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https://www.readbyqxmd.com/read/30249867/effects-of-shenfu-injection-on-chemotherapy-induced-adverse-effects-and-quality-of-life-in-patients-with-advanced-nonsmall-cell-lung-cancer-a-systematic-review-and-meta-analysis
#1
Gang Chen
Objective: To investigate the efficacy of Shenfu injection (SFI) in reducing chemotherapy-induced adverse effects in nonsmall cell lung cancer (NSCLC) patients by conducting a meta-analysis. Methods: A systematic review of Cochrane Library, PubMed, Embase, CNKI, Chinese Biomedical Literature Database, VIP, and Wanfang Database was performed from their inception to December 2015. Eligible studies were randomized controlled trials (RCTs) comparing chemotherapy with or without SFI for patients with NSCLC...
September 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30235758/efficacy-and-safety-of-shenfu-injection-for-patients-with-return-of-spontaneous-circulation-after-sudden-cardiac-arrest-protocol-for-a-systematic-review-and-meta-analysis
#2
REVIEW
Jiarong Ye, Zehao Zhu, Qianrong Liang, Xia Yan, Xiaotu Xi, Zhongde Zhang
BACKGROUND: Sudden cardiac arrest (SCA) is one of the most common critical illnesses encountered in clinical practice. Shenfu injection (SFI) has received extensive attention as an alternative therapy that can effectively maintain the autonomic circulation function after cardiopulmonary resuscitation. However, the mechanism of SFI is not yet fully understood. In addition, there has been no systematic review or meta-analysis of SFI in the treatment of patients with return of spontaneous circulation after SCA...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30053682/cross-platform-metabolic-profiling-deciphering-the-potential-targets-of-shenfu-injection-against-acute-viral-myocarditis-in-mice
#3
Guangguo Tan, Qian Zhou, Kui Liu, Xin Dong, Ling Li, Wenting Liao, Hong Wu
Acute viral myocarditis (AVMC) is typically caused by cardiotropic viral infection. There is a paucity of specific treatment options available with proven efficacy. Chinese patented pharmaceutical product Shenfu injection (SFI) has potent efficacy on treating AVMC in clinical practice. However, the molecular mechanism is still unknown. We employed cross-platform metabolomics combined with computational systems analysis, based on reversed-phase liquid chromatography-mass spectrometry (RPLC-MS), hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) and gas chromatography-mass spectrometry (GC-MS), to deciphering the targeted metabolic pathways of SFI against AVMC induced by coxsackievirus B3 (CVB3)...
October 25, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30001643/administrations-of-preoperative-shenmai-injection-and-postoperative-shenfu-injection-two-ginseng-containing-tcm-formulas-improve-cognitive-dysfunction-in-aged-rats
#4
Wei-Liang Zhang, Yong-Liang Chi, Lian-Zhu Wang, Hui Liu, Lu-Xi Zhao, Fan Su
Postoperative cognitive dysfunction (POCD) is one of the major complications in patients who have undergone surgeries. Reduction of surgery-induced inflammation and perioperative stress responses may prevent the development of POCD. As recent experimental data have suggested, Shenmai and Shenfu injections, two ginseng containing formulations, may improve cognition. We designed this study using aged rats as an experimental model to determine the effect of combined perioperative Shenmai injection and Shenfu injection in preventing the development of POCD and exploring the underlying mechanism of this intervention...
2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29910216/protective-effects-of-shenfu-injection-against-myocardial-ischemia-reperfusion-injury-via-activation-of-enos-in-rats
#5
Yan-Yan Wang, Yan-Yan Li, Lin Li, Dong-Li Yang, Kun Zhou, Yu-Hong Li
The aim of the present study was to investigate the protective effects of Shenfu injection (SFI) against myocardial ischemia-reperfusion injury (MIRI) in model rats and to explore its mechanism of action. Sprague-Dawley (SD) rats were pretreated with SFI and NG -nitro-L-arginine methyl ester (L-NAME) via tail vein injection and then rats were subjected to ischemia by occlusion of the left anterior descending coronary artery for 30 min followed by reperfusion for 120 min. Left ventricular function was evaluated by echocardiography...
September 1, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29901192/-corrigendum-long-non%C3%A2-coding-rna-h19-promotes-cell-proliferation-and-invasion-by-acting-as-a-cerna-of-mir%C3%A2-138-and-releasing-ezh2-in-oral-squamous-cell-carcinoma
#6
Yonglong Hong, Haitao He, Wen Sui, Jingge Zhang, Shenfu Zhang, Dajiang Yang
Following the publication of this article, we realize that the title appeared incorrectly: This appeared in print as "Long non‑coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma", and the corrected title is now featured above ("H1" should have read as "H19"). Note that this error did not have any bearing on the results reported in the paper, or on the conclusions therein. We regret any inconvenience that this mistake has caused...
