Isabelle Martinier, Florian Fage, Alshaba Kakar, Alessia Castagnino, Emeline Saindoy, Joni Frederick, Ilaria Onorati, Valérie Besnard, Abdul I Barakat, Nicolas Dard, Emmanuel Martinod, Carole Planes, Léa Trichet, Francisco M Fernandes
Synthetic tubular grafts currently used in clinical context fail frequently, and the expectations that biomimetic materials could tackle these limitations are high. However, developing tubular materials presenting structural, compositional and functional properties close to those of native tissues remains an unmet challenge. Here we describe a combination of ice templating and topotactic fibrillogenesis of type I collagen, the main component of tissues' extracellular matrix, yielding highly concentrated yet porous tubular collagen materials with controlled hierarchical architecture at multiple length scales, the hallmark of native tissues' organization...
May 13, 2024: Biomaterials Science