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Fabian Itel, Jesper Skovhus Thomsen, Brigitte Städler
Therapeutic cell mimicry aims to provide a source of cell-like assemblies, which exhibits the core structural or functional properties of their natural counterparts with broad envisioned applications in biomedicine. Bone tissue engineering (BTE) aims at promoting and inciting the natural healing process of for instance critically-sized bone defects. Microreactors designed to co-assemble with biological bone-forming osteoblast like SaOS-2 cells to kick-start biomineralization are reported for the first time...
August 16, 2018: ACS Applied Materials & Interfaces
Lingzhi Kong, Zhi Wu, Huakun Zhao, Haomin Cui, Ji Shen, Jiang Chang, Haiyan Li, Yaohua He
Diabetic wound is hard to heal mainly because of the difficulty in vascularization in the wound area. Accumulating evidences have shown that desferrioxamine (DFO) can promote secretion of hypoxia inducible factor-1 (HIF-1α), thereby upregulating the expression of angiogenic growth factors and facilitating revascularization. Our preliminary study has demonstrated that Si ions in bioglass (BG) can upregulate vascular endothelial growth factor (VEGF) expression, thus promoting revascularization. It is hypothesized that the combined use of BG and DFO may have a synergistic effect in promoting VEGF expression and revascularization...
August 16, 2018: ACS Applied Materials & Interfaces
Lennart Kappelmann, Karen Krüger, Jan-Hendrik Hehemann, Jens Harder, Stephanie Markert, Frank Unfried, Dörte Becher, Nicole Shapiro, Thomas Schweder, Rudolf I Amann, Hanno Teeling
Marine algae convert a substantial fraction of fixed carbon dioxide into various polysaccharides. Flavobacteriia that are specialized on algal polysaccharide degradation feature genomic clusters termed polysaccharide utilization loci (PULs). As knowledge on extant PUL diversity is sparse, we sequenced the genomes of 53 North Sea Flavobacteriia and obtained 400 PULs. Bioinformatic PUL annotations suggest usage of a large array of polysaccharides, including laminarin, α-glucans, and alginate as well as mannose-, fucose-, and xylose-rich substrates...
August 15, 2018: ISME Journal
Shinobu Oda, Yusuke Hayashi, Ryosuke Kido
Two novel types of non-aqueous bioconversion systems using fungal spores, either adsorbed on the surface of a filter pad or entrapped in calcium alginate beads, were constructed and applied for a model reaction: reduction of benzil to benzoin by Aspergillus sojae NBRC 32074. The spores adsorbed on a filter pad catalyzed the reduction in some toxic organic solvents, such as methylcyclohexane (log P : 3.61) and di-n-butyl ether (3.21). For the relationship between the reduction activity and the log P value of the organic solvent, a highly positive correlation (R2 : 0...
August 14, 2018: Journal of Oleo Science
Dafang Fu, Rajendra Prasad Singh, Xinde Yang, C S P Ojha, Rao Y Surampalli, Alagarasan Jagadeesh Kumar
A field study was carried out to investigate the sediment in-situ bioremediation by adding microbial activated beads. In this work, Calcium carbonate, silicon dioxide, activated carbon powder, attapulgite powder, sodium alginate, microbial liquid and polyvinyl alcohol were utilized to make the immobilized microbial activated beads. Field experiment results showed that the removal rate of NH4 + -N, TN and COD in overlying water reached about 61.8%, 87.5% and 87.1%, respectively. The initial concentration of NH4 + -N, TN and COD was 159 mg/L, 6...
August 11, 2018: Journal of Environmental Management
Haitong Tang, Xinru Yu, Shi Jin, Fanling Meng, Yan Yan, Zhongmin Gao
Hierarchical carbon nanofibre (CNF)/SnO2 /Ni nanostructures of graphitized carbon nanofibres and SnO2 nanocrystallines and Ni nanocrystallines have been prepared via divalent tin-alginate assembly on polyacrylonitrile (PAN) fibres, controlled pyrolysis and ball milling. Fabrication is implemented in three steps: (1) formation of a tin-alginate layer on PAN fibres by coating sodium alginate on PAN in a water medium followed by polycondensation in SnCl2 solution; (2) heat treatment at 450°C in a nitrogen atmosphere; (3) ball milling the mixture of CNF/SnO2 fibres and Ni powder...
