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Interferon AND diabetic Macular Edema

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https://www.readbyqxmd.com/read/29030692/changes-in-aqueous-concentrations-of-various-cytokines-after-intravitreal-bevacizumab-and-subtenon-triamcinolone-injection-for-diabetic-macular-edema
#1
RANDOMIZED CONTROLLED TRIAL
Seung-Young Yu, Dong Heun Nam, Dae Yeong Lee
PURPOSE: The purpose of this study was to compare the changes in the aqueous cytokine levels after intravitreal bevacizumab with those after combined intravitreal bevacizumab and subtenon triamcinolone injection in diabetic macular edema (DME). METHODS: This study examined 24 eyes of 23 patients with DME. Each patient with DME received randomly either an intravitreal injection of bevacizumab (IVBe) or IVBe with a subtenon triamcinolone injection (IVBe + STTA)...
January 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28564655/aqueous-humor-levels-of-soluble-vascular-endothelial-growth-factor-receptor-and-inflammatory-factors-in-diabetic-macular-edema
#2
Hidetaka Noma, Tatsuya Mimura, Kanako Yasuda, Ryosuke Motohashi, Osamu Kotake, Masahiko Shimura
Aqueous levels of soluble vascular endothelial growth factor receptor (sVEGFR) and inflammatory factors were measured in 35 patients (37 eyes) with diabetic macular edema (DME) receiving anti-vascular endothelial growth factor (VEGF) therapy. Aqueous levels of growth factors (VEGF, placental growth factor [PlGF], and platelet-derived growth factor AA [PDGF-AA]), sVEGFR-1 and -2, soluble intercellular adhesion molecule 1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, -8, -12, and -13, and interferon-inducible 10-kDa protein (IP-10) were significantly higher in the DME group than in the nondiabetic control group...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/26044469/comparison-of-aqueous-concentrations-of-angiogenic-and-in%C3%AF-ammatory-cytokines-based-on-optical-coherence-tomography-patterns-of-diabetic-macular-edema
#3
COMPARATIVE STUDY
Moosang Kim, Yonguk Kim, Seung-Jun Lee
PURPOSE: The purpose was to compare aqueous inflammatory and angiogenic cytokine levels in diabetic macular edema (DME). MATERIALS AND METHODS: Aqueous samples were obtained from 50 eyes with DME and 12 normal eyes (control group). DME was classified according to the morphologic pattern based on optical coherence tomography: Diffuse retinal thickening (DRT; n = 19), cystoid macular edema (CME; n = 17), or serous retinal detachment (SRD; n = 14). Aqueous samples were collected just before intravitreal injection and at the beginning of cataract surgery in the control group...
April 2015: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/25811020/aqueous-cytokines-as-predictors-of-macular-edema-in-patients-with-diabetes-following-uncomplicated-phacoemulsification-cataract-surgery
#4
Ning Dong, Bing Xu, Bingsong Wang, Liqun Chu, Xin Tang
This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentrations of 27 cytokines were measured in aqueous humor using the multiplex bead immunoassay. At the final follow-up examination, 116 patients completed 4 weeks of follow-up, and the incidence of macular edema was 29...
2015: BioMed Research International
https://www.readbyqxmd.com/read/24165224/subtenon-injection-of-natural-leukocyte-interferon-%C3%AE-2a-in-diabetic-macular-edema-a-case-report
#5
Mauro Cellini, Nicole Balducci, Ernesto Strobbe, Emilio C Campos
BACKGROUND: To report the effect of subtenon injections of natural leukocyte interferon α-2a (IFNα) on best corrected visual acuity (BCVA) and central macular thickness (CMT) in a patient with diabetic macular edema (DME). CASE PRESENTATION: A 66-year-old man affected by DME, with glycated hemoglobin (HbA1c) at 6.9%, refractory to laser grid treatment and intravitreal injections of triamcinolone, was selected to receive a cycle of three subtenon injections/week of IFNα (1×106 IU/ml)...
