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Subclinic hypothyroidism

Mariella Valenzise, Federica Porcaro, Giuseppina Zirilli, Filippo De Luca, Maurizio Cinquegrani, Tommaso Aversa
Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs...
December 5, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Carmen Castillo, Nicole Lustig, Paula Margozzini, Andrea Gomez, María Paulina Rojas, Santiago Muzzo, Lorena Mosso
BACKGROUND: Thyroid dysfunction is associated with negative neonatal and obstetric outcomes. Large differences in thyroid function reference intervals exist across different populations. These differences can be explained by population-specific factors, such as iodine status. Many countries in Latin America report iodine sufficiency, but relatively few countries have published up-to-date data on iodine levels and thyroid function in the overall population, and especially in pregnant women...
December 2018: Endocrinology and Metabolism
Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Claudia Caruso, Giovanni Guglielmi, Alessandro Antonelli
Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns is involved in the intracellular thyroid-stimulating hormone (TSH) signaling, via Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) (PIP-3). Moreover, the phosphatidyl inositol 3 kinases (PI3K) family of lipid kinases regulates diverse aspects of T, B, and Tregs lymphocyte behaviour...
December 3, 2018: Reviews in Endocrine & Metabolic Disorders
Chang Su, Tianlong Yu, Rencheng Zhao, Yunan Wang, Haihan Jia, Miao Jing, Peng Liu
BACKGROUND AND OBJECTIVES: When iodine intake is in excess, a susceptible population that has a genetic predisposition will have an increased risk of hypothyroidism or autoimmune thyroiditis. This study evaluated the vulnerability to iodine excess and subclinical thyroid disease through screening of single nucleotide polymorphisms (SNPs) in reproductive-age women to provide evidence to be used for the prevention of subclinical thyroid disease. METHODS AND STUDY DESIGN: In Shanxi province, four areas where a range of iodine exposures from low to high were chosen in each region, 60 women were anticipated to enrol, including 20 pregnant women, 20 lactating women, and 20 non-pregnant, non-lactating women...
2018: Asia Pacific Journal of Clinical Nutrition
Grzegorz Mieczysław Rudzki, Monika Lenart-Lipińska, Agata Smoleń, Beata E Chrapko, Beata Matyjaszek-Matuszek
Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Treatment is still controversial and its benefits are widely debated in literature...
November 27, 2018: Endokrynologia Polska
Francisco Zacaron Werneck, Emerson Filipino Coelho, Saulo Peters Almas, Marília Mendes do Nascimento Garcia, Heloina Lamha Machado Bonfante, Jorge Roberto Perrout de Lima, Patrícia Dos Santos Vigário, Míriam Raquel Meira Mainenti, Patrícia de Fátima Dos Santos Teixeira, Mário Vaisman
OBJECTIVE: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. SUBJECTS AND METHODS: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL...
October 2018: Archives of Endocrinology and Metabolism
A Tanriverdi, B Ozcan Kahraman, I Ozsoy, F Bayraktar, B Ozgen Saydam, S Acar, E Ozpelit, B Akdeniz, S Savci
PURPOSE: Physical activity is associated with many health-related benefits. However, there is a shift towards inactive lifestyles around the world. Subclinical hypothyroidism (SCH) may have adverse effects similar to hypothyroidism. The presence of symptoms and reduced physical performance in SCH may contribute to an inactive lifestyle. Therefore, the present study aimed to compare physical activity levels (PALs) between women with subclinical hypothyroidism and healthy controls. METHODS: Thirty-two women with newly diagnosed SCH and 28 healthy women were enrolled in this cross-sectional study...
November 19, 2018: Journal of Endocrinological Investigation
Allan Dong, Alex Stagnaro-Green
BACKGROUND: The reported prevalence of thyroid disease in pregnancy varies widely through the published literature. These discrepancies are due to differences in criteria for euthyroidism, nationality, iodine status and gestational age at screening. As a result, there does not currently exist an accepted rate of prevalence for the various thyroid diseases in pregnancy. Understanding the true prevalence rates of these disorders has important implications for clinical management and the ongoing discussion regarding universal screening...
