keyword
https://read.qxmd.com/read/38452669/an-integrated-approach-to-assess-human-health-risk-of-neonicotinoid-insecticides-in-surface-water-of-the-yangtze-river-basin-china
#21
JOURNAL ARTICLE
Gedion Tsegay, George Lartey-Young, Marta Sibhat, Yunze Gao, Ling-Chuan Guo, Xiang-Zhou Meng
Neonicotinoids are widely used insecticides that have raised considerable concerns for both environmental and human health. However, there lack of comprehensive evaluation of their accumulation in surface water ecosystems and exposure to various human groups. Additionally, there's a distinct lack of scientific evidence describing the carcinogenic and non-carcinogenic impacts of neonicotinoids from surface water. Using an integrated approach employing the Relative Potency Factor (RPF), Hazard Index (HI), and Monte Carlo Simulation (MCS), the study assessed neonicotinoid exposure and risk to four demographic groups via dermal contact and mistaken oral intake pathways in the Yangtze River Basin (YRB), China...
March 2, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38447517/associations-between-maternal-serum-neonicotinoid-pesticide-exposure-during-pregnancy-and-newborn-telomere-length-effect-modification-by-sampling-season
#22
JOURNAL ARTICLE
Changhui Mu, Mengrui Lin, Yantao Shao, Qian Liao, Jun Liang, Chuanxiang Yu, Xiaolin Wu, Manlin Chen, Ying Tang, Lihong Zhou, Xiaoqiang Qiu, Dongxiang Pan, Dongping Huang
BACKGROUND: An increasing amount of evidence suggests that telomere length (TL) at birth can predict lifespan and is associated with chronic diseases later in life, but newborn TL may be affected by environmental pollutants. Neonicotinoids (NEOs) are widely used worldwide, and despite an increasing number of studies showing that they may have adverse effects on birth in mammals and even humans, few studies have examined the effect of NEO exposure on newborn TLs. OBJECTIVE: To investigate the effects of prenatal exposure to NEOs and the interactions between NEOs and sampling season on newborn TL...
March 4, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38442746/mutation-v65i-in-the-%C3%AE-1-subunit-of-the-nicotinic-acetylcholine-receptor-confers-neonicotinoid-and-sulfoxaflor-resistance-in-insects
#23
JOURNAL ARTICLE
Kun Zhang, Longwei Chen, Jianwen Chen, Huixiu Huang, Kaiyang Liu, Yi Zhang, Jingfang Yang, Shaoying Wu
Neonicotinoids have been widely used to control pests with remarkable effectiveness. Excessive insecticides have led to serious insect resistance. Mutations of the nicotinic acetylcholine receptor (nAChR) are one of the reasons for neonicotinoid resistance conferred in various agricultural pests. Two mutations, V65I and V104I, were found in the nAChR β1 subunit of two neonicotinoid-resistant aphid populations. However, the specific functions of the two mutations remain unclear. In this study, we cloned and identified four nAChR subunits (α1, α2, α8, and β1) of thrips and found them to be highly homologous to the nAChR subunits of other insects...
March 5, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38441570/thiacloprid-impairs-reproductive-functions-of-male-wistar-rats
#24
JOURNAL ARTICLE
Aya Abdel Nasser Mahmoud, Ebtehal Altohamy Ahmed, Amel Ramadan Omar
Global male infertility correlated to the rise of endocrine-disrupting chemicals, including insecticides, has grown into a pressing problem. Thiacloprid is one of the most commonly used neonicotinoids that accounts for more than 25% of the global pesticide industry. However, its impact on the reproductive system and male fertility has not been fully elucidated. The object of this study was to explore the adverse effects of thiacloprid on male Wistar rats' reproductive system. Thirty healthy male rats were separated into one of three groups: control group, and two groups that were orally administered with low (22...
