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Blood cancers

Yichao Jin, Zhen Guan, Xiaochuan Wang, Zhiqiong Wang, Rong Zeng, Liangheng Xu, Ping Cao
5-Aminolevulinic acid photodynamic therapy(ALA-PDT) has been widely used for cervical cancer treatment, but the mechanisms are still not fully delineated. Here we showed that ALA-PDT significantly upregulated HMGB1 while downregulated miR-34a expression levels in cervical cancer tissues, and the percentages of mature DCs(mDCs) were increased in ALA-PDT treated patients' peripheral blood. After treating HPV-positive Hela, SiHa, Caski and HPV-negative C33 A cervical cancer cell lines with ALA-PDT, HPV-positive cells' proliferative ability was significantly inhibited and apoptosis rates were elevated, while no significant changes were found in HPV-negative C33 A cell line...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
Julius Fink, Masahito Matsumoto, Yoshifumi Tamura
Sedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resistance, increased adipose tissue and inflammation, showing a negative correlation between testosterone levels and T2D...
August 14, 2018: Steroids
Kaitlin M Curran, Shay Bracha, Carmen P Wong, Laura M Beaver, Jan F Stevens, Emily Ho
The role of epigenetic alterations during cancer has gained increasing attention and has resulted in a paradigm shift in our understanding of mechanisms leading to cancer susceptibility. Sulforaphane (SFN) is a naturally occurring isothiocyanate derived from the precursor glucosinolate, glucoraphanin (GFN), which is found in cruciferous vegetables such as broccoli. Sulforaphane has been shown to suppress tumour growth by several mechanisms including inhibiting histone deacetylases. The objective of this study was to provide a detailed analysis of sulforaphane absorption following a single oral dose of a broccoli sprout supplement in normal dogs...
August 17, 2018: Veterinary Medicine and Science
Peter Vitalevich Glybochko, Leonid Mikhailovich Rapoport, Yuri Gennadevich Alyaev, Eugene Sergeevich Sirota, Eugene Alexeevich Bezrukov, Dmitry Nikolaevich Fiev, Ildar Shamilevich Byadretdinov, Mikhail Dmitrievich Bukatov, Alexander Vasilevich Letunovskiy, Dmitry Olegovich Korolev
AIM: To evaluate the effectiveness of three-dimensional printing application in urology for localized renal cancer treatment using three-dimensional printed soft models. MATERIALS AND METHODS: The study included five patients with kidney tumors. The patients were treated in the Urology Clinic of I.M. Sechenov First Moscow State Medical University from February 2016 to June 2017. Personalized three-dimensional printed models based on computed tomographic images were created...
August 2018: Urologia
Mia M Gaudet, Emily L Deubler, Rachel S Kelly, W Ryan Diver, Lauren R Teras, James M Hodge, Keith E Levine, Laura G Haines, Thomas Lundh, Per Lenner, Domenico Palli, Paolo Vineis, Ingvar A Bergdahl, Susan M Gapstur, Soterios A Kyrtopoulos
Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition - Italy (EPIC-Italy), and the Northern Sweden Health and Disease Study (NSHDS) cohorts...
August 17, 2018: International Journal of Cancer. Journal International du Cancer
Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, Martin Bauer, Oliver Langer, Sylvain Auvity, Nicolas Tournier
BACKGROUND: Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear uptake transport of erlotinib into the liver, suggesting carrier-mediated system(s) to mediate its hepatobiliary clearance. Erlotinib has been identified in vitro as a substrate of organic anion-transporting polypeptide (OATP) transporters which expression does not restrict to hepatocytes and may impact the tissue uptake of erlotinib in vivo...
August 16, 2018: EJNMMI Research
Jiayu Liu, Jiaqian Li, Min He, Geng-Lin Zhang, Qiyi Zhao
BTLA/HVEM (B and T lymphocyte attenuator/herpes virus entry mediator) pathways play a critical role in T cell suppression in tumor. However, its dynamic changes in different T cell subsets in peripheral blood and their clinical significance are largely unclear in cancer patients. In the current study, we showed distinct changes of BTLA and HVEM expressions on peripheral blood CD4+ and CD8+ T cells in patients with hepatocellular carcinoma (HCC); BTLA expression were significantly upregulated on circulating CD4+ but not CD8+ T cells...
2018: Journal of Immunology Research
Lianguo Chen, Qinghua Weng, Feifei Li, Jinlai Liu, Xueliang Zhang, Yunfang Zhou
The aim of this study is to establish and validate a rapid, selective, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to determine tubeimoside I (TBMS-I) in ICR (Institute of Cancer Research) mouse whole blood and its application in the pharmacokinetics and bioavailability study. The blood samples were precipitated by acetonitrile to extract the analytes. Chromatographic separation was performed on a UPLC BEH C18 column (2.1 mm × 50 mm, 1.7  μ m)...
