keyword
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#1
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38364743/evaluation-of-interleukins-il-1%C3%AE-il-1ra-il-12-il-17a-il-31-and-il-33-and-chemokines-cxcl10-and-cxcl16-in-the-serum-of-male-patients-with-ankylosing-spondylitis
#2
JOURNAL ARTICLE
Hanan Y Muhsin, Ali Q Khazaal, Haneen M Ismaeel, Mohammed H Alosami, Ali H Ad'hiah
BACKGROUND: A case-control study was performed to explore eight pro-inflammatory and anti-inflammatory cytokines, namely interleukin (IL)-1α, IL-1Ra (IL-1 receptor antagonist), IL-12, IL-17A, IL-31, IL-33, CXCL10 (C-X-C motif chemokine ligand 10), and CXCL16, with the aim to understand their role in ankylosing spondylitis (AS) pathogenesis and evaluate their utility as markers to differentiate between diseased and healthy individuals. Among these cytokines, IL-31 and CXCL16 have not been well studied in AS...
February 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38317079/platelet-derived-growth-factor-signaling-in-pericytes-promotes-hypothalamic-inflammation-and-obesity
#3
JOURNAL ARTICLE
Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka
BACKGROUND: Pericytes are a vital component of the blood-brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and energy metabolism in obesity. The present study investigated the impact of pericytes on the pathophysiology of obesity by focusing on platelet-derived growth factor (PDGF) signaling, which regulates pericyte functions. METHODS: Tamoxifen-inducible systemic conditional PDGF receptor β knockout mice (Pdgfrb∆SYS -KO) and Calcium/calmodulin-dependent protein kinase type IIa (CaMKIIa)-positive neuron-specific PDGF receptor β knockout mice (Pdgfrb∆CaMKII -KO) were fed a high-fat diet, and metabolic phenotypes before and 3 to 4 weeks after dietary loading were examined...
February 5, 2024: Molecular Medicine
https://read.qxmd.com/read/38288441/valsartan-attenuates-lps-induced-ali-by-modulating-nf-%C3%AE%C2%BAb-and-mapk-pathways
#4
JOURNAL ARTICLE
Mi Zhou, Ling Meng, Qinke He, Chunguang Ren, Changyi Li
Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common respiratory disease characterized by persistent hypoxemia and an uncontrolled inflammatory response. Valsartan, an angiotensin II type 1 receptor antagonist, is clinically used to treat hypertension and has anti-inflammatory and antioxidant effects on gefitinib-induced pneumonia in rats. However, the potential therapeutic effects of valsartan on lipopolysaccharide (LPS)-induced ALI remain unclear. This study investigated the protective role of valsartan in LPS-induced ALI and its underlying mechanisms...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38245792/high-and-selective-cytotoxicity-of-ex-vivo-expanded-allogeneic-human-natural-killer-cells-from-peripheral-blood-against-bladder-cancer-implications-for-natural-killer-cell-instillation-after-transurethral-resection-of-bladder-tumor
#5
JOURNAL ARTICLE
Fangming Wang, Gang Zhang, Tianli Xu, Jianlin Ma, Jing Wang, Shuai Liu, Yuzhe Tang, Song Jin, Jianxing Li, Nianzeng Xing
BACKGROUND: Non-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical instillation of chemotherapy or Bacillus Calmette-Guérin therapy. However, these treatments have a high recurrence rate and side effects, emphasizing the need for alternative instillations. Previously, we revealed that expanded allogeneic human natural killer (NK) cells from peripheral blood are a promising cellular therapy for prostate cancer...
January 20, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38196701/ccl5-promotes-the-proliferation-and-metastasis-of-bladder-cancer-via-the-jak2-stat3-signaling-pathway
#6
JOURNAL ARTICLE
Jie Shen, Cheng Chen, Zhen Chen, Pengfeng Gong, Lui Shiong Lee, Benjamin N Schmeusser, Qianfeng Zhuang, Yangyang Sun, Dong Xue, Xiaozhou He
BACKGROUND: Non-muscle invasive bladder cancer (NMIBC) is one of the most common malignant tumors of the urinary system. There is an urgent need for further studies to elucidate the underlying mechanisms of bladder cancer (BC) progression. It has been observed that C-C chemokine ligand 5 (CCL5) and its receptor C-C chemokine receptor type 5 (CCR5) are expressed abnormally and activated in solid tumors and hematological malignancies, which is gaining increasing attention. However, the underlying mechanism of CCL5 in BC remains unclear...
