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https://www.readbyqxmd.com/read/30289086/the-effects-of-d-aspartate-in-neurosteroids-neurosteroid-receptors-and-inflammatory-mediators-in-experimental-autoimmune-encephalomyelitis
#1
Mahdi Goudarzvand, Yaser Panahi, Reza Yazdani, Hosein Miladi, Saeed Tahmasebi, Amin Sherafat, Sanaz Afraei, Kosar Abouhamzeh, Mahnaz Jamee, Kawthar Jasim Mohammad Rida Al-Hussieni, Hamed Mohammadi, Ali Mohebbi, Nikoo Hossein-Khannazer, Majid Zaki-Dizaji, Maria Maddalena Di Fiore, Antimo D'Aniello, Gholamreza Azizi
OBJECTIVE: Experimental autoimmune encephalomyelitis (EAE) is a widely used model for multiple sclerosis. The present study has been designed to compare the efficiencies of oral and intraperitoneal (IP) administration of D-aspartate (D-Asp) on the onset and severity of EAE, the production of neurosteroids, and the expression of neurosteroid receptors and inflammatory mediators in brain of EAE mice. METHODS: In this study, EAE was induced in C57BL/6 mice treated with D-Asp orally (D-Asp-Oral) or by IP injection (D-Asp-IP)...
October 4, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/30221697/streptozotocin%C3%A2-induced-diabetic-mice-exhibit-reduced-experimental-choroidal-neovascularization-but-not-corneal-neovascularization
#2
Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu
The present study aimed to investigate the effects of diabetes mellitus (DM) on the generation of experimental corneal neovascularization (CrNV) and choroidal neovascularization (ChNV). Diabetes was induced in mice by intraperitoneal injection of streptozotocin (STZ). Experimental CrNV and ChNV were induced by alkali injury and laser photocoagulation, respectively. CrNV and ChNV were compared between the STZ‑induced diabetic mice and control mice two weeks after injury. Relative expression of angiogenic factors was quantified by reverse transcription‑quantitative polymerase chain reaction, and progenitor cell or macrophage accumulation in the early phase following injury was examined by flow cytometric analysis...
September 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30193592/characterization-of-a-listeria-monocytogenes-meningitis-mouse-model
#3
Merel M Koopmans, JooYeon Engelen-Lee, Matthijs C Brouwer, Valery Jaspers, Wing Kit Man, Mercedes Vall Seron, Diederik van de Beek
BACKGROUND: Listeria monocytogenes is a common cause of bacterial meningitis. We developed an animal model of listerial meningitis. METHODS: In survival studies, C57BL/6 mice received intracisternal injections with different L. monocytogenes sequence type 1 (ST1) colony forming units per milliliter (CFU; n = 48, 105 , 106 , 107 , 108 , and 109  CFU/ml). Second, mice were inoculated with 108  CFU/ml ST1 and sacrificed at 6 h and 24 h (n = 12/group). Outcome parameters were clinical score, CFUs, cyto- and chemokine levels, and brain histopathology...
September 7, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30132565/c%C3%A2-c-chemokine-receptor-type-2-promotes-epithelial%C3%A2-to%C3%A2-mesenchymal-transition-by-upregulating-matrix-metalloproteinase%C3%A2-2-in-human-liver-cancer
#4
Huijin Li, Hui Li, Xiao-Peng Li, Haojun Zou, Liting Liu, Wangqiao Liu, Tao Duan
C‑C chemokine receptor type 2 (CCR2) is aberrantly expressed in a variety of tumor cells, and participates in the regulation of tumor cell progression, metastasis and immune escape. However, the mechanism of action of CCR2 in liver cancer remains unclear. In the present study, the aim was to elucidate the molecular mechanism underlying the regulation of epithelial‑to‑mesenchymal transition (EMT) by CCR2 in liver cancer cells. Initially, CCR2 expression in liver cancer tissues was measured, and the survival time of patients was analyzed by Kaplan‑Meier analysis...
