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https://www.readbyqxmd.com/read/30281535/role-of-the-von-willebrand-factor-and-the-vitro-score-as-predictors-for-variceal-bleeding-in-patients-with-hepatitis-c-related-cirrhosis
#1
Elsaed H Ibrahim, Salah A Marzouk, Ahmed E Zeid, Sameh A Lashen, Tarek M Taher
BACKGROUND: Noninvasive methods have been established to detect clinically significant portal hypertension in liver cirrhosis with variable limitations. The von Willebrand factor (vEF) has been found to increase in liver cirrhosis. AIM: The aim of this study was to explore the vEF and VITRO (von Willebrand factor antigen/platelet ratio) score in the prediction of variceal bleeding in patients with portal hypertension. MATERIALS AND METHODS: Fifty patients with hepatitis C-related liver cirrhosis (25 patients with variceal bleeding and 25 without variceal bleeding) as well as 80 healthy controls were included...
October 2, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30247538/biomarkers-of-maternal-environmental-enteric-dysfunction-are-associated-with-shorter-gestation-and-reduced-length-in-newborn-infants-in-uganda
#2
Jacqueline M Lauer, Christopher P Duggan, Lynne M Ausman, Jeffrey K Griffiths, Patrick Webb, Edgar Agaba, Nathan Nshakira, Hao Q Tran, Andrew T Gewirtz, Shibani Ghosh
Background: Adverse birth outcomes, including preterm birth and stunting at birth, have long-term health implications. The relation between adverse birth outcomes and chronic, asymptomatic gastrointestinal inflammation (environmental enteric dysfunction-EED) is poorly understood. Objective: We aimed to examine the relation between maternal EED and adverse birth outcomes in a sample of pregnant Ugandan women and their newborn infants. Design: We conducted a prospective cohort study in Mukono, Uganda...
September 21, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30222209/clinical-utility-of-currently-available-biomarkers-in-inflammatory-enteropathies-of-dogs
#3
Romy M Heilmann, Jörg M Steiner
Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food-responsive, antibiotic-responsive, or immunosuppressant-responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein-losing enteropathy. Disease-independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment...
September 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30217504/mesenchymal-stem-cell-treatment-attenuates-liver-and-lung-inflammation-after-ethanol-intoxication-and-burn-injury
#4
Brenda J Curtis, Jill A Shults, Devin M Boe, Luis Ramirez, Elizabeth J Kovacs
Cutaneous burn injury is one of the most devastating injuries one can obtain with tissue damage extending beyond the skin wound to distal organs, including the gastrointestinal tract, liver, and lungs. Multiple organ failure is a leading cause of death after burn injury resulting in excessive systemic and localized inflammation directly contributing to end organ damage. We postulated that the gut-liver-lung inflammatory axis underscores multiple organ failure in the context of burn injury and is hyper-activated when ethanol intoxication precedes burn...
September 11, 2018: Alcohol
https://www.readbyqxmd.com/read/30127888/clinical-significance-of-chromodomain-helicase-atpase-dna-binding-protein-1-like-and-human-mutl-homolog-1-gene-expression-in-cholangiocarcinoma
#5
Jingwen Hua, Shiniao Li, Changwen Huang
Cholangiocarcinoma is a highly malignant form of gastrointestinal cancer with an unfavorable prognosis. The novel oncogene chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) has been confirmed to serve a vital role in numerous types of cancer, including liver cancer. Mismatch repair (MMR) is a common DNA repair process that contributes to the preservation of the integrity and stability of genetic substances. Human mutL homolog 1 gene (hMLH1) is an important MMR protein family member. The present study aimed to evaluate the pathological and clinical features of cholangiocarcinoma, and to investigate the clinical significance of CHD1L and hMLH1 expression in cholangiocarcinoma...