March 5, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38441271/pesticide-contamination-levels-in-the-stomach-contents-of-wild-raccoons-procyon-lotor-and-masked-palm-civets-paguma-larvata-in-japan
#25
JOURNAL ARTICLE
So Shinya, Mariko Sashika, Miku Minamikawa, Tetsuji Itoh, Tsutomu Tanikawa, Kazuyuki D Tanaka, Shouta M M Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Pesticides, which are vital for agriculture, pose a significant threat to wildlife in transformed Japanese landscapes. Despite global reports of pesticide poisoning in animals, limited studies have examined current wildlife exposure in croplands or metropolitan areas in the region. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS), our study aimed to assess the contamination status of 368 commonly used pesticides. The stomach contents of raccoons living in croplands contained 13 pesticides, including six herbicides and 11 fungicides...
March 5, 2024: Environmental Toxicology and Chemistry
https://read.qxmd.com/read/38440844/heterologous-antigen-selection-of-chicken-single-chain-variable-fragments-against-thiamethoxam
#26
JOURNAL ARTICLE
Jinxin He, Yating Wang, Di Wang, Yayun Yang, Xianle Xue, Ting Xu, Shaopeng Gu, Fang Tang
Single-chain variable fragments (scFvs) are valuable in the development of immunoassays for pesticide detection. In this study, scFvs specific to thiamethoxam (Thi) were successfully isolated from a library generated by chicken immunization through heterologous coating selection. These scFvs were subsequently expressed with fusion with an Avi tag and alkaline phosphatase. After combination and optimization, a scFv-biotin based enzyme linked immunosorbent assay (ELISA) was developed for the detection of Thi, demonstrating an impressive half-maximum signal inhibition concentration (IC50 ) of 30 ng mL-1 and a limit of detection (LOD) of 1...
March 5, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38438029/neonicotinoid-insecticides-in-waters-of-the-northern-jiangsu-segment-of-the-beijing-hangzhou-grand-canal-environmental-and-health-implications
#27
JOURNAL ARTICLE
Xiaoxin Zhang, Yuanxin Cao, Jiachen Cao, Xiao Feng, Zhijie Zhang, Qiao Li, Yubo Yan
Neonicotinoid (NEO) insecticides have been frequently detected in natural aquatic environments. Nevertheless, the distribution of NEOs in artificial environments is not clear. The Beijing-Hangzhou Grand Canal is the longest canal in the world. The northern Jiangsu segment of the Grand Canal was selected to study the spatiotemporal variation and source of eight NEOs in the canal water and assess their ecological and health risks. The total NEO concentration in the canal water was 12-289 ng L-1 in the dry season and 18-373 ng L-1 in the wet season, which were within the concentration range in other 11 natural rivers worldwide...
March 2, 2024: Science of the Total Environment
https://read.qxmd.com/read/38432095/neonicotinoid-insecticides-and-metabolites-levels-in-neonatal-first-urine-from-southern-china-exploring-links-to-preterm-birth
#28
JOURNAL ARTICLE
Zixiong Tang, Zhiwen Su, Chunhong Jia, Xin Wei, Zhenni Zhu, Yifei Qi, Zhenyan Zhang, Linjie Yao, Haixin Tu, Xiaohui Huang, Qianqian Niu, Wenwen Sun, Haijun Wu, Renli Yin, Adela Jing Li, Fan Wu
Neonicotinoids (NEOs) have indeed become the most widely used insecticides worldwide. Concerns have been raised about their potential impact on newborns due to maternal exposure and their unique neurotoxic mode of action. However, it is still poorly understood whether in utero exposure of pregnant women to environmental NEOs and their metabolites can cause carryover effects on vulnerable newborns and subsequent health consequences. In this study, we determined the concentrations of 13 NEOs and their metabolites in the first urine collected from 92 newborns, both preterm and full-term, in southern China during 2020 and 2021...