August 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30118441/inhibition-of-c-x-c-motif-chemokine-10-cxcl10-protects-mice-from-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease
#5
Hongyu Jing, Lingyun Liu, Junfeng Zhou, Hanxin Yao
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow. COPD can progress to persistent decline of pulmonary function. This study explored the effect of CXCL10 on COPD induced by cigarette smoke (CS) and its underlying mechanism. MATERIAL AND METHODS Wild-type (WT) mice were randomly assigned into 3 groups: the control group, the CS group, and the intervention group. Mice in the CS group were exposed to CS and mice in the CXCL10 group were exposed to CS and CXCL10 neutralizing antibody...
August 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30066869/extracellular-matrix-promotes-proliferation-migration-and-adhesion-of-airway-smooth-muscle-cells-in-a-rat-model-of-chronic-obstructive-pulmonary-disease-via-upregulation-of-the-pi3k-akt-signaling-pathway
#6
Zhengyan Wang, Rui Li, Rui Zhong
Extracellular matrix (ECM) creates the tissue microenvironment and serves a role in airway wall remodeling in chronic obstructive pulmonary disease (COPD). However, the biological function of ECM in COPD remains to be elucidated. In the present study, 24 healthy Sprague Dawley rats were randomized to normal and COPD groups. COPD was established by intratracheal injection with lipopolysaccharide over 30 days. Subsequently, airway smooth muscle cells (ASMCs) were isolated from rats and served as a model to assess the effects of three ECM components, including collagen type I, laminin and collagen type III (COL‑3)...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30015967/bioinformatics-approach-reveals-the-key-role-of-c%C3%A2-x%C3%A2-c-motif-chemokine-receptor-2-in-endometriosis-development
#7
Aili Tan, Ruoyu Luo, Hua Liang, Mengru Li, Peng Ruan
Endometriosis is a common gynecological disease, affecting 6‑10% of women of reproductive age. The precise mechanisms underlying the development of endometriosis remain unclear. In the present study, a bioinformatics approach was applied to systematically identify the pathways and genes involved in the development of endometriosis and to discover potential biomarkers. The gene expression profiles of GSE6364, a microarray dataset of endometrial biopsies obtained from women with or without endometriosis, was downloaded from the Gene Expression Omnibus DataSets database that stores original submitter‑supplied records (series, samples and platforms), as well as curated datasets...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29940819/investigation-of-plasma-inflammatory-profile-in-diabetic-patients-with-abdominal-aortic-aneurysm-a-pilot-study
#8
Fabien Lareyre, Claudine Moratal, Julien Chikande, Elixène Jean-Baptiste, Réda Hassen-Khodja, Jaap Neels, Giulia Chinetti, Juliette Raffort
INTRODUCTION: Clinical studies have unraveled a negative association between diabetes and abdominal aortic aneurysm (AAA), but the mechanisms involved are still poorly understood. The aim of this study was to determine whether diabetic patients with AAA had a distinct plasma inflammatory profile compared to nondiabetic patients. METHODS: Plasma samples were obtained from 10 diabetic patients with AAA and 10 nondiabetic patients with AAA. The relative protein expression of 92 inflammatory-related human protein biomarkers was assessed by proximity extension assay technology using Proseek Multiplex Inflammation I kit (Olink)...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29928346/overexpression-of-hsa-mir-125a-5p-enhances-proliferation-migration-and-invasion-of-head-and-neck-squamous-cell-carcinoma-cell-lines-by-upregulating-c-c-chemokine-receptor-type-7
#9
Shan Jin, Min-Da Liu, Hong Wu, Pai Pang, Song Wang, Zhen-Ning Li, Chang-Fu Sun, Fa-Yu Liu
