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Vitamin d falls

Parminder Singh
Vitamin D is essential for the maintenance of calcium and phosphorus homeostasis, skeletal growth and various other metabolic processes. The prevalence of vitamin D deficiency in India is 50-90% in various studies. Factors such as low sunlight exposure, age-related decrease in cutaneous synthesis, and low dietary intake of vitamin D contribute to the high prevalence of vitamin D inadequacy which has emerged as a highly pervasive condition. Bone diseases such as rickets in children, osteomalacia and osteoporosis in adults are related with vitamin D insufficiency...
January 2018: Journal of the Association of Physicians of India
L Murthy, P Dreyer, P Suriyaarachchi, F Gomez, C L Curcio, D Boersma, G Duque
BACKGROUND: Frailty is associated with poor outcomes hence identification of risks factors is pivotal. Since the independent role of parathyroid hormone (PTH) in frailty remains unexplored, we aimed to determine this in a population of older individuals with a history of falling. DESIGN: Cross-sectional study. SETTING: Falls and Fracture Clinic, Nepean Hospital (Penrith, Australia). PARTICIPANTS: 692 subjects (mean age=79, 65% women) assessed between 2009-2015...
2018: Journal of Frailty & Aging
J Chris Gallagher
No abstract text is available yet for this article.
October 4, 2018: Lancet Diabetes & Endocrinology
Mark J Bolland, Andrew Grey, Alison Avenell
BACKGROUND: The effects of vitamin D on fractures, falls, and bone mineral density are uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin D supplementation on fractures, falls, and bone density. METHODS: In this systematic review, random-effects meta-analysis, and trial sequential analysis, we used findings from literature searches in previously published meta-analyses. We updated these findings by searching PubMed, Embase, and Cochrane Central on Sept 14, 2017, and Feb 26, 2018, using the search term "vitamin D" and additional keywords, without any language restrictions...
October 4, 2018: Lancet Diabetes & Endocrinology
Auda Fares
Fractures are major cause of morbidity, mortality, and healthcare and social services expenditure in elderly. Fractures often have multifactorial etiologies and the condition emerges due to the interaction between the different predisposing and precipitating factors. One of the most common causes leading to fractures after minimal trauma in older people is osteoporosis. The objective of this article is to describe the clinical concept and summarize the evidence and to explain the future directions for research, focusing on specific issues related to prevent fracture in the elderly...
2018: International Journal of Preventive Medicine
Miles D Witham, Margaret M Band, Rosemary J G Price, Roberta L Fulton, Clare L Clarke, Peter T Donnan, Roy L Soiza, Vera Cvoro
Background/Aims Recruitment to trials of intervention for older people who fall is challenging. Evidence suggests that the word falls has negative connotations for older people, and this may present a barrier to engaging with trials in this area. We therefore tested whether a participant information sheet that minimised reference to falls could improve recruitment rates. Methods We conducted a study within a trial, embedded within a randomised controlled trial of vitamin K versus placebo to improve postural sway in patients aged 65 and over with a history of falls...
September 27, 2018: Clinical Trials: Journal of the Society for Clinical Trials
Amie L Hiller, Charles F Murchison, Brenna M Lobb, Susan O'Connor, Morgan O'Connor, Joseph F Quinn
OBJECTIVES: To explore if short term, high dose vitamin D supplementation is safe and improves balance in persons with Parkinson's disease (PD). METHODS: A pilot randomized, double-blind intervention trial to measure the effects of 16 weeks of high dose vitamin D (10,000 IU/day) on balance as well as other motor and non-motor features of PD. We measured balance, gait, strength, falls, cognition, mood, PD severity, and quality of life before and after 16 weeks of high dose vitamin D supplementation or placebo...
2018: PloS One
K Uusi-Rasi, R Patil, S Karinkanta, K Tokola, P Kannus, C Lamberg-Allardt, H Sievänen
Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk. INTRODUCTION: Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women...
