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Treatment of chronic pain

En-Nung Kao, Kuo-Hsiu Liao, Teng-Wei Chen, De-Chuan Chan, Jyh-Cherng Yu
INTRODUCTION: Ingestion of a foreign body rarely results in perforation of the gastrointestinal tract. Foreign bodies such as dentures, fish bones, chicken bones, toothpicks and cocktail sticks have been known to cause bowel perforation; however, bowel perforation caused by shrimp leg has not been reported so far. PRESENTATION OF CASE: We report a case of a 69-years-old man who presented with a 4-months epigastric pain. Laboratory data revealed inflammation at the first hospital visit...
October 4, 2018: International Journal of Surgery Case Reports
Jessica S Merlin, Kanan Patel, Nicole Thompson, Jennifer Kapo, Frank Keefe, Jane Liebschutz, Judith Paice, Tamara Somers, Joanna Starrels, Julie Childers, Yael Schenker, Christine S Ritchie
CONTEXT: Chronic pain, or pain lasting > 3 months, is common among cancer survivors, who are often prescribed long-term opioid therapy (LTOT). OBJECTIVE: Our objective was to explore palliative care providers' experiences with managing chronic pain in cancer survivors prescribed LTOT, specifically in ambulatory palliative care settings, and their strategies for overcoming challenges. METHODS: We recruited providers through leading national palliative care organizations who manage chronic pain in cancer survivors...
October 17, 2018: Journal of Pain and Symptom Management
Carlos Martínez-Rico, Xavier Martí-Mestre, Xavier Jiménez-Guiu, Emma Espinar-Garcia, Dolors Cervellera-Garcia, Ramón Vila-Coll
INTRODUCTION: Endovascular surgery has become the initial treatment for most patients with chronic ischaemia of the lower limbs. Few studies support ultrasound surveillance (US) of this kind of procedures. The purpose of this study was to evaluate the initial efficacy of DUS as a surveillance method in endovascular treatment in symptomatic peripheral arterial disease (PAD) patients in our centre. MATERIAL AND METHODS: A total of 113 endovascular procedures were included in 106 patients between February 2013 and June 2015...
October 17, 2018: Annals of Vascular Surgery
Dionéia Araldi, Luiz F Ferrari, Jon D Levine
Stimulation of the mu-opioid receptor (MOR) on nociceptors with fentanyl can produce hyperalgesia (opioid-induced hyperalgesia, OIH) and hyperalgesic priming, a model of transition to chronic pain. We investigated if local and systemic administration of biased MOR agonists (PZM21 and TRV130), which preferentially activate G-protein over β-arrestin translocation, and have been reported to minimize some opioid side effects, also produces OIH and priming. Injected intradermally (100 ng), both biased agonists induced mechanical hyperalgesia and, when injected at the same site, 5 days later, prostaglandin E2 (PGE2 ) produced prolonged hyperalgesia (priming)...
October 17, 2018: Neuroscience
Manabu Araki
Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune diseases associated with a disease-specific autoantibody directed against the water channel protein aquaporin-4. Standard immunotherapy, immunosuppressive agents, and corticosteroids can prevent acute attacks and maintain remission in most patients with NMOSD. However, there is a strong need for additional options for patients who are refractory to standard treatments. Emerging therapies targeting specific molecules related to the pathogenicity of NMOSD are currently being developed...
October 17, 2018: Neurochemistry International
Celine-Marie Pascale, Catherine M Schaeff
OBJECTIVES: This pilot case study sought to examine the efficacy of subtle energy treatments as conducted by Buddhist healing master Segyu Rinpoche at his Juniper Integrative Clinic in Northern California. DESIGN: Over the course of a year, this study followed two patients with terminal diagnoses, their treating physicians, and Segyu Rinpoche as the patients underwent treatment at the Juniper Clinic. The patients entering the study had exhausted all known medical options...
August 21, 2018: Explore: the Journal of Science and Healing
Victoria A Farrow, Jeane Bosch, Jennifer N Crawford, Carrie Snead, Jay Schulkin
BACKGROUND: A history of childhood abuse is strongly linked to adult health problems. Obstetrician-gynecologists will undoubtedly treat abuse survivors during their careers, and a number of patient presenting problems may be related to a history of childhood abuse (e.g., chronic pelvic pain, sexual dysfunction, mental health disorders, obesity, and chronic diseases). Knowledge of abuse history may assist with treatment planning and the delivery of trauma-informed care. The current study sought to explore obstetrician-gynecologists' training, knowledge, beliefs, practice patterns, and barriers around screening for history of childhood abuse in their adult patients...