Head and neck squamous cell carcinoma (HNSCC) is usually diagnosed accompanied by lymph node metastasis. C-C chemokine receptor type 7 (CCR7) is associated with the invasion and metastasis of tumors in HNSCC through various signaling pathways. The role of hsa-miR-125a-5p in HNSCC remains unclear. The present study was performed to investigate the association between hsa-miR-125a-5p and CCR7 in HNSCC. Reverse transcription-quantitative polymerase chain reaction was applied to analyze the expression of hsa-miR-125a-5p in clinical samples...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29845205/effect-of-co%C3%A2-culture-with-amniotic-epithelial-cells-on-the-biological-characteristics-of-amniotic-mesenchymal-stem-cells
#10
Li-Jing Ran, Yun Zeng, Shao-Chun Wang, Di-Si Zhang, Min Hong, Shao-You Li, Jian Dong, Ming-Xia Shi
The aim of the present study was to investigate the effect of co‑culture with amniotic epithelial cells (AECs) on the biological characteristics of amniotic mesenchymal stem cells (AMSCs), to compare the expression of C‑X‑C motif chemokine receptor 4 (CXCR4) in co‑cultured AMSCs and to investigate the roles of the stromal cell‑derived factor‑1 (SDF‑1)/CXCR4 axis in the homing and migration of AMSCs. AMSCs were isolated from human amniotic membranes, purified and then differentiated into osteoblasts and adipocytes in vitro, which was verified by von Kossa Staining and Oil Red O staining...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29805477/high-expression-of-cxcr4-and-stem-cell-markers-in-a-monocrotaline-and-chronic-hypoxia-induced-rat-model-of-pulmonary-arterial-hypertension
#11
Tingting Zhang, Nanako Kawaguchi, Emiko Hayama, Yoshiyuki Furutani, Toshio Nakanishi
Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome. C-X-C chemokine receptor type 4 (CXCR4) is known to serve a key role in recruiting mesenchymal stem cells (MSCs) from the bone marrow. In the present study, a rat model of PAH induced by 5 weeks of chronic hypoxia and treatment with a single injection of monocrotaline (60 mg/kg) was used to investigate the involvement of CXCR4 in PAH. Successful establishment of the PAH model was confirmed by significant differences between the PAH and control groups in right ventricular systolic pressure, Fulton index, wall thickness, vascular occlusion score determined by immunohistochemical staining and the expression of inflammatory markers measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29796010/cxcr-4-expression-by-circulating-endothelial-progenitor-cells-and-sdf-1-serum-levels-are-elevated-in-septic-patients
#12
Christian Patry, Daniela Stamm, Christian Betzen, Burkhard Tönshoff, Benito A Yard, Grietje Ch Beck, Neysan Rafat
Background: Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clinical outcome. Methods: Peripheral blood mononuclear cells from septic patients ( n  = 30), ICU control patients ( n  = 11) and healthy volunteers ( n  = 15) were isolated by Ficoll density gradient centrifugation...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29787588/angiogenic-and-pleiotropic-effects-of-vegf165-and-hgf-combined-gene-therapy-in-a-rat-model-of-myocardial-infarction
#13
Pavel I Makarevich, Konstantin V Dergilev, Zoya I Tsokolaeva, Maria A Boldyreva, Evgeniy K Shevchenko, Evgeny V Gluhanyuk, Julia O Gallinger, Mikhail Yu Menshikov, Yelena V Parfyonova
Since development of plasmid gene therapy for therapeutic angiogenesis by J. Isner this approach was an attractive option for ischemic diseases affecting large cohorts of patients. However, first placebo-controlled clinical trials showed its limited efficacy questioning further advance to practice. Thus, combined methods using delivery of several angiogenic factors got into spotlight as a way to improve outcomes. This study provides experimental proof of concept for a combined approach using simultaneous delivery of VEGF165 and HGF genes to alleviate consequences of myocardial infarction (MI)...
