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Yeela Ben Naftali, Ori Samuel Duek, Ram Kalus, Marc Berns, Yaniv Zohar, Yehuda Ullmann
INTRODUCTION: Cutaneous squamous cell carcinoma (SCC) is a common skin cancer, second in incidence only to basal cell carcinoma (BCC). The incidence of SCC increases significantly with age; thus, it is rarely diagnosed in young patients. In this paper, we present two cases of young patients who presented clinically with purulent lesions that were later diagnosed as large primary SCCs. MATERIALS AND METHODS: A review of the medical records of two patients who were admitted to the department of plastic surgery with a final clinical diagnosis of cutaneous SCC was conducted...
August 8, 2018: International Journal of Surgery Case Reports
John Daniel A Ramos, Elleen L Cunanan, Lauro L Abrahan, Marc Denver A Tiongson, Felix Eduardo R Punzalan
Background: Symptoms of mitral stenosis (MS) are worsened during tachycardia and exercise. Beta-blockers are used in controlling heart rate (HR) in MS, resulting in symptom improvement, but coming with significant side effects. Ivabradine has a selective action on the sinus node devoid of the usual side effects of beta-blockers. Small studies have recently investigated the role of ivabradine in MS in sinus rhythm. Our aim was to determine the efficacy of ivabradine, compared to beta-blockers, in terms of exercise duration, maximum HR achieved, resting HR, mean gradient, and working capacity among patients with MS in sinus rhythm...
August 2018: Cardiology Research
Chen Tian, Yue-Yang Li, Dong-Zhi Hu
Although the application of combined chemotherapy has made a great progress in treatment of adult acute myeloid leukemia (AML), the overall survival rate is still not high, mainly because of high recurrence rate and drug resistance. The treatment regimen for relapsed/refractory AML is always strong. Due to the chemotherapy drugs lacking of specific identification of tumor cells, significant adverse reactions often come out and sometimes even endanger the life of patients. In order to improve the life quality and survival rate, the new treatment strategy is urgently needed...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Christian Jagsch, Alex Hofer
BACKGROUND: The number of people with diseases of the schizophrenia spectrum in old age will increase significantly in the coming years. In the literature the topics of schizophrenia and delusional disorders in older and old people are inadequately represented. AIM: This article gives an overview of the most important diagnostic and differential diagnostic characteristics. Another important aspect is the pharmacological and non-pharmacological treatment options in old age...
August 14, 2018: Zeitschrift Für Gerontologie und Geriatrie
Florian Sévellec, Sybren S Drijfhout
In a changing climate, there is an ever-increasing societal demand for accurate and reliable interannual predictions. Accurate and reliable interannual predictions of global temperatures are key for determining the regional climate change impacts that scale with global temperature, such as precipitation extremes, severe droughts, or intense hurricane activity, for instance. However, the chaotic nature of the climate system limits prediction accuracy on such timescales. Here we develop a novel method to predict global-mean surface air temperature and sea surface temperature, based on transfer operators, which allows, by-design, probabilistic forecasts...
August 14, 2018: Nature Communications
S Mellinger, D Dias, N Flores, A Palavecino, G Vigo, D Burgos, F Tomas, I Rollan, G Herrera, J Floridia, C Furlan, F Frissia, A Aleman, J Perez Frías, J Casali, M Burgos
INTRODUCTION: Multiple Sclerosis (MS) is one of the leading causes of disability in young adults. Its prevalence varies according to different countries. In Argentina there is a wide heterogeneity regarding data published in different areas of the country. Prevalence established in most studies is 17 cases per 100,000 inhabitants; however, most of the available data comes from studies that took place in Buenos Aires. There is little or no information from other provinces, especially from Northwest of Argentina (NOA), where there are no studies of the disease prevalence...
July 31, 2018: Multiple Sclerosis and related Disorders
Mohammad Akhtar Hussain, Judith M Katzenellenbogen, Frank M Sanfilippo, Kevin Murray, Sandra C Thompson
BACKGROUND: Hospitalisation for atherothrombotic disease (ATD) is expected to rise in coming decades. However, increasingly, associated comorbidities impose challenges in managing patients and deciding appropriate secondary prevention. We investigated the prevalence and pattern of multimorbidity (presence of two or more chronic conditions) in Aboriginal and non-Aboriginal Western Australian residents with ATDs. METHODS AND FINDINGS: We used population-based de-identified linked administrative health data from 1 January 2000 to 30 June 2014 to identify a cohort of patients aged 25-59 years admitted to Western Australian hospitals with a discharge diagnosis of ATD...