October 28, 2013: BMC Ophthalmology
https://www.readbyqxmd.com/read/23786783/interferon-versus-methotrexate-in-intermediate-uveitis-with-macular-edema-results-of-a-randomized-controlled-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Friederike Mackensen, Eva Jakob, Christina Springer, Bianca C Dobner, Ute Wiehler, Petra Weimer, Klaus Rohrschneider, Christoph Fiehn, Regina Max, Brigitte Storch-Hagenlocher, Matthias D Becker
PURPOSE: To compare interferon (IFN) beta with methotrexate (MTX) in the treatment of intermediate uveitis with macular edema. DESIGN: Monocentric, prospective, randomized, controlled clinical trial. METHODS: <AbstractText Label="SETTING" NlmCategory="METHODS">Specialized uveitis center at the University of Heidelberg. PATIENT OR STUDY POPULATION: Patients with either primary intermediate uveitis or uveitis associated with multiple sclerosis...
September 2013: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/23640687/drug-induced-macular-edema
#7
REVIEW
Olga E Makri, Ilias Georgalas, Constantine D Georgakopoulos
Macular edema constitutes a serious pathologic entity of ophthalmology resulting in vision loss with a remarkable impact on the quality of life of patients. It is the final common pathway of various systemic diseases and underlying intraocular conditions, with diabetes mellitus being the most frequent cause. Other causes include venous occlusive disease, intraocular surgery, and inflammatory conditions of the posterior segment of the eye. Macular edema is a recognized side effect of various systemic and local medications and requires special consideration among ophthalmologists and other clinicians...
June 2013: Drugs
https://www.readbyqxmd.com/read/23531349/ophthalmic-evaluations-in-clinical-studies-of-fingolimod-fty720-in-multiple-sclerosis
#8
RANDOMIZED CONTROLLED TRIAL
Marco A Zarbin, Lee M Jampol, Rama D Jager, Anthony T Reder, Gordon Francis, William Collins, Dejun Tang, Xiaoli Zhang
PURPOSE: To report outcomes of ophthalmic evaluations in clinical studies of patients receiving fingolimod (Gilenya; Novartis Pharma AG, Basel, Switzerland) for multiple sclerosis (MS). DESIGN: Analysis done on pooled safety data (N = 2615, all studies group) from 3 double-masked, randomized, parallel-group clinical trials (phase 2 core and extension >5 years, and phase 3 FREEDOMS and TRANSFORMS core and extension studies). PARTICIPANTS: Patients aged 18 to 55 years (18-60 years in phase 2 study) diagnosed with relapsing-remitting MS were included...
July 2013: Ophthalmology
https://www.readbyqxmd.com/read/23257933/high-vitreous-concentration-of-il-6-and-il-8-but-not-of-adhesion-molecules-in-relation-to-plasma-concentrations-in-proliferative-diabetic-retinopathy
#9
U E Koskela, S M Kuusisto, A E Nissinen, M J Savolainen, M J Liinamaa
BACKGROUND/AIM: Inflammatory markers have been observed in proliferative diabetic retinopathy (PDR). We assessed vitreous concentrations of adhesion molecules and cytokines in PDR and non-diabetic controls and plasma concentrations to differentiate local inflammation from the breakdown of the blood-retina barrier. METHODS: 38 patients with PDR and 16 controls with macular hole or epiretinal membrane underwent vitrectomy. Vitreous and plasma soluble adhesion molecules [sE-selectin, intercellular adhesion molecule (sICAM)-1 and -3, platelet-endothelial cell adhesion molecule (sPECAM)-1, sP-selectin, vascular cell adhesion molecule (sVCAM)-1] and cytokines [interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 (p70), tumour necrosis factor-α and -β, γ-interferon] were detected by the multiplex assay...
