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Chorangiosis

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https://www.readbyqxmd.com/read/29728721/characterization-of-the-placenta-in-the-newborn-with-congenital-heart-disease-distinctions-based-on-type-of-cardiac-malformation
#1
Jack Rychik, Donna Goff, Eileen McKay, Antonio Mott, Zhiyun Tian, Daniel J Licht, J William Gaynor
The placenta is a complex organ that influences prenatal growth and development, and through fetal programming impacts postnatal health and well-being lifelong. Little information exists on placental pathology in the presence of congenital heart disease (CHD). Our objective is to characterize the placenta in CHD and investigate for distinctions based on type of malformation present. Placental pathology from singleton neonates prenatally diagnosed and delivered at > 37 weeks gestation was analyzed. Placental findings of absolute weight, placental weight-to-newborn birth weight ratio, chorangiosis, villus maturity, thrombosis, and infarction were recorded and analyzed based on four physiological categories of CHD: (1) single ventricle-aortic obstruction, (2) single ventricle-pulmonic obstruction, (3) two-ventricle anomalies, and (4) transposition of the great arteries (TGA)...
August 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29684915/histological-analysis-of-term-placentas-from-hyperimmune-globulin-treated-and-untreated-mothers-with-primary-cytomegalovirus-infection
#2
Liliana Gabrielli, Maria Paola Bonasoni, Maria Pia Foschini, Enrico Maria Silini, Arsenio Spinillo, Maria Grazia Revello, Angela Chiereghin, Giulia Piccirilli, Evangelia Petrisli, Gabriele Turello, Giuliana Simonazzi, Dino Gibertoni, Tiziana Lazzarotto
BACKGROUND: The Congenital Human Cytomegalovirus Infection Prevention (CHIP) study, a randomized, blinded, placebo-controlled trial, demonstrated that the efficacy of hyperimmune globulin (HIG) was not different from that of placebo regarding transmission of cytomegalovirus (CMV) from mothers to newborns. Our aim was to analyze histologically HIG effects on placentas collected for the CHIP study. MATERIALS AND METHODS: Virological and histological analyses were performed on 40 placentas from transmitter and nontransmitter HIG-treated and untreated mothers by assessing the number of CMV-positive cells, tissue viral load, tissue damage, and compensatory mechanisms...
April 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28966481/histopathological-study-with-immunohistochemical-expression-of-vascular-endothelial-growth-factor-in-placentas-of-hyperglycemic-and-diabetic-women
#3
Debashish Bhattacharjee, Santosh Kumar Mondal, Pratima Garain, Palash Mandal, Rudra Narayan Ray, Goutam Dey
AIMS AND OBJECTIVES: Spectrum of hyperglycemia in pregnancy includes gestational diabetes mellitus (GDM), mild hyperglycemia, and overt diabetes. Many authors have worked on morphological changes of the placenta in diabetes, but few studies have correlated histopathological changes with vascular endothelial growth factor (VEGF) immunoexpression. The aim of this study was to detect different histopathological changes in various groups of diabetic placentas and to correlate with VEGF immunoexpression...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28623966/relative-amount-of-telomeric-sequences-in-terminal-villi-does-not-differ-between-normal-term-placentas-and-placentas-from-patients-with-well-controlled-type-1-diabetes-mellitus
#4
Alžběta Zinková, Dominika Marová, Júlia Koperdáková, Tomáš P Mirchi, Marie Korabečná, Marie Jirkovská
We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening.
July 2017: Placenta
https://www.readbyqxmd.com/read/28607782/placental-chorangiosis-increased-risk-for-cesarean-section
#5
Shariska S Petersen, Raminder Khangura, Dmitry Davydov, Ziying Zhang, Roopina Sangha
We describe a patient with Class C diabetes who presented for nonstress testing at 36 weeks and 4 days of gestation with nonreassuring fetal heart tones (NRFHT) and oligohydramnios. Upon delivery, thrombosis of the umbilical cord was grossly noted. Pathological analysis of the placenta revealed chorangiosis, vascular congestion, and 40% occlusion of the umbilical vein. Chorangiosis is a vascular change of the placenta that involves the terminal chorionic villi. It has been proposed to result from longstanding, low-grade hypoxia in the placental tissue and has been associated with such conditions such as diabetes, intrauterine growth restriction (IUGR), and hypertensive conditions in pregnancy...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28254209/preliminary-experience-using-three-dimensional-hdlive-rendered-images-for-antenatal-diagnosis-in-placental-chorangiosis
#6
Eisuke Inubashiri, Yukio Watanabe, Noriyuki Akutagawa, Masaki Sugawara, Katumaru Kuroki, Nobuhiko Maeda
No abstract text is available yet for this article.
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28127876/decidual-arteriolopathy-with-or-without-associated-hypertension-modifies-the-underlying-histomorphology-in-placentas-from-diabetic-mothers
#7
Jerzy Stanek
AIM: The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM). METHODS: Among all 5248 > 20 weeks' placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre-eclampsia, chronic hypertension)...
