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Large granular lymphocyte

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https://www.readbyqxmd.com/read/30078779/large-granular-lymphocytic-leukemia-cd3-cd56-a-challenge-for-the-biologist-and-the-physician
#1
Roberto Cupaiolo, Soraya Cherifi, Christophe Lelubre, Danielle Govaerts, Quentin Delefortrie, Francis Corazza, Charles Chevalier
Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules...
August 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/30067616/recent-insights-into-large-granular-lymphocytic-leukemia
#2
Loretta J Nastoupil
No abstract text is available yet for this article.
July 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/30057739/management-of-t-cell-large-granular-lymphocyte-leukemia-and-concurrent-retroperitoneal-liposarcoma
#3
Nolan R Bruce, Zachary W Tilley, Jacob T Carlson, Juan Camilo Barreto Andrade
T-cell large granular leukemia (T-LGL) is a rare lymphoproliferative disorder characterized by the clonal expansion of cytotoxic T lymphocytes. We present a unique case of T-LGL and concurrent retroperitoneal sarcoma occurring in a patient with long-standing rheumatoid arthritis. Pathology revealed a high-grade dedifferentiated liposarcoma. The diagnosis of T-LGL with a synchronous retroperitoneal sarcoma is a case that highlights the surgical management of these two rare conditions.
July 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30037803/the-use-of-immunosuppressive-therapy-in-mds-clinical-outcomes-and-their-predictors-in-a-large-international-patient-cohort
#4
Maximilian Stahl, Michelle DeVeaux, Theo de Witte, Judith Neukirchen, Mikkael A Sekeres, Andrew M Brunner, Gail J Roboz, David P Steensma, Vijaya R Bhatt, Uwe Platzbecker, Thomas Cluzeau, Pedro H Prata, Raphaël Itzykson, Pierre Fenaux, Amir T Fathi, Alexandra Smith, Ulrich Germing, Ellen K Ritchie, Vivek Verma, Aziz Nazha, Jaroslaw P Maciejewski, Nikolai A Podoltsev, Thomas Prebet, Valeria Santini, Steven D Gore, Rami S Komrokji, Amer M Zeidan
Most studies of immunosuppressive therapy (IST) in myelodysplastic syndromes (MDS) are limited by small numbers and their single-center nature, and report conflicting data regarding predictors for response to IST. We examined outcomes associated with IST and predictors of benefit in a large international cohort of patients with MDS. Data were collected from 15 centers in the United States and Europe. Responses, including red blood cell (RBC) transfusion independence (TI), were assessed based on the 2006 MDS International Working Group criteria, and overall survival (OS) was estimated by Kaplan-Meier methods...
July 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/30002792/clonal-t-cell-large-granular-lymphocytic-disorders-manifesting-in-patients-with-hiv-1-infection-case-series-and-review-of-the-literature
#5
Ashley Rose, Leidy Isenalumhe, Magali Van den Bergh, Lubomir Sokol
We report five patients with human immunodeficiency virus-1/acquired immunodeficiency syndrome (HIV-1/AIDS) who developed T-cell large granular lymphocytic proliferation (T-LGLP) or leukemia (T-LGLL). None of the patients fulfilled criteria for diagnosis of diffuse infiltrative lymphocyte syndrome (DILS) or HIV-associated CD8+ lymphocytosis syndrome at the time of diagnosis of LGL. The immunophenotype of malignant T-cells was identical in three patients with co-expression of CD3, CD8, CD57, and T-cell receptor (TCR) alpha/beta...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29963929/complete-remission-of-agranulocytosis-after-splenectomy-in-a-variant-form-of-t-cell-large-granular-lymphocyte-leukemia
#6
Claire Lozano, Sophie Brun, Anne Arnaud, Philippe Gaulard, Samia Gonzalez, Julien Crouzet, Jean-Christophe Gris
No abstract text is available yet for this article.
July 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29949739/mixed-phenotype-large-granular-lymphocytic-leukemia-lgll-a-rare-subtype-in-the-lgll-spectrum
#7
Jadee L Neff, Aruna Rangan, Dragan Jevremovic, Phuong L Nguyen, April Chiu, Ronald S Go, Dong Chen, William G Morice, Min Shi
Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which over 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL (T-LGLL) and chronic lymphoproliferative disorder of NK-cells (CLPD-NK). The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed by NK-cell, γδ T-cell, and CD4-positive/αβ T-cell types. We investigated a total of 220 LGLL cases and identified 12 mixed-phenotype LGLLs (5%): 7 cases with coexistent αβ T-cell and NK-cell clones and 5 with coexistent αβ and γδ T-cell clones...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29938921/prevalence-and-characteristics-of-persistent-clonal-t-lgl-expansions-in-rheumatoid-arthritis-a-comprehensive-analysis-of-529-patients
#8
Eva C Schwaneck, Regina Renner, Lara Junker, Hermann Einsele, Ottar Gadeholt, Eva Geissinger, Stefan Kleinert, Michael Gernert, Hans-Peter Tony, Marc Schmalzing
OBJECTIVE: Up to one third of patients with T-cell large granular lymphocyte leukemia (T-LGL-leukemia) display symptoms of rheumatoid arthritis (RA). In Crohn's disease and in psoriasis treatment with TNFα-inhibitors is associated with hepatosplenic γδT-cell-lymphoma and with clonal expansion of γδT-cells, respectively. Here, we determine the prevalence of clonal T-LGL cells in patients with RA and define risk factors for this rare hematologic malignancy. METHODS: 529 RA-patients were recruited between November, 2013 and August, 2015...