2013: Ophthalmic Research
https://www.readbyqxmd.com/read/23095769/effects-of-soluble-cd14-and-cytokine-levels-on-diabetic-macular-edema-and-visual-acuity
#10
Kazuhiko Umazume, Yoshihiko Usui, Yoshihiro Wakabayashi, Yoko Okunuki, Takeshi Kezuka, Hiroshi Goto
PURPOSE: The pathogenesis of diabetic retinopathy has been suggested to be associated with ocular inflammation. Macrophages and monocytes that infiltrate the eye are known to express CD14. After shedding from the membrane-bound CD14, soluble CD14 (sCD14) is released, which could potentially activate inflammatory signaling. In this study, the authors investigated ocular fluid and serum levels of vascular endothelial growth factor (VEGF), sCD14, and other inflammatory cytokines in patients with diabetic macular edema (DME)...
May 2013: Retina
https://www.readbyqxmd.com/read/22930681/comparison-of-aqueous-concentrations-of-angiogenic-and-inflammatory-cytokines-in-diabetic-macular-oedema-and-macular-oedema-due-to-branch-retinal-vein-occlusion
#11
COMPARATIVE STUDY
Won June Lee, Min Ho Kang, Mincheol Seong, Hee Yoon Cho
AIMS: The involvement of cytokines in the aqueous humour is important in the development and progression of diabetic macular oedema (DMO) and macular oedema (MO) due to branch retinal vein occlusion (BRVO-MO). In this study, the concentrations of cytokines in the aqueous humour of eyes with DMO and BRVO-MO were measured and compared. METHODS: Prospective, observational case series. Aqueous samples were obtained from 18 eyes with DMO (DMO group), 12 eyes with BRVO-MO (BRVO-MO group), and 16 normal eyes (control group)...
November 2012: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/22617833/cytokine-concentration-in-aqueous-humor-of-eyes-with-diabetic-macular-edema
#12
COMPARATIVE STUDY
Jost B Jonas, Rahul A Jonas, Michael Neumaier, Peter Findeisen
PURPOSE: To measure cytokine concentrations in aqueous humor of eyes with diffuse diabetic macular edema. METHODS: The interventional clinical comparative study included a study group of 23 patients with diffuse diabetic macular edema and a control group of 22 patients undergoing cataract surgery. Cytokine concentrations were measured in aqueous humor samples using a Luminex xMAP suspension array technology. RESULTS: In the study group as compared with the control group, significantly higher concentrations were measured for epidermal growth factor (P < 0...
November 2012: Retina
https://www.readbyqxmd.com/read/22371414/fingolimod-associated-macular-edema-incidence-detection-and-management
#13
REVIEW
Nieraj Jain, M Tariq Bhatti
Fingolimod (FTY-720), a sphingosine-1-phosphate receptor modulator, is the first US Food and Drug Administration (FDA)-approved oral agent for the treatment of relapsing forms of multiple sclerosis (MS). Two recent phase III clinical studies (TRANSFORMS [Trial Assessing Injectable Interferon vs FTY720 Oral in RRMS] and FREEDOMS [FTY720 Research Evaluating Effects of Daily Oral Therapy in MS]) demonstrated a significant reduction in the annualized relapse rate in patients with relapsing-remitting MS, compared to once weekly interferon β-1a and placebo...
February 28, 2012: Neurology
https://www.readbyqxmd.com/read/21782151/changes-in-aqueous-concentrations-of-various-cytokines-after-intravitreal-triamcinolone-versus-bevacizumab-for-diabetic-macular-edema
#14
COMPARATIVE STUDY
Hee Jin Sohn, Dae Heon Han, Im Tae Kim, In Kyung Oh, Kyun Hyung Kim, Dae Yeong Lee, Dong Heun Nam
PURPOSE: To investigate the changes in aqueous inflammatory and angiogenic cytokine levels after intravitreal injection of triamcinolone or bevacizumab for reducing foveal thickness in diabetic macular edema (DME). DESIGN: Prospective, interventional case series. METHODS: Twenty-two eyes of 11 patients with bilateral DME and 6 eyes of 6 patients undergoing cataract surgery participated in this study. In each DME patient, 1 eye received an intravitreal injection of 4 mg triamcinolone acetonide and the other eye received 1...
