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https://www.readbyqxmd.com/read/28212832/motor-dysfunction-and-alterations-in-glutathione-concentration-cholinesterase-activity-and-bdnf-expression-in-substantia-nigra-pars-compacta-in-rats-with-pedunculopontine-lesion
#1
Lisette Blanco-Lezcano, Javier Jimenez-Martin, Mei-Li Díaz-Hung, Esteban Alberti-Amador, Maylin Wong-Guerra, Ma Elena González-Fraguela, Bárbara Estupiñán-Díaz, Teresa Serrano-Sánchez, Liliana Francis-Turner, Susana Delgado-Ocaña, Yanier Núñez-Figueredo, Yamilé Vega-Hurtado, Isabel Fernández-Jiménez
Pedunculopontine nucleus (PPN) has been considered a critically important region in the regulation of some of the physiological functions that fail during the progression of Parkinson's disease (PD). In this paper, the effects of unilateral neurotoxic lesion of the PPN [through the injection of N-methyl-D-aspartate (NMDA) solution (concentration: 0.1 M; volume: 0.5 µL)] in motor execution and gait disorders and the changes in cellular and molecular indicators in rat nigral tissue were evaluated. The motor execution was assessed using the beam test (BT) and the gait disorders by footprint test...
February 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28209406/endocrine-and-physiological-effects-of-linuron-and-s-metolachlor-in-zebrafish-developing-embryos
#2
C Quintaneiro, D Patrício, S C Novais, A M V M Soares, M S Monteiro
Evaluation of the effects of linuron and S-metolachlor on apical, biochemical and transcriptional endpoints in zebrafish (Danio rerio) early life stages was the main purpose of this work. Embryos were exposed for 96h to a range of concentrations of each herbicide to determine lethal and sub-lethal effects on apical (e.g. malformations, hatching) and biochemical parameters (cholinesterase, ChE; catalase, CAT; glutathione S-transferase, GST; lipid peroxidation, LPO and lactate dehydrogenase, LDH). To evaluate endocrine disruption effects, embryos were exposed during 96h to 0...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28208980/contributing-factors-for-morbidity-and-mortality-in-patients-with-organophosphate-poisoning-on-mechanical-ventilation-a-retrospective-study-in-a-teaching-hospital
#3
Gurulingappa Patil, Navya Murthy, M Nikhil
INTRODUCTION: One of the most common causes of poisoning in agricultural based developing countries like India is due to Organophosphorus (OP) compound. Its widespread use and easy availability has increased the likelihood of poisoning with these compounds. AIM: To study the morbidity and mortality in patients with acute OP poisoning requiring mechanical ventilation. MATERIALS AND METHODS: This was a retrospective study constituting patients of all age groups admitted to the Intensive Care Unit (ICU) with diagnosis of OP poisoning between January 2015 to December 2015...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207552/disease-spectrum-of-alcoholic-liver-disease-in-beijing-302-hospital-from-2002-to-2013-a-large-tertiary-referral-hospital-experience-from-7422-patients
#4
Ang Huang, Binxia Chang, Yin Sun, Huiming Lin, Baosen Li, Guangju Teng, Zheng-Sheng Zou
Alcohol consumption in China has substantially increased over the last 3 decades and the number of patients with alcoholic liver disease (ALD) is rising at an alarming rate. However, accurate and representative data on time trends in its hospitalization rates are not available. The aim of this study is to assess the current status and burden of ALD in China by analyzing the data from a large tertiary referral hospital, Beijing 302 Hospital.Data were retrospectively recorded from patients diagnosed as ALD in Beijing 302 Hospital from 2002 to 2013...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28201726/discontinuation-efficacy-and-safety-of-cholinesterase-inhibitors-for-alzheimer-s-disease-a-meta-analysis-and-meta-regression-of-44-randomized-clinical-trials-enrolling-16-245-patients
#5
Lídia Blanco-Silvente, Xavier Castells, Marc Saez, Maria Antònia Barceló, Josep Garre-Olmo, Joan Vilalta-Franch, Dolors Capellà
No abstract text is available yet for this article.
February 13, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28199333/comparative-and-functional-triatomine-genomics-reveals-reductions-and-expansions-in-insecticide-resistance-related-gene-families
#6
Lucila Traverso, Andrés Lavore, Ivana Sierra, Victorio Palacio, Jesús Martinez-Barnetche, José Manuel Latorre-Estivalis, Gaston Mougabure-Cueto, Flavio Francini, Marcelo G Lorenzo, Mario Henry Rodríguez, Sheila Ons, Rolando V Rivera-Pomar
BACKGROUND: Triatomine insects are vectors of Trypanosoma cruzi, a protozoan parasite that is the causative agent of Chagas' disease. This is a neglected disease affecting approximately 8 million people in Latin America. The existence of diverse pyrethroid resistant populations of at least two species demonstrates the potential of triatomines to develop high levels of insecticide resistance. Therefore, the incorporation of strategies for resistance management is a main concern for vector control programs...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28199036/edaravone-attenuates-intracerebroventricular-streptozotocin-induced-cognitive-impairment-in-rats
#7
K H Reeta, Devendra Singh, Y K Gupta
Alzheimer's disease is a major cause of dementia worldwide. Edaravone, a potent free radical scavenger, is reported to be neuroprotective. The present study was designed to investigate the effect of chronic edaravone administration on intracerebroventricular-streptozotocin (ICV-STZ) induced cognitive impairment in male Wistar rats. Cognitive impairment was developed by single ICV-STZ (3 mg/kg) injection bilaterally on day 1. Edaravone (1, 3 and 10 mg/kg, orally, once daily) was administered for 28 days. Morris water maze and passive avoidance tests were used to assess cognitive functions at baseline and on days 14 and 28...