February 28, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38429846/anopheles-gambiae-larvae-s-ability-to-grow-and-emerge-in-water-containing-lethal-concentrations-of-clothianidin-acetamiprid-or-imidacloprid-is-consistent-with-cross-resistance-to-neonicotinoids
#29
JOURNAL ARTICLE
Marilene Ambadiang, Caroline Fouet, Fred Ashu, Calmes Bouaka, Véronique Penlap-Beng, Colince Kamdem
BACKGROUND: For decades, various agrochemicals have been successfully repurposed for mosquito control. However, preexisting resistance caused in larval and adult populations by unintentional pesticide exposure or other cross-resistance mechanisms poses a challenge to the efficacy of this strategy. A better understanding of larval adaptation to the lethal and sublethal effects of residual pesticides in aquatic habitats would provide vital information for assessing the efficacy of repurposed agrochemicals against mosquitoes...
March 1, 2024: Parasites & Vectors
https://read.qxmd.com/read/38428792/selected-legacy-and-emerging-organic-contaminants-in-sediments-of-china-s-yangtze-the-world-s-third-longest-river-response-to-anthropogenic-activities
#30
JOURNAL ARTICLE
Yulin Chen, Yang Tan, Yuying Feng, Tao Dong, Chunxia Jiang, Chen Wang, Yuyi Yang, Zulin Zhang
To explore contaminant concerns as a result of anthropogenic disturbance of the river system, this study provided the first extensive investigation of the contamination profiles, possible driving factors, and ecological risks of 40 target compounds including pharmaceuticals and personal care products (PPCPs), neonicotinoid pesticides (NNIs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) in sediments of the whole Yangtze River (the world's third longest river). Among these target compounds, PPCPs were the dominant contaminants with a total concentration (∑15 PPCPs) of 2...
February 28, 2024: Environmental Pollution
https://read.qxmd.com/read/38427964/cytochrome-p450-cyp6em1-underpins-dinotefuran-resistance-in-the-whitefly-bemisia-tabaci
#31
JOURNAL ARTICLE
Mingjiao Huang, Buli Fu, Cheng Yin, Peipan Gong, Shaonan Liu, Jing Yang, Xuegao Wei, Jinjin Liang, Hu Xue, Chao He, Tianhua Du, Chao Wang, Yao Ji, JinYu Hu, Rong Zhang, He Du, Youjun Zhang, Xin Yang
Being a destructive pest worldwide, the whitefly Bemisia tabaci has evolved resistance to neonicotinoid insecticides. The third-generation neonicotinoid dinotefuran has commonly been applied to the control of the whitefly, but its underlying mechanism is currently unknown. On the base of our transcriptome data, here we aim to investigate whether the cytochrome P450 CYP6EM1 underlies dinotefuran resistance in the whitefly. Compared to the susceptible strain, the CYP6EM1 gene was found to be highly expressed in both laboratory and field dinotefuran-resistant populations...
March 1, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38423273/a-systematic-evidence-map-and-bibliometric-analysis-of-the-behavioural-impacts-of-pesticide-exposure-on-zebrafish
#32
JOURNAL ARTICLE
Kyle Morrison, Yefeng Yang, Manuela Santana, Malgorzata Lagisz, Shinichi Nakagawa
Pesticides are indispensable in agriculture and have become ubiquitous in aquatic environments. Pesticides in natural environments can cause many negative impacts on aquatic species, ranging from mortality to sub-lethal physiological and behavioural changes. The complex sub-lethal impacts of pesticides are routinely tested on model species, with zebrafish (Danio rerio) being regularly used as a behavioural model. Although behavioural ecotoxicology research using zebrafish is increasing rapidly, we lack quantitative evidence to support which pesticides have been tested and how study designs are carried out...
