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Serum biomarkers gastrointestinal

Youwei Kou, Ren Yang, Qiang Wang
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the intestinal tract. Imatinib is used as first-line therapy for GIST patients; however, secondary imatinib resistance poses a significant clinical challenge. Here, we analyzed serum miRNA expression profiles to identify specific serum miRNAs that could be used as early diagnostic markers. Candidate miRNAs were validated using Taqman quantitative PCR with serum samples from secondary imatinibresistant GIST patients (n = 39), imatinib-sensitive GIST patients (n = 37), and healthy controls (n = 28)...
December 2018: Journal of Biosciences
James L M Ferrara, Mohammed S Chaudhry
Acute graft-versus-host disease (GVHD) targets the crypts in the gastrointestinal (GI) tract that are responsible for the self-renewal of the intestinal mucosa. Recent advances in the identification and culture of intestinal stem cells have improved our understanding of the interactions between the microbiome and the immune system (both innate and adaptive) that are key to the pathophysiology of GVHD. The identification of serum biomarkers that best predict long-term GVHD outcomes derive from the GI tract and have focused attention on cellular elements that act as shields against GVHD as well as its targets...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
James L M Ferrara, Mohammed S Chaudhry
Acute graft-versus-host disease (GVHD) targets the crypts in the gastrointestinal (GI) tract that are responsible for the self-renewal of the intestinal mucosa. Recent advances in the identification and culture of intestinal stem cells have improved our understanding of the interactions between the microbiome and the immune system (both innate and adaptive) that are key to the pathophysiology of GVHD. The identification of serum biomarkers that best predict long-term GVHD outcomes derive from the GI tract and have focused attention on cellular elements that act as shields against GVHD as well as its targets...
November 27, 2018: Blood Advances
Jinhyun Choi, Eun Jung Lee, Seung Hyun Yang, Yoo Ri Im, Jinsil Seong
We investigated the efficacy of combined radiotherapy (RT) and zoledronic acid in treating painful bone metastases from gastrointestinal cancers. Sixty patients were prospectively enrolled between November 2014 and July 2016. The most common primary cancer type was hepatocellular carcinoma (HCC, n = 25), followed by colorectal cancer (n = 6). Patients received external beam RT of 30-54 Gy in 10-17 fractions or 20 Gy in 5 fractions for symptomatic bone metastases. On the first day of RT, patients received 4 mg intravenous zoledronic acid, which was repeated monthly for a total of six cycles...
November 16, 2018: Journal of Radiation Research
Divyesh Reddy Nemakayala, Brooks D Cash
PURPOSE OF REVIEW: Irritable bowel syndrome (IBS) is among the most commonly encountered conditions in primary care and gastroenterology. There is ample evidence that an IBS diagnosis based on symptom-based criteria and exclusion of alarm features that would otherwise support diagnostic testing is accurate and durable. For many clinicians, however, IBS remains a diagnosis of exclusion because of concern surrounding missed diagnoses of inflammatory bowel disease (IBD) or other organic gastrointestinal diseases...
January 2019: Current Opinion in Gastroenterology
Christopher J Black, Lesley A Houghton, Alexander C Ford
Dyspepsia is a very common gastrointestinal (GI) condition worldwide. We critically examine the recommendations of recently published guidelines for the management of dyspepsia, including those produced jointly by the American College of Gastroenterology and the Canadian Association of Gastroenterology, and those published by the UK National Institute for Health and Care Excellence. Dyspepsia is a symptom complex, characterized by a range of upper GI symptoms including epigastric pain or burning, early satiety, and post-prandial fullness...
2018: Therapeutic Advances in Gastroenterology
Durgesh Dubey, Sandeep Kumar, Smriti Chaurasia, Anupam Guleria, Sakir Ahmed, Rajeev Singh, Reena Kumari, Dinesh Raj Modi, Ramnath Misra, Dinesh Kumar
Reactive arthritis (ReA) is a member of seronegative spondyloarthropathy (SSA), which involves an acute/subacute onset of asymmetrical lower limb joint inflammation weeks after a genitourinary/gastrointestinal infection. The diagnosis is clinical because it is difficult to culture the microbes from synovial fluid. Arthritis patients with a similar clinical picture but lapsed history of an immediate preceding infection that do not fulfill the diagnostic criteria of other members of SSA, such as ankylosing spondylitis, psoriatic arthritis, and arthritis associated with inflammatory bowel disease, are labeled as peripheral undifferentiated spondyloarthropathy (uSpA)...
