Anna M Zhang, Ahmed Elmoursi, Daniel V DiGiacomo, Baijun Zhou, Megha Tandon, Joseph S Hong, Nancy J Yang, Mei-Sing Ong, Anand S Dighe, Cristhian Berrios, Mark C Poznansky, Anthony J Iafrate, Vivek Naranbhai, Alejandro Balazs, Shiv Pillai, Jocelyn R Farmer, Sara Barmettler
BACKGROUND: Patients with predominantly antibody deficiency (PAD) have lower anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antibody levels after initial 2-dose SARS-CoV-2 vaccination than healthy controls do; however, the anti-spike antibody responses and neutralization function in patients with PAD following subsequent immunizations remain understudied. OBJECTIVE: We sought to characterize anti-spike antibody responses in adults with PAD over the course of 5 SARS-CoV-2 vaccine doses and identify diagnostic and immunophenotypic risk factors for low antibody response...
May 2024: J Allergy Clin Immunol Glob