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JOURNAL ARTICLE
Kirsten P Perrett
No abstract text is available yet for this article.
April 22, 2024: Nature Medicine
#22
JOURNAL ARTICLE
Wanicha Tepakhan, Sataron Kanjanaopas, Korntip Sreworadechpisal, Tipparat Penglong, Pornpun Sripornsawan, Chaowanee Wangchauy, Chadaporn Nokkong, Chulalak Kongkan, Saristha Buathong
Data on hemoglobin (Hb) variants in southern Thailand are lacking. This study aimed to reassess the frequency of Hb variants and the clinical aspects of compound heterozygous Hb variant with other hemoglobinopathies. We enrolled 13,391 participants from ten provinces in southern Thailand during 2015-2022. Hb analysis was performed using capillary electrophoresis, and mutations in the HBA and HBB genes were identified using PCR or DNA sequencing. Hb variants were identified in 337 (2.5%) unrelated subjects. Nine β-chain variants, namely Hb Malay (76...
April 22, 2024: Scientific Reports
#23
JOURNAL ARTICLE
Wen Pan, Chao Liu, Tao Ren, Xiaohong Chen, Cuiting Liang, Jin Wang, Jinlin Yang
A higher incidence of chronic atrophic gastritis (CAG) is generally considered as a precancerous lesion in gastric cancer (GC). The aim of this study was to identify potential molecules involved in the pathogenesis of CAG in the Tibetan plateau, hoping to help the diagnosis and management of the disease. Atrophic and non-atrophic gastric mucosal tissue samples were collected from seven patients with chronic gastritis (CG). Differentially expressed lncRNAs, circRNAs, miRNAs, and mRNAs between CAG and chronic non-atrophic gastritis (CNAG) groups were identified based on DNBSEQ-G99 RNA sequencing...
April 22, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Zhou Zhang, Liang-Xiao Ma, Ling-Hui Ma, Xu Qian, Jie-Dan Mu, Tian-Yi Sun, Xiao-Shan Huang
Hypertension is a global problem threatening human health and life. Although there are many antihypertensive drugs, the low compliance of medication affects its efficacy, and the effect in regulating hypertension has become increasingly prominent. Focusing on the new trend of proactive healthcare management, in the present paper, we made a summary about the status and existing problems of transcutaneous electrical acupoint stimulation (TEAS) in the regulation of blood pressure, and put forward some suggestions, such as selecting acupoints based on classical acupuncture theory to highlight the advantages of TEAS to control blood pressure as a whole, optimizing and screening the parameters of TEAS in the regulation of blood pressure, expanding the research observation indexes etc...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#25
REVIEW
Emma Doyle, Angus J Killean, Stephen Harrow, Iain D Phillips
BACKGROUND: Stereotactic Ablative Radiotherapy (SABR) for the treatment of oligometastatic disease can improve survival and delay the requirement for systemic therapy. The benefits of SABR in oligoprogressive disease are less well-defined. Here, we evaluate the available evidence investigating the efficacy of SABR in the treatment of oligoprogressive disease. METHODS: A systematic review was carried out following PRISMA guidelines. Medline and Embase databases were searched using the terms "stereotactic radiotherapy" OR "SABR" OR "Stereotactic Ablative Body Radiotherapy" OR "SBRT" OR "SRT" AND "oligoprogression" in May 2022, June 2023, and February 2024...
April 20, 2024: Radiotherapy and Oncology
#26
JOURNAL ARTICLE
Paula Oberth, Markus Neuschulz, Jochen Ernst, Dörte Schotte, Sven Bercker, Sebastian Stehr, Antje Lehmann-Laue, Anja Mehnert-Theuerkauf
BACKGROUND: Multi-professional inpatient palliative care services are increasingly complementing palliative care in hospitals alongside palliative care units. The present study aims to investigate the nature and frequency of patient concerns and palliative psychological interventions in the context of palliative psychological work, as well as the perceived quality of outcomes in an inpatient palliative service. METHODS: Palliative psychological interventions for terminally ill patients at the inpatient palliative care service at Leipzig University Hospital were investigated in a prospective follow-up evaluation study...
April 22, 2024: Psychotherapie, Psychosomatik, Medizinische Psychologie
#27
JOURNAL ARTICLE
First report from the european registry for anomalous aortic origin of coronary artery (EURO-AAOCA).
Christoph Gräni, Anselm W Stark, Mauro Lo Rito, Alessandro Frigiola, Matthias Siepe, Bertrand Tchana, Alberto Cipriani, Alessandro Zorzi, Valeria Pergola, Domenico Crea, George Sarris, Elephterios Protopapas, Domenico Sirico, Giovanni Di Salvo, Cinzia Pegoraro, Patrizio Sarto, Katrien Francois, Alessandra Frigiola, Alessandra Cristofaletti, Ryan E Accord, Alvaro Gonzalez Rocafort, Geoffroy Debeco, Massimo Padalino
OBJECTIVES: Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations. The lifetime-risk of an individual living with AAOCA is unknown, and data from multicentre registries are urgently needed to adapt current recommendations and guide optimal patient management. The European AAOCA Registry (EURO-AAOCA) aims to assess differences with regard to AAOCA management between centers. METHODS: EURO-AAOCA is a prospective, multicentre registry including 13 european centers...
