREADY: mRNAs of AQP1-4 and AQP9 have been detected in human GCs...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26630693/phenotypic-variations-in-osmotic-lysis-of-sahel-goat-erythrocytes-in-non-ionic-glucose-media
#16
Nanacha Afifi Igbokwe, Ikechukwu Onyebuchi Igbokwe
BACKGROUND: Erythrocyte osmotic lysis in deionised glucose media is regulated by glucose influx, cation efflux, and changes in cell volume after water diffusion. Transmembrane fluxes may be affected by varied expression of glucose transporter protein and susceptibility of membrane proteins to glucose-induced glycosylation and oxidation in various physiologic states. METHODS: Variations in haemolysis of Sahel goat erythrocytes after incubation in hyposmotic non-ionic glucose media, associated with sex, age, late pregnancy, and lactation, were investigated...
March 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26581304/pregnancy-outcomes-in-aquaporin-4-positive-neuromyelitis-optica-spectrum-disorder
#17
Matthew M Nour, Ichiro Nakashima, Ester Coutinho, Mark Woodhall, Filipa Sousa, Jon Revis, Yoshiki Takai, Jithin George, Joanna Kitley, Maria Ernestina Santos, Joseph M Nour, Fan Cheng, Hiroshi Kuroda, Tatsuro Misu, Ana Martins-da-Silva, Gabriele C DeLuca, Angela Vincent, Jacqueline Palace, Patrick Waters, Kazuo Fujihara, Maria Isabel Leite
OBJECTIVE: To investigate the association between neuromyelitis optica spectrum disorder (NMOSD) and pregnancy outcome. METHODS: An international cohort of women with aquaporin-4 antibody-positive NMOSD and ≥1 pregnancy was studied retrospectively. Multivariate logistic regression was used to investigate whether pregnancy after NMOSD onset was associated with an increased risk of miscarriage (cohort of 40 women) or preeclampsia (cohort of 57 women). RESULTS: Miscarriage rate was higher in pregnancies after NMOSD onset (42...
January 5, 2016: Neurology
https://www.readbyqxmd.com/read/26490114/regulation-and-localization-of-vascular-endothelial-growth-factor-within-the-mammary-glands-during-the-transition-from-late-gestation-to-lactation
#18
M K VanKlompenberg, R Manjarín, C E Donovan, J F Trott, R C Hovey
The vascular network within the developing mammary gland (MG) grows in concert with the epithelium to prepare for lactation, although the mechanisms coordinating this vascular development are unresolved. Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and vascular permeability in the MG during pregnancy and lactation, where its expression is upregulated by prolactin. Given our previous finding that late-gestational hyperprolactinemia induced by domperidone (DOM) increased subsequent milk yield from gilts, we sought to establish changes in vascular development during late gestation and lactation in the MGs of these pigs and determine whether DOM altered MG angiogenesis and the factors regulating it...
January 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/26472158/toxicological-responses-of-environmental-mixtures-environmental-metal-mixtures-display-synergistic-induction-of-metal-responsive-and-oxidative-stress-genes-in-placental-cells
#19
Oluwadamilare A Adebambo, Paul D Ray, Damian Shea, Rebecca C Fry
Exposure to elevated levels of the toxic metals inorganic arsenic (iAs) and cadmium (Cd) represents a major global health problem. These metals often occur as mixtures in the environment, creating the potential for interactive or synergistic biological effects different from those observed in single exposure conditions. In the present study, environmental mixtures collected from two waste sites in China and comparable mixtures prepared in the laboratory were tested for toxicogenomic response in placental JEG-3 cells...
December 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26207951/aquaporins-and-fetal-membranes-from-diabetic-parturient-women-expression-abnormalities-and-regulation-by-insulin
#20
Damien Bouvier, Marion Rouzaire, Geoffroy Marceau, Cécile Prat, Bruno Pereira, Romain Lemarié, Philippe Deruelle, Isabelle Fajardy, Denis Gallot, Loïc Blanchon, Anne Vambergue, Vincent Sapin
CONTEXT: During pregnancy, aquaporins (AQPs) expressed in fetal membranes are essential for controlling the homeostasis of the amniotic volume, but their regulation by insulin was never explored in diabetic women. OBJECTIVE: The aim of our study was to investigate the involvement of AQPs 1, 3, 8, and 9 expressed in fetal membranes in diabetic parturient women and the control of their expression by insulin. DESIGN AND PARTICIPANTS: From 129 fetal membranes in four populations (controls, type 1, type 2 [T2D], and gestational diabetes [GD]), we established an expression AQP profile...
October 2015: Journal of Clinical Endocrinology and Metabolism
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