2018: PloS One
Maria Magdalena Buijs, Mohammed Hossain Ramezani, Jürgen Herp, Rasmus Kroijer, Morten Kobaek-Larsen, Gunnar Baatrup, Esmaeil S Nadimi
Background and study aims:  The aim of this study was to develop a machine learning-based model to classify bowel cleansing quality and to test this model in comparison to a pixel analysis model and assessments by four colon capsule endoscopy (CCE) readers. Methods:  A pixel analysis and a machine learning-based model with four cleanliness classes (unacceptable, poor, fair and good) were developed to classify CCE videos. Cleansing assessments by four CCE readers in 41 videos from a previous study were compared to the results both models yielded in this pilot study...
August 2018: Endoscopy International Open
Claire Friedemann Smith, Alice C Tompson, Nicholas Jones, Josh Brewin, Elizabeth A Spencer, Clare R Bankhead, Fd Richard Hobbs, Brian D Nicholson
BACKGROUND: Direct access (DA) testing allows GPs to refer patients for investigation without consulting a specialist. The aim is to reduce waiting time for investigations and unnecessary appointments, enabling treatment to begin without delay. AIM: To establish the proportion of patients diagnosed with cancer and other diseases through DA testing, time to diagnosis, and suitability of DA investigations. DESIGN AND SETTING: Systematic review assessing the effectiveness of GP DA testing in adults...
August 13, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Sara Hernández Sánchez, Rubén Fernández Pozo, Luis A Hernández Gómez
Characterization of driving maneuvers or driving styles through motion sensors has become a field of great interest. Before now, this characterization used to be carried out with signals coming from extra equipment installed inside the vehicle, such as On-Board Diagnostic (OBD) devices or sensors in pedals. Nowadays, with the evolution and scope of smartphones, these have become the devices for recording mobile signals in many driving characterization applications. Normally multiple available sensors are used, such as accelerometers, gyroscopes, magnetometers or the Global Positioning System (GPS)...
August 10, 2018: Sensors
Md Sakhawat Hossain, Amresh Kumar, A F M Akhtar Hossain, Md Mahshin, Abhijit Sharma, Md Akter Hossain, Varun Sharma, Rashidul Haque, A K M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal
BACKGROUND: Adverse effects of antileishmanial drugs can affect patients' quality of life and adherence to therapy for visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL). In Bangladesh, there are 26 treatment centers that manage leishmaniasis cases coming from 100 endemic upazilas (subdistricts) of 26 districts (these include VL, PKDL, treatment failure, and relapse VL and cutaneous leishmaniasis cases). This study aimed to investigate the feasibility of using focused pharmacovigilance for VL (VLPV) in Bangladesh's National Kala-azar Elimination Programme for the early detection and prevention of expected and unexpected adverse drug reactions (ADRs)...
August 13, 2018: Infectious Diseases of Poverty
Manuel Lozano, Lara Manyes, Juanjo Peiró, Francisco Montes
OBJECTIVE: The aim of this study was to identify the most relevant variables defining the dietary, social, and health patterns of elderly populations with disabilities, considering their geographic profile. METHODS: A cross-sectional study was carried out in a sample of 354 disabled, free-living elderly adults from three different geographic profiles (metropolitan, rural, and mixed profile). The dietary data were obtained through a validated food habit questionnaire...
June 19, 2018: Nutrition
Charlotte J Green, Siôn A Parry, Pippa J Gunn, Carlo D L Ceresa, Fredrik Rosqvist, Marie-Eve Piché, Leanne Hodson
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own specific caveats. Here, we review the human-based models and discuss their advantages and limitations in regards to studying the development and progression of NAFLD. Overall, in vivo whole-body human studies are advantageous in that they allow for investigation within the physiological setting, however, limited accessibility to the liver makes direct investigations challenging...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
S C Nwanya, C A Mgbemene, C C Ezeoke, O C Iloeje
Gas pipeline vandalism is a huge threat factor to steady electricity generation and energy materials flow in the power sector of Nigeria. It imposes huge cost of risk to that sector. Due to incessant pipeline vandalism, power availability is subject to elements of chance and with undesired out comes that adversely impact on power generation value chain. To this end, this study seeks to develop a model for estimating the cost of risk to a power generation company (Genco) and calculating plant unavailability indices by applying the dispersion technique...