September 2018: Oncology Letters
https://www.readbyqxmd.com/read/30113465/intestinal-fatty-acid-binding-protein-as-a-predictor-of-prognosis-in-postoperative-cardiac-surgery-patients
#6
Lei Zou, Xiaochun Song, Liang Hong, Xiao Shen, Jiakui Sun, Cui Zhang, Xinwei Mu
During the perioperative period of cardiac disease, as many risk factors exist, such as primary cardiac diseases, the use of vasopressors, ischemia-reperfusion injury during cardiopulmonary bypass (CPB), and surgical stress, the gut suffered from ischemia, anoxia and oxidative stress, which would lead to the enterocyte injury. The aim of this study was to explore whether serum intestinal fatty acid-binding protein (IFABP), which is excreted specifically from damaged intestinal enterocytes, as a predictor of prognosis in postoperative cardiac surgery patients...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30106382/survival-signal-reg3-%C3%AE-prevents-crypt-apoptosis-to-control-acute-gastrointestinal-graft-versus-host-disease
#7
Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Joel K Greenson, Mohammed S Chaudhry, Matthias Hoepting, Erik R Anderson, Marcel Rm van den Brink, Jonathan U Peled, Antonio Lc Gomes, Ann E Slingerland, Michael J Donovan, Andrew C Harris, John E Levine, Umut Özbek, Lora V Hooper, Thaddeus S Stappenbeck, Aaron M Ver Heul, Ta-Chiang Liu, Pavan Reddy, James Lm Ferrara
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and non-relapse mortality after bone marrow transplantation (BMT). The Paneth cell protein, regenerating islet-derived 3-alpha (REG3α), is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homologue of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome...
August 14, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30073458/insight-into-inflammatory-cell-and-cytokine-profiles-in-adult-iga-vasculitis
#8
T Kuret, K Lakota, P Žigon, M Ogrič, Snezna Sodin-Šemrl, S Čučnik, M Tomšič, A Hočevar
Immunoglobulin A vasculitis (IgAV) is an immune complex, small vessel vasculitis with dominant IgA deposits in vessel walls, predominantly affecting the pediatric population. However, adults frequently have more severe gastrointestinal tract (GIT) and renal involvements as compared to children. Our aim was to study serological and cellular biomarkers to support clinicians in their diagnosis and the course of IgAV in adult patients. This cross-sectional study included 62 adult IgAV patients and 53 healthy blood donors (HBDs)...
August 2, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30054517/greater-microbial-translocation-and-vulnerability-to-metabolic-disease-in-healthy-aged-female-monkeys
#9
Quentin N Wilson, Magan Wells, Ashley T Davis, Christina Sherrill, Matthew C B Tsilimigras, Roshonda B Jones, Anthony A Fodor, Kylie Kavanagh
Monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (MT) and inflammation with ageing despite equivalent health status, and lifelong diet and environmental conditions. We evaluated colonic structural, microbiomic and functional changes in old female vervet monkeys (Chlorocebus aethiops sabeus) and how age-related leaky gut alters responses to Western diet. We additionally assessed serum bovine immunoglobulin therapy to lower MT burden...
July 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30030909/serum-type-xvi-collagen-is-associated-with-colorectal-cancer-and-ulcerative-colitis-indicating-a-pathological-role-in-gastrointestinal-disorders
#10
Christina Jensen, Signe H Nielsen, Joachim H Mortensen, Jens Kjeldsen, Lone G Klinge, Aleksander Krag, Henrik Harling, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen
Altered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col-16) plays a role in pathogenesis by affecting ECM architecture and induce cell invasion. Measuring col-16 in serum may therefore have biomarker potential in GI disorders such as colorectal cancer (CRC) and ulcerative colitis (UC). The aim of this study was to determine whether col-16 can serve as a biomarker for altered ECM remodeling in patients with CRC and UC...
