Shuai Zhao, Hengfei Li, Xuan Jing, Xuebin Zhang, Ronghua Li, Yinghao Li, Chenguang Liu, Jie Chen, Guoxia Li, Wenfei Zheng, Qian Li, Xue Wang, Letian Wang, Yuanyuan Sun, Yunsheng Xu, Shihua Wang
Introduction: Type 2 diabetes (T2D) is a multifactorial complex chronic disease with a high prevalence worldwide, and Type 2 diabetes patients with different comorbidities often present multiple phenotypes in the clinic. Thus, there is a pressing need to improve understanding of the complexity of the clinical Type 2 diabetes population to help identify more accurate disease subtypes for personalized treatment. Methods: Here, utilizing the traditional Chinese medicine (TCM) clinical electronic medical records (EMRs) of 2137 Type 2 diabetes inpatients, we followed a heterogeneous medical record network (HEMnet) framework to construct heterogeneous medical record networks by integrating the clinical features from the electronic medical records, molecular interaction networks and domain knowledge...
2023: Frontiers in Pharmacology