February 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28198801/inhibitory-effects-of-cholinesterase-inhibitor-donepezil-on-the-kv1-5-potassium-channel
#8
Kai Li, Neng Cheng, Xian-Tao Li
Kv1.5 channels carry ultra-rapid delayed rectifier K(+) currents in excitable cells, including neurons and cardiac myocytes. In the current study, the effects of cholinesterase inhibitor donepezil on cloned Kv1.5 channels expressed in HEK29 cells were explored using whole-cell recording technique. Exposure to donepezil resulted in a rapid and reversible block of Kv1.5 currents, with an IC50 value of 72.5 μM. The mutant R476V significantly reduced the binding affinity of donepezil to Kv1.5 channels, showing the target site in the outer mouth region...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#9
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28188819/potential-short-term-neurobehavioral-alterations-in-children-associated-with-a-peak-pesticide-spray-season-the-mother-s-day-flower-harvest-in-ecuador
#10
Jose R Suarez-Lopez, Harvey Checkoway, David R Jacobs, Wael K Al-Delaimy, Sheila Gahagan
BACKGROUND: Exposures to cholinesterase inhibitor pesticides (e.g. organophosphates) have been associated with children's neurobehavioral alterations, including attention deficit and impulsivity. Animal studies have observed transient alterations in neurobehavioral performance in relation to cholinesterase inhibitor pesticide exposures; however, limited evidence exists regarding transient effects in humans. METHODS: We estimated the associations between neurobehavioral performance and time after Mother's Day flower harvest (the end of a heightened pesticide usage period) among 308 4-to 9-year-old children living in floricultural communities in Ecuador in 2008 who participated in the ESPINA study...
February 7, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28188320/effects-of-glyphosate-based-herbicide-sub-lethal-concentrations-on-fish-feeding-behavior
#11
Percilia Cardoso Giaquinto, Marina Borges de Sá, Vanessa Seiko Sugihara, Bruno Bastos Gonçalves, Helton Carlos Delício, Assaf Barki
Glyphosate-based herbicides are widely used in agricultural systems. Although the target organism are particularly plant organisms, there are numerous studies showing adverse effects in aquatic animals, such as inhibition of acetyl cholinesterase, effects on kidney, liver, and gill and stressors effects. This study analyzed the effects of commercial formulation of glyphosate on feeding behavior in Pacu (Piaractus mesopotamicus). Fish were exposed to three glyphosate concentrations (0.2, 0.6, and 1.8 ppm) for 15 days...
February 10, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28183359/unexpected-extrapyramidal-symptoms-and-pulmonary-aspergillosis-in-exertional-heatstroke-with-fulminant-liver-failure-a-case-report
#12
Jie Jiao, Feihu Zhou, Hongjun Kang, Chao Liu, Mengmeng Yang, Jie Hu
BACKGROUND: Exertional heatstroke is a life-threatening condition with high mortality because of the rapid progress of multiple organ dysfunction syndrome even if aggressive treatments are initiated rapidly. Mild to moderate hepatic injury is common in exertional heatstroke, while fulminant liver failure is rare. Extrapyramidal symptoms and pulmonary aspergillosis secondary to liver failure induced by exertional heatstroke have never been reported in prior cases. CASE PRESENTATION: A 25-year-old Han Chinese man presented with exertional heatstroke with fulminant liver failure, subsequent pulmonary aspergillosis, and extrapyramidal symptoms...
February 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28174780/shedding-light-on-the-biological-and-chemical-fingerprints-of-three-achillea-species-a-biebersteinii-a-millefolium-and-a-teretifolia
#13
Gokhan Zengin, Abdurrahman Aktumsek, Ramazan Ceylan, Sengul Uysal, Andrei Mocan, Gokalp Ozmen Guler, M Fawzi Mahomoodally, Jasmina Glamočlija, Ana Ćirić, Marina Soković
Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28169440/lipophilic-properties-of-anti-alzheimer-s-agents-determined-by-micellar-electrokinetic-chromatography-and-reversed-phase-thin-layer-chromatography
#14
Justyna Godyń, Michalina Hebda, Anna Więckowska, Krzysztof Więckowski, Barbara Malawska, Marek Bajda
Lipophilicity as one of the most important physicochemical properties of the biologically active compounds is closely related to their pharmacokinetic parameters and therefore, it is taken into account at the design stage of new drugs. Among the novel, fast and reliable methods for determination of the lipophilicity of compounds micellar electrokinetic chromatography (MEKC) is considered to be an appropriate one for bioactive molecules, as it closely mimics the physiological conditions. In this paper MEKC was used for the estimation of log P values for 49 derivatives of phthalimide, tetrahydroisochinoline and indole, designed and synthesized as potential anti-Alzheimer's agents with cholinesterase inhibitory activity...
