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https://www.readbyqxmd.com/read/30450013/a-novel-cancer-syndrome-caused-by-kcnq1-deficiency-in-the-golden-syrian-hamster
#1
Rong Li, Jinxin Miao, Alexandru-Flaviu Tabaran, M Gerard O'Sullivan, Kyle J Anderson, Patricia M Scott, Zhongde Wang, Robert T Cormier
BACKGROUND: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is KCNQ1 which encodes for the KCNQ1 potassium channel and also has been implicated as a tumor suppressor gene. MATERIALS AND METHODS: We generated KCNQ1 knockout (KO) hamsters by CRISPR/Cas9-mediated gene targeting and investigated the effects of KCNQ1-deficiency on tumorigenesis...
2018: Journal of Carcinogenesis
https://www.readbyqxmd.com/read/30416887/sociality-genes-are-associated-with-human-directed-social-behaviour-in-golden-and-labrador-retriever-dogs
#2
Mia E Persson, Ann-Sofie Sundman, Lise-Lotte Halldén, Agaia J Trottier, Per Jensen
Background: Dogs have human-directed social skills that allow them to communicate and cooperate with humans. We have previously identified two loci on chromosome 26 associated with human contact-seeking behaviors during an unsolvable problem task in laboratory beagles (Persson et al., 2016). The aim of the present study was to verify the single nucleotide polymorphisms (SNPs) in additional dog breeds. We also studied how the allele frequencies have changed during domestication and recent selection...
2018: PeerJ
https://www.readbyqxmd.com/read/30397353/radiotherapy-induces-responses-of-lung-cancer-to-ctla-4-blockade
#3
Silvia C Formenti, Nils-Petter Rudqvist, Encouse Golden, Benjamin Cooper, Erik Wennerberg, Claire Lhuillier, Claire Vanpouille-Box, Kent Friedman, Lucas Ferrari de Andrade, Kai W Wucherpfennig, Adriana Heguy, Naoko Imai, Sacha Gnjatic, Ryan O Emerson, Xi Kathy Zhou, Tuo Zhang, Abraham Chachoua, Sandra Demaria
Focal radiation therapy enhances systemic responses to anti-CTLA-4 antibodies in preclinical studies and in some patients with melanoma1-3 , but its efficacy in inducing systemic responses (abscopal responses) against tumors unresponsive to CTLA-4 blockade remained uncertain. Radiation therapy promotes the activation of anti-tumor T cells, an effect dependent on type I interferon induction in the irradiated tumor4-6 . The latter is essential for achieving abscopal responses in murine cancers6 . The mechanisms underlying abscopal responses in patients treated with radiation therapy and CTLA-4 blockade remain unclear...
November 5, 2018: Nature Medicine
https://www.readbyqxmd.com/read/30390005/flow-cytometric-analysis-of-xenopus-laevis-and-x-tropicalis-blood-cells-using-acridine-orange
#4
Kei Sato, Azusa Uehara, Sayaka Kinoshita, Ikki Nomura, Minami Yagi, Yuta Tanizaki, Yu Matsuda-Shoji, Atsushi Matsubayashi, Nobuyasu Endo, Yutaka Nagai, Takashi Kato
Automated blood cell counters can distinguish cells based on their size and the presence or absence of a nucleus. However, most vertebrates have nucleated blood cells that cannot be counted automatically. We established an alternative automatic method for counting peripheral blood cells by staining cells with the fluorescent dye acridine orange (AO) and analysing cell populations using flow cytometry (FCM). As promising new animal models, we chose Xenopus laevis and three inbred strains of X. tropicalis. We compared the haematological phenotypes, including blood cell types, cell sizes, cellular structure, and erythrocyte lifespans/turnover rate among X...