2018: PloS One
https://www.readbyqxmd.com/read/29762844/free-fatty-acids-mediates-human-umbilical-vein-endothelial-cells-inflammation-through-toll-like-receptor-4
#14
L Chen, C-X Yu, B Song, W Cai, C Liu, Q-B Guan
OBJECTIVE: To investigate the role of Toll-like receptor-4 (TLR4) in the free fatty acids (FFAs) induced human umbilical vein endothelial cells (HUVECs) inflammation and to explore the underlying mechanisms. MATERIALS AND METHODS: HUVECs and HEK293 cell lines were obtained from Shanghai Type Culture Collection. Cell counting kit-8 (CCK8) and flow cytometry (FCM) were performed to examine the cell viability and apoptosis rate of HUVECs induced by FFAs treatments with or without infection of toll-like receptor-4 interference (TLR4i) adenovirus...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#15
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29693177/the-therapeutic-effect-of-artesunate-on-rosacea-through-the-inhibition-of-the-jak-stat-signaling-pathway
#16
Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu
Acne rosacea is a type of chronic dermatosis with the characteristics of erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to the side effects. Artesunate demonstrated a promising therapeutic efficacy with a high safety margin. HaCaT cells were treated with antibacterial peptide LL‑37 to simulate rosacea caused by Demodex folliculorum (D. folliculorum) infection. Cell Counting kit 8 and flow cytometry assays were performed to measure cellular proliferation, apoptosis, the stage of the cell cycle and reactive oxygen species generation in order to determine the level of cell damage...
June 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29662241/low-mother-to-child-ccl22-chemokine-levels-are-inversely-related-to-mite-sensitization-and-asthma-in-early-childhood
#17
Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
Few studies have addressed the mother-to-child transmission of Th2 immunity and the impact on the development of atopic diseases in early childhood. We investigated 186 children who were followed-up regularly for 4 years in a birth cohort study. The levels of Th2 related chemokine (C-C motif) ligand 17 (CCL17) and CCL22 were quantified in cord blood and at 1.5 years-of-age using multiplex Luminex kits. The levels of 125 pairs of CCL17 and CCL22 chemokines from birth to 1.5 years were recorded in this study...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29520864/complex-association-patterns-for-inflammatory-mediators-in-induced-sputum-from-subjects-with-asthma
#18
A T Hastie, C Steele, C W Dunaway, W C Moore, B M Rector, E Ampleford, H Li, L C Denlinger, N Jarjour, D A Meyers, E R Bleecker
BACKGROUND: The release of various inflammatory mediators into the bronchial lumen is thought to reflect both the type and degree of airway inflammation, eosinophilic Th2, and Th9, or neutrophilic Th1, and Th17, in patients with asthma. AIMS: We investigated whether cytokines and chemokines differed in sputum from subjects with more severe compared with milder asthma and whether unbiased factor analysis of cytokine and chemokine groupings indicates specific inflammatory pathways...
July 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29520695/akip1-promotes-angiogenesis-and-tumor-growth-by-upregulating-cxc-chemokines-in-cervical-cancer-cells
#19
Wenying Zhang, Qiongwei Wu, Chao Wang, Longtao Yang, Ping Liu, Chengbin Ma
Upregulation of A-kinase-interacting protein 1 (AKIP1) has been observed in breast and esophageal cancers, indicating that AKIP1 may be a potent oncogenic protein. However, the role of AKIP1 in cervical cancer still remains unknown. This study aimed to explore the role of AKIP1 in cervical cancer and to investigate the underlying mechanism of AKIP1 in tumor growth. Expression of AKIP1 in cervical cancer cells was determined by qRT-PCR and western blotting. Cell-Light EdU and colony formation assays were used to determine cell proliferation...
March 8, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29434741/inhibition-of-c-x-c-motif-chemokine-10-reduces-graft-loss-mediated-by-memory-cd8-t-cells-in-a-rat-cardiac-re-transplant-model
#20
Jiacheng Xu, Teng Ma, Guorong Deng, Jiawei Zhuang, Cheng Li, Shaohu Wang, Chen Dai, Xiaobiao Zhou, Zhonggui Shan, Zhongquan Qi
The interaction of chemokine (C-X-C motif) ligand 10 (CXCL10) with its receptor (CXCR3) is a critical process in recruiting donor reactive T cells to a graft and alloantigen-specific memory T (Tm) cells exert a principal function in promoting graft dysfunction during accelerated cardiac rejection. However, whether CXCL10 chemokine exerts any effects on acute accelerated rejection mediated by CD8+ Tm cells in a re-transplant model has remained elusive. The present study established a cardiac transplant model by advanced microsurgery technology and improved organ storage...
February 2018: Experimental and Therapeutic Medicine
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