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Blood cancers

Teng Liu, Qiong Zhang, Jiankun Zhang, Chao Li, Ya-Ru Miao, Qian Lei, Qiubai Li, An-Yuan Guo
Extracellular vesicles (EVs), such as exosomes and microvesicles, acted as cell-to-cell communication vectors and potential biomarkers for diseases. microRNAs (miRNAs) are the most well studied molecules in EVs, thus a comprehensive investigation of miRNA expression profiles in EVs will be helpful to explore their functions and biomarkers. We curated 462 small RNA sequencing samples of EVs from 17 sources/diseases and constructed the EVmiRNA database ( to show the miRNA expression profiles...
October 18, 2018: Nucleic Acids Research
Haobin Zhao, Junjun Li, Yawen Zhang, Shuzhen Lei, Xixi Zhao, Dongyan Shao, Chunmei Jiang, Junling Shi, Hui Sun
The iturin produced by Bacillus subtilis was previously found to exhibit significant antifungal activities, showing potential for application to food to protect it from spoilage and decay. However, its safe level must be evaluated before it can be used in foods consumed by mammals. Therefore, we carried out acute toxicity (7 days) and subacute toxicity (28 days) evaluations by intragastric administration of the iturin at 5000 mg per kg (bw) and 2000 mg per kg (bw) to Kunming mice. At the end of the subacute toxicity evaluation, the blood parameters of the mice were evaluated, and the visceral organs and intestinal flora were examined...
October 18, 2018: Food & Function
Zujie Mao, Alin Ji, Kebing Yang, Wei He, Yingfang Hu, Qi Zhang, Dahong Zhang, Liping Xie
OBJECTIVES: The prostate cancer gene 3 (PCA3), human kallikrein 2, and miRNA-141 are promising prostate cancer (Pca) specific biomarkers. Our aim was to evaluate the detection of PCA3, human glandular kallikrein 2 (hk2), and miRNA-141 mRNA in peripheral blood of patients received prostate biopsy. What's more, we want to detect the value of combination of PSA (prostate specific antigen) in the early diagnosis of PCa. MATERIALS AND METHODS: Hundred patients were divided into 2 groups according to the results of pathologic diagnosis...
October 2018: Medicine (Baltimore)
André F Moreira, Carolina F Rodrigues, Catarina A Reis, Elisabete C Costa, Paula Ferreira, Ilídio J Correia
AIM: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. METHODS: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. RESULTS: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices' surface charge, from -30 to -15 mV, which improved nanoparticles' biocompatibility, namely by decreasing the blood hemolysis to negligible levels...
October 18, 2018: Nanomedicine
Pablo Zubiaur, Miriam Saiz-Rodríguez, Dora Koller, María Carmen Ovejero-Benito, Aneta Wojnicz, Francisco Abad-Santos
Several polymorphisms have been identified in ABCB1, the gene encoding for the P-glycoprotein. This transporter alters the pharmacokinetics or effectiveness of drugs by excreting them from cells where it is expressed (e.g., blood-brain barrier, intestine or tumors). No consensus has been reached regarding the functional consequences of these polymorphisms in the transporter's function. The aim of this review was to describe a methodology that allows the assessment of P-gp function when harboring polymorphisms...
October 18, 2018: Pharmacogenomics
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han
AIM: To identify novel candidate genes for pancreatic cancer. METHODS: We performed a transcriptome-wide association study (TWAS) analysis of pancreatic cancer (PC). GWAS summary data were driven from the published studies of PC, totally involving 558 542 SNPs in 1896 individuals with pancreatic cancer and 1939 healthy controls. FUSION software was applied to the PC GWAS summary data for tissue-related TWAS analysis, including whole blood, peripheral blood, adipose, and pancreas...
October 18, 2018: Cancer Medicine
Takashi Ueki, Shuntato Nagai, Tatsuya Manabe, Ryo Koba, Kinuko Nagayoshi, Masafumi Nakamura, Masao Tanaka
Laparoscopic D3 lymph node dissection for transverse colon cancer is technically demanding because of complicated anatomy. Here, we reviewed the vascular structure of the transverse mesocolon, explored the extent of the base of the transverse mesocolon, and evaluated the feasibility and oncological safety of D3 lymph node dissection. We retrospectively reviewed the clinical records of 42 patients with advanced transverse colon cancer who underwent curative surgery and D3 dissection at Kyushu University Hospital between January 2008 and December 2015...