October 30, 2018: Journal of Proteome Research
Shu-Ling Wang, Guan-Yu Yu, Jun Yao, Zhao-Shen Li, An-Rong Mao, Yu Bai
AIM: Over the past decades, carbohydrate antigen 72-4(CA72-4) was considered as a tumor marker that was elevated in normal people and patients with malignancies, including gastrointestinal malignancies, ovarian malignancies, endometrium malignancies, lung malignancies and so on. Besides, researches showed that elevated serum CA72-4 might predict digestive tumors, especially gastric tumors, although there was still neither sensitive nor specific tumor biomarker for gastric cancer. This study was aimed to evaluate the diagnostic accuracy of CA72-4 in predicting malignancies, especially the gastric cancer...
October 22, 2018: Journal of Digestive Diseases
Elsaed H Ibrahim, Salah A Marzouk, Ahmed E Zeid, Sameh A Lashen, Tarek M Taher
BACKGROUND: Noninvasive methods have been established to detect clinically significant portal hypertension in liver cirrhosis with variable limitations. The von Willebrand factor (vEF) has been found to increase in liver cirrhosis. AIM: The aim of this study was to explore the vEF and VITRO (von Willebrand factor antigen/platelet ratio) score in the prediction of variceal bleeding in patients with portal hypertension. MATERIALS AND METHODS: Fifty patients with hepatitis C-related liver cirrhosis (25 patients with variceal bleeding and 25 without variceal bleeding) as well as 80 healthy controls were included...
October 2, 2018: European Journal of Gastroenterology & Hepatology
Jacqueline M Lauer, Christopher P Duggan, Lynne M Ausman, Jeffrey K Griffiths, Patrick Webb, Edgar Agaba, Nathan Nshakira, Hao Q Tran, Andrew T Gewirtz, Shibani Ghosh
Background: Adverse birth outcomes, including preterm birth and stunting at birth, have long-term health implications. The relation between adverse birth outcomes and chronic, asymptomatic gastrointestinal inflammation (environmental enteric dysfunction-EED) is poorly understood. Objective: We aimed to examine the relation between maternal EED and adverse birth outcomes in a sample of pregnant Ugandan women and their newborn infants. Design: We conducted a prospective cohort study in Mukono, Uganda...
October 1, 2018: American Journal of Clinical Nutrition
Romy M Heilmann, Jörg M Steiner
Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food-responsive, antibiotic-responsive, or immunosuppressant-responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein-losing enteropathy. Disease-independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment...
September 2018: Journal of Veterinary Internal Medicine
Brenda J Curtis, Jill A Shults, Devin M Boe, Luis Ramirez, Elizabeth J Kovacs
Cutaneous burn injury is one of the most devastating injuries one can obtain with tissue damage extending beyond the skin wound to distal organs, including the gastrointestinal tract, liver, and lungs. Multiple organ failure is a leading cause of death after burn injury resulting in excessive systemic and localized inflammation directly contributing to end organ damage. We postulated that the gut-liver-lung inflammatory axis underscores multiple organ failure in the context of burn injury and is hyper-activated when ethanol intoxication precedes burn...
September 11, 2018: Alcohol
Jingwen Hua, Shiniao Li, Changwen Huang
Cholangiocarcinoma is a highly malignant form of gastrointestinal cancer with an unfavorable prognosis. The novel oncogene chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) has been confirmed to serve a vital role in numerous types of cancer, including liver cancer. Mismatch repair (MMR) is a common DNA repair process that contributes to the preservation of the integrity and stability of genetic substances. Human mutL homolog 1 gene (hMLH1) is an important MMR protein family member. The present study aimed to evaluate the pathological and clinical features of cholangiocarcinoma, and to investigate the clinical significance of CHD1L and hMLH1 expression in cholangiocarcinoma...
September 2018: Oncology Letters
Lei Zou, Xiaochun Song, Liang Hong, Xiao Shen, Jiakui Sun, Cui Zhang, Xinwei Mu
During the perioperative period of cardiac disease, as many risk factors exist, such as primary cardiac diseases, the use of vasopressors, ischemia-reperfusion injury during cardiopulmonary bypass (CPB), and surgical stress, the gut suffered from ischemia, anoxia and oxidative stress, which would lead to the enterocyte injury. The aim of this study was to explore whether serum intestinal fatty acid-binding protein (IFABP), which is excreted specifically from damaged intestinal enterocytes, as a predictor of prognosis in postoperative cardiac surgery patients...