June 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29937462/lymphoma-associated-hemophagocytic-syndrome-in-six-dogs
#9
Akihisa Suwa, Tetsuya Shimoda
Hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by histiocytic proliferation, with marked hemophagocytosis in the reticuloendothelial organs. HPS caused by lymphoma is termed lymphoma-associated hemophagocytic syndrome (LAHS), and there are few reports on canine and feline LAHS. The objective of this study was to examine the clinical, diagnostic, and clinicopathologic features of LAHS in six dogs. The diagnostic criteria of LAHS consisted of lymphoma, bicytopenia or pancytopenia in the blood, and increased hemophagocytosis in the reticuloendothelial organs...
June 25, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29921385/pure-red-cell-aplasia-with-t-cell-large-granular-lymphocytic-leukemia
#10
G Shi, C M Hu, Q Yu, N Yang, Z S Xue, B Zhao, M Guo, Y Zheng
Pure red cell aplasia (PRCA) develops as a result of erythroid precursors failing to reach maturity in the bone marrow, which eventually leads to anemia. Here we present a case of a 64-year-old Asian male with a medical history of colorectal adenocarcinoma who had been treated with 6 cycles of oxaliplatin and capecitabine four years ago. The patient was diagnosed with PRCA and T-cell large granular lymphocyte leukemia.
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29907868/t-cell-directed-il-17-production-by-lung-granular-%C3%AE-%C3%AE-t-cells-is-coordinated-by-a-novel-il-2-and-il-1%C3%AE-circuit
#11
Antoine Ménoret, James A Buturla, Maria M Xu, Julia Svedova, Sanjeev Kumar, Vijay A K Rathinam, Anthony T Vella
Immune-mediated lung is considered the result of an exacerbated innate injury immune response, although a role for adaptive lymphocytes is emerging. αβ T cells specific for S. aureus enterotoxin A orchestrate a Tγδ17 response during lung injury. However, the mechanism driving IL-17 production is unclear. Here, we show a role for IL-2 triggering IL-17 production by lung granular γδ T cells as IL-17 synthesis and neutrophil recruitment was reduced by IL-2 blocking mAbs in vitro and in vivo. Mass cytometry analysis revealed that lung γδ T cells responded directly to IL-2 as evident from STAT5 phosphorylation and RoRγt expression...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29904591/predicting-ionizing-radiation-exposure-using-biochemically-inspired-genomic-machine-learning
#12
Jonathan Z L Zhao, Eliseos J Mucaki, Peter K Rogan
Background: Gene signatures derived from transcriptomic data using machine learning methods have shown promise for biodosimetry testing. These signatures may not be sufficiently robust for large scale testing, as their performance has not been adequately validated on external, independent datasets. The present study develops human and murine signatures with biochemically-inspired machine learning that are strictly validated using k-fold and traditional approaches. Methods: Gene Expression Omnibus (GEO) datasets of exposed human and murine lymphocytes were preprocessed via nearest neighbor imputation and expression of genes implicated in the literature to be responsive to radiation exposure (n=998) were then ranked by Minimum Redundancy Maximum Relevance (mRMR)...
