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cholangiocarcinoma and hilar

Ryusei Matsuyama, Daisuke Morioka, Ryutaro Mori, Yasuhiro Yabushita, Seigo Hiratani, Yohei Ota, Takafumi Kumamoto, Itaru Endo
BACKGROUND: The concept of "borderline resectable" was recently introduced to the field of surgery for pancreatic cancer, and surgical outcomes for this disease with extremely dismal prognosis have improved since the introduction of this concept. However, no such concept has yet been introduced to the field of surgery for hilar cholangiocarcinoma (HCca). AIM: To determine a definition and criteria for "borderline resectable" in the field of surgery for HCca...
December 7, 2018: World Journal of Surgery
Yu A Kovalenko, Yu O Zharikov, I A Kukeev, V A Vishnevsky, A V Chzhao
AIM: To determine significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma. MATERIAL AND METHODS: Analysis included 49 out of 84 patients who were operated at the Vishnevsky Institute of Surgery in 2003-2016. Morphological examination (2011-2016) revealed great percentage of following positive variables: micro- (42.9%) and lymphovascular invasion (11.8%), positive resection margin (59.2%), perineural invasion (83.3%), depth of invasion - (83...
2018: Khirurgiia
Ryusei Yamamoto, Yasuji Mokuno, Hideo Matsubara, Hirokazu Kaneko, Yozo Sato, Shinsuke Iyomasa
BACKGROUND: Chylothorax is the accumulation of chyle within the pleural space. Chylothorax can occur as a complication after multiple different types of surgery, most frequently after thoracic surgery, albeit with an incidence rate of less than 1%. Chylothorax after abdominal surgery is extremely rare, and there are only a few case reports. CASE PRESENTATION: A 74-year-old Japanese woman presented with jaundice. She was diagnosed as having hilar cholangiocarcinoma and underwent right hepatectomy, caudate lobectomy, extrahepatic bile duct resection, and lymph node dissection after preoperative percutaneous transhepatic portal vein embolization...
November 26, 2018: Journal of Medical Case Reports
Ming-Liang Wang, Zhang-Yan Ke, Shuai Yin, Chen-Hai Liu, Qiang Huang
BACKGROUND: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative adjuvant chemotherapy for resectable cholangiocarcinoma. DATA SOURCES: Relevant research articles published before 1st March 2018 in PubMed, Embase and the Cochrane library databases were retrieved. Published data were extracted and analyzed by RevMan 5...
November 14, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Sven Jonas, Felix Krenzien, Georgi Atanasov, Hans-Michael Hau, Matthias Gawlitza, Michael Moche, Georg Wiltberger, Johann Pratschke, Moritz Schmelzle
Background: A right trisectionectomy with portal vein resection represents the conventional approach for hilar cholangiocarcinoma. Here, we present a technical modification of hilar en bloc resection in order to increase the remnant volume by partially preserving liver segment 4. Methods: The caudal parenchymal dissection line starts centrally between the left lateral and left medial segments. Cranially, the resection line switches to the right towards Cantlie's line and turns again upwards perpendicularly...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
Claudio F Feo, Giorgio C Ginesu, Michele Barmina, Antonio Pinna, Antonio M Scanu, Maria L Cossu, Alessandro Fancellu, Alberto Porcu
No abstract text is available yet for this article.
January 1, 2018: American Surgeon
Claudio F Feo, Giorgio C Ginesu, Michele Barmina, Antonio Pinna, Antonio M Scanu, Maria L Cossu, Alessandro Fancellu, Alberto Porcu
No abstract text is available yet for this article.
January 1, 2018: American Surgeon
Atsushi Nanashima, Naoya Imamura, Masahide Hiyoshi, Koichi Yano, Takeomi Hamada, Teru Chiyotanda, Kenzo Nagatomo, Rouko Hamada, Hiroshi Ito
INTRODUCTION: The present case report demonstrated the successfully radical operation (R0) for the highly advanced cholangiocarcinoma involving hilar hepatic arteries and portal vein, The careful preoperative diagnosis to define the adequate resection area and the expert operation was achieved without postoperative severe complications. PRESENTATION OF CASE: A 55-year-old male was admitted to our hospital with obstructive jaundice, and the perihilar cholangiocarcinoma (PC) was found...