November 16, 2018: Thyroid: Official Journal of the American Thyroid Association
Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao
Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism. However, the underlying molecular mechanism is not yet clearly established. This study aimed to assess the effect of palmitic acid stimulation on thyrocyte function. Upon palmitic acid stimulation, intracellular contents of lipids, as well as the expression and activity of three key molecules in thyroid hormone synthesis (i...
2018: International Journal of Endocrinology
Zenshi Miyake, Kazuhiro Ishii, Akira Tamaoka
RATIONALE: Antiepileptic drugs (AEDs) are one of the causative drugs of drug-induced hypothyroidism. In most cases, AED-induced hypothyroidism is subclinical and indicated only by abnormalities of free thyroxine (T4) and/or thyroid-stimulating hormone (TSH) levels. Severe symptomatic hypothyroidism following AEDs is rarely reported in the literature. PATIENT CONCERNS: A 75-year-old man experienced neurologic symptoms including memory impairment, ataxic gait, sensory polyneuropathy and myopathy, lethargy, and edema of the face and lower extremities...
October 2018: Medicine (Baltimore)
N Pelzer, E S Hoogeveen, J Haan, R Bunnik, C C Poot, E W van Zwet, A Inderson, A J Fogteloo, M E J Reinders, H A M Middelkoop, M C Kruit, A M J M van den Maagdenberg, M D Ferrari, G M Terwindt
BACKGROUND: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a small vessel disease caused by C-terminal truncating TREX1 mutations. The disease is typically characterized by vascular retinopathy and focal and global brain dysfunction. Systemic manifestations have also been reported but not yet systematically investigated. METHODS: In a cross-sectional study, we compared the clinical characteristics of 33 TREX1 mutation carriers (MC+) from three Dutch RVCL-S families with those of 37 family members without TREX1 mutation (MC-)...
November 8, 2018: Journal of Internal Medicine
Peter N Taylor, Stamatios Zouras, Thinzar Min, Kalyani Nagarahaj, John H Lazarus, Onyebuchi Okosieme
Universal thyroid screening in pregnancy is a key debate in thyroidology and obstetrics. It is well-established that thyroid hormones are essential for maintaining pregnancy and optimal fetal development. Thyroid dysfunction is common in women of child-bearing age and also results in substantial adverse obstetric and child neurodevelopmental outcomes. Furthermore, thyroid dysfunction is readily diagnosed with reliable blood tests and easily corrected with inexpensive and available treatments. Screening only high-risk patients appears to miss the majority of cases and economic models show that compared to high-risk screening, universal screening is cost effective even if only overt hypothyroidism was assumed to have adverse obstetric effects...
2018: Frontiers in Endocrinology
Litao Bai, Jing Zhao, Jialiang Gao, Fei Li, Fan Wei, Jun Li, Yao Xiao, Xu Han, Yaoli Wang, Danwei Wang, Fangying Wu, Junping Wei
INTRODUCTION: Mild subclinical hypothyroidism (SCH) can cause depression, fatigue, cognitive dysfunction, or other hypothyroid symptoms, and even progress to hypothyroidism. The treatment of mild SCH is controversial. Shuganjianpihuatanxingqi decoction (SD) is a frequently prescribed Chinese herbal medicine in patients with mild SCH. However, scientific evidence is needed to confirm the therapeutic effect of SD. METHODS AND ANALYSIS: This study is a randomized, double-blind, and controlled clinical trial...
November 2018: Medicine (Baltimore)
Hongbo Yang, Hao Zhao, Xufei Huang, Xinxin Cao, Daobin Zhou, Jian Li
Hypothyroidism is the most common endocrine disorder in POEMS syndrome. In this single-center prospective study, 36 patients with newly diagnosed POEMS syndrome were treated with lenalidomide (10 mg daily for 21 days) and dexamethasone (40mg once per week) for 12 cycles. Hypothyroidism was demonstrated in 58.5% (24/41) at baseline, including 25% (6/24) of clinical hypothyroidism and 75% (18/24) of subclinical hypothyroidism. After 12-month treatment, the percentages of clinical hypothyroidism and subclinical hypothyroidism had decreased 11...