2018: Journal of Analytical Methods in Chemistry
Abdulbari Bener, Yasar Ozdenkaya, Abdulla O A A Al-Hamaq, Cem Cahit Barisik, Mustafa Ozturk
Background: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients. Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions...
September 2018: Journal of Clinical Medicine Research
Sun-Young Lee, Sery Lim, Dong-Hyu Cho
A 16-year-old female with Ewing sarcoma, a very rare disease with poor prognosis in women, was admitted to the hospital with abdominal pain. Diagnostic laparotomy revealed the Ewing sarcoma originating from the extramural uterus. Histological examination yielded positive test results for CD99, vimentin, S-100, eosin 5-maleimide and periodic acid-Shiff. EWS-FLI1 type 1 translocation was confirmed. Fibroblast growth factor receptor (FGFR) 4 (c.1162G> A) and HRas proto-oncogene (HRAS; c.182A> G) mutations were also detected...
August 2018: Experimental and Therapeutic Medicine
Shiping Yu, Yi Zhang, Lin Chen, Qiang Li, Jinglei Du, Yuduan Gao, Li Zhang, Yongzhen Yang
To improve the bio-solubility and sustained-release properties of a carbon nanotube (CNT)-drug complex, the present study used a hydrophilic polymer, polyethylene glycol (PEG), and β-estradiol (E2), which targets the estrogen receptor in human breast cancer cells (HBCCs), to modify CNTs carrying lobaplatin (LBP) to form E2-PEG-CNT-LBP. The in vitro inhibitory effects against HBCCs and the in vivo pharmacological effect of the complex on heart, liver and kidney tissues were also evaluated. The results indicated that the inhibitory effects of this complex against HBCCs reached 80...
August 2018: Experimental and Therapeutic Medicine
Yanming Sun, Zhitao Yao, Zhihua Zhao, Haifeng Xiao, Mengting Xia, Xiaojun Zhu, Xuelu Jiang, Chuntao Sun
Ovarian cancer has the highest mortality rate and is the most common of all gynecologic malignancies. Novel treatments for ovarian cancer are urgently required to improve outcomes and the overall survival of patients. The present study investigated whether immunotherapy with natural killer (NK) cells affected the survival of mice with ovarian cancer. Results analysis identified adjunctive NK cells as a potential therapeutic method in ovarian cancer. Patient-derived ovarian cells were isolated, cultured and subsequently injected subcutaneously into immune deficient BALB/c-nude mice...
August 2018: Experimental and Therapeutic Medicine
Xi Ou, Jing Guan, Jing-Sen Chen, Jie-Cao Ying, Xiao-Ping Liu, Pei-Kai Tian, Ji-Kui Liu, Li-Ping Nie, Yang Zhao, Guang-Yin Yu
The purpose of the present study was to investigate the role of latency-associated peptide (LAP)+ CD4+ T cells in hepatocellular carcinoma (HCC) immunity. Flow cytometric analysis was performed to detect the proportion of LAP+ CD4+ T cells among the peripheral blood mononuclear cells (PBMCs) of 30 HBV-infected HCC patients at the pre-operative and post-operative stages, as well as 30 hepatitis B virus (HBV)-infected volunteers as a control group. Furthermore, tumor tissues and peri-tumor tissues from 28 patients with HCC, as well as hepatic tissues from 28 HBV-infected patients with benign lesions were subjected to immunohistochemical analysis with double staining for LAP and CD4, and the average number of the LAP+ CD4+ T cells in each visual field was quantified...
August 2018: Experimental and Therapeutic Medicine
Yih Ho, Yan-Fang Chen, Li-Hsuan Wang, Kuang-Yang Hsu, Yu-Tang Chin, Yu-Chen S H Yang, Shwu-Huey Wang, Yi-Ru Chen, Ya-Jung Shih, Leroy F Liu, Kuan Wang, Jacqueline Whang-Peng, Heng-Yuan Tang, Hung-Yun Lin, Hsuan-Liang Liu, Shwu-Jiuan Lin
Traditional herb medicine, golden thread ( Anoectochilus formosanus Hayata) has been used to treat various diseases. Hyperglycemia induces generation of reactive oxygen species (ROS) and enhancement of oxidative stress which are risk factors for cancer progression and metastasis. In this study, we evaluated hypoglycemic effect of A. formosanus extracts (AFEs) in an inducible hyperglycemia animal model and its capacity of free-radical scavenging to establish hyperglycemia-related carcinogenesis. AFE reduced blood glucose in hyperglycemic mice while there was no change in control group...