October 25, 2018: International Journal of Surgery Case Reports
Takehiro Noji, Satoshi Hirano, Takahiro Tsuchikawa, Keisuke Okamura, Toru Nakamura, Toshimichi Asano, Yoshitsugu Nakanishi, Kimitaka Tanaka
No abstract text is available yet for this article.
October 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Ichiro Onishi, Masato Kayahara, Ryohei Takei, Naoki Makita, Masayoshi Munemoto, Yasumichi Yagi, Atsuhiro Kawashima
BACKGROUND: Most colorectal cancer liver metastases form nodules within the hepatic parenchyma, and hepatectomy is the only radical treatment for synchronous metastases. There is concern about intrabiliary tumor growth which may affect the surgical margin, resulting in local recurrence after hepatectomy for colorectal cancer liver metastasis; however, there has been no report of the dissemination in the bile duct after hepatectomy. Here, we report an unusual case of biliary dissemination of colorectal cancer that caused recurrent intrabiliary growth after hepatectomy, and discuss the management of intrabiliary metastasis of colorectal cancer...
October 27, 2018: Journal of Medical Case Reports
Stefan Stremitzer, Robert P Jones, Leonard M Quinn, Stephen W Fenwick, Rafael Diaz-Nieto, Graeme J Poston, Hassan Z Malik
BACKGROUND: Liver transplantation in patients with unresectable early-stage (<3 cm, node negative) hilar cholangiocarcinoma has been recently reported to be associated with longer survival compared to liver resection and therefore suggested as potential treatment option also in resectable disease. Here, we investigated the outcome of resection in early-stage tumours as the standard of care in an experienced European centre. METHODS: Patients with de novo resectable hilar cholangiocarcinomas who underwent liver resection between mid-2009 and December 2017 were classified as early-stage (<3 cm and node negative) or later-stage tumours (≥3 cm and/or node positive), and were investigated with respect to clinical outcome...
October 16, 2018: European Journal of Surgical Oncology
Meredith E Pittman, Andrea S Kierans, Deepthi Rao, Rhonda K Yantiss, Benjamin Samstein, Jose Jessurun
Objectives: Portal cavernoma cholangiopathy (formerly portal biliopathy) is a type of biliary injury that occurs in association with a portal vein thrombus or cavernoma. Although the radiographic features of portal cavernoma cholangiopathy have been enumerated in the literature, its histologic features have not been described in detail. Methods: We describe the histologic findings in liver specimens from three patients with radiologically confirmed portal cavernoma cholangiopathy...
October 24, 2018: American Journal of Clinical Pathology
Mariko Tanaka, Junji Shibahara, Shumpei Ishikawa, Tetsuo Ushiku, Teppei Morikawa, Aya Shinozaki-Ushiku, Akimasa Hayashi, Kento Misumi, Atsushi Tanaka, Hiroto Katoh, Kei Sakuma, Takashi Kokudo, Yoshinori Inagaki, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Masashi Fukayama
Ecotropic virus integration site 1 protein homolog (EVI1), a well-known oncogenic transcriptional factor of hematopoietic cells, contributes to pancreatic cancer oncogenicity through increased expression of KRAS. Because EVI1 was upregulated in cholangiocarcinoma by referring The Cancer Genome Atlas, we investigated the importance of EVI1 in intrahepatic cholangiocarcinoma (ICC) which has been regarded as a heterogeneous group of cancers. Immunohistochemical analysis results demonstrated that EVI1 was overexpressed in about half of ICC (53/101, 52...