November 8, 2018: Leukemia & Lymphoma
Tomas Salek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalova
AIM: The aim of this study was to determine the prevalence of maternal hypothyroidism in the first trimester from 11 to 14 weeks of gestation according to the American Thyroid Association (ATA) guidelines from 2017 and to compare the rates for singleton and twin pregnancies. METHODS: A total of 4965 consecutive Caucasian singleton pregnancies and 109 Caucasian twin pregnancies were included in the investigation. Patients with a history of thyroid gland disorder were excluded...
November 6, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Michelle A Kominiarek, Marcela C Smid, Lisa Mele, Brian M Casey, Yoram Sorokin, Uma M Reddy, Ronald J Wapner, John M Thorp, George R Saade, Alan T N Tita, Dwight J Rouse, Baha Sibai, Jay D Iams, Brian M Mercer, Jorge Tolosa, Steve N Caritis
OBJECTIVE: To study the association of prepregnancy body mass index (BMI) and gestational weight gain with child neurodevelopmental outcomes. METHODS: We performed a secondary analysis of data from two parallel, multicenter, randomized, double-blind, placebo-controlled thyroxine replacement trials in pregnant women with either hypothyroxinemia or subclinical hypothyroidism who delivered at term. Body mass index was categorized as normal (18.5-24.9), overweight (25...
December 2018: Obstetrics and Gynecology
T Zhao, B M Chen, X M Zhao, Z Y Shan
BACKGROUND: To assess whether elevated thyroid-stimulating hormone (TSH) levels before conception can predict poor outcomes of assisted reproductive technology (ART). METHODS: Prior to July 2018, we searched the PubMed, EMBASE, COCHRANE, Google Scholar, and CNKI databases for studies. Retrospective or prospective reports that compared ART results in patients with subclinical hypothyroidism (SCH) with normal thyroid function were selected. Two reviewers separately reviewed each potential article for qualification, analyzed the quality of the studies according to the Newcastle-Ottawa scale, and extracted the data...
November 5, 2018: Reproductive Biology and Endocrinology: RB&E
W Luo, P Mao, L Zhang, Z Yang
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, the pathogenesis of which remains elusive. The deficiency or excess of thyroid hormone is defined as thyroid dysfunction, including (subclinical) hypothyroidism and (subclinical) hyperthyroidism. Autoimmune factors are likely to be relevant to the development of SLE and thyroid dysfunction. Recently, many studies have indicated that the prevalence of thyroid dysfunction is higher in SLE patients than in the general population...
November 2018: Lupus
T Zhao, B M Chen, X M Zhao, Z Y Shan
The objective of this study was to evaluate the relationship between subclinical hypothyroidism (SCH) and depression. We also analysed the effect of levothyroxine (L-T4) on depression in SCH patients. We found an insignificant difference for the composite endpoint: standard mean difference (SMD) of 0.23 (95% confidence interval (CI) -0.03, 0.48, P = 0.08, I2  = 73.6%). The odds ratio (OR) for depressive patients was 1.75 (95% CI 0.97, 3.17 P = 0.064, I2  = 64.6%). Furthermore, sub-group analysis according to age found that SCH was related to depression in younger patients (<60 years old), as defined by the diagnosis of depression: OR of 3...
October 30, 2018: Translational Psychiatry
Jacqueline Jonklaas, Eshetu Tefera, Nawar Shara
Background Physician characteristics and perceptions and their effect on choice of therapies for patients with thyroid cancer have been well-studied. Some data also exist about physician characteristics and prescribing treatment for subclinical hypothyroidism. The effect of physician characteristics on prescribing thyroid preparations for treating overt hypothyroidism is less studied. Methods Members of the American Thyroid Association were surveyed in 2017. Physicians were presented with thirteen different theoretical patients with hypothyroidism and asked to choose among 6 therapeutic options, including levothyroxine, synthetic combination therapy, thyroid extract, and liothyronine monotherapy...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
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