April 22, 2024: Interdiscip Cardiovasc Thorac Surg
#28
REVIEW
Maxim D'heedene, Tim Vanuytsel, Lucas Wauters
BACKGROUND & AIMS: Celiac disease (CD) is a chronic inflammatory disease of the small intestine induced and maintained by gluten ingestion in susceptible individuals. Current treatment consists of strict adherence to a lifelong gluten-free diet (GFD) which is considered safe and effective in the large majority of patients. However, since adherence to a GFD is difficult and has a negative impact on quality of life, an increasing interest in other treatment options has emerged. Moreover, in some individuals a GFD is not sufficiently effective, necessitating alternative treatments...
April 15, 2024: Clinical Nutrition
#29
JOURNAL ARTICLE
Abel A Pavía-López, José A Magaña-Serrano, José A Cigarroa-López, Adolfo Chávez-Mendoza, José L Mayorga-Butrón, Diego Araiza-Garaygordobil, Juan B Ivey-Miranda, Gustavo F Méndez-Machado, Héctor González-Godínez, Luisa F Aguilera-Mora, Antonio Jordán-Ríos, Luis Olmos-Domínguez, Marcos J Olalde-Román, Emma M Miranda-Malpica, Zuilma Vázquez-Ortiz, Jorge Rayo-Chávez, Alexandra A Mendoza, Manlio F Márquez-Murillo, Sergio A Chávez-Leal, Amada Álvarez-San Gabriel, Marissa A Silva-García, Alex D Pacheco-Bouthiller, Jorge A Aldrete-Velazco, Carlos A Guizar-Sánchez, Efraín Gaxiola-López, Arturo Guerra-López, Lourdes Figueiras-Graillet, Gustavo Sánchez-Miranda, Genaro H Mendoza-Zavala, Moisés Aceves-García, Adolfo Chávez-Negrete, Marisol Arroyo-Hernández, Bertha B Montaño-Velázquez, Luis F Romero-Moreno, María M Baquero-Hoyos, Liliana Velasco-Hidalgo, Ana L Rodríguez-Lozano, Nancy E Aguilar-Gómez, Mario Rodríguez-Vega, Jorge E Cossío-Aranda
Chronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients...
2024: Archivos de Cardiología de México
#30
JOURNAL ARTICLE
Nawar Shara, Roxanne Mirabal-Beltran, Bethany Talmadge, Noor Falah, Maryam Ahmad, Ramon Dempers, Samantha Crovatt, Steven Eisenberg, Kelley Anderson
BACKGROUND: Cardiovascular conditions (eg, cardiac and coronary conditions, hypertensive disorders of pregnancy, and cardiomyopathies) were the leading cause of maternal mortality between 2017 and 2019. The United States has the highest maternal mortality rate of any high-income nation, disproportionately impacting those who identify as non-Hispanic Black or Hispanic. Novel clinical approaches to the detection and diagnosis of cardiovascular conditions are therefore imperative. Emerging research is demonstrating that machine learning (ML) is a promising tool for detecting patients at increased risk for hypertensive disorders during pregnancy...
April 22, 2024: JMIR Cardio
#31
JOURNAL ARTICLE
Li-Ling Hope Pan, Yu-Hsiang Ling, Kuan-Lin Lai, Yen-Feng Wang, Fu-Jung Hsiao, Shih-Pin Chen, Hung-Yu Liu, Wei-Ta Chen, Shuu-Jiun Wang
OBJECTIVE: Quantitative sensory testing is widely used in clinical and research settings to assess the sensory functions of healthy subjects and patients. It is of importance to establish normative values in a healthy population to provide reference for studies involving patients. Given the absence of normative values for pain thresholds in Taiwan, the aim of this study was to report the normative values for future reference in the Taiwanese population and compare the differences between male and female participants...
April 2024: Brain and Behavior
#32
JOURNAL ARTICLE
Hope Eleri Jones, Serica Battaglia, Lisa Hurt, Orhan Uzun, Sinead Brophy
BACKGROUND: Echogenic Intracardiac Foci (EIF) are non-structural markers identified during the routine 18-20-week foetal anomaly ultrasound scan yet their clinical significance on future outcomes for the infant is unclear. OBJECTIVE: To examine the association between EIF and risk of preterm birth, chromosomal abnormalities, and cardiac abnormalities. DESIGN: A review across four databases to identify English language journal articles of EIF using a cohort study design...
2024: PloS One
#33
JOURNAL ARTICLE
Shiau-Shian Huang, Yu-Fan Lin, Anna YuQing Huang, Ji-Yang Lin, Ying-Ying Yang, Sheng-Min Lin, Wen-Yu Lin, Pin-Hsiang Huang, Tzu-Yao Chen, Stephen J H Yang, Jiing-Feng Lirng, Chen-Huan Chen
BACKGROUND: Medical students need to build a solid foundation of knowledge to become physicians. Clerkship is often considered the first transition point, and clerkship performance is essential for their development. We hope to identify subjects that could predict the clerkship performance, thus helping medical students learn more efficiently to achieve high clerkship performance. METHODS: This cohort study collected background and academic data from medical students who graduated between 2011 and 2019...
