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large granular leukemia

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https://www.readbyqxmd.com/read/30078779/large-granular-lymphocytic-leukemia-cd3-cd56-a-challenge-for-the-biologist-and-the-physician
#1
Roberto Cupaiolo, Soraya Cherifi, Christophe Lelubre, Danielle Govaerts, Quentin Delefortrie, Francis Corazza, Charles Chevalier
Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules...
August 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/30067616/recent-insights-into-large-granular-lymphocytic-leukemia
#2
Loretta J Nastoupil
No abstract text is available yet for this article.
July 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/30057739/management-of-t-cell-large-granular-lymphocyte-leukemia-and-concurrent-retroperitoneal-liposarcoma
#3
Nolan R Bruce, Zachary W Tilley, Jacob T Carlson, Juan Camilo Barreto Andrade
T-cell large granular leukemia (T-LGL) is a rare lymphoproliferative disorder characterized by the clonal expansion of cytotoxic T lymphocytes. We present a unique case of T-LGL and concurrent retroperitoneal sarcoma occurring in a patient with long-standing rheumatoid arthritis. Pathology revealed a high-grade dedifferentiated liposarcoma. The diagnosis of T-LGL with a synchronous retroperitoneal sarcoma is a case that highlights the surgical management of these two rare conditions.
July 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30002792/clonal-t-cell-large-granular-lymphocytic-disorders-manifesting-in-patients-with-hiv-1-infection-case-series-and-review-of-the-literature
#4
Ashley Rose, Leidy Isenalumhe, Magali Van den Bergh, Lubomir Sokol
We report five patients with human immunodeficiency virus-1/acquired immunodeficiency syndrome (HIV-1/AIDS) who developed T-cell large granular lymphocytic proliferation (T-LGLP) or leukemia (T-LGLL). None of the patients fulfilled criteria for diagnosis of diffuse infiltrative lymphocyte syndrome (DILS) or HIV-associated CD8+ lymphocytosis syndrome at the time of diagnosis of LGL. The immunophenotype of malignant T-cells was identical in three patients with co-expression of CD3, CD8, CD57, and T-cell receptor (TCR) alpha/beta...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29963929/complete-remission-of-agranulocytosis-after-splenectomy-in-a-variant-form-of-t-cell-large-granular-lymphocyte-leukemia
#5
Claire Lozano, Sophie Brun, Anne Arnaud, Philippe Gaulard, Samia Gonzalez, Julien Crouzet, Jean-Christophe Gris
No abstract text is available yet for this article.
July 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29949739/mixed-phenotype-large-granular-lymphocytic-leukemia-lgll-a-rare-subtype-in-the-lgll-spectrum
#6
Jadee L Neff, Aruna Rangan, Dragan Jevremovic, Phuong L Nguyen, April Chiu, Ronald S Go, Dong Chen, William G Morice, Min Shi
Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which over 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL (T-LGLL) and chronic lymphoproliferative disorder of NK-cells (CLPD-NK). The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed by NK-cell, γδ T-cell, and CD4-positive/αβ T-cell types. We investigated a total of 220 LGLL cases and identified 12 mixed-phenotype LGLLs (5%): 7 cases with coexistent αβ T-cell and NK-cell clones and 5 with coexistent αβ and γδ T-cell clones...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29938921/prevalence-and-characteristics-of-persistent-clonal-t-lgl-expansions-in-rheumatoid-arthritis-a-comprehensive-analysis-of-529-patients
#7
Eva C Schwaneck, Regina Renner, Lara Junker, Hermann Einsele, Ottar Gadeholt, Eva Geissinger, Stefan Kleinert, Michael Gernert, Hans-Peter Tony, Marc Schmalzing
OBJECTIVE: Up to one third of patients with T-cell large granular lymphocyte leukemia (T-LGL-leukemia) display symptoms of rheumatoid arthritis (RA). In Crohn's disease and in psoriasis treatment with TNFα-inhibitors is associated with hepatosplenic γδT-cell-lymphoma and with clonal expansion of γδT-cells, respectively. Here, we determine the prevalence of clonal T-LGL cells in patients with RA and define risk factors for this rare hematologic malignancy. METHODS: 529 RA-patients were recruited between November, 2013 and August, 2015...
