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https://www.readbyqxmd.com/read/30336216/pretransplant-angiotensin-ii-type-1-receptor-antibodies-point-to-an-increase-in-renal-graft-sub-intimal-fibrosis-in-living-donor-kidney-transplant-recipients
#1
Alberto González-Almada, José M Arreola-Guerra, José Argenis López-Sánchez, Eric Cuevas, Mario Vilatoba, Alan G Contreras, Luis E Morales-Buenrostro, Josefina Alberu, Norma O Uribe-Uribe
The association between anti-AT1Rabs and microvascular injury observed in antibody-mediated rejection has been described in kidney graft Biopsies (KGBx). METHODS: We herein describe the histopathologic findings of KGBx performed during the first year of transplantation (Tx) in 134 patients tested for pre-Tx anti-AT1Rabs in cryopreserved sera (04/2009 to 09/2013). Protocol KGBx before implantation (time-zero), 1 year after Tx and for cause KGBx were included. 21/134 Tx patients were anti-AT1Rab positive (≥17 U/mL); 7/21 experienced acute rejection...
October 15, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/30325212/moral-reasoning-and-decision-making-in-adolescents-who-sustain-traumatic-brain-injury
#2
M H Beauchamp, E Vera-Estay, F Morasse, V Anderson, J Dooley
OBJECTIVE: Emerging evidence suggests that moral processes are disrupted by traumatic brain injury (TBI). The objective of this study was to explore moral reasoning (MR) and decision-making in adolescents with TBI, and to examine potential associations with global manifestations of social competence. DESIGN: This retrospective, cross-sectional research design compared MR and decision-making in adolescents with mild TBI (n = 20), moderate-severe TBI (n = 23) and typically developing controls (n = 93)...
October 16, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/30316913/too-many-patients%C3%A2-a-framework-to-guide-statewide-allocation-of-scarce-mechanical-ventilation-during-disasters
#3
REVIEW
Elizabeth Lee Daugherty Biddison, Ruth Faden, Howard S Gwon, Darren P Mareiniss, Alan C Regenberg, Monica Schoch-Spana, Jack Schwartz, Eric S Toner
The threat of a catastrophic public health emergency causing life threatening illness or injury on a massive scale has prompted extensive federal, state, and local preparedness efforts. Modeling studies suggest that an influenza pandemic similar to that of 1918 would require ICU and mechanical ventilation capacity that is significantly greater than what is available. Several groups have published recommendations for allocating life-support measures during a public health emergency. Because there are multiple ethically permissible approaches to allocating scarce life-sustaining resources and because the public will bear the consequences of these decisions, knowledge of public perspectives and moral points of reference on these issues is critical...
October 11, 2018: Chest
https://www.readbyqxmd.com/read/30316719/type-of-blunt-expansion-of-the-low-transverse-uterine-incision-during-caesarean-section-and-the-risk-of-postoperative-complications-a-prospective-randomized-controlled-trial
#4
Alberto Morales, Osvaldo Reyes, Gerardo Cárdenas
OBJECTIVE: To evaluate two techniques of uterine incision expansion (cephalad-caudad vs. transverse) during CS. METHODS: A total of 839 patients were randomized to either a cephalad-caudad blunt expansion of uterine incision during CS versus a transverse (lateral-lateral) expansion. The primary outcome was blood loss, measured with the descent of hemoglobin level. Secondary outcomes were the need for blood transfusion and the number of surgical or postoperative complications presented in both groups...
October 10, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/30312754/distinct-behavioral-response-of-primary-motor-cortex-stimulation-in-itch-and-pain-after-burn-injury
#5
Aurore Thibaut, Emily A Ohrtman, Leon Morales-Quezada, Laura C Simko, Colleen M Ryan, Ross Zafonte, Jeffrey C Schneider, Felipe Fregni
It is still unclear whether chronic neuropathic pain and itch share similar neural mechanisms. They are two of the most commonly reported challenges following a burn injury and can be some of the most difficult to treat. Transcranial direct current stimulation (tDCS) has previously been studied as a method to modulate pain related neural circuits. Therefore, we aimed to test the effects of tDCS on post-burn neuropathic pain and itch as to understand whether this would induce a simultaneous modulation of these two sensory manifestations...
October 10, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/30304990/tensions-living-out-professional-values-for-physical-therapists-treating-injured-workers
#6
Anne Hudon, Debbie Ehrmann Feldman, Matthew Hunt
Health care services provided by workers' compensation systems aim to facilitate recovery for injured workers. However, some features of these systems pose barriers to high quality care and challenge health care professionals in their everyday work. We used interpretive description methodology to explore ethical tensions experienced by physical therapists caring for patients with musculoskeletal injuries compensated by Workers' Compensation Boards. We conducted in-depth interviews with 40 physical therapists and leaders in the physical therapy and workers' compensation fields from three Canadian provinces and analyzed transcripts using concurrent and constant comparative techniques...