January 27, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28083057/effects-of-diet-and-metformin-on-placental-morphology-in-gestational-diabetes-mellitus
#8
Rabia Arshad, Muhammad Adnan Kanpurwala, Nasim Karim, Jahan Ara Hassan
OBJECTIVE: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). METHODS: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control...
November 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27817070/-incidental-chorangiocarcinoma-case-report-immunohistochemistry-and-theories-of-possible-histogenesis
#9
M Guschmann, K Schulz-Bischof, M Vogel
We describe the third case world-wide of a chorangiocarcinoma, a tumour with an abnormal trophoblast proliferation in combination with a hypervascular chorangiosis of the villous stroma. The lesion was an incidential finding by a healthy 31-year-old woman, gravida 1, para 1 when the pregnancy was terminated at 34 weeks gestation because of fetal distress and intrauterine growth restriction. Hormonal levels were within the normal range. Mother and infant had an uneventful postpartum course. Immunohistochemical studies of the abnormal trophoblasts demonstrated strong immunoreactivity for HCG and in 80% for Ki 67...
March 2003: Der Pathologe
https://www.readbyqxmd.com/read/27649292/placental-pathology-in-relation-to-uterine-artery-doppler-findings-in-pregnancies-with-severe-intrauterine-growth-restriction-and-abnormal-umbilical-artery-doppler-changes
#10
Khrystyna Levytska, Mary Higgins, Sarah Keating, Nir Melamed, Melissa Walker, Neil J Sebire, John C P Kingdom
Objectives  Current guidelines for diagnosis and management of early-onset intrauterine growth restriction (IUGR) rely on umbilical artery Doppler (UAD), without including uterine artery Doppler (UtAD). We hypothesized that IUGR cases with abnormal UAD but normal UtAD has a different spectrum of placental pathology compared with those with abnormal UtAD. Study Design  Retrospective review of pregnancies with sonographic evidence of IUGR and abnormal UAD prior to delivery. Cases with ≥ 1 UtAD record(s) after 18+0 weeks' gestation and placental pathology were included...
April 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/27232351/chorangiosis-of-chorionic-villi-what-does-it-really-mean
#11
Jerzy Stanek
CONTEXT: -Chorangiosis has been regarded as a result of low-grade placental hypoxia associated with pregnancy risk factors and abnormal outcomes. It is unknown whether these are a consequence of chorangiosis itself or of associated other placental pathology. OBJECTIVE: -To prove that chorangiosis itself does not portend an increased risk for pregnancy unless associated with other placental pathology. DESIGN: -This retrospective statistical study analyzes 1231 consecutive placentas with diffuse or focal hypervascularity of chorionic villi: 328 with preuterine pattern of chronic hypoxic placental injury (group 1), 297 with uterine type of chronic hypoxic placental injury (group 2), and 606 cases with chorangiosis (group 3) not fulfilling the inclusion criteria for groups 1 or 2...
June 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26492420/meconium-associated-umbilical-vascular-myonecrosis-correlations-with-adverse-outcome-and-placental-pathology
#12
Adela Cimic, Rebecca N Baergen
Intrauterine passage of meconium is common, occurring in approximately 10-15% of term births. Uncommonly, long-standing meconium exposure is associated with umbilical vascular myonecrosis, but few studies have evaluated specific clinical and pathologic features. This is a retrospective study of 481 term placentas: 139 with meconium-associated myonecrosis, 139 with meconium in fetal membranes, only 62 with meconium in the cord without myonecrosis, and 139 controls without meconium. We studied clinical factors, including clinical evidence of meconium discharge, fetal distress, APGAR scores, intrauterine growth restriction (IUGR), and intrauterine fetal demise (IUFD), and histologic factors, including acute chorioamnionitis, umbilical cord complications, uteroplacental malperfusion, fetal thrombosis, chorangiosis, and fetal nucleated red blood cells...
July 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26303757/type-1-type-2-and-gestational-diabetes-mellitus-differentially-impact-placental-pathologic-characteristics-of-uteroplacental-malperfusion
#13
Jennifer Huynh, Jessica Yamada, Catherine Beauharnais, Julia B Wenger, Ravi I Thadhani, Deborah Wexler, Drucilla J Roberts, Rhonda Bentley-Lewis
INTRODUCTION: During a pregnancy complicated by diabetes, the placenta undergoes a number of functional and structural pathologic changes. However, differences across studies may reflect pathophysiologic differences of diabetes types under investigation. METHODS: We examined placental pathology from women ages 18-40 years with self-identified race/ethnicity; singleton, live births; and type 1 (T1DM; n = 36), type 2 (T2DM; n = 37), or gestational diabetes mellitus (GDM; n = 126)...
October 2015: Placenta
https://www.readbyqxmd.com/read/26071574/placental-pathologic-changes-in-gestational-diabetes-mellitus
#14
REVIEW
Patrycja Jarmuzek, Miroslaw Wielgos, Dorota Bomba-Opon
Nowadays, the continuous rise of maternal obesity is followed by increased gestational diabetes mellitus incidence. GDM is associated with adverse fetal and neonatal outcome that often presents with macrosomia, birth trauma, neonatal hypoglycemia, and respiratory distress syndrome. Inclusion of GDM into 'the great obstetrical syndromes' emphasizes the role of the placenta in interactions of the maternal and fetal unit. The placenta acts as a natural selective barrier between maternal and fetal blood circulations...
