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https://www.readbyqxmd.com/read/29677036/coupled-opg-fc-on-decellularized-aortic-valves-by-edc-nhs-attenuates-rat-mscs-calcification-in-vitro
#1
Qiao Zhang, Si Chen, Jiawei Shi, Fei Li, Xucong Shi, Xingjian Hu, Cheng Deng, Feng Shi, Guichun Han, Nianguo Dong
Valve calcification commonly damages natural human heart valves and tissue-engineered heart valves (TEHVs), and no ideal intervention is available in clinical practice. It is increasingly considered that osteoprotegerin (OPG) inhibits vascular calcification. We aimed to explore whether free OPG-Fc fusion protein or coupled OPG-Fc on decellularized aortic valves attenuates calcification. Calcification of rat bone marrow-derived mesenchymal stromal cells (MSCs) was induced by osteogenic differentiation media, and the effects of free OPG-Fc or OPG-Fc coupled on the decellularized porcine aortic heart valve leaflet scaffolds by coupling agents 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) on calcification were observed...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29517511/implanted-in-body-tissue-engineered-heart-valve-can-adapt-the-histological-structure-to-the-environment
#2
Yoshiaki Takewa, Hirohito Sumikura, Satoru Kishimoto, Noritsugu Naito, Kei Iizuka, Daichi Akiyama, Ryosuke Iwai, Eisuke Tatsumi, Yasuhide Nakayama
Tissue-engineered heart valves (TEHVs) are expected to be viable grafts. However, it is unknown whether they transit their histological structure after implantation. We developed a novel autologous TEHV (named stent biovalve) for transcatheter implantation, using in-body tissue engineering based on a tissue encapsulation phenomenon. In this study, a time-course histological transition of implanted biovalves was investigated in goats. Three types of stent biovalves were prepared by 2 month embedding of plastic molds mounted with metallic stents, in the subcutaneous spaces...
March 5, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29505894/human-ipsc-derived-mesenchymal-stem-cells-encapsulated-in-pegda-hydrogels-mature-into-valve-interstitial-like-cells
#3
Aline L Y Nachlas, Siyi Li, Rajneesh Jha, Monalisa Singh, Chunhui Xu, Michael E Davis
Despite recent advances in tissue engineered heart valves (TEHV), a major challenge is identifying a cell source for seeding TEHV scaffolds. Native heart valves are durable because valve interstitial cells (VICs) maintain tissue homeostasis by synthesizing and remodeling the extracellular matrix. This study demonstrates that induced pluripotent stem cells (iPSC)-derived mesenchymal stem cells (iMSCs) can be derived from iPSCs using a feeder-free protocol and then further matured into VICs by encapsulation within 3D hydrogels...
March 2, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29327671/tissue-engineered-heart-valves-a-call-for-mechanistic-studies
#4
Kevin M Blum, Joseph D Drews, Christopher K Breuer
Heart valve disease carries a substantial risk of morbidity and mortality. Outcomes are significantly improved by valve replacement, but currently available mechanical and biological replacement valves are associated with complications of their own. Mechanical valves have a high rate of thromboembolism and require lifelong anticoagulation. Biological prosthetic valves have a much shorter lifespan, and they are prone to tearing and degradation. Both types of valves lack the capacity for growth, making them particularly problematic in pediatric patients...
February 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29171921/developing-a-clinically-relevant-tissue-engineered-heart-valve-a-review-of-current-approaches
#5
REVIEW
Aline L Y Nachlas, Siyi Li, Michael E Davis
Tissue engineered heart valves (TEHVs) have the potential to address the shortcomings of current implants through the combination of cells and bioactive biomaterials that promote growth and proper mechanical function in physiological conditions. The ideal TEHV should be anti-thrombogenic, biocompatible, durable, and resistant to calcification, and should exhibit a physiological hemodynamic profile. In addition, TEHVs may possess the capability to integrate and grow with somatic growth, eliminating the need for multiple surgeries children must undergo...
December 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28763463/recellularization-of-a-novel-off-the-shelf-valve-following-xenogenic-implantation-into-the-right-ventricular-outflow-tract
#6
Ryan S Hennessy, Jason L Go, Rebecca R Hennessy, Brandon J Tefft, Soumen Jana, Nicholas J Stoyles, Mohammed A Al-Hijji, Jeremy J Thaden, Sorin V Pislaru, Robert D Simari, John M Stulak, Melissa D Young, Amir Lerman
Current research on valvular heart repair has focused on tissue-engineered heart valves (TEHV) because of its potential to grow similarly to native heart valves. Decellularized xenografts are a promising solution; however, host recellularization remains challenging. In this study, decellularized porcine aortic valves were implanted into the right ventricular outflow tract (RVOT) of sheep to investigate recellularization potential. Porcine aortic valves, decellularized with sodium dodecyl sulfate (SDS), were sterilized by supercritical carbon dioxide (scCO2) and implanted into the RVOT of five juvenile polypay sheep for 5 months (n = 5)...