July 2018: Heliyon
Elizabeth M Lawrence, Robert A Hummer, Benjamin W Domingue, Kathleen Mullan Harris
Widening educational differences in overall health and recent stagnation in cardiovascular disease mortality rates highlight the critical need to describe and understand educational disparities in cardiovascular health (CVH) among U.S. young adults. We use two data sets representative of the U.S. population to examine educational disparities in CVH among young adults (24-34) coming of age in the 21st century: the National Health and Nutrition Examination Survey (2005-2010; N= 689) and the National Longitudinal Study of Adolescent to Adult Health (2007-2008; N=11,200)...
August 2018: SSM—Population Health
André Vicente Guimarães, Rogério Aparecido Dedivitis, Leandro Luongo Matos, Felipe Toyama Aires, Claudio Roberto Cernea
A therapeutic decision in the treatment of Tis/T1a glottic carcinoma with radiotherapy (RT) or transoral laser surgery (TOS) is still an open issue. Oncologic outcome and voice quality may support the choice for the latter To conduct a systematic review and meta-analysis to compare oncologic and functional outcomes of TOS and RT as treatment options for Tis/T1a glottic cancer. Literature research on online databases was carried out. Potentially eligible articles were reviewed. Relevant articles were selected and evaluated...
August 9, 2018: Scientific Reports
Ali Hassan A Ali, Sameer Al-Ghamdi, Mohammed H Karrar, Saud A Alajmi, Osama S Almutairi, Ahmed M Aldalbahi, Yazeed M Alotaibi, Sattam A Alruwaili, Abubaker Y Elamin
Introduction: Headache disorders are one of the most prevalent global public-health problems that require placing high demand on health-care Services. Since it is one of the most frequent complaints in clinical practice worldwide, it causes a considerable burden in terms of the social cost. The study aimed to give a guide for the decision on the utilization of computed tomography (CT) in the diagnostic workup and identify if patients require neurological imaging (CT) for proper diagnosis or not...
March 2018: Journal of Family Medicine and Primary Care
Ellen A Schmid, Armin Pircher Verdorfer, Claudia V Peus
Destructive leadership comes in many shapes and forms. From reviewing the literature, we conclude that three major forms of destructive leader behaviors are described: (1) follower-directed destructive behaviors, i.e., genuine abusive forms of destructive leadership, (2) organization-directed behaviors, i.e., behaviors such as stealing from the organization or embezzlement, and (3) self-interested destructive leader behavior, i.e., leader who exploit others to reach their goals. One can easily imagine that these three types of leader behavior have very different effects on followers...
2018: Frontiers in Psychology
Vijayanth Kanagaraju, P K Karthik Yelamarthy, Harvinder Singh Chhabra, Ajoy Prasad Shetty, Ankur Nanda, Gururaj M Sangondimath, Kali Dutta Das, Murari Lal Bansal, Bibhudendu Mohapatra, Nishit Patel, Rainer Abel, Sagun Tuli, Tarsissio Barros, Vikas Tandon
STUDY DESIGN: A psychometrics study. OBJECTIVES: To determine intra and inter-observer reliability of Allen Ferguson system (AF) and sub-axial injury classification and severity scale (SLIC), two sub axial cervical spine injury (SACI) classification systems. SETTING: Online multi-national study METHODS: Clinico-radiological data of 34 random patients with traumatic SACI were distributed as power point presentations to 13 spine surgeons of the Spine Trauma Study Group of ISCoS from seven different institutions...
August 8, 2018: Spinal Cord
V Kocevski
Despite the known temperature effects on the optical and photoluminescence properties of silicon nanocrystals (Si NCs), most of the density functional theory calculations thus far have been carried out at zero temperature, i.e., fixed atomic positions. We present a study of the effect of finite temperature on the radiative lifetimes and bandgaps of Si NCs capped with six different organic ligands, CH3 , C2 H5 , C2 H4 Cl, C2 H4 OH, C2 H4 SH, and C2 H4 NH2 . In addition, we show the differences in electronic and optical properties, as well as the wavefunctions (WFs) around the bandgap, of the capped Si NCs at zero temperature...
August 7, 2018: Journal of Chemical Physics
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