October 16, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Dekun Yin, Yonglin Chen, Rongxiang Lu, Bingbing Fan, Shunxing Zhu, Xingguo Xu, Zhongling Xu
Neuropathic pain is a severe debilitating state caused by injury or dysfunction of somatosensory nervous system, and the clinical treatment is still challenging. Translocation associated membrane protein 1 (TRAM1), an adapter protein, participates in a variety of transduction pathways and mediates the biological functions such as cell proliferation, activation, and differentiation. However, whether TRAM1 is involved in the pathogenesis of neuropathic pain is still unclear. In our study, we reported the role of TRAM1 in the maintenance of neuropathic pain induced by chronic constriction injury (CCI) on rats...
October 18, 2018: Journal of Molecular Neuroscience: MN
Maryam Noroozian, Shima Raeesi, Rezvan Hashemi, Leila Khedmat, Zahra Vahabi
BACKGROUND: As the elderly population increases dramatically, the chronic age-related disease should be noted. In the elderly, chronic pain is a common health problem. METHODS: This search was performed in 3 databases (PubMed, Google Scholar, Embase). We have reviewed articles related to pain management in the elderly. RESULT: The prevalence of pain in people aged above 60 is twice that in younger people. Pain is estimated to be 45-85 per cent in the elderly...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Tun Hing Lui
Os calcaneus secundarius is an accessory ossicle resulting from a secondary ossification center of the anterior facet of the calcaneus. It may cause chronic pain and limitation in inversion motion after inversion ankle sprain. Excision of the ossicle is indicated if the symptoms do not resolve with conservative treatment. A case of symptomatic os calcaneus secundarius, which was successfully resected endoscopically, is presented.
April 30, 2018: Foot
Jing Zhou, Yan Liu, Chunbin Li, Zhishun Liu
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder. Some studies have indicated that acupuncture may ameliorate the symptoms of CP/CPPS. However, results are varied and range widely, perhaps due to different modes of assessment including timepoints, places of assessment, and especially subjective scales. We propose to determine the efficacy of acupuncture relative to sham acupuncture for patients with CP/CPPS, and compare different modes of assessment regarding the therapeutic effects of acupuncture...
October 2018: Medicine (Baltimore)
Fenglin Zhao, Min Liu, Jie Chen, Cuihong Jin, Fuqiang Chen, Jinxin Cao, Yuchen Liu
BACKGROUND: Incarceratedgroin hernias are a common presentation as surgical emergencies. Other surgical treatment modalities are becoming more widely accepted including the use of prosthetic mesh and laparoscopy for assessment of hernia content viability and for repair. Our study were to report our current experience with the use of prosthetic mesh in the treatment of incarcerated hernias and to compare the effects of different operative approaches. METHODS: This retrospective study included 219 consecutive patients who underwent herniorrhaphy for incarcerated hernia between January 2013 and December 2017 in Beijing Chao-Yang Hospital...
October 18, 2018: Minerva Chirurgica
Ying Li
Human brain imaging studies have demonstrated the importance of cortical neuronal networks in the perception of pain in patients with functional bowel disease such as irritable bowel syndrome (IBS).Studies have identified an enhanced response in the anterior cingulate cortex (ACC) to colorectal distension in viscerally hypersensitive (VH) rats. Electrophysiological recordings show long-lasting potentiation of local field potential (LFP) in the medial thalamus (MT)-ACC synapses in VH rats. Theta burst stimulation in the MT reliably induced long-term potentiation (LTP) in the MT-ACC pathway in normal rats, but was occluded in the VH state...
2018: Advances in Neurobiology
Asghar Farajzadeh, S Zahra Bathaie, Jalil Arabkheradmand, Seyed Mohammad Ghodsi, Soghrat Faghihzadeh
Trigeminal neuralgia (TN) with chronic and severe neuropathic pain leads to remarkable interference in daily living activities of patients. Unknown molecular mechanisms involved in TN pathophysiology are a challenge for complete treatment of the disease. The present study was conducted to investigate changes in the plasma proteome beside biochemical parameters, including calcitonin gene-related peptide (CGRP), nitric oxide (NO), amino acids, and vitamin D (Vit D) in different pain states in TN patients. Plasma samples were obtained from the control group (#13) and patients with purely paroxysmal type of classical TN (#13) before and after microvascular decompression (MVD)...