2017: PloS One
https://www.readbyqxmd.com/read/28754074/detection-of-mycoplasma-spp-herpesviruses-topiviruses-and-ferlaviruses-in-samples-from-chelonians-in-europe
#7
Ekaterina Kolesnik, Anna Obiegala, Rachel E Marschang
We tested samples from 1,015 chelonians in Europe for Mycoplasma spp., herpesviruses, ranaviruses, picornaviruses, and ferlaviruses by PCR. Mycoplasma spp. were detected in 42.1% and herpesviruses were detected in 8.0% of tested chelonians. Differentiation of the herpesviruses revealed that 46.9% of the detected chelonian viruses were testudinid herpesvirus 1 (TeHV-1) and 54.3% were TeHV-3, including co-detections of TeHV-1 and -3 in 3 tortoises. TeHV-4 was detected in a leopard tortoise ( Stigmochelys pardalis), and a herpesvirus that could not be further characterized was found in a pond slider ( Trachemys scripta)...
November 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28482571/optimization-and-development-of-maghemite-%C3%AE-fe2o3-filled-poly-l-lactic-acid-plla-thermoplastic-polyurethane-tpu-electrospun-nanofibers-using-taguchi-orthogonal-array-for-tissue-engineering-heart-valve
#8
Ehsan Fallahiarezoudar, Mohaddeseh Ahmadipourroudposht, Ani Idris, Noordin Mohd Yusof
Tissue engineering (TE) is an advanced principle to develop a neotissue that can resemble the original tissue characteristics with the capacity to grow, to repair and to remodel in vivo. This research proposed the optimization and development of nanofiber based scaffold using the new mixture of maghemite (γ-Fe2O3) filled poly-l-lactic acid (PLLA)/thermoplastic polyurethane (TPU) for tissue engineering heart valve (TEHV). The chemical, structural, biological and mechanical properties of nanofiber based scaffold were characterized in terms of morphology, porosity, biocompatibility and mechanical behaviour...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28453437/umbilical-cord-as-human-cell-source-for-mitral-valve-tissue-engineering-venous-vs-arterial-cells
#9
Axel Malischewski, Ricardo Moreira, Luis Hurtado, Valentine Gesché, Thomas Schmitz-Rode, Stefan Jockenhoevel, Petra Mela
Around 2% of the population in developed nations are affected by mitral valve disease and available valvular replacements are not designed for the atrioventricular position. Recently our group developed the first tissue-engineered heart valve (TEHV) specifically designed for the mitral position - the TexMi valve. The valve recapitulates the main components of the native valve, i.e. annulus, asymmetric leaflets and the crucial chordae tendineae. In the present study, we evaluated the human umbilical cord as a clinically applicable cell source for the TexMi valve...
October 26, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28110071/living-nano-micro-fibrous-woven-fabric-hydrogel-composite-scaffolds-for-heart-valve-engineering
#10
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T Butcher
Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27995570/hydrodynamic-assessment-of-aortic-valves-prepared-from-porcine-small-intestinal-submucosa
#11
Sharan Ramaswamy, Makensley Lordeus, Omkar V Mankame, Lilliam Valdes-Cruz, Steven Bibevski, Sarah M Bell, Ivan Baez, Frank Scholl
Infants and children born with severe cardiac valve lesions have no effective long term treatment options since currently available tissue or mechanical prosthetic valves have sizing limitations and no avenue to accommodate the growth of the pediatric patient. Tissue engineered heart valves (TEHVs) which could provide for growth, self-repair, infection resistance, and long-term replacement could be an ideal solution. Porcine small intestinal submucosa (PSIS) has recently emerged as a potentially attractive bioscaffold for TEHVs...
March 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27856282/numerical-investigation-of-the-influence-of-pattern-topology-on-the-mechanical-behavior-of-pegda-hydrogels
#12
Tao Jin, Ilinca Stanciulescu
Poly(ethylene glycol) diacrylate (PEGDA) hydrogels can be potentially used as scaffold material for tissue engineered heart valves (TEHVs) due to their good biocompatibility and biomechanical tunability. The photolithographic patterning technique is an effective approach to pattern PEGDA hydrogels to mimic the mechanical behavior of native biological tissues that are intrinsically anisotropic. The material properties of patterned PEGDA hydrogels largely depend on the pattern topology. In this paper, we adopt a newly proposed computational framework for fibrous biomaterials to numerically investigate the influence of pattern topology, including pattern ratio, orientation and waviness, on the mechanical behavior of patterned PEGDA hydrogels...