August 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29746994/shenfu-formula-reduces-cardiomyocyte-apoptosis-in-heart-failure-rats-by-regulating-micrornas
#7
Xu Yan, Hongjin Wu, Jianxun Ren, Yuna Liu, Shengqi Wang, Jiyuan Yang, Shuyan Qin, Delin Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu decoction consists of the water extract from the dried root or rootstalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (Fuzi, Heishunpian in Chinese). Shenfu Formula has been used as a folk Chinese medicine for thousands of years. Recent studies have shown that Shenfu injection can enhance cardiac function and regulate arrhythmia. AIM OF THE STUDY: Shenfu Formula plays an important role in the treatment of heart failure...
December 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29737088/-effects-of-shenfu-injection-on-peripheral-neurotoxicity-of-paclitaxel
#8
Shao-Quan Xiong, Xiao-Ling Zou, Qiao Zheng, Shuai Jin, Mei Xie, Li-Juan Wang, Ting-Ting Song, Cheng-Shi He, Li Wan
OBJECTIVE: To investigate the effects and the underlying mechanisms of ShenFu Injection on paclitaxel-induced peripheral neuropathy. METHODS: Twenty-eight adult male Wister rats were randomized into 4 groups ( n =7) : control group, paclitaxel group, paclitaxel combined with low or high dose of ShenFu Injection groups. Rats were intraperitoneally injected with paclitaxel 8 mg/kg every 4 d for a total of 4 doses except control group. From Day 1 of the experiment (injection),low dose (4 mL/kg) and high dose (8 mL/kg) of Shenfu Injection were intraperitoneally injected daily in the combination groups for a total of 21 d respectively,while normal saline (NS) was injected in control group in the same way instead...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29676136/-network-meta-analysis-of-chinese-medical-injections-for-heart-failure
#9
Feng-Wen Yang, Jia-Han Zou, Yuan Wang, Chong-Xiang Sun, Long Ge, Jin-Hui Tian, Jun-Hua Zhang
To assess the clinical efficacy of Chinese medical injection (CMI) for heart failure by using network Meta-analysis method. The relative randomized controlled trials (RCTs) of CMI for heart failure were retrieved from China National Knowledge Infrastructure (CNKI), WanFang Database, Chinese Biomedical Literature Database (SinoMed), PubMed, Cochrane Library and EMbase in July 2017. RCTs on the comparison of two kinds of CMIs for heart failure were included. Two researchers independently completed the literature screening, data extraction and quality evaluation according to the pre-determined inclusion and exclusion criteria, and the results were crossed checked...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29549288/shenfu-injection-attenuates-rat-myocardial-hypertrophy-by-up-regulating-mir-19a-3p-expression
#10
Zhu-Jun Mao, Quan-Long Zhang, Jia Shang, Ting Gao, Wen-Jun Yuan, Lu-Ping Qin
Shenfu Injection (SFI) is a classical Chinese medicine used to treat heart failure. Our previous study demonstrated that miRNAs underwent changes in rats with myocardial hypertrophy induced by abdominal aortic constriction. Interestingly, there was a significant change in miR-19a-3p, whose target gene is known to be associated with MEF2 signaling. However, whether and how SFI regulates miR-19a-3p in the treatment of myocardial hypertrophy has not been investigated. The purpose of the present study was to investigate the regulatory effect of SFI on miR-19a-3p in MEF2 signaling in the rat hypertrophic myocardium...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29486473/shenfu-preparation-protects-aml12-cells-against-palmitic-acid-induced-injury-through-inhibition-of-both-jnk-nox4-and-jnk-nf%C3%AE%C2%BAb-pathways
#11
Jia-Fu Ji, Wan-Zhen Jiao, Yan Cheng, Hua Yan, Fan Su, Li-Li Chi
BACKGROUND/AIMS: Nonalcoholic steatohepatitis includes steatosis along with liver inflammation, hepatocyte injury and fibrosis. In this study, we investigated the protective role and the potential mechanisms of a traditional Chinese medicine ShenFu (SF) preparation in an in vitro hepatic steatosis model. METHODS: In palmitic acid (PA)-induced murine hepatic AML12 cell injury, effects of SF preparation on cellular apoptosis and intracellular triglyceride (iTG) level were assessed using TUNEL and TG Colorimetric Assay...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29474341/shenfu-injection-after-in-hospital-cardiac-arrest-a-question-regarding-funding
#12
Peter W Hart
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29386000/comparative-efficacy-of-chinese-herbal-injections-for-treating-chronic-heart-failure-a-network-meta-analysis
#13
Kai-Huan Wang, Jia-Rui Wu, Dan Zhang, Xiao-Jiao Duan, Meng-Wei Ni
BACKGROUND: On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF. METHODS: Literature search was conducted in Embase, the Cochrane Library, Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database from inception to June 12nd 2017, and study selection was abided by a prior eligible criteria...
January 31, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29344674/long-non-coding-rna-h1-promotes-cell-proliferation-and-invasion-by-acting-as-a-cerna-of-mir%C3%A2-138-and-releasing-ezh2-in-oral-squamous-cell-carcinoma
#14
Yonglong Hong, Haitao He, Wen Sui, Jingge Zhang, Shenfu Zhang, Dajiang Yang
Long non-coding RNAs (lncRNAs) have been shown to play pivotal roles in various types of human cancer, including oral squamous cell carcinoma (OSCC). However, the potential mechanisms of action of lncRNAs in OSCC remain to be fully elucidated. The aim of the present study was to further explore the potential mechanisms of action of lncRNAs in OSCC. We first analyzed Gene Expression Omnibus (GEO) datasets to investigate aberrantly expressed lncRNAs which may be involved in the development of OSCC. Reverse transcription‑quantitative PCR (RT‑qPCR) was performed to analyze the expression levels of lncRNA H19...