April 18, 2024: Journal of the Chinese Medical Association: JCMA
#34
JOURNAL ARTICLE
Navkiranjit Gill, Jim E Banta, Leonard Gashugi, Sean D Young
HIV-related stigma is a primary barrier to seeking HIV care. Online social media interventions utilizing peer-led approaches provide an opportunity to revolutionize HIV health behavior change. Secondary analysis of the UCLA HOPE Study (6 waves) was done to examine the effectiveness of an online peer-led intervention in reducing HIV-related internalized stigma (IS), association between IS and sexual risk behaviors (SRB), and associated costs for changing the likelihood of HIV testing. Among 897 participants, an inverse relationship between IS (Discomfort with people with HIV, Stereotypes, Moral Judgment) and SRB (Number of Sexual Partners, Sexual Encounters) factors was identified over time ( p < ...
April 2024: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
#35
JOURNAL ARTICLE
Melissa Nickles, Samantha Hunt, Saul Turcios-Escobar, Amaara Babwah, Nisreen Mobayed, Carlos Murga-Zamalloa, Michelle Bain, John Quigley, Paul Rubinstein, Carlos Galvez
Richter syndrome (RS) describes a phenomenon in which a patient with chronic lymphocytic leukemia (CLL) develops an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). Reports of cutaneous RS remain exceedingly rare. We report a 61-year-old woman with relapsed/refractory CLL presenting with several subcutaneous nodules on her arms and legs and a single dermal plaque on her abdomen. Skin biopsy revealed a diagnosis of DLBCL, ABC-type, and her clinical status rapidly deteriorated following diagnosis...
April 23, 2024: American Journal of Dermatopathology
#36
JOURNAL ARTICLE
Kenneth S Peterson
E Pluribus Unum , out of many, one. This is intended to signify unification and inclusion for the people of the United States. I , a cis-gendered, gay man, have come to appreciate the meaning in a different way. The following poem is a critical reflection of how I came to understand me , as a member of an interconnected society. This piece reflects my lived experiences as an out of the mainstream masculine male, despite my white privilege. In the poem, I include a powerful derogatory word often used by others to destructively affect queer people like me...
March 2024: Families, Systems & Health: the Journal of Collaborative Family Healthcare
#37
JOURNAL ARTICLE
Atish Ghosh, Priya Das, Subhash Kumar, Pranab Sarkar
In order to develop an efficient metal-free solar energy harvester, we herein performed the electronic structure calculation, followed by the hot carrier relaxation dynamics of two dimensional (2D) aza-covalent organic framework by time domain density functional calculations in conjunction with non-adiabatic molecular dynamics (NAMD) simulation. The electronic structure calculation shows that the aza-covalent organic framework (COF) is a direct bandgap semiconductor with acute charge separation and effective optical absorption in the UV-visible region...
April 28, 2024: Journal of Chemical Physics
#38
JOURNAL ARTICLE
Matthew B Flynn, James F Flynn, Ana M Palacios
Regulatory agencies must balance patient demands to access new treatments for fatal diseases with limited treatment options while ensuring drug safety and efficacy. However, questionable U.S. regulatory actions resulted in the early approval of AMX0035 to treat amyotrophic lateral sclerosis (ALS) by reconvening advisory commissions to obtain positive decisions and designating the drug as a new molecular entity. Data from one randomized clinical trial suggests minimal delays in disease progression and longer survivability, but debate remains about the lack of confirmatory evidence of effectiveness owing to study limitations...
April 22, 2024: Int J Soc Determinants Health Health Serv
#39
JOURNAL ARTICLE
Aardra B S, Vasugi Suresh, Menaka S, Pitchiah Sivaperumal
Introduction Marine actinobacteria are promising sources of novel bioactive compounds due to their distinct ecological niches and diverse secondary metabolite production capabilities. Among these, Microbispora sp. T3S11 is notable for its unique spore chain structure, which allows for both morphological and genetic identification. Despite its potential, little is understood about the secondary metabolites produced by this strain. In this study, we hope to fill this gap by extracting and analyzing the antibacterial activities of secondary metabolites from Microbispora sp...
March 2024: Curēus
#40
REVIEW
Tara C Prakash, Steven Enkemann
The use of tyrosine kinase inhibitors (TKIs) has become the mainstay of treatment in patients suffering from chronic myeloid leukemia (CML), an adult leukemia caused by a reciprocal translocation between chromosomes 9 and 22, which creates an oncogene resulting in a myeloproliferative neoplasm. These drugs function by inhibiting the ATP-binding site on the fusion oncoprotein and subsequently halting proliferative activity. The goal of this work is to investigate the current state of research into genetic factors that influence the efficacy of four FDA-approved TKIs used to treat CML...
March 2024: Curēus
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