February 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27843569/conceptual-model-for-early-health-technology-assessment-of-current-and-novel-heart-valve-interventions
#13
Simone A Huygens, Maureen P M H Rutten-van Mölken, Jos A Bekkers, Ad J J C Bogers, Carlijn V C Bouten, Steven A J Chamuleau, Peter P T de Jaegere, Arie Pieter Kappetein, Jolanda Kluin, Nicolas M D A van Mieghem, Michel I M Versteegh, Maarten Witsenburg, Johanna J M Takkenberg
OBJECTIVE: The future promises many technological advances in the field of heart valve interventions, like tissue-engineered heart valves (TEHV). Prior to introduction in clinical practice, it is essential to perform early health technology assessment. We aim to develop a conceptual model (CM) that can be used to investigate the performance and costs requirements for TEHV to become cost-effective. METHODS: After scoping the decision problem, a workgroup developed the draft CM based on clinical guidelines...
2016: Open Heart
https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#14
REVIEW
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27780149/nanofibrous-bioengineered-heart-valve-application-in-paediatric-medicine
#15
REVIEW
Mehrdad Namdari, Ali Eatemadi
Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27414719/micro-and-nanotechnologies-in-heart-valve-tissue-engineering
#16
REVIEW
Anwarul Hasan, John Saliba, Hassan Pezeshgi Modarres, Ahmed Bakhaty, Amir Nasajpour, Mohammad R K Mofrad, Amir Sanati-Nezhad
Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs). Despite the significant progress in recent years in improving the design and performance of TEHV constructs, viable and functional human implantable TEHV constructs have remained elusive. The recent advances in micro and nanoscale technologies including the microfabrication, nano-microfiber based scaffolds preparation, 3D cell encapsulated hydrogels preparation, microfluidic, micro-bioreactors, nano-microscale biosensors as well as the computational methods and models for simulation of biological tissues have increased the potential for realizing viable, functional and implantable TEHV constructs...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/26707568/melatonin-reverses-flow-shear-stress-induced-injury-in-bone-marrow-mesenchymal-stem-cells-via-activation-of-amp-activated-protein-kinase-signaling
#17
Yang Yang, Chongxi Fan, Chao Deng, Lin Zhao, Wei Hu, Shouyin Di, Zhiqiang Ma, Yu Zhang, Zhigang Qin, Zhenxiao Jin, Xiaolong Yan, Shuai Jiang, Yang Sun, Wei Yi
Tissue-engineered heart valves (TEHVs) are a promising treatment for valvular heart disease, although their application is limited by high flow shear stress (FSS). Melatonin has a wide range of physiological functions and is currently under clinical investigation for expanded applications; moreover, extensive protective effects on the cardiovascular system have been reported. In this study, we investigated the protection conferred by melatonin supplementation against FSS-induced injury in bone marrow mesenchymal stem cells (BMSCs) and elucidated the potential mechanism in this process...
March 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/26608336/a-computational-analysis-of-cell-mediated-compaction-and-collagen-remodeling-in-tissue-engineered-heart-valves
#18
Sandra Loerakker, Tommaso Ristori, Frank P T Baaijens
One of the most critical problems in heart valve tissue engineering is the progressive development of valvular insufficiency due to leaflet retraction. Understanding the underlying mechanisms of this process is crucial for developing tissue-engineered heart valves (TEHVs) that maintain their functionality in the long term. In the present study, we adopted a computational approach to predict the remodeling process in TEHVs subjected to dynamic pulmonary and aortic pressure conditions, and to assess the risk of valvular insufficiency...
May 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/26536240/differentiation-and-distribution-of-marrow-stem-cells-in-flex-flow-environments-demonstrate-support-of-the-valvular-phenotype
#19
Sasmita Rath, Manuel Salinas, Ana G Villegas, Sharan Ramaswamy
For treatment of critical heart valve diseases, prosthetic valves perform fairly well in most adults; however, for pediatric patients, there is the added requirement that the replacement valve grows with the child, thus extremely limiting current treatment options. Tissue engineered heart valves (TEHV), such as those derived from autologous bone marrow stem cells (BMSCs), have the potential to recapitulate native valve architecture and accommodate somatic growth. However, a fundamental pre-cursor in promoting directed integration with native tissues rather than random, uncontrolled growth requires an understanding of BMSC mechanobiological responses to valve-relevant mechanical environments...
2015: PloS One
https://www.readbyqxmd.com/read/26469196/design-and-efficacy-of-a-single-use-bioreactor-for-heart-valve-tissue-engineering
#20
Gabriel L Converse, Eric E Buse, Kari R Neill, Christopher R McFall, Holley N Lewis, Mitchell C VeDepo, Rachael W Quinn, Richard A Hopkins
Heart valve tissue engineering offers the promise of improved treatments for congenital heart disorders; however, widespread clinical availability of a tissue engineered heart valve (TEHV) has been hindered by scientific and regulatory concerns, including the lack of a disposable, bioreactor system for nondestructive valve seeding and mechanical conditioning. Here we report the design for manufacture and the production of full scale, functional prototypes of such a system. To evaluate the efficacy of this bioreactor as a tool for seeding, ovine aortic valves were decellularized and subjected to seeding with human mesenchymal stem cells (hMSC)...
February 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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