Ru-Li Li, Cai-Li Zhuo, Xin Yan, He Li, Lan Lin, Ling-Yu Li, Qiying Jiang, Die Zhang, Xue-Mei Wang, Lin-Ling Liu, Wen-Jing Huang, Ying-Ling Wang, Xin-Yue Li, Yan Mao, Yixin Chen, Xiao Liu, Quan-Chen Xu, Yu-Yan Cai, Xi-Jing Yang, Hong-Ying Chen, Si-Si Wu, Wei Jiang
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment. Irisin, a newly discovered myokine and adipokine, has been found to have beneficial effects on various cardiovascular diseases. However, the pharmacological effect of irisin in antagonizing hypertension-induced vascular remodeling is not well understood. In the present study, we investigated the protection and mechanisms of irisin against hypertension and vascular remodeling induced by angiotensin II (Ang II)...
2024: International Journal of Biological Sciences