October 17, 2018: Surgical Endoscopy
Yasushi Ohmura, Hiromitsu Suzuki, Kazutoshi Kotani, Atsushi Teramoto
BACKGROUND: Several types of robotic scope holders have been developed to date, but there are only some experimental reports or the results of small clinical cases. The Soloassist® system is a unique robotic scope holder with which the surgeon can control the field of view by a joystick. We evaluated the efficacy of Soloassist in laparoscopic resection for colorectal cancer. MATERIALS AND METHODS: We investigated operative time, blood loss, setup time, length of hospital stay, and the number of participating surgeons in 273 laparoscopic colorectal resections, including 130 cases with human assistant (HA group) and 143 cases with Soloassist (SA group)...
October 17, 2018: Surgical Endoscopy
Hannah M Pezzi, David J Guckenberger, Jennifer L Schehr, Jacob Rothbauer, Charlotte Stahlfeld, Anupama Singh, Sacha Horn, Zachery D Schultz, Rory M Bade, Jamie M Sperger, Scott M Berry, Joshua M Lang, David J Beebe
Rare cell populations provide a patient-centric tool to monitor disease treatment, response, and resistance. However, understanding rare cells is a complex problem, which requires cell isolation/purification and downstream molecular interrogation - processes challenged by non-target populations, which vary patient-to-patient and change with disease. As such, cell isolation platforms must be amenable to a range of sample types while maintaining high efficiency and purity. The multiplexed technology for automated extraction (mTAE) is a versatile magnetic bead-based isolation platform that facilitates positive, negative, and combinatorial selection with integrated protein staining and nucleic acid isolation...
October 18, 2018: Lab on a Chip
Zijian Liu, Yuzhu Li, Quanxiang Luo
Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second Hospital of Shandong University in Zhaoyuan City from January 2013 to March 2017 were selected as the study group. At the same time, 150 patients with benign colitis were also included to serve as the control group...
November 2018: Oncology Letters
Zeng Wang, Yunsong Peng, Xinjun Cai, Yingying Cao, Guonong Yang, Ping Huang
BACKGROUND/OBJECTIVES: Abdominal surgery significantly affects the structure and function of the gastrointestinal system of patients, total parenteral nutrition (TPN) is an important nutrition support method for postoperative patients. However, in the process of TPN practice, the excessive fat emulsion and compound amino-acid prescriptions ratio are often prescribed by doctors. To address the problem, we developed the computerized TPN prescription management system to promote the personalized provision of TPN...
October 17, 2018: European Journal of Clinical Nutrition
Fei Chen, Qilai Long, Da Fu, Dexiang Zhu, Yan Ji, Liu Han, Boyi Zhang, Qixia Xu, Bingjie Liu, Yan Li, Shanshan Wu, Chen Yang, Min Qian, Jianmin Xu, Suling Liu, Liu Cao, Y Eugene Chin, Eric W-F Lam, Jean-Philippe Coppé, Yu Sun
Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 expression by engaging NF-κB and C/EBP, while paracrine SPINK1 promotes cancer cell aggressiveness particularly chemoresistance...
October 17, 2018: Nature Communications
Ronald E Myers, Brian Stello, Constantine Daskalakis, Randa Sifri, Evelyn T Gonzalez, Melissa DiCarlo, Melanie B Johnson, Sarah E Hegarty, Kyle Shaak, Alicia Rivera, Lucas Gordils-Molina, Anett Petrich, Beth Careyva, Rosa de-Ortiz, Liselly Diaz
BACKGROUND: Effective strategies are needed to raise colorectal cancer (CRC) screening rates among Hispanics Methods: We surveyed and randomized 400 Hispanic primary care patients either to a Decision Support and Navigation Intervention (DSNI) Group (n=197) or a Standard Intervention (SI) Group (n=203). Both groups received a CRC screening kit (bilingual informational booklet, fecal immunochemical stool blood test (SBT), and colonoscopy screening instructions). The DSNI Group received a telephone contact from a patient navigator...