October 2011: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/21538000/expression-profiles-of-cytokines-and-chemokines-in-vitreous-fluid-in-diabetic-retinopathy-and-central-retinal-vein-occlusion
#15
COMPARATIVE STUDY
Yukihiko Suzuki, Mitsuru Nakazawa, Kaori Suzuki, Hitoshi Yamazaki, Yasuhiro Miyagawa
PURPOSE: The involvement of cytokines and chemokines in vitreous fluid is important in the development and progression of diabetic retinopathy (DR) and central retinal vein occlusion (CRVO). In this study, the concentrations of cytokines and chemokines in the vitreous fluid of eyes with DR and CRVO were measured and compared. METHODS: We studied 76 eyes with proliferative DR and diabetic macular edema (DR group), 10 eyes with CRVO (CRVO group), and 23 eyes with an epiretinal membrane and macular hole (control group), among a series of 160 eyes from which vitreous fluid samples were collected during vitrectomy...
May 2011: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/16705506/-interferon-causes-ischemic-ocular-diseases-case-studies-and-review-of-the-literature
#16
REVIEW
B M Stoffelns
BACKGROUND: Reports of interferon-associated retinopathy mainly originate from Japanese working groups. Only a few cases have been described in Europe. PATIENTS AND METHODS: We have performed a retrospective analysis of the patients who were examined in the University Eye Clinic in Mainz complaining of visual loss associated with systemic interferon therapy in the time span between January 2001 and December 2003. RESULTS: 12 patients (age 35 - 67 years), undergoing treatment with interferon alpha for hepatitis C, metastatic renal cell carcinoma, leukaemia and malignant melanoma of the skin, complained of blurred vision 2 - 10 weeks after the start of interferon therapy...
May 2006: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/16249511/serum-inflammatory-markers-in-diabetic-retinopathy
#17
Annal D Meleth, Elvira Agrón, Chi-Chao Chan, George F Reed, Kiran Arora, Gordon Byrnes, Karl G Csaky, Frederick L Ferris, Emily Y Chew
PURPOSE: To evaluate the association of serum factors with the severity of diabetic retinopathy and to assess their presence in retinal tissue obtained at autopsy. METHODS: The following serum factors of 93 subjects were examined at the National Eye Institute (NEI) clinical center: the chemokines regulated on activation, normal T-cell expressed and presumably secreted (RANTES)/CCL5, epithelial neutrophil activator (ENA)-78/CXCL5, interferon-induced protein (IP)-10/CXCL10, stromal cell-derived factor (SDF)-1alpha/CXCLl2, monocyte chemoattractant protein (MCP)-1/CCL2, macrophage inflammatory protein (MIP)-1alpha/CCL3, interleukin (IL)-8/CXCL8; the cytokine IL-6; the cell adhesion molecules intercellular adhesion molecule (ICAM-1/CD54) and vascular cell adhesion molecule (VCAM/CD106); and the growth factor vascular endothelial growth factor (VEGF)...
November 2005: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/15523197/pharmacotherapy-for-diabetic-retinopathy
#18
REVIEW
Grant M Comer, Thomas A Ciulla
PURPOSE OF REVIEW: Diabetic retinopathy (DR) is a potentially visually devastating complication of chronic hyperglycemia and other associated systemic abnormalities. Numerous large, prospective, randomized clinical trials have delineated the current standard prevention and treatment protocols including intensive glycemic and blood pressure control and laser photocoagulation for neovascularization and clinically significant macular edema. However, despite standard intervention, vision loss from DR still occurs at an alarming rate...
December 2004: Current Opinion in Ophthalmology
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