June 2018: Royal Society Open Science
Bo Xiao, Qiubing Chen, Zhan Zhang, Lixin Wang, Timothy Denning, Yuejun Kang, Didier Merlin
Pro-resolving factors that are critical for colonic epithelial restitution were down-regulated during the treatment with inhibitor of pro-inflammatory cytokines (e.g., anti-TNFα antibody) in ulcerative colitis (UC) therapy. We hypothesized that increased amounts of factors such as interleukin-22 (IL-22) during the therapeutic inhibition of TNFα could facilitate the resolution of intestinal inflammation. As combination therapy is an emerging strategy for UC treatment, we attempt to treat established UC based on the combination of TNFα siRNA (siTNF) and IL-22...
August 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Alexandre Hardy, Cendrine Seguin, Anaïs Brion, Philippe Lavalle, Pierre Schaaf, Sylvie Fournel, Line Bourel-Bonnet, Benoit Frisch, Dr Marcella De Giorgi
Nowadays, the need for therapeutic biomaterials displaying anti-inflammatory properties to fight against inflammation-related diseases is continuously increasing. Compact PolyElectrolyte Complexes (CoPECs) represent a new class of materials obtained by ultracentrifugation of a polyanion/polycation complexes suspension in the presence of salt. Here, a non-cytotoxic β-cyclodextrin-functionalized chitosan/alginate CoPEC was formulated, characterized and described as a promising drug carrier displaying an intrinsic anti-inflammatory property...
August 14, 2018: ACS Applied Materials & Interfaces
Tim W G M Spitters, Parker L Andersen, Chloé Martel, Patrick Vermette
The lack of understanding on how to treat pancreas-related diseases and develop new therapeutics is partly due to the unavailability of appropriate models. In vitro models fail to provide a physiological environment. Testing new drug targets in these models can give rise to bias and misleading results. Therefore, we developed an in vivo model for drug testing on full pancreatic digests, which maintains the interactions between endo- and exocrine tissues and allows retrieving the samples for further analyses...
August 14, 2018: Assay and Drug Development Technologies
Enrique Sodupe-Ortega, Andres Sanz-Garcia, Alpha Pernia-Espinoza, Carmen Escobedo-Lucea
Most of the studies in three-dimensional (3D) bioprinting have been traditionally based on printing a single bioink. Addressing the complexity of organ and tissue engineering, however, will require combining multiple building and sacrificial biomaterials and several cells types in a single biofabrication session. This is a significant challenge, and, to tackle that, we must focus on the complex relationships between the printing parameters and the print resolution. In this paper, we study the influence of the main parameters driven multi-material 3D bioprinting and we present a method to calibrate these systems and control the print resolution accurately...
August 10, 2018: Materials
Katsuhito Nagai, Sachiko Omotani, Akihiko Ito, Ikumi Nishimura, Yasutoshi Hatsuda, Junji Mukai, Hitomi Teramachi, Michiaki Myotoku
OBJECTIVE: The use of enteral nutrients plays an extremely important role in accurate nutrition management. Sodium alginate (SA) is frequently used for the semi-solidification of enteral nutrients. In the present study, we investigated whether the pharmacokinetic profile of orally administered carbamazepine (CBZ) is altered by a treatment with SA immediately before and after dosing of the drug. Furthermore, the adsorption effects of SA on CBZ were examined using an in vitro analysis. METHOD: SA was orally administered to rats just before and immediately after CBZ dosing...
August 13, 2018: Drug Research
Junhao Sun, Yan Chen, Haiqin Yu, Liangguo Yan, Bin Du, Zhiguo Pei
In this work, the magnetic alginate microsphere of Fe3 O4 /MgAl-LDH (Fe3 O4 /LDH-AM) was prepared by immobilizing the Fe3 O4 /LDH with calcium alginate (CA) and was used to remove Cd2+ , Pb2+ , and Cu2+ from aqueous solutions. The obtained Fe3 O4 /LDH-AM was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and Brunauer-Emmett-Teller surface area determination. The results indicated that the surface groups of the alginate and LDH were retained and so was the crystal structure in the alginate microsphere...