October 10, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/30302338/social-cognition-through-the-lens-of-cognitive-and-clinical-neuroscience
#7
REVIEW
Maria Arioli, Chiara Crespi, Nicola Canessa
Social cognition refers to a set of processes, ranging from perception to decision-making, underlying the ability to decode others' intentions and behaviors to plan actions fitting with social and moral, besides individual and economic considerations. Its centrality in everyday life reflects the neural complexity of social processing and the ubiquity of social cognitive deficits in different pathological conditions. Social cognitive processes can be clustered in three domains associated with (a) perceptual processing of social information such as faces and emotional expressions (social perception), (b) grasping others' cognitive or affective states (social understanding), and (c) planning behaviors taking into consideration others', in addition to one's own, goals (social decision-making)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30300280/emerging-ethical-challenges-raised-by-the-evolution-of-vascularized-composite-allotransplantation
#8
Arthur L Caplan, Brendan Parent, Jeffrey Kahn, Wendy Dean, Laura L Kimberly, W P Andrew Lee, Eduardo D Rodriguez
BACKGROUND: Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplant to how to conduct them ethically. METHODS: Leaders of each program performing and/or evaluating VCA in the United States were invited to participate in a working group to assess the state and future of VCA ethics and policy. Four meetings were held over the course of 1 year to describe key challenges and potential solutions...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30296911/contemporary-insights-from-biblical-combat-veterans-through-the-lenses-of-moral-injury-and-post-traumatic-stress-disorder
#9
Jan Grimell
This psychological exegesis reconsiders biblical characters through recent theories on moral injury and post-traumatic stress disorder (PTSD). The purposes of this article are to shed new light on these characters and to engage in conversations of what the findings may mean for pastoral care and their connections to theology. The findings include the proposal of four categorical types of combat veterans that illustrate the development of PTSD, resilience, moral injury, and unfaltering abidance to the warrior ethics...
October 8, 2018: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/30282800/tlt-1-is-a-prognostic-indicator-in-ali-ards-and-prevents-tissue-damage-in-the-lungs-in-a-mouse-model
#10
Jessica Morales-Ortíz, Victoria Deal, Fiorella Reyes, Gerónimo Maldonado-Martínez, Nahomy Ledesma, Franklin Staback, Cheyanne Croft, Amanda Pacheco, Humberto Ortiz-Zuazaga, C Christian Yost, Jesse W Rowley, Bismark Madera, Alex St John, Junmei Chen, Jose Lopez, Matthew T Rondina, Robert Hunter, Angela Gibson, A Valance Washington
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect over 200,000 individuals yearly with a 40% mortality rate. While platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering Receptor Expressed in Myeloid cells (TREM)-Like Transcript (TLT)-1 is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of sTLT-1 from the ARDSNET clinical trial and show that patients whose sTLT-1 levels were >1200pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (p<0...
October 3, 2018: Blood
https://www.readbyqxmd.com/read/30273931/inflammation-in-diabetic-kidney-disease
#11
REVIEW
Rosa E Pérez-Morales, María Dolores Del Pino, José Manuel Valdivielso, Alberto Ortiz, Carmen Mora-Fernández, Juan F Navarro-González
BACKGROUND: Diabetes is a growing public health problem. Diabetic kidney disease (DKD) is the most prevalent chronic renal disease and the major cause of end-stage renal failure worldwide, predominantly due to the increase of Type 2 diabetes associated with obesity. The intimate mechanisms leading to the development and progression of renal injury in DKD are not well understood, but current knowledge indicates that its pathogenesis is multifactorial, where the immune response and inflammation appear to be relevant factors...
October 1, 2018: Nephron
https://www.readbyqxmd.com/read/30266290/long-term-survival-and-five-year-hospital-resource-usage-following-traumatic-brain-injury-in-scotland-from-1997-to-2015-a-population-based-retrospective-cohort-study
#12
James J M Loan, Neil W Scott, Jan O Jansen
BACKGROUND: It is unclear if traumatic brain injury (TBI) results in excess mortality compared with head injury without injury to neural structures (HI). Because TBI populations exhibit significant demographic differences from uninjured populations, to determine the effect of TBI on survival, it is essential that a similarly injured control population be used. We aimed to determine if survival and hospital resource usage differ following TBI compared with HI. METHODS: This retrospective population-based cohort study included all 25 319 patients admitted to a Scottish NHS hospital from 1997 to 2015 with TBI...
September 14, 2018: Injury
https://www.readbyqxmd.com/read/30261301/the-clotting-system-in-decapod-crustaceans-history-current-knowledge-and-what-we-need-to-know-beyond-the-models
#13
REVIEW
Rolando Perdomo-Morales, Vivian Montero-Alejo, Erick Perera
Hemolymph coagulation is among the major arms of the humoral immune response in crustaceans. According to the current model, hemolymph clotting in decapod crustacean relies mostly on the polymerization of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutaminase (TGase) released from hemocytes upon microbial stimulus or injury. However, the type of hemocytes containing TGase, and hence how the TGase is released, might vary among species. Thus, we discourse here about possible mechanisms for clotting initiation...
