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Leopoldo Staiano, Maria Antonietta De Matteis
Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI-kinases and PI-phosphatases. The number of PI metabolizing enzymes exceeds the number of PIs with, in many cases, more than one enzyme controlling the same biochemical step. This would suggest that the PI system has an intrinsic ability to buffer and compensate for the absence of a specific enzymatic activity. However, there are several examples of severe inherited human diseases caused by mutations in one of the PI-enzymes, although other enzymes with the same activity are fully functional...
October 12, 2018: Journal of Lipid Research
Eduardo Anitua, María de la Fuente, Francisco Muruzabal, Ronald Mauricio Sánchez-Ávila, Jesús Merayo-Lloves, Mikel Azkargorta, Felix Elortza, Gorka Orive
PURPOSE: The main objective of this study is to compare the protein expression of human keratocytes treated with Plasma rich in growth factors (PRGF) or autologous serum (AS) and previously induced to myofibroblast by TGF-β1 treatment. METHODS: Blood from healthy donor was collected and processed to obtain AS and PRGF eye drops. Blood derivates were aliquoted and stored at -80°C until use. Keratocyte cells were pretreated for 60 minutes with 2.5 ng/ml TGF-β1...
2018: PloS One
Paul Osterman
The American system of long-term care is disorganized and expensive. Obtaining care for a loved one is a confusing and difficult journey. When it comes to paying for that care, a bit over half who receive care are supported at least partially by insurance, and those with no insurance pay entirely out of pocket. The costs are exorbitant. What makes the system function is reliance on unpaid family members, who care for their loved ones often at considerable cost to themselves. As the baby boom generation ages, this creaky system will become increasingly dysfunctional, and a likely shortage of caregivers will be at the heart of the difficulties...
September 2018: Hastings Center Report
Yusri Yusup, John Stephen Kayode, Abbas F M Alkarkhi
Data on the micrometeorological parameters and Energy Fluxes at an intertidal zone of a Tropical Coastal Ocean was carried out on an installed eddy covariance instruments at a Muka head station in the north-western end of the Pinang Island (5°28'06''N, 100°12'01''E), Peninsula Malaysia. The vast source of the supply of energy and heat to the hydrologic and earth׳s energy cycles principally come from the oceans. The exchange of energies via air-sea interactions is crucial to the understanding of climate variability, energy, and water budget...
December 2018: Data in Brief
Karsten Hank, Giulia Cavrini, Giorgio Di Gessa, Cecilia Tomassini
Against the background of a 'new wave' of empirical studies investigating various aspects of grandparenthood across a broad range of regional contexts, this article aims to take stock of what has been achieved so far and which lessons we can learn from this for the future. Our focus is on the measurement of grandparenthood and grandparenting in quantitative social surveys and the implications this has for the substantive questions we can ask and the answers we can get out of such data. For several broader questions-who is a grandparent and when does this transition happen; what does it mean to be a grandparent; and what are the implications of grandparenthood for families?-we review previous questionnaire items from a variety of surveys as well as studies in which they were used...
September 2018: European Journal of Ageing
Luke A Schwerdtfeger, Stuart A Tobet
Methods used to study neuroendocrinology have been as diverse as the discoveries to come out of the field. Maintaining live neurons outside of a body in vitro was important from the beginning, building on methods that dated back to at least the first decade of the 20th century. Neurosecretion defines an essential foundation of neuroendocrinology based on work that began in the 1920's and 1930's. Throughout the first half of the 20th century, many paradigms arose for studying everything from single neurons to whole organs in vitro...
October 11, 2018: Journal of Neuroendocrinology
Seth Frey, Karsten Donnay, Dirk Helbing, Robert W Sumner, Maarten W Bos
Even though human behavior is largely driven by real-time feedback from others, this social complexity is underrepresented in psychological theory, largely because it is so difficult to isolate. In this work, we performed a quasi-experimental analysis of hundreds of millions of chat room messages between young people. This allowed us to reconstruct how-and on what timeline-the valence of one message affects the valence of subsequent messages by others. For the highly emotionally valenced chat messages that we focused on, we found that these messages elicited a general increase of 0...