September 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30011858/differential-roles-of-tumor-necrosis-factor-ligand-superfamily-members-as-biomarkers-in-pancreatic-cancer
#11
Ines Pombeiro, Sven H Loosen, Sanchari Roy, Florian Schueller, Lukas Niewenhuisen, Mark Luedde, Mihael Vucur, Frank Tacke, Marcel Binnebösel, Wenzel Schoening, Christian Trautwein, Tom Luedde, Ulf Peter Neumann, Christoph Roderburg
The tumor necrosis factor⁻related weak inducer of apoptosis (TWEAK) belongs to the tumor necrosis factor ligand superfamily, which was shown to play an important role in inflammatory and malignant gastrointestinal diseases, including colitis or colorectal cancer. However, in contrast to other members of the TNF ligand superfamily, its role as a biomarker in pancreatic cancer is currently unknown. We analyzed serum levels of A proliferation-inducing ligand (APRIL) and TWEAK in 134 patients with pancreatic cancer...
July 13, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29998822/evaluating-ibd-specific-antiglycan-antibodies-in-serum-of-patients-with-spondyloarthritis-and-rheumatoid-arthritis-are-they-really-specific
#12
Valerie Aloush, Iris Dotan, Jacob Nadav Ablin, Ori Elkayam
OBJECTIVES: The presence of serological markers associated with inflammatory bowel disease (IBD) has been studied in spondyloarthritis with conflicting results. The anti-glycan antibodies: anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies (ALCA, ACCA, and AMCA) are serological markers previously associated with IBD. We aim to investigate the prevalence of these antibodies in spondyloarthritis in comparison with rheumatoid arthritis (RA) patients. METHODS: Serum samples were obtained from consecutive patients with spondyloarthritis and were compared to RA and healthy controls...
June 25, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29997457/-bacillus-coagulans-mtcc-5856-for-the-management-of-major-depression-with-irritable-bowel-syndrome-a-randomised-double-blind-placebo-controlled-multi-centre-pilot-clinical-study
#13
Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Shaheen Majeed, Furqan Ali
Background: The modification of microbial ecology in human gut by supplementing probiotics may be an alternative strategy to ameliorate or prevent depression. Objective: The current study was conducted to assess the safety and efficacy of the probiotic strain Bacillus coagulans MTCC 5856 for major depressive disorder (MDD) in IBS patients. Method: Patients ( n = 40) diagnosed for MDD with IBS were randomized (1:1) to receive placebo or B. coagulans MTCC 5856 at a daily dose of 2 × 109 cfu (2 billion spores) and were maintained to the end of double-blind treatment (90 days)...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29991933/a-noninvasive-method-to-assess-mucosal-healing-in-patients-with-crohn-s-disease
#14
William J Sandborn, Maria T Abreu, Marla C Dubinsky
Ongoing inflammation in the gastrointestinal tract and loss of the mucosal barrier are key components of Crohn's disease. Current treatment paradigms, including treat-to-target, are based on improvement of both clinical and endoscopic symptoms. Endoscopy is an essential tool for the evaluation of mucosal healing, but patients may be reluctant to undergo repeated procedures. Surrogate markers of inflammation, such as C-reactive protein and fecal calprotectin, are being used, yet they have several limitations in the assessment of mucosal healing...
May 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29945311/identification-of-serum-periostin-as-a-potential-diagnostic-and-prognostic-marker-for-colorectal-cancer
#15
Dong Dong, Lufang Zhang, Li Jia, Wei Ji, Zhiyong Wang, Li Ren, Ruifang Niu, Yunli Zhou
BACKGROUND: Periostin (POSTN) plays an important role in numerous cancers, especially in gastrointestinal malignancy. The objective of this study was to investigate the diagnostic and prognostic role of serum POSTN in colorectal cancer (CRC). METHODS: Serum periostin, together with CEA, CA19.9, CA72.4, and CA242 levels were measured in samples from 108 patients with CRC and 56 healthy controls, and their correlation with clinical characteristics was further analyzed...