June 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29921385/pure-red-cell-aplasia-with-t-cell-large-granular-lymphocytic-leukemia
#8
G Shi, C M Hu, Q Yu, N Yang, Z S Xue, B Zhao, M Guo, Y Zheng
Pure red cell aplasia (PRCA) develops as a result of erythroid precursors failing to reach maturity in the bone marrow, which eventually leads to anemia. Here we present a case of a 64-year-old Asian male with a medical history of colorectal adenocarcinoma who had been treated with 6 cycles of oxaliplatin and capecitabine four years ago. The patient was diagnosed with PRCA and T-cell large granular lymphocyte leukemia.
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29744070/large-granular-lymphocytic-leukemia-complicating-autoimmune-polyglandular-syndrome-type-1-in-siblings
#9
Jonathan S Harrison, Harsh Parmar, Xiangbing D Wang
Autoimmune polyglandular syndrome type 1 (APS1) is a rare autosomal recessive disorder, and large granular lymphocytic leukemia (LGLL) may, even more rarely, complicate APS1. LGLL may be subtle in presentation, but it is imperative to recognize LGLL in APS1 promptly, as outcome may otherwise be fatal, as described herein.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29699990/trail-mediates-and-sustains-constitutive-nf-%C3%AE%C2%BAb-activation-in-lgl-leukemia
#10
Jun Yang, Francis R LeBlanc, Shubha A Dighe, Cait E Hamele, Thomas L Olson, David J Feith, Thomas P Loughran
Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysregulation of apoptosis and resistance to activation-induced cell death. We reported previously that nuclear factor κB (NF-κB) is a central regulator of the survival network for leukemic LGL. However, the mechanisms that trigger constitutive activation of NF-κB in LGL leukemia remain undefined...
June 21, 2018: Blood
https://www.readbyqxmd.com/read/29682368/transformation-of-t-cell-acute-lymphoblastic-lymphoma-to-peripheral-t-cell-lymphoma-a-report-of-two-cases
#11
Michael Markow, Abu-Sayeef Mirza, Lia Perez, Haipeng Shao, Pedro Horna, Claudio Anasetti, Lubomir Sokol, Mohammad O Hussaini
Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNC γδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNC γδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29607828/t-cell-large-granular-lymphocytic-leukemia-with-pulmonary-hypertension
#12
Sidra Khalid, Hamed Daw, Miriam Jacob, Megan Nakashima
T cell large granular lymphocytic leukemia is a hematological disorder which is characterized by the proliferation of CD 3+ cytotoxic T cells. We present a case about a patient who was diagnosed with T cell large granular lymphocytic leukemia and then developed pulmonary hypertension. He was treated for his leukemia with methotrexate and simultaneously treated for his pulmonary hypertension with selexipag and ambrisentan. As his leukemia improved, we also noticed an improvement in his pulmonary hypertension from a NYHA class IV to class I...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29559980/next-generation-sequencing-analysis-of-the-human-tcr%C3%AE-%C3%AE-t-cell-repertoire-reveals-shifts-in-v%C3%AE-and-v%C3%AE-usage-in-memory-populations-upon-aging
#13
Martine J Kallemeijn, François G Kavelaars, Michèle Y van der Klift, Ingrid L M Wolvers-Tettero, Peter J M Valk, Jacques J M van Dongen, Anton W Langerak
Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to autoimmunity and cancer development at older age. Even though TCRαβ+ and TCRγδ+ T-cells follow similar paths of development involving V(D)J-recombination of TCR genes in the thymus, TCRγδ+ T-cells tend to be more subjected to peripheral rather than central selection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29474442/dysregulation-of-the-ifn-%C3%AE-stat1-signaling-pathway-in-a-cell-line-model-of-large-granular-lymphocyte-leukemia
#14
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflammatory environment...
2018: PloS One
https://www.readbyqxmd.com/read/29473430/lymphomatoid-granulomatosis-and-large-granular-lymphocyte-leukemia-a-rare-association-of-two-lymphoproliferative-disorders
#15
Giulia De Luca, Stefania Trasarti, Luisa Bizzoni, Ilaria Del Giudice, Irene Della Starza, Maria Stefania De Propris, Giuseppe Gentile, Francesca Mancini, Sara Mantovani, Luigi Petrucci, Valentina Tabanelli, Anna Guarini, Marco Vignetti, Robin Foà
No abstract text is available yet for this article.