November 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30293391/-the-value-of-ultrasound-classification-in-bi-rads-category-4-of-breast-complex-cystic-masses
#5
J P Yao, L J Niu, Y Wang, C Y Geng, Q Chang, Y Chen, L Zhu
Objective: To analyze the feature of breast complex cystic masses and to classify it at ultrasonography (US), which applied to the Breast Imaging Reporting and Data System (BI-RADS) categories 4a to 4c with pathological results as the golden standards. Methods: The ultrasonographic data and clinical features of 78 patients with complex cystic masses confirmed by pathology in Cancer Hospital from July 2014 to June 2017 were retrospectively reviewed. The complex cystic breast masses were divided into four classes on the basis of their US features: type 1 [thick wall and (or) thick septa (> 0...
September 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29933869/a-case-risk-study-of-lactic-acidosis-risk-by-metformin-use-in-type-2-diabetes-mellitus-tuberculosis-coinfection-patients
#6
Bernadette Dian Novita, Agung Pranoto, Wuryani, Endang Isbandiati Soediono, Ni Made Mertaniasih
Metformin (MET) has possibilities to be utilized as an adjunct of tuberculosis (TB) therapy for controlling the growth of Mycobacterium tuberculosis (M. tuberculosis). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion; those mechanism are important in M. tuberculosis elimination. Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown. This result contributes much to our understanding about the clinical effect of MET use in type 2 DM-TB coinfection...
July 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29925312/a-pilot-and-comparative-study-between-pathological-and-serological-levels-of-immunoglobulin-and-complement-among-three-kinds-of-primary-glomerulonephritis
#7
Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan, Yong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. However, the relationship between IF intensities of immune proteins and the corresponding serum levels remained unclear, and seldom studies combine histopathological examination results and blood tests together for a predictive purpose...
June 20, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29910744/yangxue-qingnao-wan-and-silibinin-capsules-the-two-chinese-medicines-attenuate-cognitive-impairment-in-aged-ldlr-golden-syrian-hamsters-involving-protection-of-blood-brain-barrier
#8
You-Yu Gu, Ping Huang, Quan Li, Yu-Ying Liu, George Liu, Yu-Hui Wang, Ming Yi, Li Yan, Xiao-Hong Wei, Lei Yang, Bai-He Hu, Xin-Rong Zhao, Xin Chang, Kai Sun, Chun-Shui Pan, Yuan-Chen Cui, Qing-Fang Chen, Chuan-She Wang, Jing-Yu Fan, Zhi-Zhong Ma, Jing-Yan Han
The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29780721/type-b-aortic-dissection-new-perspectives
#9
REVIEW
Marc A A M Schepens
Background: Stanford type B aortic dissection is one of the aortic catastrophes with a high mortality and morbidity that needs immediate or delayed treatment, either surgically or endovascularly. This comprehensive review article addresses the current status of open, endovascular and hybrid treatment options for type B aortic dissections with the focus on new therapeutic perspectives. Methods: Evaluation of currently available evidence based on randomized and registry data and personal experience...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29723549/genomic-structure-and-molecular-characterization-of-toll-like-receptors-1-and-2-from-golden-pompano-trachinotus-ovatus-linnaeus-1758-and-their-expression-response-to-three-types-of-pathogen-associated-molecular-patterns
#10
Meng Wu, Liang Guo, Ke-Cheng Zhu, Hua-Yang Guo, Bo Liu, Shi-Gui Jiang, Dian-Chang Zhang
Toll-like receptors (TLRs) play an essential role in the immune response. Here two Toll-like receptors from golden pompano (Trachinotus ovatus), ToTLR1 and ToTLR2, were characterized, the full-length cDNAs were 3126 bp and 7430 bp, and the deduced proteins consisted of 801 and 825 amino acids, respectively. ToTLR1 and ToTLR2 both contained the typical TLR domain architecture including signal peptide, leucine rich repeat (LRR), C-terminal LRR domain at the extracellular region and Toll/interleukin (IL)-1 receptor (TIR) domain in the cytoplasmic region...