March 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29234363/shenfu-injection-adjunct-with-platinum-based-chemotherapy-for-the-treatment-of-advanced-non-small-cell-lung-cancer-a-meta-analysis-and-systematic-review
#15
REVIEW
Ailing Cao, Hailang He, Mengxin Jing, Beibei Yu, Xianmei Zhou
Platinum-based chemotherapy is one of the standard treatments for non-small-cell lung cancer (NSCLC), while its high toxicity and limited clinical effects raise big concerns. Shenfu injection (SFI) has been commonly used as an adjutant chemotherapy drug for NSCLC in China. We ascertained the beneficial and adverse effects of SFI in combination with platinum-based chemotherapy for advanced NSCLC by using meta-analysis methods. The randomized controlled trials (RCTs) involving advanced NSCLC treatment with SFI plus platinum-based chemotherapy versus chemotherapy alone were searched on 6 medical databases up to February 2017...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29181161/effects-of-hydration-combined-with-shenfu-injection-on-contrast-induced-acute-kidney-injury-in-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention
#16
Zhen Guo, Dandan Niu, Yaren Yu, Di Zhen, Wenhua Li
The aim of the present study was to evaluate the efficacy and safety of the Shenfu injection (SFI) in the prevention of contrast-induced acute kidney injury (CI-AKI) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). A single-center prospective and randomized controlled trial was performed and 148 ACS patients undergoing PCI were divided randomly into control (n=74; receiving only 0.9% sodium chloride solution for routine hydration) and intervention (n=74; based upon routine hydration and receiving SFI) groups...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29139250/-clinical-safety-imtensive-hospital-monitoring-on-shenfu-injection-with-30-106-cases
#17
Zhi-Fei Wang, Jin-Yang Yu, Yan-Ming Xie
This paper is to report the implementation and results of safety monitoring of Shenfu injection. Prospective, multicenter, large sample, registry-type centralized hospital monitoring mode was used, and the three-level quality control and anti-omissive mechanisms were used strictly. In the monitoring was carried out in 28 hospitals and lasted for 4 years. 30 106 patients were registered; ADE occurred in 114 patients, and ADR was identified in 23 patients with an incidence rate of 0.076% for ADR [95% confidence interval (0...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29133875/heart-function-and-thoracic-aorta-gene-expression-profiling-studies-of-ginseng-combined-with-different-herbal-medicines-in-enos-knockout-mice
#18
Yuchen Qian, Pan Li, Bin Lv, Xiaoqing Jiang, Ting Wang, Han Zhang, Xiaoying Wang, Xiumei Gao
Ginseng, a popular herbal remedy, is often used in combination with other drugs to achieve the maximum therapeutic response. Shenfu (SFI) and Shenmai injection (SMI) have been widely used to treat cardiovascular disease in China. Our study explored the cardiovascular protection of SFI and SMI in eNOS knockout mice to investigate the differences and similarities of the two ginseng-combinations. Transthoracic echocardiography was performed to evaluate the left ventricular structure and function at baseline and 3, 7, and 14 days after drug administration...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925115/-simultaneous-determination-of-14-organic-acids-in-shenfu-injection-by-hydrophilic-interaction-chromatography-tandem-mass-spectrometry
#19
Yao Liu, Na Zhang, She-Po Shi, Qing-Qing Song, Jun Li, Yue-Lin Song, Peng-Fei Tu
Organic acids are widely distributed in plants and related products, and participate in a wide range of metabolic pathways (e.g. tricarboxylic acid cycle), showing diverse pharmacological activities. As a widely used Chinese patent medicine, its adverse reactions are often reported. Therefore, we should further clarify the chemical components of Shenfu injection, and prepare strict quality standards to ensure the safety and effectiveness of its clinical use. Shenfu injection is prepared from red ginseng (steamed roots of Panax ginseng) and black prepared lateral roots of Aconitum carmichaelii (Heishunpian) by using modern extraction process, and organic acids are regarded as one of its main components...
September 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28923754/temporal-and-spatial-variations-of-polycyclic-aromatic-hydrocarbons-pahs-in-soils-from-a-typical-organic-sewage-irrigation-area
#20
Bo Wu, Shuhai Guo, Xiaojun Li, Jianing Wang
In the water shortage countries and areas, untreated sewage irrigation led to the extensive organic pollution of farmland soil, which seriously threatened environmental security. In this study, we selected Shenfu irrigation area (SIA) as the study area, and it was the first and largest organic sewage irrigation area in China. We analyzed the temporal and spatial variations in concentrations, risk and sources of polycyclic aromatic hydrocarbons (PAHs) in soil of the SIA. The results show that the PAH concentrations decreased slowly and environmental risk fluctuated after stopping sewage irrigation...
February 1, 2018: Science of the Total Environment
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