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Vitamin d falls

Bernard Cortet, Stéphanie Lucas, Isabelle Legroux-Gerot, Guillaume Penel, Christophe Chauveau, Julien Paccou
Both type 1 and type 2 diabetes mellitus are associated with bone disorders, albeit via different mechanisms. Early studies in patients with type 1 diabetes suggested a 10-fold increase in the hip fracture risk compared to nondiabetic controls. Metaanalyses published more recently indicate a somewhat smaller risk increase, with odds ratios of 6 to 7. Diminished bone mineral density is among the contributors to the increased fracture risk. Both types of diabetes are associated with decreased bone strength related to low bone turnover...
August 8, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Mehdi Safarpour, Seyed Reza Hosseini, Masume Mohamadzade, Ali Bijani, Akbar Fotouhi
Objective: To determine the incidence and predictive factors of the falls in elderly women in Northern Iran. Methods: A total of 717 elderly women aged 60 years and above in Amirkola, Northern of Iran participated in this study. Age, history of falls during the 12 months leading to the study, accompanying diseases, status of balance, cognitive status, orthostatic hypotension, state of depressive symptoms, strength of quadriceps muscles and serum vitamin D level were assessed as independent variables during baseline measurement...
July 2018: Bulletin of Emergency and Trauma
Branko Gabrovec, Gregor Veninšek, Luz López Samaniego, Ana Maria Carriazo, Eleftheria Antoniadou, Marjetka Jelenc
BACKGROUND AND PURPOSE: There is sufficient evidence that nutrition and frailty status are related. In order to deliver quality management of frail and pre-frail patients, clinicians and dieticians should understand the role of nutrition in the concept of frailty. This study examines the role of nutrition in ageing in general, malnutrition and the risk of frailty, individual nutritional factors as the risk factors of frailty and lastly nutritional interventions that have a significant role in frailty...
August 3, 2018: European Journal of Internal Medicine
Gillian Wheater, Mohsen Elshahaly, Kamran Naraghi, Stephen P Tuck, Harish K Datta, Jacob M van Laar
Data describing the effect of in vivo B cell depletion on general bone loss in patients with rheumatoid arthritis (RA) are limited. Given the pathogenetic role of B cells in RA, it is tempting to speculate that B cell depletion might have a beneficial effect on bone loss. We prospectively investigated the changes in bone mineral density (BMD), bone turnover, inflammation and disease activity before and after rituximab in 45 RA patients over a 12 month period, 36 patients of whom completed the study and were included in the analysis...
2018: PloS One
Claire L Wood, Volker Straub
PURPOSE OF REVIEW: Muscle and bone are intrinsically linked, and therefore, it is not surprising that many muscular dystrophies are associated with impaired bone health and increased risk of osteoporosis. Osteoporotic fracture is an important and preventable cause of morbidity and mortality. This article will firstly review the general causes of impaired bone health in muscular dystrophies and then focus on the evidence available for the diagnosis and treatment of osteoporosis in specific conditions...
August 4, 2018: Current Opinion in Neurology
Simon Ghaly, Nadeem O Kaakoush, Frances Lloyd, Terence McGonigle, Danny Mok, Angela Baird, Borut Klopcic, Lavinia Gordon, Shelley Gorman, Cynthia Forest, Roger Bouillon, Ian C Lawrance, Prue H Hart
Vitamin D has been suggested as a possible adjunctive treatment to ameliorate disease severity in human inflammatory bowel disease. In this study, the effects of diets containing high (D++, 10,000 IU/kg), moderate (D+, 2,280 IU/kg) or no vitamin D (D-) on the severity of dextran sodium sulphate (DSS) colitis in female C57Bl/6 mice were investigated. The group on high dose vitamin D (D++) developed the most severe colitis as measured by blinded endoscopic (p < 0.001) and histologic (p < 0.05) assessment, weight loss (p < 0...