October 23, 2018: Virchows Archiv: An International Journal of Pathology
Zhaobo Liu, Yunjin Zang, Xinxin Wang, Ning Li, Dongdong Lin
RATIONALE: Primary mucosa-associated lymphoid tissue (MALT) lymphomas rarely originate in the hilar bile duct. Preoperative diagnosis of a primary MALT lymphoma of the hilar bile duct is difficult owing to the rarity of this disease. Differentiating between obstructive jaundice caused by MALT lymphoma of the hilar bile duct and hilar cholangiocarcinoma (the most common form of bile duct cancer) is challenging. PATIENT CONCERNS: A 57-year-old man presented to our hospital in August 2012 with fluctuant obstructive jaundice...
October 2018: Medicine (Baltimore)
Florence K Keane, Andrew X Zhu, Theodore S Hong
Biliary tract cancers (BTCs), including intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder cancers, are a heterogeneous cohort of tumors that tend to present with advanced stage and with high rates of recurrence after surgical resection. While liver-directed radiotherapy was traditionally restricted to the palliative setting given concerns over hepatotoxicity, modern radiotherapy techniques have enabled safe and effective treatment of a variety of hepatic tumors, thereby expanding the role of liver-directed radiotherapy in the management of BTCs...
October 2018: Seminars in Radiation Oncology
Volkan Öter, İlter Özer, Tahsin Dalgıç, Cemil Binarbaşı, Murat Ulaş, Erdal Birol Bostancı
BACKGROUND/AIMS: Hilar cholangiocarcinoma (HC) is a tumor that invades the confluence of the left and right hepatic bile ducts. Surgery is the definitive treatment but is also technically demanding. Here, we report our experience on 42 patients who underwent surgical resection for HC. The aim of the present study was to evaluate the margin status of resected specimens on frozen sections and the impact of R1 resection margin on survival. MATERIALS AND METHODS: A total of 42 patients with HC who underwent surgical resection in our clinic between January 2008 and January 2017 were included in the study...
October 9, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Nicholas Bird, Adrian McKenna, Declan Dunne, Ben Francis, Stephen Fenwick, Graeme Poston, Robert Jones, Hassan Malik
AIMS: Cholangiocarcinoma is a rare cancer arising from the biliary tree. Case series indicate that 25-40% of all borderline resectable primary tumours are potentially resectable. The Memorial Sloane Kettering System (MSKCC) stratifies patients for resectability by longitudinal and radial extension of the hilar tumour. The Bismuth-Corlette system describes the longitudinal extension of the tumour within the biliary duct system. We sought to validate and, if possible, augment these two scores within an independent validation cohort...
September 11, 2018: European Journal of Surgical Oncology
Fabio Bagante, Timothy M Pawlik
No abstract text is available yet for this article.
October 4, 2018: Annals of Surgical Oncology
Hai-Ping Zhao, Zheng-Hua Zhang, Ai-Hong Zheng
The clinical significance of palliative interventional therapy in the management of patients with advanced hilar cholangiocarcinoma (HCCA; stages III-IV) has yet to be studied. The present work was aimed to compare the clinical outcomes of the patients treated with surgery or interventional therapy.A total of 90 patients with advanced HCCA, who admitted Fuyang First People's Hospital from May 2015 to February 2016, were enrolled. Forty-five of them were assigned to the experimental group receiving biliary drainage as the interventional therapy, and the remaining 45 patients were designated as the conventional group receiving radical/palliative surgery...
September 2018: Medicine (Baltimore)
Yuichi Goto, Satoki Kojima, Yoriko Nomura, Daisuke Muroya, Syoichiro Arai, Hisamune Sakai, Ryuichi Kawahara, Toru Hisaka, Yoshito Akagi, Hiroyuki Tanaka, Koji Okuda
BACKGROUND: We experienced a rare case of benign arterial stricture of the right posterior hepatic artery (RPHA) caused by atherosclerosis in a patient with hilar cholangiocarcinoma. CASE PRESENTATION: A 75-year-old man was referred to our hospital for the detailed investigation of serum hepatobiliary enzyme elevation. The patient had a history of hypertension, type 2 diabetes mellitus, and an operative history of coronary artery bypass grafting 10 years before...
September 24, 2018: BMC Surgery
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