July 31, 2018: Journal of Colloid and Interface Science
Lívia Pinto Heckert Bastos, Carlos Wanderlei Piler de Carvalho, Edwin Elard Garcia-Rojas
The aim of this study was to evaluate the influence of some parameters (pH, NaCl, and ratio of biopolymers) on the formation of the complex coacervates of lactoferrin and sodium alginate. Different ratios of lactoferrin:sodium alginate were tested (1:1, 1:2, 1:4,1:8, 2:1, 4:1, and 8:1) at pH levels ranging from 2.0 to 7.0 with different concentrations of NaCl (0, 50, 100, 150, and 200 mM). Sodium alginate has a molecular weight of 138 kDa ± 0.07. The ratio of 8:1(lactoferrin: sodium alginate) at a pH of 4...
August 10, 2018: International Journal of Biological Macromolecules
Awatief F Hifney, Mustafa A Fawzy, Khayria M Abdel-Gawad, Mohamed Gomaa
The seaweed Cystoseira trinodis was fermented by different fungi prior to extraction of fucoidan and alginate to enhance their antioxidative potential. All the investigated fungi were able to produce fucoidanase (1.05-3.41 U/ml) and alginate lyase (7.27-18.59 U/mL). Different fungal species induced a reduction in the molecular weight (MW) of fucoidan and alginate in comparison to the unfermented control. The MW of fucoidan reduced by 41-81.5%, while the MW of alginate was reduced by 28-75%, depending on the fungal species...
December 15, 2018: Food Chemistry
Zhang Yuan, Peng Liu, Yansha Hao, Yao Ding, Kaiyong Cai
In orthopedic fields, effective anti-infection property and promotive biocompatibility on surface of titanium implants are two crucial factors for long-term successful implants. Herein, Ag nanoparticles (NPs) loaded TiO2 nanotubes (TNT) arrays were fabricated on Ti substrates with assistance of ultraviolet irradiation. Then, bioactive multilayer films of chitosan (CHI) and dialdehyde alginate (ADA) pair were deposited onto the Ag-loaded TNT arrays via a layer-by-layer (LBL) self-assembly technique, which could effectively achieve the impactful antibacterial ability of titanium and endow the substrates with favorable biocompatibility...
July 29, 2018: Colloids and Surfaces. B, Biointerfaces
Juan Liu, Congming Xiao
Lay-by-layer (LbL) assembly among water-soluble chitosan (WSC), sodium alginate (SA) and copper ion was applied to form polysaccharide-based flame retardant coating on polyester fabric. Thermogravimetric analysis (TGA) results indicated the thermal decomposition temperature of the surface-modified sample was higher than that of the original one, and increased with increasing the layers. Microscale combustion calorimetry (MCC) measurements exhibited that the heat release rate (HRR) values of the samples containing various layers were lower than that of unmodified sample and decreased as increasing layers...
August 9, 2018: International Journal of Biological Macromolecules
S S Patil, K C Nune, Rdk Misra
A covalently cross-linked injectable hybrid hydrogel, namely, alginate/poly(amidoamine) (PAMAM), with the objective of cell delivery was innovatively designed and synthesized using tetra-amino-functional PAMAM dendrimer as the cross-linker. With the increase in percentage of PAMAM cross-linker, the pore size and swelling ratio of hydrogels were in the range of 57 ± 18 μm to 88 ± 25 μm and 110 ± 16 to 157 ± 20, respectively. The study of attachment and proliferation of MC3T3-E1 pre-osteoblasts using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay through indirect and direct contact methods indicated a continuous increase in metabolically active live cells with time, implying non-cytotoxicity of the synthesized hydrogel...
August 2018: Journal of Biomaterials Applications
Ranjith Kumar Kankala, Feng-Jun Lu, Chen-Guang Liu, Shan-Shan Zhang, Ai-Zheng Chen, Shi-Bin Wang
In recent times, cartilage defects have been the most common athletic injuries, often leading to dreadful consequences such as osteoarthritis, pain, joint deformities, and other symptoms. It is also evident that damage to articular cartilage is often difficult to recover or self-heal because of poor vascular, nervous, and lymphatic supplies. Moreover, cartilage cells have poor regeneration ability and high maturity. Inspired by these facts and the rapid advances in the field of tissue engineering (TE), we fabricated highly porous three-dimensional (3D) scaffold architectures based on cell-responsive polymeric inks, i...
August 9, 2018: Materials
T G Sahana, P D Rekha
Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process...
August 9, 2018: Molecular Biology Reports
Xiaojie Lv, Wenchang Zhang, Yunen Liu, Yan Zhao, Jinsong Zhang, Mingxiao Hou
Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility...
October 15, 2018: Carbohydrate Polymers
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