February 27, 2024: Environmental Pollution
https://read.qxmd.com/read/38419506/discovery-of-potential-neonicotinoid-insecticides-by-an-artificial-intelligence-generative-model-and-structure-based-virtual-screening
#33
JOURNAL ARTICLE
Yijin Kong, Cong Zhou, Du Tan, Xiaoyong Xu, Zhong Li, Jiagao Cheng
The identification of neonicotinoid insecticides bearing novel scaffolds is of great importance for pesticide discovery. Here, artificial intelligence-based tools and virtual screening strategy were integrated to discover potential leads of neonicotinoid insecticides. A deep generative model was successfully constructed using a recurrent neural network combined with transfer learning. The model evaluation showed that the pretrained model could accurately grasp the SMILES grammar of drug-like molecules and generate potential neonicotinoid compounds after transfer learning...
February 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38381590/synthesis-and-insecticidal-evaluation-of-3-5-dicyanopyridines-against-cotton-aphids-via-microwave-assisted-multicomponent-reactions
#34
JOURNAL ARTICLE
Mohamed Ahmed Gad, Hany M Abd El-Lateef, Mai M Khalaf, Mohamed Gouda, Antar Ahmed Abdelhamid, Amer Anwar Amer, Ali Moustafa Drar, Abdelrahim Fathy Ismail
Certain 2-amino-6-alkoxy-4-arylpyridine-3,5-dicyanide 1a-e were prepared via a straightforward process using microwave technology rather than conventional methods. This involved reaction of arylidenemalononitrile thru propanedinitrile in the occurrence of sodium alkoxide under MW. While, their positional isomer 4-amino-6-alkoxy-2-arylpyridine-3,5-dicyanide 3a-j have been separated from the reaction of aryl aldehydes with 2-aminoprop-1-ene-1,1,3-tricarbonitrile 2 in the presence of sodium alkoxide using microwave technic...
February 21, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38377137/dual-mutations-in-the-whitefly-nicotinic-acetylcholine-receptor-%C3%AE-1-subunit-confer-target-site-resistance-to-multiple-neonicotinoid-insecticides
#35
JOURNAL ARTICLE
Cheng Yin, Andrias O O'Reilly, Shao-Nan Liu, Tian-Hua Du, Pei-Pan Gong, Cheng-Jia Zhang, Xue-Gao Wei, Jing Yang, Ming-Jiao Huang, Bu-Li Fu, Jin-Jin Liang, Hu Xue, Jin-Yu Hu, Yao Ji, Chao He, He Du, Chao Wang, Rong Zhang, Qi-Mei Tan, Han-Tang Lu, Wen Xie, Dong Chu, Xu-Guo Zhou, Ralf Nauen, Lian-You Gui, Chris Bass, Xin Yang, You-Jun Zhang
Neonicotinoid insecticides, which target insect nicotinic acetylcholine receptors (nAChRs), have been widely and intensively used to control the whitefly, Bemisia tabaci, a highly damaging, globally distributed, crop pest. This has inevitably led to the emergence of populations with resistance to neonicotinoids. However, to date, there have been no reports of target-site resistance involving mutation of B. tabaci nAChR genes. Here we characterize the nAChR subunit gene family of B. tabaci and identify dual mutations (A58T&R79E) in one of these genes (BTβ1) that confer resistance to multiple neonicotinoids...
February 2024: PLoS Genetics
https://read.qxmd.com/read/38376791/molecular-docking-analysis-at-the-human-%C3%AE-7-nachr-and-proliferative-and-evoked-calcium-changes-in-sh-sy5y-cells-by-imidacloprid-and-acetamiprid-insecticides
#36
JOURNAL ARTICLE
Marcelo S Guzman-Vallejos, Lenin J Ramirez-Cando, Luis Aguayo, Santiago J Ballaz
Acetamiprid (ACE) and Imidacloprid (IMI) are widely-used neonicotinoid insecticides (NNIs) with functional activity at human acetylcholine nicotinic receptors and, therefore, with putative toxic effects. The objective of this study was the evaluation of the interactions between NNIs and α7-nAChR, as this receptor keeps intracellular Ca2+ ([Ca2+]i) to an optimum for an adequate neuronal functioning. Possible interactions between NNIs and the cryo-EM structure of the human α-7 nAChR were identified by molecular docking...
