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large granular leukemia

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https://www.readbyqxmd.com/read/30334691/dysfunction-of-immune-system-in-the-development-of-large-granular-lymphocyte-leukemia
#1
Houfang Sun, Sheng Wei, Lili Yang
OBJECTIVES: Large granular lymphocyte (LGL) leukemia is a rare type of lymphoproliferative disease caused by clonal antigenic stimulation of T cells and natural killer (NK) cells. METHODS: In this review, we focus on the current knowledge of the immunological dysfunctions associated with LGL leukemia and the associated disorders coexistent with this disease. Novel therapeutic options targeting known molecular mechanisms are also discussed. RESULTS AND DISCUSSION: The pathogenesis of LGL leukemia involves the accumulation of gene mutations, dysregulated signaling pathways and immunological dysfunction...
October 18, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/30283618/clinical-significance-of-dasatinib-induced-pleural-effusion-in-patients-with-de-novo-chronic-myeloid-leukemia
#2
Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura
Dasatinib is currently approved for clinical use as a first-line treatment agent for newly diagnosed chronic myeloid leukemia (CML). However, only a few clinical trials have been performed to evaluate dasatinibinduced PE following first-line therapy. We investigated the incidence and clinical features of dasatinib-induced PE following first-line therapy in Japanese CML patients of real world clinical practice settings. Among 22 patients, the median age of PE-positive patients was higher than that of PE-negative patients...
September 5, 2018: Hematology Reports
https://www.readbyqxmd.com/read/30237273/t-cell-large-granular-lymphocytic-leukemia-and-plasma-cell-disorders
#3
M Hasib Sidiqi, Mohammed A Aljama, David S Viswanatha, David Dingli
No abstract text is available yet for this article.
September 20, 2018: Haematologica
https://www.readbyqxmd.com/read/30231346/latest-advances-in-the-diagnosis-and-treatment-of-large-granular-lymphocytic-leukemia
#4
Aline Moignet, Thierry Lamy
Large granular lymphocyte (LGL) leukemia has been recognized in the World Health Organization classifications among mature T cell and natural killer cell neoplasms and is divided into three categories. Chronic T cell leukemia and natural killer cell lymphocytosis can be considered as a similar spectrum of an indolent disease characterized by cytopenias and autoimmune conditions. The last category, aggressive natural killer cell LGL leukemia is very rare, related to Epstein-Barr virus, and seen mainly in young Asian people...
May 23, 2018: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/30222473/marantic-endocarditis-associated-with-t-cell-large-granular-lymphocytic-leukemia-first-report-of-its-occurrence-with-a-lymphoproliferative-malignancy-in-adults
#5
Salman Ahmed, Prachi Jani, Mohamad H Yamani, Sikander Ailawadhi, Victoria R Alegria, Meghna Ailawadhi
No abstract text is available yet for this article.
October 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30151740/dasatinib-induced-anti-leukemia-cellular-immunity-through-a-novel-subset-of-cd57-positive-helper-cytotoxic-cd4-t-cells-in-chronic-myelogenous-leukemia-patients
#6
Naoki Watanabe, Tomoiku Takaku, Kazuyoshi Takeda, Shuichi Shirane, Tokuko Toyota, Michiaki Koike, Masaaki Noguchi, Takao Hirano, Hiroshi Fujiwara, Norio Komatsu
Dasatinib induces lymphocytosis of large granular lymphocytes (LGLs) in a proportion of patients with chronic myelogenous leukemia (CML), and is associated with better clinical outcomes. LGLs consist of cytotoxic T lymphocytes and natural killer cells; however, the context and phenotypic/functional features of each type of LGL are unknown. To better define features of these LGLs, we investigated lymphocytosis in CML patients treated with dasatinib. D57-positive and CD4-positive type I T-helper (Th) cells (CD57+ Th cells) rarely occur in CML patients without lymphocytosis and in healthy individuals; however, a substantial increase in the proportion of CD57+ Th cells was observed in CML patients treated with dasatinib...