December 31, 2023: Translational Andrology and Urology
https://read.qxmd.com/read/38173425/hsa_circ_0136666-mediates-the-antitumor-effect-of-curcumin-in-colorectal-carcinoma-by-regulating-cxcl1-via-mir-1301-3p
#7
JOURNAL ARTICLE
Shi Chen, Wei Li, Chen-Gong Ning, Feng Wang, Li-Xing Wang, Chen Liao, Feng Sun
BACKGROUND: This study investigate the anti-tumor effect of curcumin and whether its mediated by hsa_circ_0136666 through miR-1301-3p/ CXCL1 in colorectal carcinoma (CRC). Through multiple experiments, we have drawn the conclusion that curcumin inhibited CRC development through the hsa_circ_0136666/miR-1301-3p/ CXCL1 axis, hinting at a novel treatment option for curcumin to prevent CRC development. AIM: To determine whether hsa_circ_0136666 involvement in curcumin-triggered CRC progression was mediated by sponging miR-1301-3p...
December 15, 2023: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38163133/jianpi-yangxue-qufeng-compound-alleviates-atopic-dermatitis-via-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#8
JOURNAL ARTICLE
Xuesong Yang, Zhimin Wang, Hong Huang, Guangyun Luo, Lin Cong, Jianting Yang, Jianzhou Ye
BACKGROUND: Jianpi Yangxue Qufeng Compound (JPYXQFC) is a Chinese medicine widely used in the clinical treatment of atopic dermatitis (AD) and has a significantly therapeutic effect. However, the mechanism of JPYXQFC in AD has been not understood clearly. OBJECTIVE: This study aimed to explore the effect of JPYXQFC on AD model cells and rats by regulating TLR4/MyD88/NF-κB signaling pathway. METHODS: The rats (n > 5) were given JPYXQFC decoction orally twice a day for three days, and their abdominal aortic blood was collected...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38114183/-protective-effect-of-liujing-toutong-tablets-on-rats-with-permanent-cerebral-ischemia-via-nf-%C3%AE%C2%BAb-signaling-pathway
#9
JOURNAL ARTICLE
Zi-Han Yu, Ke Pei, Ting-Ting Zhao, Hong-Chang Li, Qin-Qing Li, Wen-Jing Zhou, Wen-Bin He, Jun-Long Zhang
This study investigated the neuroprotective effects and underlying mechanism of Liujing Toutong Tablets(LJTT) on a rat model of permanent middle cerebral artery occlusion(pMCAO). The pMCAO model was established using the suture method. Eighty-four male SPF-grade SD rats were randomly divided into a sham operation group, a model group, a nimodipine group(0.020 g·kg~(-1)), and high-, medium-, and low-dose LJTT groups(2.8, 1.4, and 0.7 g·kg~(-1)). The Longa score, adhesive removal test and laser speckle contrast imaging technique were used to evaluate the degree of neurological functional impairment and changes in local cerebral blood flow...
November 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38106812/multifactorial-comparative-analysis-of-platelet-rich-plasma-and-serum-prepared-using-a-commercially-available-centrifugation-kit
#10
JOURNAL ARTICLE
Takayuki Okumo, Atsushi Sato, Kanako Izukashi, Masataka Ohta, Jun Oike, Saki Yagura, Naoki Okuma, Takayuki Koya, Masataka Sunagawa, Koji Kanzaki
Background Platelet-rich plasma (PRP) is an autologous product prepared by centrifuging whole blood. PRP is reported to have high tissue repair potential and anti-inflammatory properties. Recently, PRP has become a potential treatment option for osteoarthritis, contributing to pain relief and locomotive improvement. However, the underlying therapeutic mechanisms and key biochemical factors in PRP remain unclear. This study aimed to estimate the major factors for tissue repair involved in PRP treatment by comparing between serum and PRP prepared from the same patients using the Luminex assay...