February 20, 2024: Neurotoxicity Research
https://read.qxmd.com/read/38364586/occurrence-distribution-and-health-risk-assessment-of-pyrethroid-and-neonicotinoid-insecticides-in-aquatic-products-of-china
#37
JOURNAL ARTICLE
Manni Wu, Jingjing Miao, Wenhao Zhang, Qiaoqiao Wang, Ce Sun, Lu Wang, Luqing Pan
Synthetic pyrethroid insecticides (SPIs) and neonicotinoid insecticides (NEOs), now dominant in the insecticide market, are increasingly found in aquatic environments. This study focused on six SPIs and five NEOs in aquatic products from four Chinese provinces (Shandong, Hubei, Shanxi and Zhejiang) and the risk assessment of the safety for the residents was conducted. It revealed significantly higher residues of Σ6 SPIs (6.27-117.19 μg/kg) compared to Σ5 NEOs (0.30-14.05 μg/kg), with SPIs more prevalent in fish and NEOs in shellfish...
February 15, 2024: Science of the Total Environment
https://read.qxmd.com/read/38360305/comprehensive-analysis-of-neonicotinoids-in-chinese-commercial-honey-and-pollen-a-corresponding-health-risk-assessment-for-non-targeted-organisms
#38
JOURNAL ARTICLE
Jing Zhang, Yunyun Wang, Shanbaga Wurjihu, Haonan Ruan, Ying Huang, Mengyue Guo, Dandan Kong, Jiaoyang Luo, Meihua Yang
Neonicotinoids are broad-spectrum and highly effective insecticides that work by affecting neural activity in insects. Neonicotinoids are systemic pesticides that are absorbed by plants, transported, and accumulated in plant tissues, including nectar and pollen. Currently, there is a lack of a comprehensive assessment of the level of neonicotinoid contamination and the associated health risks to non-targeted organisms in commercial honey and pollen produced in China. This study collected 160 batches of honey and 26 batches of pollen from different regions and plant sources in China, analyzed the residue patterns of neonicotinoid pesticides, and comprehensively evaluated the exposure risks to non-targeted organisms including bees (adults and larvae) and humans...
February 13, 2024: Science of the Total Environment
https://read.qxmd.com/read/38358646/toxicological-assessments-of-agrochemicals-in-stingless-bees-in-brazil-a-systematic-review
#39
REVIEW
Lorena Lisbetd Botina, Wagner Faria Barbosa, Gustavo Ferreira Martins
The growing concern with the decline of pollinators worldwide is centered on honey bees, due to their wide distribution, economic, and ecological importance. This type of concern remained less evident for stingless bees, which are widely distributed in the Neotropics, until recently. Since exposure to agrochemicals has been identified as one of the potential threats to bees, the present systematic review compiled information from toxicological evaluations in stingless bees in Brazil, home to a considerable portion of the existing species...
February 15, 2024: Neotropical Entomology
https://read.qxmd.com/read/38356650/the-domestic-chick-as-an-animal-model-of-autism-spectrum-disorder-building-adaptive-social-perceptions-through-prenatally-formed-predispositions
#40
REVIEW
Toshiya Matsushima, Takeshi Izumi, Giorgio Vallortigara
Equipped with an early social predisposition immediately post-birth, humans typically form associations with mothers and other family members through exposure learning, canalized by a prenatally formed predisposition of visual preference to biological motion, face configuration, and other cues of animacy. If impaired, reduced preferences can lead to social interaction impairments such as autism spectrum disorder (ASD) via misguided canalization. Despite being taxonomically distant, domestic chicks could also follow a homologous developmental trajectory toward adaptive socialization through imprinting, which is guided via predisposed preferences similar to those of humans, thereby suggesting that chicks are a valid animal model of ASD...
2024: Frontiers in Neuroscience
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