October 10, 2018: Behavior Research Methods
John O Olawepo, Jennifer R Pharr, Axenya Kachen
Social marketing campaigns have been increasingly used in HIV prevention efforts to address barriers to HIV testing. The purpose of this review is to evaluate the social marketing campaigns in the past ten years (2008-2017) that have targeted HIV testing or intent to test as an outcome, and synthesize the results to determine which campaigns work or do not work. The search was conducted using PubMed, Scopus, PsycINFO, EMBASE, and ABI/Inform. The quality assessment tool for quantitative studies developed by the Effective Public Health Practice Project was used to assess study quality...
October 10, 2018: AIDS Care
Daria Terescenco, Geraldine Savary, Celine Picard, Florence Clemenceau, Emmanuelle Merat, Michel Grisel
The sensory perception of cosmetic emulsions is complex as it is governed by an important number of parameters like the choice of raw materials, their interactions, the structural organisation of the system, etc. The aim of the present work was to go further in the interpretation of the emollient-surfactant interactions, towards the emulsions applicative properties. For this purpose, two systems containing liquid crystals of the lamellar type were formulated, differing only in the selected emollient METHODS: First, the liquid crystals types were checked using different tools like the optical microscopy under the bright and polarized light, the wide-angle X rays diffraction and, finally, thermogravimetric analysis...
October 10, 2018: International Journal of Cosmetic Science
Karianne Oldertrøen Solli, Marjolein de Boer, Kari Nyheim Solbraekke, Lisbeth Thoresen
AIMS AND OBJECTIVES: This study aims to develop knowledge on the experiences of male partners of women with cervical cancer during and after the illness. We explore men's experiences of becoming caregivers as well as how the illness trajectory affects or has affected the relationship. BACKGROUND: Receiving a cancer diagnosis has a significant impact on the lives of both the cancer patient and their family members. However, studies of male partners' experiences with cancer patients are scarce...
October 9, 2018: Journal of Clinical Nursing
N F Benatta, D D Batouche, S Benouaz, M A Djazouli
INTRODUCTION: Infectious endocarditis (IE) is a serious disease that has continued to evolve in diagnostic and therapeutic terms. AIM: To analyze the diagnostic and out come profile. METHODS: We collected 57 (IE) cases with a definite diagnosis according to the modified Duke criteria. Patients were admitted consecutively to the Cardiology Department of the Oran university hospital from January 2011 to June 2017. Among the variables studied: clinical data, paraclinic data, therapeutic management and hospital outcome...
October 6, 2018: Annales de Cardiologie et D'angéiologie
Julien Seroussi
The International Criminal Court (ICC) investigates international crimes committed in different parts of the world. Earlier scholarly analysis of the work performed by the ICC judges has pointed out that judges often lack cultural and national understanding of the local norms and customs of regions where defendants come from. This article treats this lack of contextual knowledge displayed by the court as a case of structural ignorance rather than an aberration to be 'exposed' or censured. International lawyers indeed must ground their legal narratives with plausible sociological explanations of contextual elements to overcome their lack of familiarity with the field and the scarcity of their investigative resources...
October 9, 2018: British Journal of Sociology
Myrthe Faber, Sidney K D'Mello
What do we think about when we mind wander and where do these thoughts come from? We tested the idea that semantically rich stimuli yield patterns of mind wandering that are closely coupled with the stimuli compared to being more internally triggered. We analyzed the content of 949 self-reported zone outs (1218 thoughts) and 519 of their triggers from 88 participants who read an instructional text and watched a film for 20 min each. We found that mind wandering associated with memory retrieval was more frequent than prospection and introspection across both stimuli...
September 26, 2018: Cognitive Research: Principles and Implications
Xiuxia Ren, Ya Liu, Hai Kyoung Jeong, Byoung Ryong Jeong
Codonopsis lanceolata is widely used in traditional medicine and diets. However, there is no optimal protocol for the commercial production of C. lanceolata seedlings. This study was carried out to find the optimum supplementary light source for the production of C. lanceolata seedlings. Seedlings were grown for four weeks in a glasshouse with an average daily light intensity of 490 μmol·m-2 ·s-1 photosynthetic photon flux density (PPFD) coming from the sun and a 16-h daily supplementary lighting at 120 μmol·m-2 ·s-1 PPFD from either high-pressure sodium (HPS), metal halide (MH), far-red (FR), white LED (LED-w), or mixed (white: red: blue = 1:2:1) LEDs (LED-mix)...