February 7, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28167443/polybrominated-diphenyl-ethers-pbdes-effects-on-chironomus-sancticaroli-larvae-after-short-term-exposure
#15
Angela Maria Palacio-Cortés, Isadora de Lourdes Signorini-Souza, Emerson Luis Yoshio Hara, Rodrigo Geonildo Disner, Debora Rebechi, Marco Tadeu Grassi, Marta Margarete Cestari, Mario Antônio Navarro-Silva
In-vivo effects of polybrominated diphenyl ethers (PBDEs) containing 3, 4 and 5 bromine atoms were tested on fourth-instar larvae of Chironomus sancticaroli (Diptera: Chironomidae) after 48h of exposure, by measuring the activity of the acetyl cholinesterase, alpha and beta esterases and glutathione S-transferase. The PBDE congeners 2,2',4-triBDE (BDE-17), 2,2',4,4'-tetraBDE (BDE-47) and 2,2',4,4',5-pentaBDE (BDE-99) were evaluated at 0.5, 1.0, 2.0 and 3.0ngmL(-1). Acetyl cholinesterase activity decreased significantly (p≤0...
February 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28163969/assessment-of-in-vitro-cholinesterase-inhibitory-and-thrombolytic-potential-of-bark-and-seed-extracts-of-tamarindus-indica-l-relevant-to-the-treatment-of-alzheimer-s-disease-and-clotting-disorders
#16
Kushal Biswas, A K Azad, Taposhi Sultana, Farzana Khan, Saiyara Hossain, Sanzida Alam, Rayhan Chowdhary, Yasmin Khatun
BACKGROUND: Low level of acetylcholine (ACh) is an important hallmark of Alzheimer's disease (AD), a common type of progressive neurodegenerative disorder. Effective treatment strategies rely mostly on either enhancing the cholinergic function of the brain by improving the level of ACh from being a breakdown by cholinesterase enzymes. Again atherothrombosis is major life-threatening cerebral diseases. Traditionally Tamarindus indica (L.) has widely known for its medicinal values. Our aim is to investigate the cholinesterase inhibitory activities as well as thrombolytic activities of the bark and seeds crude methanolic extracts (CMEs) in the treatment of AD and clotting disorder...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28154487/evaluation-of-antioxidant-anti-cholinesterase-and-anti-inflammatory-effects-of-culinary-mushroom-pleurotus-pulmonarius
#17
Trung Kien Nguyen, Kyung Hoan Im, Jaehyuk Choi, Pyung Gyun Shin, Tae Soo Lee
Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius were evaluted. The 1,1-diphenyl-2-picryl-hydrazy free radical scavenging activity of ME at 2.0 mg/mL was comparable to that of butylated hydroxytoluene, the standard reference. The ME exhibited significantly higher hydroxyl radical scavenging activity than butylated hydroxytoluene. ME showed slightly lower but moderate inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase than galantamine, a standard AChE inhibitor...
December 2016: Mycobiology
https://www.readbyqxmd.com/read/28153340/microwave-assisted-synthesis-of-novel-hybrid-tacrine-sulfonamide-derivatives-and-investigation-of-their-antioxidant-and-anticholinesterase-activities
#18
Ramazan Ulus, Belma Zengin Kurt, Isil Gazioğlu, Muharrem Kaya
A novel series of tacrine derivatives containing sulfonamide group were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. The result showed that all the synthesized tacrine-sulfonamides (VIIIa-o) exhibited inhibitory activity on both cholinesterases. VIIIg showed the highest inhibitory activity on AChE IC50=0.009μM. This value is 220-fold greater than that of galantamine (IC50=2.054μM) and 6-fold greater than tacrine (IC50=0.055μM). VIIIf displayed the strongest inhibition of BuChE (IC50=2...
January 9, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#19
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28152479/inhibitor-of-phosphodiestearse-4-improves-memory-deficits-oxidative-stress-neuroinflammation-and-neuropathological-alterations-in-mouse-models-of-dementia-of-alzheimer-s-type
#20
Amit Kumar, Nirmal Singh
The study investigates the potential of Rolipram a phosphodiesterase-4 inhibitor in cognitive deficits induced by streptozotocin (STZ, 3mg/kg intracerebroventricularly) and natural ageing in mice. Morris water maze (MWM) test was employed to evaluate learning and memory of the animals. Extent of oxidative stress was measured by estimating the levels of brain glutathione (GSH) and thiobarbituric acid reactive species (TBARS). Brain acetylcholinestrase (AChE) activity was also estimated. The brain activity of myeloperoxidase (MPO) was measured as a marker of inflammation...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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