June 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29923196/circulating-micrornas-as-diagnostic-and-therapeutic-biomarkers-in-gastric-and-esophageal-cancers
#16
REVIEW
Leila Jamali, Roghayeh Tofigh, Sara Tutunchi, Ghodratollah Panahi, Fatemeh Borhani, Saeedeh Akhavan, Parisa Nourmohammadi, Sayyed M H Ghaderian, Milad Rasouli, Hamed Mirzaei
Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers...
November 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29881282/surgical-injury-comparing-open-surgery-and-laparoscopy-by-markers-of-tissue-damage
#17
Jan Máca, Matúš Peteja, Petr Reimer, Ondřej Jor, Věra Šeděnková, Lucie Panáčková, Peter Ihnát, Michal Burda, Pavel Ševčík
Background: Major abdominal surgery (MAS) is high-risk intervention usually accompanied by tissue injury leading to a release of signaling danger molecules called alarmins. This study evaluates the surgical injury caused by two fundamental types of gastrointestinal surgical procedures (open surgery and laparoscopy) in relation to the inflammation elicited by alarmins. Patients and methods: Patients undergoing MAS were divided into a mixed laparoscopy group (LPS) and an open surgery group (LPT)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29872151/prognostic-role-of-carcinoembryonic-antigen-and-carbohydrate-antigen-19-9-in-metastatic-colorectal-cancer-a-braf-mutant-subset-with-high-ca-19-9-level-and-poor-outcome
#18
Maria Thomsen, Eva Skovlund, Halfdan Sorbye, Nils Bolstad, Kjell Johannes Nustad, Bengt Glimelius, Per Pfeiffer, Elin H Kure, Julia S Johansen, Kjell Magne Tveit, Thoralf Christoffersen, Tormod Kyrre Guren
BACKGROUND: Mutation status of RAS and BRAF, as well as serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), are biomarkers used in clinical management of patients with gastrointestinal cancers. This study aimed to examine the prognostic role of these biomarkers in a patient population that started first-line chemotherapy for unresectable metastatic colorectal cancer (mCRC) in the NORDIC-VII study. METHODS: CEA and CA 19-9 were measured in serum samples from 545 patients obtained before the start of chemotherapy...
June 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29756637/withdrawal-of-immunosuppressant-or-biologic-therapy-for-patients-with-quiescent-crohn-s-disease
#19
REVIEW
Ray K Boyapati, Joana Torres, Carolina Palmela, Claire E Parker, Orli M Silverberg, Sonam D Upadhyaya, Tran M Nguyen, Jean-Frédéric Colombel
BACKGROUND: Crohn's disease (CD) is a chronic, relapsing and remitting disease of the gastrointestinal tract that can cause significant morbidity and disability. Current treatment guidelines recommend early intervention with immunosuppressant or biological therapy in high-risk patients with a severe disease phenotype at presentation. The feasibility of therapeutic de-escalation once remission is achieved is a commonly encountered question in clinical practice, driven by patient and clinician concerns regarding safety, adverse events, cost and national regulations...
May 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29730783/tissue-indices-of-telomere-length-and-p53-in-patients-with-different-gastrointestinal-tumors-correlation-with-clinicopathological-status
#20
Hala M ElBadre, Reham I El-Mahdy, Nahed A Mohamed, Madeha M Zakhary, Doaa W Maximous
Telomere length dysfunction is involved in the generation of genomic rearrangements that drive progression to malignancy. A set of serological markers for telomere dysfunction, namely chitinase and N-acetylglucosaminidase (NAG), DNA damage, and tissue alteration of p53 have been identified. The probability that genomic damage, accumulation of reactive oxygen species, and shorter telomeres may be related to the onset and advancement of gastrointestinal (GI) tumors. A total of 40 patients with GI tumors and 20 healthy controls with matched age and sex were included...
November 2018: Applied Biochemistry and Biotechnology
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