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cholangiocarcinoma and hilar

Zhaobo Liu, Yunjin Zang, Xinxin Wang, Ning Li, Dongdong Lin
RATIONALE: Primary mucosa-associated lymphoid tissue (MALT) lymphomas rarely originate in the hilar bile duct. Preoperative diagnosis of a primary MALT lymphoma of the hilar bile duct is difficult owing to the rarity of this disease. Differentiating between obstructive jaundice caused by MALT lymphoma of the hilar bile duct and hilar cholangiocarcinoma (the most common form of bile duct cancer) is challenging. PATIENT CONCERNS: A 57-year-old man presented to our hospital in August 2012 with fluctuant obstructive jaundice...
October 2018: Medicine (Baltimore)
Florence K Keane, Andrew X Zhu, Theodore S Hong
Biliary tract cancers (BTCs), including intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder cancers, are a heterogeneous cohort of tumors that tend to present with advanced stage and with high rates of recurrence after surgical resection. While liver-directed radiotherapy was traditionally restricted to the palliative setting given concerns over hepatotoxicity, modern radiotherapy techniques have enabled safe and effective treatment of a variety of hepatic tumors, thereby expanding the role of liver-directed radiotherapy in the management of BTCs...
October 2018: Seminars in Radiation Oncology
Volkan Öter, İlter Özer, Tahsin Dalgıç, Cemil Binarbaşı, Murat Ulaş, Erdal Birol Bostancı
BACKGROUND/AIMS: Hilar cholangiocarcinoma (HC) is a tumor that invades the confluence of the left and right hepatic bile ducts. Surgery is the definitive treatment but is also technically demanding. Here, we report our experience on 42 patients who underwent surgical resection for HC. The aim of the present study was to evaluate the margin status of resected specimens on frozen sections and the impact of R1 resection margin on survival. MATERIALS AND METHODS: A total of 42 patients with HC who underwent surgical resection in our clinic between January 2008 and January 2017 were included in the study...
October 9, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Nicholas Bird, Adrian McKenna, Declan Dunne, Ben Francis, Stephen Fenwick, Graeme Poston, Robert Jones, Hassan Malik
AIMS: Cholangiocarcinoma is a rare cancer arising from the biliary tree. Case series indicate that 25-40% of all borderline resectable primary tumours are potentially resectable. The Memorial Sloane Kettering System (MSKCC) stratifies patients for resectability by longitudinal and radial extension of the hilar tumour. The Bismuth-Corlette system describes the longitudinal extension of the tumour within the biliary duct system. We sought to validate and, if possible, augment these two scores within an independent validation cohort...
September 11, 2018: European Journal of Surgical Oncology
Fabio Bagante, Timothy M Pawlik
No abstract text is available yet for this article.
October 4, 2018: Annals of Surgical Oncology
Hai-Ping Zhao, Zheng-Hua Zhang, Ai-Hong Zheng
The clinical significance of palliative interventional therapy in the management of patients with advanced hilar cholangiocarcinoma (HCCA; stages III-IV) has yet to be studied. The present work was aimed to compare the clinical outcomes of the patients treated with surgery or interventional therapy.A total of 90 patients with advanced HCCA, who admitted Fuyang First People's Hospital from May 2015 to February 2016, were enrolled. Forty-five of them were assigned to the experimental group receiving biliary drainage as the interventional therapy, and the remaining 45 patients were designated as the conventional group receiving radical/palliative surgery...
September 2018: Medicine (Baltimore)
Yuichi Goto, Satoki Kojima, Yoriko Nomura, Daisuke Muroya, Syoichiro Arai, Hisamune Sakai, Ryuichi Kawahara, Toru Hisaka, Yoshito Akagi, Hiroyuki Tanaka, Koji Okuda
BACKGROUND: We experienced a rare case of benign arterial stricture of the right posterior hepatic artery (RPHA) caused by atherosclerosis in a patient with hilar cholangiocarcinoma. CASE PRESENTATION: A 75-year-old man was referred to our hospital for the detailed investigation of serum hepatobiliary enzyme elevation. The patient had a history of hypertension, type 2 diabetes mellitus, and an operative history of coronary artery bypass grafting 10 years before...