August 27, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/30078779/large-granular-lymphocytic-leukemia-cd3-cd56-a-challenge-for-the-biologist-and-the-physician
#7
Roberto Cupaiolo, Soraya Cherifi, Christophe Lelubre, Danielle Govaerts, Quentin Delefortrie, Francis Corazza, Charles Chevalier
Large granular lymphocyte leukemia (LGL) are chronic lymphoproliferative disorders classified into three main groups: T-cell LGL leukemia (T-LGL), aggressive NK-cell leukemia and chronic lymphoproliferative disorder of NK cells (NK-LGL). Patients with LGL leukemia exhibit chronic (>3 months) and moderate (<1G/L) to substantial monoclonal expansion of large granular lymphocytes in the peripheral blood. Cytologically, large granular lymphocytes are medium to large cells which are further characterized by an eccentric nucleus and a slightly basophilic cytoplasm containing azurophilic granules...
August 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/30067616/recent-insights-into-large-granular-lymphocytic-leukemia
#8
Loretta J Nastoupil
No abstract text is available yet for this article.
July 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/30057739/management-of-t-cell-large-granular-lymphocyte-leukemia-and-concurrent-retroperitoneal-liposarcoma
#9
Nolan R Bruce, Zachary W Tilley, Jacob T Carlson, Juan Camilo Barreto Andrade
T-cell large granular leukemia (T-LGL) is a rare lymphoproliferative disorder characterized by the clonal expansion of cytotoxic T lymphocytes. We present a unique case of T-LGL and concurrent retroperitoneal sarcoma occurring in a patient with long-standing rheumatoid arthritis. Pathology revealed a high-grade dedifferentiated liposarcoma. The diagnosis of T-LGL with a synchronous retroperitoneal sarcoma is a case that highlights the surgical management of these two rare conditions.
July 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30002792/clonal-t-cell-large-granular-lymphocytic-disorders-manifesting-in-patients-with-hiv-1-infection-case-series-and-review-of-the-literature
#10
Ashley Rose, Leidy Isenalumhe, Magali Van den Bergh, Lubomir Sokol
We report five patients with human immunodeficiency virus-1/acquired immunodeficiency syndrome (HIV-1/AIDS) who developed T-cell large granular lymphocytic proliferation (T-LGLP) or leukemia (T-LGLL). None of the patients fulfilled criteria for diagnosis of diffuse infiltrative lymphocyte syndrome (DILS) or HIV-associated CD8+ lymphocytosis syndrome at the time of diagnosis of LGL. The immunophenotype of malignant T-cells was identical in three patients with co-expression of CD3, CD8, CD57, and T-cell receptor (TCR) alpha/beta...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29963929/complete-remission-of-agranulocytosis-after-splenectomy-in-a-variant-form-of-t-cell-large-granular-lymphocyte-leukemia
#11
Claire Lozano, Sophie Brun, Anne Arnaud, Philippe Gaulard, Samia Gonzalez, Julien Crouzet, Jean-Christophe Gris
No abstract text is available yet for this article.
July 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29949739/mixed-phenotype-large-granular-lymphocytic-leukemia-lgll-a-rare-subtype-in-the-lgll-spectrum
#12
Jadee L Neff, Aruna Rangan, Dragan Jevremovic, Phuong L Nguyen, April Chiu, Ronald S Go, Dong Chen, William G Morice, Min Shi
Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which over 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL (T-LGLL) and chronic lymphoproliferative disorder of NK-cells (CLPD-NK). The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed by NK-cell, γδ T-cell, and CD4-positive/αβ T-cell types. We investigated a total of 220 LGLL cases and identified 12 mixed-phenotype LGLLs (5%): 7 cases with coexistent αβ T-cell and NK-cell clones and 5 with coexistent αβ and γδ T-cell clones...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29938921/prevalence-and-characteristics-of-persistent-clonal-t-lgl-expansions-in-rheumatoid-arthritis-a-comprehensive-analysis-of-529-patients
#13
Eva C Schwaneck, Regina Renner, Lara Junker, Hermann Einsele, Ottar Gadeholt, Eva Geissinger, Stefan Kleinert, Michael Gernert, Hans-Peter Tony, Marc Schmalzing
OBJECTIVE: Up to one third of patients with T-cell large granular lymphocyte leukemia (T-LGL-leukemia) display symptoms of rheumatoid arthritis (RA). In Crohn's disease and in psoriasis treatment with TNFα-inhibitors is associated with hepatosplenic γδT-cell-lymphoma and with clonal expansion of γδT-cells, respectively. Here, we determine the prevalence of clonal T-LGL cells in patients with RA and define risk factors for this rare hematologic malignancy. METHODS: 529 RA-patients were recruited between November, 2013 and August, 2015...