August 2018: Medicine (Baltimore)
Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Joel K Greenson, Mohammed S Chaudhry, Matthias Hoepting, Erik R Anderson, Marcel Rm van den Brink, Jonathan U Peled, Antonio Lc Gomes, Ann E Slingerland, Michael J Donovan, Andrew C Harris, John E Levine, Umut Ozbek, Lora V Hooper, Thaddeus S Stappenbeck, Aaron Ver Heul, Ta-Chiang Liu, Pavan Reddy, James Lm Ferrara
Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homolog of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome...
November 1, 2018: Journal of Clinical Investigation
T Kuret, K Lakota, P Žigon, M Ogrič, Snezna Sodin-Šemrl, S Čučnik, M Tomšič, A Hočevar
Immunoglobulin A vasculitis (IgAV) is an immune complex, small vessel vasculitis with dominant IgA deposits in vessel walls, predominantly affecting the pediatric population. However, adults frequently have more severe gastrointestinal tract (GIT) and renal involvements as compared to children. Our aim was to study serological and cellular biomarkers to support clinicians in their diagnosis and the course of IgAV in adult patients. This cross-sectional study included 62 adult IgAV patients and 53 healthy blood donors (HBDs)...
August 2, 2018: Clinical Rheumatology
Quentin N Wilson, Magan Wells, Ashley T Davis, Christina Sherrill, Matthew C B Tsilimigras, Roshonda B Jones, Anthony A Fodor, Kylie Kavanagh
Monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (MT) and inflammation with ageing despite equivalent health status, and lifelong diet and environmental conditions. We evaluated colonic structural, microbiomic and functional changes in old female vervet monkeys (Chlorocebus aethiops sabeus) and how age-related leaky gut alters responses to Western diet. We additionally assessed serum bovine immunoglobulin therapy to lower MT burden...
July 27, 2018: Scientific Reports
Christina Jensen, Signe H Nielsen, Joachim H Mortensen, Jens Kjeldsen, Lone G Klinge, Aleksander Krag, Henrik Harling, Lars N Jørgensen, Morten A Karsdal, Nicholas Willumsen
Altered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col-16) plays a role in pathogenesis by affecting ECM architecture and induce cell invasion. Measuring col-16 in serum may therefore have biomarker potential in GI disorders such as colorectal cancer (CRC) and ulcerative colitis (UC). The aim of this study was to determine whether col-16 can serve as a biomarker for altered ECM remodeling in patients with CRC and UC...
September 2018: Cancer Medicine
Ines Pombeiro, Sven H Loosen, Sanchari Roy, Florian Schueller, Lukas Niewenhuisen, Mark Luedde, Mihael Vucur, Frank Tacke, Marcel Binnebösel, Wenzel Schoening, Christian Trautwein, Tom Luedde, Ulf Peter Neumann, Christoph Roderburg
The tumor necrosis factor⁻related weak inducer of apoptosis (TWEAK) belongs to the tumor necrosis factor ligand superfamily, which was shown to play an important role in inflammatory and malignant gastrointestinal diseases, including colitis or colorectal cancer. However, in contrast to other members of the TNF ligand superfamily, its role as a biomarker in pancreatic cancer is currently unknown. We analyzed serum levels of A proliferation-inducing ligand (APRIL) and TWEAK in 134 patients with pancreatic cancer...
July 13, 2018: Journal of Clinical Medicine
Valerie Aloush, Iris Dotan, Jacob Nadav Ablin, Ori Elkayam
OBJECTIVES: The presence of serological markers associated with inflammatory bowel disease (IBD) has been studied in spondyloarthritis with conflicting results. The anti-glycan antibodies: anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies (ALCA, ACCA, and AMCA) are serological markers previously associated with IBD. We aim to investigate the prevalence of these antibodies in spondyloarthritis in comparison with rheumatoid arthritis (RA) patients. METHODS: Serum samples were obtained from consecutive patients with spondyloarthritis and were compared to RA and healthy controls...
June 25, 2018: Clinical and Experimental Rheumatology
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