Sean M Hughes, Claire N Levy, Fernanda L Calienes, Joanne D Stekler, Urvashi Pandey, Lucia Vojtech, Alicia R Berard, Kenzie Birse, Laura Noël-Romas, Brian Richardson, Jackelyn B Golden, Michael Cartwright, Ann C Collier, Claire E Stevens, Marcel E Curlin, Timothy H Holtz, Nelly Mugo, Elizabeth Irungu, Elly Katabira, Timothy Muwonge, Javier R Lama, Jared M Baeten, Adam Burgener, Jairam R Lingappa, M Juliana McElrath, Romel Mackelprang, Ian McGowan, Ross D Cranston, Mark J Cameron, Florian Hladik
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are used for HIV treatment and prevention. Previously, we found that topical rectal tenofovir gel caused immunological changes in the mucosa. Here, we assess the effect of oral TDF/FTC in three HIV pre-exposure prophylaxis trials, two with gastrointestinal and one with cervicovaginal biopsies. TDF/FTC induces type I/III interferon-related (IFN I/III) genes in the gastrointestinal tract, but not blood, with strong correlations between the two independent rectal biopsy groups (Spearman r = 0...
September 22, 2020: Cell reports medicine