June 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29921385/pure-red-cell-aplasia-with-t-cell-large-granular-lymphocytic-leukemia
#14
G Shi, C M Hu, Q Yu, N Yang, Z S Xue, B Zhao, M Guo, Y Zheng
Pure red cell aplasia (PRCA) develops as a result of erythroid precursors failing to reach maturity in the bone marrow, which eventually leads to anemia. Here we present a case of a 64-year-old Asian male with a medical history of colorectal adenocarcinoma who had been treated with 6 cycles of oxaliplatin and capecitabine four years ago. The patient was diagnosed with PRCA and T-cell large granular lymphocyte leukemia.
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29744070/large-granular-lymphocytic-leukemia-complicating-autoimmune-polyglandular-syndrome-type-1-in-siblings
#15
Jonathan S Harrison, Harsh Parmar, Xiangbing D Wang
Autoimmune polyglandular syndrome type 1 (APS1) is a rare autosomal recessive disorder, and large granular lymphocytic leukemia (LGLL) may, even more rarely, complicate APS1. LGLL may be subtle in presentation, but it is imperative to recognize LGLL in APS1 promptly, as outcome may otherwise be fatal, as described herein.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29699990/trail-mediates-and-sustains-constitutive-nf-%C3%AE%C2%BAb-activation-in-lgl-leukemia
#16
Jun Yang, Francis R LeBlanc, Shubha A Dighe, Cait E Hamele, Thomas L Olson, David J Feith, Thomas P Loughran
Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysregulation of apoptosis and resistance to activation-induced cell death. We reported previously that nuclear factor κB (NF-κB) is a central regulator of the survival network for leukemic LGL. However, the mechanisms that trigger constitutive activation of NF-κB in LGL leukemia remain undefined...
June 21, 2018: Blood
https://www.readbyqxmd.com/read/29682368/transformation-of-t-cell-acute-lymphoblastic-lymphoma-to-peripheral-t-cell-lymphoma-a-report-of-two-cases
#17
Michael Markow, Abu-Sayeef Mirza, Lia Perez, Haipeng Shao, Pedro Horna, Claudio Anasetti, Lubomir Sokol, Mohammad O Hussaini
Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNC γδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNC γδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29607828/t-cell-large-granular-lymphocytic-leukemia-with-pulmonary-hypertension
#18
Sidra Khalid, Hamed Daw, Miriam Jacob, Megan Nakashima
T cell large granular lymphocytic leukemia is a hematological disorder which is characterized by the proliferation of CD 3+ cytotoxic T cells. We present a case about a patient who was diagnosed with T cell large granular lymphocytic leukemia and then developed pulmonary hypertension. He was treated for his leukemia with methotrexate and simultaneously treated for his pulmonary hypertension with selexipag and ambrisentan. As his leukemia improved, we also noticed an improvement in his pulmonary hypertension from a NYHA class IV to class I...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29559980/next-generation-sequencing-analysis-of-the-human-tcr%C3%AE-%C3%AE-t-cell-repertoire-reveals-shifts-in-v%C3%AE-and-v%C3%AE-usage-in-memory-populations-upon-aging
#19
Martine J Kallemeijn, François G Kavelaars, Michèle Y van der Klift, Ingrid L M Wolvers-Tettero, Peter J M Valk, Jacques J M van Dongen, Anton W Langerak
Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to autoimmunity and cancer development at older age. Even though TCRαβ+ and TCRγδ+ T-cells follow similar paths of development involving V(D)J-recombination of TCR genes in the thymus, TCRγδ+ T-cells tend to be more subjected to peripheral rather than central selection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29474442/dysregulation-of-the-ifn-%C3%AE-stat1-signaling-pathway-in-a-cell-line-model-of-large-granular-lymphocyte-leukemia
#20
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflammatory environment...
2018: PloS One
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