October 17, 2018: Cancer Epidemiology, Biomarkers & Prevention
Sonja H Brunvoll, Inger Thune, Hanne Frydenberg, Vidar G Flote, Gro F Bertheussen, Ellen Schlichting, Kristian S Bjerve, Anette Hjartåker
BACKGROUND: The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods for measuring the intake of n-3 PUFAs. The aim of the current study is to validate two different methods used to assess the intake of selected n-3 PUFAs as well as food sources of long-chained n-3 PUFAs. Also, we aim to study how stable the intake of fatty acids is during breast cancer treatment...
October 17, 2018: Nutrition Journal
Yuanyuan Song, Peng Liu, Yu Huang, Yanfang Guan, Xiaohong Han, Yuankai Shi
BACKGROUND: Leptomeningeal metastases (LM) are much more frequent in patients of non-small lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) shows promising efficacy for LM. OBJECTIVE: The aim of this study was to analyze the concentration of osimertinib and gene variation of circulating tumor DNA (ctDNA) in human plasma and cerebrospinal fluid (CSF)...
October 17, 2018: Current Cancer Drug Targets
Justin C Brown, Andrew D Rhim, Sara L Manning, Luke Brennan, Alexandra I Mansour, Anil K Rustgi, Nevena Damjanov, Andrea B Troxel, Michael R Rickels, Bonnie Ky, Babette S Zemel, Kerry S Courneya, Kathryn H Schmitz
BACKGROUND: Physical activity is associated with a lower risk of disease recurrence among colon cancer patients. Circulating tumor cells (CTC) are prognostic of disease recurrence among stage I-III colon cancer patients. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in CTCs. METHODS: Participants included 23 stage I-III colon cancer patients randomized into one of three groups: usual-care control, 150 min∙wk-1 of aerobic exercise (low-dose), and 300 min∙wk-1 of aerobic exercise (high-dose) for six months...
2018: PloS One
Tran Thi Xuan Mai, Yoon Young Lee, Mina Suh, Eunji Choi, Eun Young Lee, Moran Ki, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Jin Kyoung Oh, Kui Son Choi
PURPOSE: This study aimed to investigate inequalities in colorectal cancer (CRC) screening rates in Korea and trends therein using the slope index of inequality (SII) and relative index of inequality (RII) across income and education groups. MATERIALS AND METHODS: Data from the Korean National Cancer Screening Survey, an annually conducted, nationwide cross-sectional survey, were utilized. A total of 17174 men and women aged 50 to 74 years were included for analysis...
November 2018: Yonsei Medical Journal
Thomas R Cimato, Alexis Conway, Julianne Nichols, Paul K Wallace
BACKGROUND: Circulating hematopoietic progenitors (HPCs) are involved in inflammatory diseases such as atherosclerosis, the immune response to cancer, and disorders of the hematopoietic system. HPC characterization by flow cytometry typically utilizes CD34 in combination with other cell surface markers to identify cell populations that give rise to specific hematopoietic lineages. CD133, also known as prominin-1, is a cell surface protein found in HPCs that has a similar but not interchangeable expression pattern with CD34 for characterization of HPC populations...
October 16, 2018: Cytometry. Part B, Clinical Cytometry
Ulrike Haug
Colon cancer is currently the third leading cause of cancer death in men and women in Germany, with a total of about 25,000 deaths per year. Established methods for early detection of colorectal cancer include lower gastrointestinal endoscopy and fecal occult blood testing. For both procedures, there is evidence of a reduction in colorectal cancer-specific mortality and for endoscopy a reduction of colorectal cancer incidence has been shown.In Germany, the guaiac test for fecal occult blood has been offered since 1977...
October 16, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Sherif Melak, Fang-Fang Jia, Mir Hassan Khoso, Zong-Tao Zhu, Lu-Ji Zhang, Rokayya Sami, Xiang-Chen Meng
Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease. Notably, Lactobacillus brevis is the most common species of LAB that produces γ -aminobutyric acid (GABA). The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, different levels of pH, and intestinal juices in aerobic or anaerobic conditions and the effect of interactions between these factors on the potential properties of KLDS 1.0727 and KLDS 1.0373, furthermore, antagonistic activity against foodborne pathogens...
2018: BioMed Research International
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