September 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29527311/development-and-validation-of-a-prediction-model-for-insulin-associated-hypoglycemia-in-non-critically-ill-hospitalized-adults
#11
Nestoras Nicolas Mathioudakis, Estelle Everett, Shuvodra Routh, Peter J Pronovost, Hsin-Chieh Yeh, Sherita Hill Golden, Suchi Saria
Objective: To develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. Research design and methods: We collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <54 mg/dL, respectively) occurring within 24 hours of the index day...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29187176/frequency-of-dea-1-antigen-in-1037-mongrel-and-purebreed-dogs-in-italy
#12
E Carli, A Carminato, S Ravagnan, K Capello, M T Antognoni, A Miglio, T Furlanello, D Proverbio, E Spada, A Stefani, F Mutinelli, M Vascellari
BACKGROUND: The prevalence of dog erythrocyte antigen (DEA 1) in canine population is approximately 40-60%. Often data are limited to a small number of breeds and/or dogs. The aims of this study were to evaluate frequency of DEA 1 in a large population of purebred and mongrel dogs including Italian native breeds and to recognize a possible association between DEA 1 and breed, sex, and genetic and phenotypical/functional classifications of breeds. Frequencies of DEA 1 blood group collected from screened/enrolled blood donors and from healthy and sick dogs were retrospectively evaluated...
November 29, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29083383/evaluation-of-multiple-diagnostic-indicators-in-comparison-to-the-intestinal-biopsy-as-the-golden-standard-in-diagnosing-celiac-disease-in-children
#13
Elisabet Hollén, Malin Farnebäck, Tony Forslund, Karl-Eric Magnusson, Tommy Sundqvist, Karin Fälth-Magnusson
Celiac disease (CD) is a chronic small intestinal enteropathy triggered by gluten in genetically predisposed individuals. The susceptibility is strongly associated with certain human leukocyte antigen (HLA)-genes, but efforts are being made in trying to find non-HLA genes that are predictive for the disease. The criteria for diagnosing CD were previously based primarily on histologic evaluation of small intestinal biopsies, but nowadays are often based only on blood tests and symptoms. In this context, we elucidated the accuracy of three diagnostic indicators for CD, alone or in combination...
November 25, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/28880895/lag-3-potentiates-the-survival-of-mycobacterium-tuberculosis-in-host-phagocytes-by-modulating-mitochondrial-signaling-in-an-in-vitro-granuloma-model
#14
Bonnie L Phillips, Uma S Gautam, Allison N Bucsan, Taylor W Foreman, Nadia A Golden, Tianhua Niu, Deepak Kaushal, Smriti Mehra
CD4+ T-cell mediated Th1 immune responses are critical for immunity to TB. The immunomodulatory protein, lymphocyte activation gene-3 (LAG-3) decreases Th1-type immune responses in T-cells. LAG-3 expression is significantly induced in the lungs of macaques with active TB and correlates with increased bacterial burden. Overproduction of LAG-3 can greatly diminish responses and could lead to uncontrolled Mtb replication. To assess the effect of LAG-3 on the progression of Mtb infection, we developed a co-culture system wherein blood-derived macrophages are infected with Mtb and supplemented with macaque blood or lung derived CD4+ T-cells...
2017: PloS One
https://www.readbyqxmd.com/read/28674887/simultaneous-enrichment-of-plasma-extracellular-vesicles-and-glycoproteome-for-studying-disease-biomarkers
#15
Sunil S Adav, Siu Kwan Sze
To detect disease at an early stage and to develop effective disease treatment therapies, reliable biomarkers of diagnosis, disease progression, and its status remain a research priority. A majority of disease pathologies are primarily associated with different subsets of cells of different tissues, discrete compartments, and areas. These subsets of cells release glycoproteins and specific extracellular vesicles (EVs) including microvesicles and exosomes that carry bioactive cargoes of proteins, nucleic acids, and metabolites...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28583470/insights-into-the-current-management-of-older-adults-with-type-2-diabetes-in-the-ontario-primary-care-setting
#16
Graydon S Meneilly, Lori D Berard, Alice Y Y Cheng, Peter J Lin, Lori MacCallum, Ross T Tsuyuki, Jean-François Yale, Nahal Nasseri, Jean-François Richard, Lianne Goldin, Anatoly Langer, Mary K Tan, Lawrence A Leiter
OBJECTIVE: The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS: Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and were taking 1 antihyperglycemic agent or more; they were managed by 64 physicians from 36 Ontario clinics. RESULTS: More than half (53%) had glycated hemoglobin (A1C) levels of 7...