November 2023: Curēus
https://read.qxmd.com/read/38023351/hyperforin-modulates-mapk-ccl11-signaling-to-reduce-the-inflammatory-response-of-nasal-mucosal-epithelial-cells-caused-by-allergic-rhinitis-by-targeting-bcl6
#11
JOURNAL ARTICLE
Chen Xu, Wen Su
Hyperforin is a type of bicyclic tetraketone with four isoprenoid chains extracted from Hypericum perforatum L. that has multiple biological activities such as anti-diabetes, antitumor and anti-inflammation. However, the role and potential mechanism of hyperforin in allergic rhinitis (AR) remains to be clarified. In the present study, cell viability was analyzed using Cell Counting Kit-8 assay, while inflammation was detected using ELISA and reverse transcription-quantitative PCR. Epithelial cell barrier damage was measured using western blotting and immunofluorescence staining...
December 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/37972879/comprehensive-immunoprofiling-of-neurodevelopmental-disorders-suggests-three-distinct-classes-based-on-increased-neurogenesis-th-1-polarization-or-il-1-signaling
#12
JOURNAL ARTICLE
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Neurodevelopmental disorders (NDDs) are a spectrum of conditions with commonalities as well as differences in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. Immune dysregulation has surfaced as a major pathway in NDDs. However, it is not known if neurodevelopmental disorders share a common immunopathogenetic mechanism. In this study, we explored the possibility of a shared immune etiology in three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD)...
November 14, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37957089/aconite-aqueous-extract-inhibits-the-growth-of-hepatocellular-carcinoma-through-ccl2-dependent-enhancement-of-natural-killer-cell-infiltration
#13
JOURNAL ARTICLE
Kang-Di Yang, Xu Zhang, Ming-Cong Shao, Li-Na Wang
OBJECTIVE: Aconite is a traditional Chinese herbal medicine that has been found to inhibit the development of liver cancer; however, its exact molecular mechanisms in this process remain unclear. This study explores how aconite aqueous extract (AAE) inhibits hepatocellular carcinoma (HCC). METHODS: An in vivo mouse model of subcutaneous liver cancer was established. After AAE treatment, immunohistochemistry (IHC) was used to determine the effect of AAE on natural killer (NK) cells...
October 29, 2023: Journal of Integrative Medicine
https://read.qxmd.com/read/37855059/ccn1-inhibition-affects-the-function-of-endothelial-progenitor-cells-under-high-glucose-condition
#14
JOURNAL ARTICLE
Yanting Dong, Xiaohui Zhou, Nan Zhang
BACKGROUND: The impact of cysteine-rich angiogenic inducer 61 (Cyr61, also called CCN1) on endothelial progenitor cells (EPCs) from diabetic-rat-derived whole peripheral and bone marrow remains poorly understood. Therefore, the expression levels of CCN1, CCN1-induced C-X-C chemokine receptor type 4 (CXCR4), and stromal-cell-derived factor-1 (SDF-1) were explored under high glucose (HG) conditions. OBJECTIVES: The aim of the study was to explore the effects of high CCN1 levels on EPC activity in diabetic rats through mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway modulation...
October 19, 2023: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/37854863/pcsk9-promotes-tumor-cell-proliferation-and-migration-by-facilitating-ccl25-secretion-in-esophageal-squamous-cell-carcinoma
#15
JOURNAL ARTICLE
Haijun Wang, Qiang Guo, Mingbo Wang, Changjiang Liu, Ziqiang Tian
Proprotein convertase subtilisin/kexin type 9 (PCSK9) serves an important role in maintaining plasma cholesterol levels, and fatty acid metabolism is involved in the progression of various types of cancer. In the present study, the role of PCSK9 in the development of esophageal squamous cell carcinoma (ESCC) was investigated. PCSK9 expression was compared between ESCC and normal esophageal epithelial tissues using reverse transcription-quantitative PCR. In addition, the association between PCSK9 expression and clinical staging and prognosis was assessed by immunohistochemistry...
