Atsuki Fukada, Tomoyuki Fujisawa, Hironao Hozumi, Keigo Koda, Taisuke Akamatsu, Yoshiyuki Oyama, Yasuomi Satake, Mitsuru Niwa, Yusuke Kaida, Hiroyuki Matsuda, Koshi Yokomura, Naoki Koshimizu, Mikio Toyoshima, Shiro Imokawa, Dai Hashimoto, Akira Yoshida, Takahisa Gono, Masataka Kuwana, Yasuhiko Yamano, Yasuhiro Kondoh, Keita Yamashita, Masato Maekawa, Kazutaka Mori, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Naoki Inui, Takafumi Suda
OBJECTIVE: Interferon-lambda 3 (IFN-λ3) is a cytokine with antiviral functions on barrier surfaces, and it is associated with disease activity in autoimmune diseases. This study assessed the clinical significance of serum IFN-λ3 levels in polymyositis (PM)/dermatomyositis (DM)-associated interstitial lung disease (ILD). METHODS: We measured serum IFN-λ3 levels in 221 patients with PM/DM-ILD (155 in the derivation cohort, 66 in the validation cohort) and 38 controls...
December 25, 2023: Arthritis & Rheumatology