September 25, 2018: Osteoporosis International
Donald C McMillan, Donogh Maguire, Dinesh Talwar
Micronutrients such as trace elements and vitamins are important as enzyme cofactors in the metabolism of all cells in the body and therefore key to determining nutritional status. The present systematic review examined the evidence of the impact of the systemic inflammatory response on plasma micronutrient status in acute (surgical) and chronic tissue injury. A literature review using targeted subject headings was carried out. Plasma C-reactive protein was used to classify minor (80 mg/l) inflammation. The literature search produced 2344 publications and plasma vitamin D, zinc and carotenoids were most commonly studied and plasma vitamins K, B2 and B6 were least studied...
September 17, 2018: Proceedings of the Nutrition Society
Julia J Rucklidge, Matthew J F Eggleston, Kathryn A Darling, Aaron J Stevens, Martin A Kennedy, Christopher M Frampton
BACKGROUND: Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement, but no group differences on clinician, parent and teacher ratings of overall ADHD symptoms. There was an advantage of micronutrients over placebo in improving overall function, emotional regulation, aggression, and reducing impairment as well as improving inattention based on clinician but not parent observation...
September 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Ian D Cameron, Suzanne M Dyer, Claire E Panagoda, Geoffrey R Murray, Keith D Hill, Robert G Cumming, Ngaire Kerse
BACKGROUND: Falls in care facilities and hospitals are common events that cause considerable morbidity and mortality for older people. This is an update of a review first published in 2010 and updated in 2012. OBJECTIVES: To assess the effects of interventions designed to reduce the incidence of falls in older people in care facilities and hospitals. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (August 2017); Cochrane Central Register of Controlled Trials (2017, Issue 8); and MEDLINE, Embase, CINAHL and trial registers to August 2017...
September 7, 2018: Cochrane Database of Systematic Reviews
Stephany I Adame Perez, Peter A Senior, Catherine J Field, Kailash Jindal, Diana R Mager
OBJECTIVES: Frailty can cause increased vulnerability to adverse health outcomes, such as falls, fractures, depression and reduced health-related quality of life (HRQoL). This cross-sectional study compared the differences in body composition, HRQoL, mental health and cognitive and vitamin D (vitD) status with health-care utilization by frail and nonfrail adults with diabetes mellitus (type 1 and type 2) and with chronic kidney disease (stages 1 through 5). METHODS: We studied adults with type 1 and type 2 diabetes and chronic kidney disease stages 1 through 5 who were participating in a longitudinal follow-up study (41 to 83 years of age; n=41)...
June 20, 2018: Canadian Journal of Diabetes
Erin D Michos, Christine M Mitchell, Edgar R Miller, Alice L Sternberg, Stephen P Juraschek, Jennifer A Schrack, Sarah L Szanton, Jeremy D Walston, Rita R Kalyani, Timothy B Plante, Robert H Christenson, Dave Shade, James Tonascia, David L Roth, Lawrence J Appel
Prior evidence suggests that vitamin D supplementation may reduce fall risk, but existing data are inconsistent and insufficient to guide policy. We designed a two-stage Bayesian response-adaptive dose-finding and seamless confirmatory randomized trial of vitamin D supplementation to prevent falls. Up to 1200 community-dwelling persons, aged ≥70 years, of predominantly white and African-American race, with serum 25(OH)D concentrations of 10-29 ng/mL and at elevated fall risk, will be randomized to one of four vitamin D3 (cholecalciferol) supplement doses: 200 (control), 1000, 2000, or 4000 IU/day and treated for up to 2 years...
October 2018: Contemporary Clinical Trials
Peter Ebeling, Robert Adler, Glenville Jones, Uri A Liberman, Gherando Mazziotti, Salvatore Minisola, Craig Munns, Nicola Napoli, Anastassios Pittas, Andrea Giustina, John P Bilezikian, Rene Rizzoli
Objective: The central role of vitamin D in bone health is well recognized. However, controversies regarding its clinical application remain. We therefore aimed to review the definition of hypovitaminosis D, the skeletal and extra-skeletal effects of vitamin D and the available therapeutic modalities. Design: Narrative and systematic literature review. Methods: An international working group that reviewed the current evidence linking bone and extra-skeletal health and vitamin D therapy to identify knowledge gaps for future research...