September 24, 2018: BMC Surgery
Ji-Qiao Zhu, Qiang He, Xian-Liang Li
No abstract text is available yet for this article.
September 13, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Jian Shi, Xiaohua Li, Fan Zhang, Linqun Kong, Xingyuan Zhang, Yu Cheng, Qinghai Guan, Xuefeng Cao, Wentao Zhu, Kun Ou, Qiangpu Chen, Sanyuan Hu
BACKGROUND & AIMS: Current studies have indicated that long non-coding RNAs (lncRNAs) could act as tumor biomarkers for disease diagnosis and prognosis prediction. In this study, we mainly focused on determining the expression of circulating lncRNAs in patients suffering for hilar cholangiocarcinoma (HC), aiming to reveal the potential lncRNA as a fingerprint. METHODS: A total 12 lncRNAs were previously proven to be aberrantly expressed in HC tumor tissues. All of the 12 lncRNAs were selected as candidate targets for subsequent circulating lncRNA assay...
2018: Cellular Physiology and Biochemistry
Nozha Toumi, Hanene Abid, Salah Henchir, Houssem Harbi, Nejmeddine Affes, Khaireddine Ben Mahfoudh
Magnetic resonance cholangiopancreatography is a non-invasive imaging, highly performant in detecting and locating biliary stenosis and in predicting its malignancy. The combination of two and three-dimensional MRI sequences is recommended to assess a biliary obstacle. Cholangiopathies are the main differential diagnosis of cholangiocarcinomas. In addition to bile duct abnormalities beyond the stenosis, the predictive signs of malignancy are: asymmetric irregular luminal narrowing (longer than 3mm and thicker than 13mm), abrupt discontinuation of stenosis, and enhancement superior to that of the adjacent hepatic parenchyma during arterial and portal acquisitions...
September 14, 2018: La Presse Médicale
Wen-Jie Ma, Zhen-Ru Wu, Anuj Shrestha, Qin Yang, Hai-Jie Hu, Jun-Ke Wang, Fei Liu, Rong-Xing Zhou, Quan-Sheng Li, Fu-Yu Li
Background: The survival benefits of additional resection of the positive proximal ductal margin (PM) in hilar cholangiocarcinoma (HCCA) remains controversial. This retrospective study investigated the effectiveness of additional resection of the invasive cancer PM under different levels of preoperative carbohydrate antigen 19-9 (CA19-9). Methods: Patients who underwent hepatectomy for HCCA from 2000 to 2017 were analyzed. Surgical variables, resection margin status, length of the PM (LPM), prognostic factors, and survival were evaluated...
August 2018: Hepatobiliary Surgery and Nutrition
J Lu, X-Z Xiong, N-S Cheng
No abstract text is available yet for this article.
September 14, 2018: Journal of Gastroenterology and Hepatology
Darren Chua, Albert Low, Yexin Koh, Brian Goh, Peng Chung Cheow, Juinn Har Kam, Jin Yao Teo, Ek Khoon Tan, Alexander Chung, London Lucien Ooi, Chung Yip Chan, Ser Yee Lee
Backgrounds/Aims: Hilar cholangiocarcinomas (HCCAs) are tumors that involve the biliary confluence; at present, radical surgery offers the only chance of long-term survival, but this can be challenging given the complexity of the hilar anatomy. Blumgart and Jarnagin described a preoperative staging system that incorporates the effect of local tumor extent and its impact on adjacent structures and that has been demonstrated to correlate better with actual surgical resectability. The primary aim of this study is to describe the correlation between preoperative Blumgart-Jarnagin staging and its correlation with surgical resectability...
August 2018: Annals of Hepato-Biliary-Pancreatic Surgery
Naokazu Chiba, Yuta Abe, Kei Yokozuka, Kosuke Hikita, Toshimichi Kobayashi, Toru Sano, Koichi Tomita, Rina Tsutsui, Shigeyuki Kawachi
BACKGROUND: The combination of major hepatectomy and pancreatoduodenectomy (PD), that is, a hepatopancreatoduodenectomy (HPD), is the only curative treatment for bile duct cancer with extensive horizontal tumor spread invading both the hepatic hilum and the intrapancreatic bile duct. However, this aggressive procedure remains controversial with regard to the balance between the survival benefit and high risk of mortality and morbidity, especially the risk for postoperative hepatic failure and postoperative pancreatic fistula...