September 24, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30246000/comparison-of-the-effects-of-volemic-reposition-with-7-5-nacl-or-blood-in-an-experimental-model-of-muscular-compression-and-hemorrhagic-shock
#14
Mauricio Wanderley Moral Sgarbi, Bomfim Alves Silva Júnior, Daniel de Almeida Pires, Irineu Tadeu Velasco
Objective: Crush syndrome is characterized by traumatic muscular injuries with severe systemic clinical repercussions. The systemic inflammatory reaction characterized acutely by infiltration of neutrophils in the lungs has been studied as part of the spectrum of crush syndrome. Experimental research may demonstrate alternative treatments for crush syndrome. The authors studied the hypothesis that hypertonic saline solution (7.5% NaCl) could minimize the local and systemic effects in a model of muscular compression and hemorrhagic shock...
September 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/30245293/subacute-intoxication-with-sodium-nitrate-induces-hematological-and-biochemical-alterations-and-liver-injury-in-male-wistar-rats
#15
M F González Delgado, A González Zamora, M E Gonsebatt, E Meza Mata, G G García Vargas, E Y Calleros Rincón, R Pérez Morales
Nitrate pollution has emerged as a problem of great importance because in recent years, the levels of nitrate in soil and groundwater have increased, mainly through anthropogenic activities, such as the use of fertilizers in agriculture, domestic wastewater and septic tanks, industrial waste and deforestation. In animals, nitrate reduction to nitrite (NO2 ) and nitric oxide (NO) promote the formation of methemoglobin in the blood and the generation of highly reactive intermediates that induce oxidative stress in target organs...
September 20, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30234322/sex-differences-in-mental-health-symptoms-and-substance-use-and-their-association-with-moral-injury-in-veterans
#16
Michelle L Kelley, Abby L Braitman, Tyler D White, Sarah J Ehlke
OBJECTIVE: This study examines potential sex differences in 3 types of experiences (i.e., atrocities of war, cognitive and emotional changes from combat, and leadership failure or betrayal) that may result in moral injury (i.e., guilt, shame, inability to forgive one's self, inability to forgive others, and withdrawn behavior associated with these three types of experiences). In addition, we examine whether moral injury results in different associations with mental health and substance use outcomes for female versus male veterans...
September 20, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/30233429/association-between-trust-and-mental-social-and-physical-health-outcomes-in-veterans-and-active-duty-service-members-with-combat-related-ptsd-symptomatology
#17
Marek S Kopacz, Donna Ames, Harold G Koenig
Background: Trust represents a complex emotion and interpersonal concept which assumes abandoning control over a given situation or set of circumstances, in turn yielding such control to another party. Advances in our knowledge of post-traumatic stress disorder and moral injury have underscored the need to more closely examine how trust stands to impact health outcomes in these disorders. The aim of the present study is to examine and identify relationships linking general trust with select health outcomes in a mixed sample of Veterans and Service members with a self-reported history of deployment to a combat theater and PTSD symptomatology...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30197612/effective-treatment-of-veterans-with-ptsd-comparison-between-intensive-daily-and-weekly-emdr-approaches
#18
E C Hurley
The effectiveness of EMDR therapy in treating veterans diagnosed with PTSD was evaluated in this study using two treatment formats: intensive daily EMDR treatment provided twice a day during a 10-day period and a second format of one session each week. The study used archived outcome data previously collected and stored at Soldier Center. Both formats provided 18-20 treatment sessions of EMDR therapy to veterans diagnosed with PTSD that included dissociative exhibitions and moral injury issues. Questions addressed included: (1) does EMDR therapy administered twice daily ameliorate veterans' PTSD symptoms; (2) does EMDR therapy administered twice daily provide equivalent outcome results as EMDR therapy administered weekly for 18-20 sessions; and (3) does the treatment outcome persist...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30195745/moral-injury-suicide-ideation-and-behavior-among-combat-veterans-the-mediating-roles-of-entrapment-and-depression
#19
Yossi Levi-Belz, Gadi Zerach
Combat veterans have been identified as a major at-risk group for suicide. Moral injury (MI) experiences have recently been acknowledged as significant stressful combat events that may lead to psychopathology, such as suicidal ideation and behaviors (SIB). In this study, we aimed to examine to what extent potential MI events may comprise risk factors for SIB and to explore the mediating role of the entrapment experience in this relationship. A sample of 191 Israeli combat veterans (Mag e   = 25.39, SD = 2...
August 27, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30189040/why-moral-enhancement-isn-t-always-moral-enhancement-the-case-of-traumatic-brain-injury-in-american-vets
#20
Valerie Gray Hardcastle
In this article, I argue that as we learn more about how we might intervene in the brain in ways that impact human behavior, the scope of what counts as "moral behavior" becomes smaller and smaller because things we successfully manipulate using evidence-based science are often things that fall outside the sphere of morality. Consequently, the argument that we are morally obligated to morally enhance our neighbors starts to fall apart, not because humans should be free to make terrible choices, but because morality is not something subject to such manipulation...
September 5, 2018: Journal of Medicine and Philosophy
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