2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/25762365/placental-hypoxic-overlap-lesions-a-clinicoplacental-correlation
#15
Jerzy Stanek
AIM: This retrospective analysis is aimed to study clinical and placental associations of placental acute, chronic, and acute-on-chronic (overlap) hypoxic lesions. MATERIAL AND METHODS: Frequencies of 32 clinical (maternal and fetal) and 47 placental (gross and microscopic) phenotypes were compared by the Yates χ(2) with the Holm-Bonferroni correction among consecutive placentas from 2831 ≥ 16-week gestations: 778 placentas with chronic hypoxic lesion(s) (diffuse patterns of hypoxic placental injury, chorangiosis, excessive extravillous trophoblasts, microscopic chorionic pseudocysts, clusters of decidual multinucleate trophoblasts), 481 placentas with acute hypoxic lesion(s) (infarction, intravillous hemorrhage, deep meconium penetration, membrane laminar necrosis), 585 placentas with hypoxic overlap lesion(s) (coexisting at least one lesion from each of the above groups), and 987 placentas without placental hypoxic lesions, adjusted for gestational age...
March 2015: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/25725662/placental-changes-in-pregnancy-induced-hypertension-and-its-impacts-on-fetal-outcome
#16
L Nahar, K Nahar, M I Hossain, H Yasmin, B M Annur
A descriptive cross sectional study was carried out in the Gynae and Obstetrics & Pathology department of Mymensingh Medical College & Hospital (MMCH) to see the placental changes in normal & pregnancy induced hypertension (PIH) and its impacts on fetus for one year period. Total 80 placentas were collected, 40 from normal pregnant mothers having no hypertension and 40 from PIH group (one from gestational hypertension, 17 from pre-eclampsia and 22 from eclampsia. Macroscopic study of the placenta revealed placental weight, surface area and number of cotyledons were less in study group...
January 2015: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/25506430/a-prospective-study-of-villous-capillary-lesions-in-complicated-pregnancies
#17
Anu Priyadharshini Srinivasan, B O Parijatham Omprakash, Kandhimalla Lavanya, Priyadharshini Subbulakshmi Murugesan, Saraswathi Kandaswamy
The vascularity of placental tissue is dependent on various factors of which fetomaternal hypoxia plays a major role. Hypoxia can be of different types and each type influences the vascularity of the villi, especially terminal villi, in its own way. In this study, we attempted to identify villous vascular changes in a group of term placentae from mothers with diseases complicating pregnancy. Chorangiosis was the most frequently identified lesion while chorangioma was found in only 2 cases. There were no cases of chorangiomatosis...
2014: Journal of Pregnancy
https://www.readbyqxmd.com/read/25406659/chorangiomatosis-evaluation-of-a-placental-vascular-lesion-and-related-clinical-effects
#18
Amir Momeni Boroujeni, Elham Yousefi, Miriam T Vincent, Virginia Anderson
BACKGROUND: Chorangiomatosis is a unique placental vascular abnormality that can cause growth retardation and even fetal demise in severe cases. In this study we aim to better understand this lesion and the possible clinical implications. METHODS AND MATERIALS: In this study 170 placentas were evaluated, both grossly and microscopically. The patients' charts were reviewed and relevant clinical data were extracted. In the histological examination, presence of placental lesions including chorangiomatosis (focal, multifocal and diffuse) and chorangiosis was determined and possible correlation between placental findings and clinical outcomes investigated...
October 2014: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/25225057/gestational-diabetes-as-one-of-the-great-obstetrical-syndromes-the-maternal-placental-and-fetal-dialog
#19
REVIEW
Rinat Gabbay-Benziv, Ahmet A Baschat
Gestational diabetes mellitus (GDM)-associated fetal and neonatal adverse outcome results from the metabolic milieu projected on the fetus via the placental interface. Therefore, it can be considered to be one of the great obstetrical syndromes. Placentas from GDM pregnancies differ from nondiabetic pregnancies by an increased placental to fetal ratio and by histological findings such as villous fibrinoid necrosis, villous immaturity, chorangiosis, and ischemic changes. While early onset diabetes is more associated with marked structural changes of the placenta, GDM that rises at late gestation is associated more with placental functional changes...
February 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/24619761/placental-histomorphometry-in-gestational-diabetes-mellitus-the-relationship-between-subsequent-type-2-diabetes-mellitus-and-race-ethnicity
#20
Rhonda Bentley-Lewis, Deanna L Dawson, Julia B Wenger, Ravi I Thadhani, Drucilla J Roberts
OBJECTIVES: We examined placental histomorphometry in gestational diabetes mellitus (GDM) for factors associated with race/ethnicity and subsequent type 2 diabetes mellitus (T2DM). METHODS: We identified 124 placentas from singleton, full-term live births whose mothers had clinically defined GDM and self-reported race/ethnicity. Clinical and placental diagnoses were abstracted from medical records. RESULTS: Forty-eight white and 76 nonwhite women were followed for 4...
April 2014: American Journal of Clinical Pathology
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