September 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Zhe Kong, Jian-Jun Hu, Xin-Lan Ge, Ke Pan, Chong-Hui Li, Jia-Hong Dong
In certain cases, major hepatectomy is essential and inevitable in patients with hilar cholangiocarcinoma and obstructive jaundice (OJ). The current study was designed to evaluate effects of a novel method of portal blood occlusion, where the portal vein was occluded (OPV) and the hepatic artery flow was preserved in rats with OJ that underwent partial hepatectomy. OJ was induced in rats by ligation of the common bile duct for 7 days. Subsequently, OJ rats underwent hepatectomy removing 76% of the liver following occlusion of the portal triad (OPT), OPV or without portal blood occlusion...
September 2018: Experimental and Therapeutic Medicine
Thomas Resch, Hannah Esser, Benno Cardini, Benedikt Schaefer, Heinz Zoller, Stefan Schneeberger
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
Masanori Kobayashi, Shomei Ryozawa, Ryuichiro Araki, Koji Nagata, Yuki Tanisaka, Akashi Fujita, Tsutomu Kobatake
Objectives While bile duct brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) is a well-established procedure for detecting malignant biliary stricture, its sensitivity is reportedly low. We aimed to determine the pre-ERCP factors affecting brush cytology sensitivity. Methods We retrospectively analyzed 185 patients who underwent brush cytology during the first ERCP for undiagnosed biliary stricture at our institution between January 2014 and December 2016. We analyzed the relationship of age, sex, final diagnosis, stricture location, tumor size, stricture length, total bilirubin level, white blood cell count, and C-reactive protein level with brush cytology sensitivity...
August 24, 2018: Internal Medicine
Yudong Wang, Wenkang Fu, Zengwei Tang, Wenbo Meng, Wence Zhou, Xun Li
BACKGROUND: The aim of this study was to compare the clinical outcomes between patients with preoperative cholangitis and noncholangitis patients to determine whether the preoperative cholangitis would be able to serve as an independent predictive factor on hilar cholangiocarcinoma (HCC) outcomes. METHODS: A systematic literature search for reported preoperative cholangitis in patients with hilar cholangiocarcinoma was performed in 4 databases: PubMed, Web of Science, Embase, and the Cochrane Library, published from 1979 to 2017...
August 2018: Medicine (Baltimore)
Hai-Jie Hu, Zhen-Ru Wu, Yan-Wen Jin, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Fei Liu, Fu-Yu Li
BACKGROUND: Hilar cholangiocarcinoma (HCCA) occurs in the core section of the biliary system and has a strong tendency to broadly invade the surrounding vascular system, perineural tissue and major liver parenchyma. Thus, minimally invasive resection can only be achieved in limited cases. This article reviews the current laparoscopic and robotic surgery techniques for HCCA and analyses the difficulties and limitations of the current minimally invasive surgical techniques for HCCA. METHODS: A systematic literature search was conducted using multiple electronic databases...
August 22, 2018: ANZ Journal of Surgery
Yu A Kovalenko, V A Vishnevsky, A V Chzhao, Yu O Zharikov
AIM: To develop new criteria of radical surgery for hilar cholangiocarcinoma (HCC). MATERIAL AND METHODS: There were 165 HCC patients who underwent surgery in 1986-2016 at the Vishnevsky Institute of Surgery. TNM stage distribution: stage I - 4 (2.4%), II - 45 (27.3%) (29 of them are referred to the 1st period of work), IIIA - 23 (13.9%), IIIB - 41 (24.8%), IVA - 35 (21.2%), IVB - 17 (10.3%). 80 (48%) patients underwent hemihepatectomy, 17 (10%) - advanced hemihepatectomy, 16 (10%) - minor liver resection with common bile duct repair, 52 (32%) - common bile duct repair resection...
2018: Khirurgiia
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