2018: F1000Research
https://www.readbyqxmd.com/read/29805960/clinical-response-to-a-lomustine-cytarabine-based-chemotherapy-protocol-in-a-case-of-canine-large-granular-lymphocyte-t-cell-lymphoma-with-spinal-involvement
#13
Elisabetta Treggiari, Lorna Provan Arrol
A 7-year-old, female neutered cross-breed dog was referred to our institution with a history of progressive hind limb weakness, which then progressed to paraplegia. An MRI of the spine revealed severe meningeal infiltrate consistent with lymphoma involvement, located at the level of L2-L7 with concurrent lymph node enlargement and abnormal bone marrow. Abdominal ultrasonography also identified changes in the spleen and confirmed enlargement of the lumbar aortic lymph node. Cytology of lymph nodes and spleen confirmed a high-grade lymphoma with features of a large granular lymphocyte (LGL) variant; PCR for antigen receptor re-arrangements (PARR) was positive for a clonal T-cell receptor rearrangement...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29755462/comparison-of-phenotypic-and-functional-characteristics-between-canine-non-b-non-t-natural-killer-lymphocytes-and-cd3-cd5-dim-cd21-cytotoxic-large-granular-lymphocytes
#14
Soo-Hyeon Lee, Dong-Jun Shin, Yoseop Kim, Cheol-Jung Kim, Je-Jung Lee, Mee Sun Yoon, Tung Nguyen Thanh Uong, Dohyeon Yu, Ji-Youn Jung, Duck Cho, Bock-Gie Jung, Sang-Ki Kim, Guk-Hyun Suh
Natural killer (NK) cells play a pivotal role in the immune response against infections and malignant transformation, and adopted transfer of NK cells is thought to be a promising therapeutic approach for cancer patients. Previous reports describing the phenotypic features of canine NK cells have produced inconsistent results. Canine NK cells are still defined as non-B and non-T (CD3- CD21- ) large granular lymphocytes. However, a few reports have demonstrated that canine NK cells share the phenotypic characteristics of T lymphocytes, and that CD3+ CD5dim CD21- lymphocytes are putative canine NK cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29744070/large-granular-lymphocytic-leukemia-complicating-autoimmune-polyglandular-syndrome-type-1-in-siblings
#15
Jonathan S Harrison, Harsh Parmar, Xiangbing D Wang
Autoimmune polyglandular syndrome type 1 (APS1) is a rare autosomal recessive disorder, and large granular lymphocytic leukemia (LGLL) may, even more rarely, complicate APS1. LGLL may be subtle in presentation, but it is imperative to recognize LGLL in APS1 promptly, as outcome may otherwise be fatal, as described herein.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29733502/natural-killer-cell-immunotherapy-against-multiple-myeloma-progress-and-possibilities
#16
REVIEW
Pan Liu, Yanxia Jin, Haseeb Sattar, Hailing Liu, Weiling Xie, Fuling Zhou
Multiple myeloma (MM) is a complex aggressive mature B-cell malignancy. Although with the wide application of chemotherapy drugs, it remains incurable and the vast majority of patients relapse. Natural killer (NK) cells, also known as CD56+ CD3- large granular lymphocytes, are cytotoxic innate immune cells against MM without prior sensitization steps. NK cell-based immunotherapy is extensively promising in a wide range of clinical settings. It is worthy of note that some novel drugs such as monoclonal antibodies (mAbs), proteasome inhibitors (PIs), and immunomodulators (IMiDs) directly or indirectly activate NK cells to enhance their antitumor activity, and the combined regimens significantly improve the prognosis of MM patients...
May 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29721441/indolent-t-cell-large-granular-lymphocytic-leukaemia-in-a-dog-presenting-with-severe-neutropenia-and-an-absence-of-lymphocytosis
#17
James Elliott, Elizabeth Villiers
In humans, large granular lymphocytic leukaemia (LGLL) is a low-grade, indolent lymphoproliferative disorder of large granular lymphocytes (LGL) associated with autoimmune disorders; including rheumatoid arthritis and single or multiple cytopenias; particularly neutropenia. Therapy largely centres around immunosuppression which aims to resolve the immune-mediated secondary pathology, often without eradicating the neoplastic clone. The most effective agents appear to be cyclophosphamide, cyclosporine and methotrexate...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29699990/trail-mediates-and-sustains-constitutive-nf-%C3%AE%C2%BAb-activation-in-lgl-leukemia
#18
Jun Yang, Francis R LeBlanc, Shubha A Dighe, Cait E Hamele, Thomas L Olson, David J Feith, Thomas P Loughran
Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysregulation of apoptosis and resistance to activation-induced cell death. We reported previously that nuclear factor κB (NF-κB) is a central regulator of the survival network for leukemic LGL. However, the mechanisms that trigger constitutive activation of NF-κB in LGL leukemia remain undefined...
June 21, 2018: Blood
https://www.readbyqxmd.com/read/29607828/t-cell-large-granular-lymphocytic-leukemia-with-pulmonary-hypertension
#19
Sidra Khalid, Hamed Daw, Miriam Jacob, Megan Nakashima
T cell large granular lymphocytic leukemia is a hematological disorder which is characterized by the proliferation of CD 3+ cytotoxic T cells. We present a case about a patient who was diagnosed with T cell large granular lymphocytic leukemia and then developed pulmonary hypertension. He was treated for his leukemia with methotrexate and simultaneously treated for his pulmonary hypertension with selexipag and ambrisentan. As his leukemia improved, we also noticed an improvement in his pulmonary hypertension from a NYHA class IV to class I...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29570200/microfluidic-determination-of-lymphocyte-vascular-deformability-effects-of-intracellular-complexity-and-early-immune-activation
#20
Ning Kang, Quan Guo, Emel Islamzada, Hongshen Ma, Mark D Scott
Despite the critical importance of mechanical (rheological + extrudability) deformability in the vascular flow of lymphocytes, it has been poorly investigated due to the limitations of existing technological tools. Microfluidics analysis of leukocyte deformability offers significant advantages in that it offers high throughput, large sample population and the ability to analyze a heterogeneous population. These advantages are in stark contrast to previous approaches that focused on single cell measurements...
April 23, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
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