February 23, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29435021/long-lasting-memory-of-cellular-immunity-in-a-chronic-myeloid-leukemia-patient-maintains-molecular-response-5-after-cessation-of-dasatinib
#16
Tatsuro Jo, Kazuhiro Noguchi, Shizuka Hayashi, Sadaharu Irie, Risa Hayase, Haruna Shioya, Youhei Kaneko, Kensuke Horio, Jun Taguchi
Tyrosine kinase inhibitors (TKIs), including imatinib, dasatinib and nilotinib are primarily used in the initial treatment of chronic phase (CP)-chronic myeloid leukemia (CML), as CMLs harbor the BCR-ABL fusion product. An increased number of lymphocytes and large granular lymphocytes (LGLs) have been observed in patients treated with dasatinib, but not other TKIs. The LGLs have been reported to be primarily natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). In the present study, a CP-CML patient who has maintained molecular response 5 for >2...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29417693/mutations-in-the-signal-transducer-and-activator-of-transcription-family-of-genes-in-cancer
#17
REVIEW
Nahid Shahmarvand, Alexandra Nagy, Jahanbanoo Shahryari, Robert S Ohgami
In recent years, it has become clear that members of the signal transducer and activator of transcription (STAT) family of genes play an important role in cancer. The STAT family consists of seven genes, STAT1-4, STAT5A, STAT5B and STAT6, that are involved in regulating cellular proliferation, apoptosis, angiogenesis and the immune system response. Constitutive activation of STAT3, via mutational changes, is important in oncogenesis in both solid and hematopoietic cancers. In the case of hematopoietic neoplasms, STAT3 driver mutations have been described in T-cell large granular lymphocytic (T-LGL) leukemia and chronic natural killer lymphoproliferative disorders (CLPD-NK) and are seen in 30%-40% of T-LGL leukemia patients...
April 2018: Cancer Science
https://www.readbyqxmd.com/read/29416058/divergent-roles-for-antigenic-drive-in-the-aetiology-of-primary-versus-dasatinib-associated-cd8-tcr-v%C3%AE-expansions
#18
Anna Lissina, James E McLaren, Mette Ilander, Emma I Andersson, Catherine S Lewis, Mathew Clement, Andrew Herman, Kristin Ladell, Sian Llewellyn-Lacey, Kelly L Miners, Emma Gostick, J Joseph Melenhorst, A John Barrett, David A Price, Satu Mustjoki, Linda Wooldridge
CD8+ T-cell expansions are the primary manifestation of T-cell large granular lymphocytic leukemia (T-LGLL), which is frequently accompanied by neutropenia and rheumatoid arthritis, and also occur as a secondary phenomenon in leukemia patients treated with dasatinib, notably in association with various drug-induced side-effects. However, the mechanisms that underlie the genesis and maintenance of expanded CD8+ T-cell receptor (TCR)-Vβ+ populations in these patient groups have yet to be fully defined. In this study, we performed a comprehensive phenotypic and clonotypic assessment of expanded (TCR-Vβ+ ) and residual (TCR-Vβ- ) CD8+ T-cell populations in T-LGLL and dasatinib-treated chronic myelogenous leukemia (CML) patients...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29403218/fine-needle-aspiration-cytology-of-granulocytic-sarcoma-presenting-as-a-breast-lump-report-of-a-rare-case-with-a-comprehensive-literature-search
#19
Abhishek Sharma, Anjan Kr Das, Subrata Pal, Subodh Bhattacharyya
Myeloid sarcoma is a neoplasm of myeloid cells that can arise before or concurrent with or may follow acute myeloid leukemia. Very rarely, it can present as an isolated breast lump. We have diagnosed a case of myeloid sarcoma by fine-needle aspiration cytology (FNAC), in a 52-year-old woman who presented with the right-sided breast lump. FNAC showed hypercellular smears with immature myeloid cells few neutrophils and many large round cells with high nuclear-cytoplasmic ratio, prominent nucleoli and a moderate amount of granular cytoplasm...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29365010/t-cell-large-granular-lymphocytic-leukemia-and-coexisting-b-cell-lymphomas-a-study-from-the-bone-marrow-pathology-group
#20
Tanu Goyal, Beenu Thakral, Sa A Wang, Carlos E Bueso-Ramos, Min Shi, Dragan Jevremovic, William G Morice, Qian-Yun Zhang, Tracy I George, Kathryn K Foucar, Siddharth Bhattacharyya, Adam Bagg, Heesun J Rogers, Juraj Bodo, Lisa Durkin, Eric D Hsi
Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma...
January 29, 2018: American Journal of Clinical Pathology
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