Farhad Shiri, Junseo Choi, Chad Vietz, Chathurika Rathnayaka, Anishkumar Manoharan, Suresh Shivanka, Guoqiang Li, Chengbin Yu, Michael C Murphy, Steven A Soper, Sunggook Park
While injection molding is becoming the fabrication modality of choice for high-scale production of microfluidic devices, especially those used for in vitro diagnostics, its translation into the growing area of nanofluidics (structures with at least one dimension <100 nm) has not been well established. Another prevailing issue with injection molding is the high startup costs and the relatively long time between device iterations making it in many cases impractical for device prototyping. We report, for the first time, functional nanofluidic devices with dimensions of critical structures below 30 nm fabricated by injection molding for the manipulation, identification, and detection of single molecules...
October 23, 2023: Lab on a Chip