July 31, 2018: Scientific Reports
David A Smith
Falls are common in nursing homes (NHs) and may result in serious injury to the resident as well as legal and regulatory liability for the NH. Some of these falls and injuries might be avoided if attending physicians were involved in risk reduction. I developed a communication tool to solicit from attending physicians specific risks for patients most likely to experience a fall and injury, and to consider strategies to reduce those risks. The communication tool addresses medications, osteopenia, vitamin D deficiency, vision, hearing, gait/balance/peripheral sensation, injury mitigation, altered mental status, restraints, and philosophy of treatment...
August 2018: Journal of the American Medical Directors Association
Olive Tang, Stephen P Juraschek, Lawrence J Appel
Recent guidelines have advocated against the use of vitamin D supplementation as a means to prevent falls in older adults. However, meta-analyses of the available trials have reached divergent conclusions, and the key design features of these trials have not been well characterized. We conducted a systematic review of 30 randomized trials that reported the effects of vitamin D supplements on falls. Trials were identified by reviewing references of published meta-analyses and updated with a systematic PubMed search...
July 26, 2018: Nutrients
LaVerne L Brown, Barbara Cohen, Derrick Tabor, Giovanna Zappalà, Padma Maruvada, Paul M Coates
The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, all components of the U.S. National Institutes of Health, co-sponsored an expert panel meeting to discuss the vitamin D paradox in Black Americans. The paradox is that despite markedly low (or "deficient") measures of vitamin D status in Black Americans, the incidence of falls, fractures, or osteopenia are significantly lower compared to White American counterparts with similar vitamin D status...
2018: BMC Proceedings
Patricia Lanz, Heike A Bischoff-Ferrari
The Influence of Protein on the Prevention of Fragility Fractures Among Senior Adults Abstract. The aim of this review article is to discuss protein intake in senior adults at risk for fragility fractures as a modifiable factor for fracture prevention. Proteins are building blocks of the bone matrix and the muscles. This dual function fits in with the concept of prevention of fragility fractures in senior adults aimed at reducing both bone loss and falls. In older adults, a protein-rich diet could be another simple and effective way to promote bone and muscle health, in addition to the established recommendations for adequate vitamin D and calcium intake...
July 2018: Praxis
A L Goldman, C M Donlon, N R Cook, J E Manson, J E Buring, T Copeland, C Y Yu, M S LeBoff
We investigated the association of clinical variables with TBS at baseline in the bone health sub-cohort of the VITamin D and OmegA-3 TriaL (VITAL). Lower TBS was associated with female sex, aging, BMI ≥ 25 kg/m2 , SSRI use, high alcohol intake, and presence of diabetes; there was a trend towards significance between lower TBS and history of fragility fractures. INTRODUCTION: We investigated whether TBS differs by sex, race, body mass index (BMI), and other clinical variables. METHODS: The VITamin D and OmegA-3 TriaL (VITAL) is determining effects of vitamin D3 and/or omega-3 fatty acid (FA) supplements in reducing risks of cancer and cardiovascular disease...
July 18, 2018: Osteoporosis International
Heike A Bischoff-Ferrari, E John Orav, Andreas Egli, Bess Dawson-Hughes, Karina Fischer, Hannes B Staehelin, Rene Rizzoli, Juerg Hodler, Arnold von Eckardstein, Gregor Freystaetter, Ursina Meyer, Thomas Guggi, Peter Burckhardt, Simeon Schietzel, Patricia Chocano-Bedoya, Robert Theiler, Walter C Willett, David Felson
Objective: To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Methods: Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D3 . The primary endpoints were symptoms (Western Ontario and McMaster Universities Arthritis Index pain and function scores) assessed at baseline, 6, 12, 18 and 24 months in both knees, and the rate of falls over 24 months...
2018: RMD Open
Kristian F Axelsson, Malin Werling, Björn Eliasson, Eva Szabo, Ingmar Näslund, Hans Wedel, Dan Lundh, Mattias Lorentzon
Gastric bypass surgery constitutes the most common and effective bariatric surgery to treat obesity. Gastric bypass leads to bone loss, but fracture risk following surgery has been insufficiently studied. Furthermore, the association between gastric bypass and fracture risk has not been studied in patients with diabetes, which is a risk factor for fracture and affected by surgery. In this retrospective cohort study using Swedish national databases, 38 971 obese patients undergoing gastric bypass were identified, 7758 with diabetes and 31 213 without...