February 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28443226/a-novel-pcr-assay-for-detecting-brucella-abortus-and-brucella-melitensis
#17
Saeed Alamian, Majid Esmaelizad, Taghi Zahraei, Afshar Etemadi, Mohsen Mohammadi, Davoud Afshar, Soheila Ghaderi
OBJECTIVES: Brucellosis is a major zoonotic disease that poses a significant public health threat worldwide. The classical bacteriological detection process used to identify Brucella spp. is difficult and time-consuming. This study aimed to develop a novel molecular assay for detecting brucellosis. METHODS: All complete sequences of chromosome 1 with 2.1-Mbp lengths were compared among all available Brucella sequences. A unique repeat sequence (URS) locus on chromosome 1 could differentiate Brucella abortus from Brucella melitensis...
February 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28333831/deployed-skills-training-for-whole-blood-collection-by-a-special-operations-expeditionary-surgical-team
#18
Linda C Benavides, Iain M Smith, Jerome M Benavides, Douglas M Bowley, Heidi A Doughty, Jonathan B Lundy
BACKGROUND: Noncompressible hemorrhage is the leading cause of potentially preventable battlefield death. Combining casualty retrieval from the battlefield and damage control resuscitation (DCR) within the "golden hour" increases survival. However, transfusion requirements may exceed the current blood component stocks held by forward surgical teams. Warm fresh whole blood (WFWB) is an alternative. We report WFWB transfusion training developed by and delivered to a US Golden Hour Offset Surgical Treatment Team and the resulting improvement in confidence with WFWB transfusion...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28002030/anti-hyperglycemic-activity-of-aegle-marmelos-l-corr-is-partly-mediated-by-increased-insulin-secretion-%C3%AE-amylase-inhibition-and-retardation-of-glucose-absorption
#19
Prawej Ansari, Nadia Afroz, Shahnaz Jalil, Sohel Bin Azad, Md Gazi Mustakim, Sabbir Anwar, S M Nazmul Haque, Saad Mosharraf Hossain, Ramisha Rifat Tony, J M A Hannan
BACKGROUND: Aegle marmelos (commonly known as Bael, golden apple) was formerly described to have anti-hyperglycemic activity. The present study aimed to explore the possible effects, in depth, of A. marmelos extracts on carbohydrate absorption, glucose utilization, and α-amylase inhibition and insulin content in pancreases of type 2 diabetic rats. METHODS: This research begins with fasting blood glucose and oral glucose tolerance test (OGTT) to evaluate the primary anti-hyperglycemic effect in chemically induced type 2 diabetic rats...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27977896/healing-acceleration-of-oral-mucositis-induced-by-5-fluorouracil-with-pistacia-atlantica-bene-essential-oil-in-hamsters
#20
Nader Tanideh, Mehdy Davarmanesh, Azadeh Andisheh-Tadbir, Zahra Ranjbar, Peiman Mehriar, Omid Koohi-Hosseinabadi
BACKGROUND: Oral mucositis is a common debilitating condition in patients with cancer receiving cytotoxic therapies. This study aimed to evaluate the effects of topical administrations of the essential oil extracted from hull of Pistacia atlantica fruit (bene) on healing of oral mucositis in golden hamsters. METHODS: Forty hamsters with oral mucositis induced by 5-fluorouracil administered on days 0, 5 and 10 and buccal mucosal scratching were randomly divided into four equal groups: group 1 received no additional treatment, group 2 received gel base, and groups 3 and 4 received gels containing 5% and 10% oil, respectively...
October 2017: Journal of Oral Pathology & Medicine
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