November 2023: Oncology Letters
https://read.qxmd.com/read/37835681/bovine-c-x-c-motif-chemokine-ligand-14-expression-is-regulated-by-alternative-polyadenylation-and-micrornas
#16
JOURNAL ARTICLE
Wei Zhao, Xueyan Liu, Chengping Li, Xuyong Qin, Shizhong Ren, Shujun Cao, Guoli Zhou
Alternative polyadenylation (APA), including APA that occurs only in the 3' UTR (3' UTR-APA), is an important post-transcriptional regulatory mechanism that leads to distinct 3' UTRs for some genes, increasing the complexity of the transcriptome. The post-transcriptional events regulating the expression of bovine, the C-X-C motif chemokine ligand 14 (CXCL14) gene, remains largely unknown. Here, we find that the bovine CXCL14 gene produces two different lengths of mRNA isoforms due to 3' UTR-APA, and the short and long 3' UTR is 126 bp and 1155 bp, respectively...
September 30, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37805854/-construction-and-functional-analysis-of-egfrviii-car-t-cells-co-expressing-il-15-and-ccl19
#17
JOURNAL ARTICLE
Wanqiong Chen, Na Xian, Shaomei Lin, Wanting Liao, Mingzhu Chen
The aim of this study was to investigate the functional characteristics and in vitro specific killing effect of EGFRvIII CAR-T cells co-expressing interleukin-15 and chemokine CCL19, in order to optimize the multiple functions of CAR-T cells and improve the therapeutic effect of CAR-T cells targeting EGFRvIII on glioblastoma (GBM). The recombinant lentivirus plasmid was obtained by genetic engineering, transfected into 293T cells to obtain lentivirus and infected T cells to obtain the fourth generation CAR-T cells targeting EGFRvIII (EGFRvIII-IL-15-CCL19 CAR-T)...
September 25, 2023: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/37802708/cxcl1-promotes-immune-escape-in-colorectal-cancer-by-autophagy-mediated-mhc-i-degradation
#18
JOURNAL ARTICLE
Jianqiao Kong, Song Xu, Peng Zhang, Yun Zhao
BACKGROUND: Immunotherapy is now seen as a potential remedy for colorectal cancer (CRC). Chemokines play a crucial role in tumors, including CRC, which contains CXCL1. We attempted to study how CXCL1 impacts immune escape in CRC. METHODS: Bioinformatics analysis was used to examine CXCL1 level in CRC. qRT-PCR was used to assess CXCL1 and MHC-I (HLA-A, B, C) levels. Cell Counting Kit-8 (CCK-8) was used to measure cell viability. Cytotoxicity assay kit was utilized to assay CD8+ T cell cytotoxicity against CRC...
October 4, 2023: Human Immunology
https://read.qxmd.com/read/37790560/the-brain-bone-marrow-axis-implications-for-chronic-traumatic-brain-injury-and-age-related-neurodegeneration
#19
Junfang Wu, Rodney Ritzel, Yun Li, Yun Jiao, Sarah Doran, Niaz Khan, Rebecca Henry, Kavitha Brunner, David Loane, Alan Faden, Gregory Szeto
Introduction: It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem cells/progenitors chronically and to what extent such changes may negatively impact innate immunity and neurological function has not been examined. Methods: To further understand the role of BM cell derivatives on TBI outcome, we generated BM chimeric mice by transplanting BM from chronically injured or sham (i...
September 21, 2023: Research Square
https://read.qxmd.com/read/37789740/neuroinflammatory-markers-in-patients-with-haemophilia-and-healthy-controls-where-are-the-differences
#20
JOURNAL ARTICLE
Udo F Wehmeier, Valerie Orth, Vanessa Höppe, Leonard A Valentino, Thomas Hilberg
INTRODUCTION: People with haemophilia (PwH) suffer from haemophilic arthropathy which is accompanied by acute and chronic inflammation. The aim of this study was to examine the neuroinflammatory network operative in PwH and to compare it to healthy controls. MATERIAL AND METHODS: Blood samples were collected from 41 PwH (age 54.7 ± 11.7 years) and 33 healthy controls (age 50.9 ± 10.5 years) and the levels of 13 neuroinflammatory markers were analyzed by applying an antibody-based detection kit in a flow cytometer...
October 3, 2023: Haemophilia: the Official Journal of the World Federation of Hemophilia
keyword
keyword
162584
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.