October 17, 2018: Journal of Molecular Neuroscience: MN
Bárbara B Garrido-Suárez, Gabino Garrido, Marian Castro-Labrada, Zenia Pardo-Ruíz, Addis Bellma Menéndez, Evelyn Spencer, Jozi Godoy-Figueiredo, Sergio H Ferreira, René Delgado-Hernández
The present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible transient and long-term anti-allodynic effect of mangiferin (MG); as well as its potential beneficial interactions with some standard analgesic drugs and sympathetic-mediated vasoconstriction and vasodilator agents during the earlier stage of the pathology. A single dose of MG (50 and 100 mg/kg, p.o.) decreased mechanical allodynia 72 h post-ischemia-reperfusion (I/R)...
2018: Frontiers in Pharmacology
Yuji Kasukawa, Naohisa Miyakoshi, Masazumi Suzuki, Hiroyuki Tsuchie, Chie Sato, Tetsuya Kawano, Manabu Akagawa, Yuichi Ono, Yoichi Shimada
We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0...
2018: Biomedical Research
Nobuhide Kido, Sohei Tanaka, Tomoko Omiya, Yasuyuki Shoji, Masaru Senzaki, Sayuri Hanzawa, Masato Ando, Tomohiro Osaki, Hitoshi Hatai, Noriaki Miyoshi, Tatsuro Hifumi, Naomi Suzuki, Shigehisa Kawakami
Asian and African elephants are frequently afflicted by foot disorders that can be very challenging to manage even with aggressive therapy. Such conditions may have indirect life-threatening effects. Mohs' paste (zinc chloride based escharotic agent) was used to treat a female Indian elephant (Elephas maximus indicus) aged 39 years with foot disorder at Kanazawa Zoological Gardens. Degenerated hyperplastic tissue was observed inside the hoofs of digits 2 and 5. Mohs' paste was applied on the lesions, which coagulated the hyperplastic tissue and restrained its proliferation...
October 16, 2018: Journal of Veterinary Medical Science
R Philpott, K Gulabivala, R Leeson, Y-L Ng
AIMS: To investigate the prevalence, pain catastrophizing and other predictive factors, and clinical course of persistent pain/discomfort associated with teeth displaying periapical healing following non-surgical root canal treatment (NSRCT). METHODOLOGY: One-hundred-ninety-eight patients (264 teeth) who had NSRCT were reviewed at 5-14 months, post-operatively. Teeth with persistent post-treatment pain or discomfort, plus evidence of periapical healing were further monitored 0...
October 17, 2018: International Endodontic Journal
Nikola Sekulovski, Allison E Whorton, Mingxin Shi, James A MacLean Ii, Kanako Hayashi
Endometriosis causes severe chronic pelvic pain and infertility. We have recently reported that niclosamide treatment reduces growth and progression of endometriosis-like lesions and inflammatory signaling (NFĸB and STAT3) in a mouse model. In the present study, we examined further inhibitory mechanisms by which niclosamide affects endometriotic lesions using an endometriotic epithelial cell line, 12Z, and macrophages differentiated from a monocytic THP-1 cell line. Niclosamide dose dependently reduced 12Z viability, reduced STAT3 and NFĸB activity, and increased both cleaved caspase-3 and cleaved PARP...
October 16, 2018: Biology of Reproduction
Carolina Baeza-Velasco, Emilie Olié, Séverine Béziat, Sébastien Guillaume, Philippe Courtet
BACKGROUND: Major Depression (MD) is often a chronic condition requiring a long-term pharmacologic treatment. Despite the efficacy of antidepressants, the medication adherence in those affected is usually very poor. In this scenario, further research concerning drivers of suboptimal adherence is needed. We aimed to explore medication adherence in patients with a MD episode, and to identify sociodemographic, clinical (psychiatric antecedents, comorbidities, medication, pain, and medication side effects), and psychosocial factors (negative life events, childhood trauma, and attitudes to medication) related to adherence status...
October 17, 2018: Depression and Anxiety
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