2018: Frontiers in Pharmacology
Dorian Forte, Daria Sollazzo, Martina Barone, Marisole Allegri, Angela di Martella Orsi, Marco Romano, Barbara Sinigaglia, Giuseppe Auteri, Nicola Vianelli, Michele Cavo, Francesca Palandri, Lucia Catani
Inflammation may play a role in cancer. However, the contribution of cytokine-mediated crosstalk between normal hemopoietic stem/progenitor cells (HSPCs) and their (inflammatory) microenvironment is largely elusive. Here we compared survival, phenotype, and function of neonatal (umbilical cord blood (CB)) and adult (normal G-CSF-mobilized peripheral blood (mPB)) CD34+ cells after in vitro exposure to combined crucial inflammatory factors such as interleukin- (IL-) 1 β , IL-6, tumor necrosis factor- (TNF-) α , or tissue inhibitor of metalloproteinases-1 (TIMP-1)...
2018: Mediators of Inflammation
Mette Ø Agerbæk, Sara R Bang-Christensen, Ming-Hsin Yang, Thomas M Clausen, Marina A Pereira, Shreya Sharma, Sisse B Ditlev, Morten A Nielsen, Swati Choudhary, Tobias Gustavsson, Poul H Sorensen, Tim Meyer, David Propper, Jonathan Shamash, Thor G Theander, Alexandra Aicher, Mads Daugaard, Christopher Heeschen, Ali Salanti
Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for disease monitoring and molecular characterization. Despite the development of many new CTC isolation platforms in the last decade, their isolation and detection has remained a challenge due to the lack of specific and sensitive markers. In this feasibility study, we present a method for CTC isolation based on the specific binding of the malaria rVAR2 protein to oncofetal chondroitin sulfate (ofCS). We show that rVAR2 efficiently captures CTCs from hepatic, lung, pancreatic, and prostate carcinoma patients with minimal contamination of peripheral blood mononuclear cells...
August 16, 2018: Nature Communications
Chen Qian, Asurayya Worrede-Mahdi, Fei Shen, Anthony DiNatale, Ramanpreet Kaur, Qiang Zhang, Massimo Cristofanilli, Olimpia Meucci, Alessandro Fatatis
Circulating Tumor Cells (CTCs) are commonly detected in the systemic blood of cancer patients with metastatic tumors. However, the mechanisms controlling the viability of cancer cells in blood and length of time spent in circulation, as well as their potential for generating additional tumors are still undefined. Here, it is demonstrated that CX3CR1, a chemokine receptor, drives reseeding of breast CTCs to multiple organs. Antagonizing this receptor dramatically impairs the progression of breast cancer cells in a relevant model of human metastatic disease, by affecting both tumor growth and numerical expansion...
August 16, 2018: Molecular Cancer Research: MCR
Michal R Tomaszewski, Marcel Gehrung, James Joseph, Isabel Quiros Gonzalez, Jonathan A Disselhorst, Sarah E Bohndiek
Measuring the functional status of tumour vasculature, including blood flow fluctuations and changes in oxygenation, is important in cancer staging and therapy monitoring. Current clinically approved imaging modalities suffer long procedure times and limited spatio-temporal resolution. Optoacoustic tomography (OT) is an emerging clinical imaging modality that overcomes these challenges. By acquiring data at multiple wavelengths, OT can interrogate haemoglobin concentration and oxygenation directly and resolve contributions from injected contrast agents...
August 16, 2018: Cancer Research
Nadine Wiesmann, Martin Kluenker, Philipp Demuth, Walburgis Brenner, Wolfgang Tremel, Juergen Brieger
The predicted global cancer burden is expected to surpass 20 million new cancer cases by 2025. Despite recent advancement in tumor therapy, a successful cancer treatment remains challenging. The emerging field of nanotechnology offers great opportunities for diagnosis, imaging, as well as treatment of cancer. Zinc oxide nanoparticles (ZnO NP) were shown to exert selective cytotoxicity against tumor cells via a yet unknown mechanism, most likely involving the generation of reactive oxygen species (ROS). These nanoparticles are a promising therapeutic opportunity as zinc is a nontoxic trace element and its application in medically-related products is considered to be safe...
August 7, 2018: Journal of Trace Elements in Medicine and Biology
Soumyalekshmi Nair, Kai Dun Tang, Liz Kenny, Chamindie Punyadeera
Over the past decade, there has been emerging research in the field of extracellular vesicles, especially those originating from endosomes, referred to as 'exosomes. Exosomes are membrane-bound nanovesicles secreted by most cell types upon fusion of multivesicular bodies (MVBs) to the cell plasma membrane. These vesicles are present in almost all body fluids such as blood, urine, saliva, breast milk, cerebrospinal and peritoneal fluids. Exosomes participate in intercellular communication by transferring the biologically active molecules like proteins, nucleic acids, and lipids to neighboring cells...
September 2018: Oral Oncology
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