October 12, 2018: European Journal of Endocrinology
Jia Xuan Siew, Fabian Yap
A 14-year-old athletic girl with a history of intermittent aches and pains following sports presented with right shoulder pain after a fall during basketball. On examination, tenderness over the anterolateral deltoid to the mid-humeral shaft was noted, extremes of shoulder movement were limited, but no deformity was present. No other injuries were present. A right shoulder X-ray was requested (figure 1). edpract;archdischild-2018-315774v1/F1F1F1Figure 1Right shoulder X-ray. QUESTIONS 1: 1. What abnormalities are visible on the shoulder X-ray? QUESTION 2: 2...
August 21, 2018: Archives of Disease in Childhood. Education and Practice Edition
María Julia Ferronato, Diego Javier Obiol, Eliana Noelia Alonso, Josefina Alejandra Guevara, Silvina Mariela Grioli, Marilina Mascaró, Marcos Lois Rivadulla, Andrea Martínez, Generosa Gómez, Yagamare Fall, Mario Alfredo Quevedo, Alejandro Carlos Curino, María Marta Facchinetti
Calcitriol analogs have shown promising potential as compounds to be used in cancer chemotherapy. This report presents the synthesis of a novel vitamin D3 derivative with an amide and a carboxyl group in its side chain, called ML-344. In addition, we report its in vitro antitumor activity and its in vivo calcemic effects. We demonstrate that the analog decreases cell viability and retards cell migration of different breast, glioblastoma and head and neck cancer cell lines. Additionally, unlike calcitriol, ML-344 does not display citotoxicity to the murine non-malignant mammary cells and human astrocytes...
August 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
Judy A Stevens, Robin Lee
INTRODUCTION: Falls often cause severe injuries and are one of the most costly health conditions among older adults. Yet, many falls are preventable. The number of preventable medically treated falls and associated costs averted were estimated by applying evidence-based fall interventions in clinical settings. METHODS: A review of peer-reviewed literature was conducted in 2017 using literature published between 1994 and 2017, the authors estimated the prevalence of seven fall risk factors and the effectiveness of seven evidence-based fall interventions...
September 2018: American Journal of Preventive Medicine
Bernard Cortet, Stéphanie Lucas, Isabelle Legroux-Gerot, Guillaume Penel, Christophe Chauveau, Julien Paccou
Both type 1 and type 2 diabetes mellitus are associated with bone disorders, albeit via different mechanisms. Early studies in patients with type 1 diabetes suggested a 10-fold increase in the hip fracture risk compared to non-diabetic controls. Meta-analyses published more recently indicate a somewhat smaller risk increase, with odds ratios of 6 to 7. Diminished bone mineral density is among the contributors to the increased fracture risk. Both types of diabetes are associated with decreased bone strength related to low bone turnover...
August 8, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Mehdi Safarpour, Seyed Reza Hosseini, Masume Mohamadzade, Ali Bijani, Akbar Fotouhi
Objective: To determine the incidence and predictive factors of the falls in elderly women in Northern Iran. Methods: A total of 717 elderly women aged 60 years and above in Amirkola, Northern of Iran participated in this study. Age, history of falls during the 12 months leading to the study, accompanying diseases, status of balance, cognitive status, orthostatic hypotension, state of depressive symptoms, strength of quadriceps muscles and serum vitamin D level were assessed as independent variables during baseline measurement...
July 2018: Bulletin of Emergency and Trauma
Branko Gabrovec, Gregor Veninšek, Luz López Samaniego, Ana Maria Carriazo, Eleftheria Antoniadou, Marjetka Jelenc
BACKGROUND AND PURPOSE: There is sufficient evidence that nutrition and frailty status are related. In order to deliver quality management of frail and pre-frail patients, clinicians and dieticians should understand the role of nutrition in the concept of frailty. This study examines the role of nutrition in ageing in general, malnutrition and the risk of frailty, individual nutritional factors as the risk factors of frailty and lastly nutritional interventions that have a significant role in frailty...
October 2018: European Journal of Internal Medicine
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