July 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jing Li, Wenqing Ding, Juan Cao, Lijiao Sun, Shanghong Liu, Jianjun Zhang, Haiping Zhao
Although vitamin D is essential for bone health, little is known about prevalence of vitamin D deficiency and low bone mineral density (BMD) among children, especially those in developing countries. It also remains unclear whether serum 25-hydroxyvitamin D [25(OH)D] is associated with BMD among children. We investigated these questions among children and adolescents in Yinchuan (latitude: 38° N), Ningxia, an economically underdeveloped province in Northwest China. A total of 1582 children (756 boys and 826 girls), aged 6-18 years, were recruited from schools using the stratified random sampling method in fall 2015...
July 10, 2018: Bone
Michael Minsu Shu, Andre Langes Canhos, Guilherme Pereira Ocampos, Perola Grimberg Plapler, Olavo Pires Camargo, Marcia Uchoa DE Rezende
Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary orthopedic hospital. Methods: Using questionnaires, 70 patients with osteoporotic fractures (OF) were compared with 50 outpatients with multiple osteoarthritis (OA) followed through an outpatient clinic. Results: The OF group was older (p <0.001), less heavy (p=0.003), had lower BMI (p=0.006), was more likely to be white (p=0.011), was less likely to be married (p=0...
March 2018: Acta Ortopedica Brasileira
Laura J Lutz, Erin Gaffney-Stomberg, J Philip Karl, Julie M Hughes, Katelyn I Guerriere, James P McClung
Introduction: The military dietary reference intakes (MDRIs), outlined in Army Regulation 40-25, OPNAVINST 10110.1/MCO10110.49, AFI 44-141, establish standards intended to meet the nutrient requirements of Warfighters. Therefore, the purpose of this study was to comprehensively compare the revised MDRIs, published in 2017, with estimated dietary intakes in U.S. military personnel. Materials and Methods: During this cross-sectional study, Block food frequency questionnaires were administered at the end of the 9-week basic combat training course to estimate dietary intake during basic combat training in male (n = 307) and female (n = 280) recruits...
July 3, 2018: Military Medicine
Jenny E Gunton, Christian M Girgis
Vitamin D is increasingly recognised to play an important role in normal muscle function. Low vitamin D status is associated with an increased risk of falls and proximal weakness. Since vitamin D deficiency is very common, and the signs are non-specific, it is important to maintain a high index of suspicion of vitamin D deficiency in patients with muscle pain and weakness, and it is simple to measure serum 25(OH) vitamin D. Therapy is cheap, safe and effective, but sometimes a larger dose may be needed, and, as shown in our case report, willingness of people to pay for an over the counter medication can be an issue...
June 2018: Bone Reports
Elizabeth Eckstrom, Erin M Parker, Gwendolyn H Lambert, Gray Winkler, David Dowler, Colleen M Casey
Background and Objectives: Falls are the leading cause of injury-related deaths in older adults. Objectives include describing implementation of the Centers for Disease Control and Prevention's Stopping Elderly Accidents, Deaths, and Injuries (STEADI) initiative to help primary care providers (PCPs) identify and manage fall risk, and comparing a 12-item and a 3-item fall screening questionnaire. Design and Methods: We systematically incorporated STEADI into routine patient care via team training, electronic health record tools, and tailored clinic workflow...
September 2017: Innovation in Aging
Atsushi Suzuki
Nutritional guidance and exercise should be beneficial as well as pharmacotherapy in life style-related diseases including diabetes and osteoporosis. Sufficient and appropriate energy intake with protein, calcium and vitamin D is good for bone and muscles in osteoporotic patient. Diabetes patients are often recommended to reduce body weight. However, losing weight could be related to bone loss. Therefore, we should pay attention to keep balance between glucose metabolism and bone metabolism in the patients with both diseases...
2018: Clinical Calcium
Carolyn J Crandall, Sowmya Vasan, Andrea LaCroix, Meryl S LeBoff, Jane A Cauley, John A Robbins, Rebecca D Jackson, Douglas C Bauer
Current guidelines recommend that serum C-terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline...
July 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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