October 8, 2018: International Journal of Molecular Sciences
Hugo Tavares, Annabel Whibley, David L Field, Desmond Bradley, Matthew Couchman, Lucy Copsey, Joane Elleouet, Monique Burrus, Christophe Andalo, Miaomiao Li, Qun Li, Yongbiao Xue, Alexandra B Rebocho, Nicolas H Barton, Enrico Coen
Genomes of closely-related species or populations often display localized regions of enhanced relative sequence divergence, termed genomic islands. It has been proposed that these islands arise through selective sweeps and/or barriers to gene flow. Here, we genetically dissect a genomic island that controls flower color pattern differences between two subspecies of Antirrhinum majus , A.m.striatum and A.m.pseudomajus , and relate it to clinal variation across a natural hybrid zone. We show that selective sweeps likely raised relative divergence at two tightly-linked MYB -like transcription factors, leading to distinct flower patterns in the two subspecies...
October 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
Khawar Hussain, Maria-Angeliki Gkini, Ruth Taylor, Satwinder Shinhmar, Anthony Bewley
A 57-year-old Caucasian female presented to our clinic with her 23-year-old son, who was profoundly autistic. Our patient was convinced that her son had an infestation with fibers and believed that he had developed the condition as a young child. She described the symptoms of the infestation in her son's skin on his behalf, as he was not able to communicate. She identified dietary factors as a causative factor and wanted them removed from his diet. Her son had seborrhoeic dermatitis on examination, with no evidence of an infestation...
October 8, 2018: Dermatologic Therapy
Meenakshi Gothwal, Garima Yadav, Meenakshi Rao, Pratibha Singh, Aasma Nalwa
Endometrial stromal sarcomas (ESSs) are rare malignant tumors of the uterus that arise from the endometrial stroma, the annual incidence of ESS being 1-2/million women. Patients present with nonspecific complaints of abnormal uterine bleeding, pelvic pain, and pressure symptoms. Postmenopausal women rarely present with a low-grade ESS, as it is more common in younger women. ESS is usually confused with leiomyomas radiologically. Histopathological examination and immunohistochemistry are essential for the diagnosis...
July 2018: Journal of Mid-life Health
Sembagamuthu Sembiah, Bobby Paul, Aparajita Dasgupta, Lina Bandyopadhyay
Indian health sector is a complex admixture of public and private providers, but several lacunae of public health service delivery system in terms of human resource, access, and quality have resulted in unprecedented growth of private sector. Although seamless delivery of services at rural and urban areas, timely approach, and improved information technology system are the strength of the private sector, this package comes at the cost of high out-of-pocket expenditure. Mobilization of private sector health workforce by their capacity building in terms of orientation toward public health services is one of the available solutions to move toward wider coverage of public health services...
July 2018: Indian Journal of Community Medicine
E Metsälä, K Fridell
INTRODUCTION: The aim of this article is to give an insight into radiography as a science and a discipline from the viewpoints of knowledge interest and methodological approach and design. METHODS: Original articles published in Radiography (n = 184) and the Journal of Clinical Radiography and Radiotherapy (n = 10) at the timeline 2015 to 3/2017 were reviewed for research focus and the methodology used. To abstract the results, thematisation analysis was used...
November 2018: Radiography
Olivier Sémétey, Jonathan Gaudin, Jean-Luc Danet, Pascal Salar, Sébastien Theil, Marie Fontaine, Michel Krausz, Eric Chaisse, Sandrine Eveillard, Eric Verdin, Xavier Foissac
Lavender decline compromises the French lavender production, and preliminary data have suggested the involvement of " Candidatus Phytoplasma solani" in the etiology of the disease. In order to evaluate " Ca. P. solani" epidemiological role, a three year survey was conducted in Southeastern France. " Ca. P. solani" was detected in 19 to 56 % of the declining plants, depending on seasons and cultivars, and its prevalence was correlated with symptom severity. Autumn was more favorable than spring for phytoplasma detection, and " Ca...
October 5, 2018: Applied and Environmental Microbiology
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