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Subclinic hypothyroidism

Agata Bielecka-Dabrowa, Breno Godoy, Tsuyoshi Suzuki, Maciej Banach, Stephan von Haehling
The prevalence of subclinical hypothyroidism (SCH) ranges from 5 to 15% of the general population. However, it remains controversial if SCH warrants life-long thyroxine replacement therapy. Patients with a thyroid-stimulating hormone (TSH) level > 10 mIU/L have a higher risk of developing heart failure with reduced ejection fraction as compared to subjects with normal thyroid function. However, abnormally high TSH levels could also be connected with an overall lower metabolic rate and better survival in elderly subjects...
August 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Alessandro Mantovani, Fabio Nascimbeni, Amedeo Lonardo, Giacomo Zoppini, Enzo Bonora, Christos S Mantzoros, Giovanni Targher
BACKGROUND: It is currently uncertain whether primary hypothyroidism is associated with non-alcoholic fatty liver disease (NAFLD). We performed a meta-analysis of relevant studies to quantify the magnitude of association between primary hypothyroidism and risk of NAFLD. METHODS: We searched PubMed, Web of Science and Scopus databases from January 2000 to March 2018 using predefined keywords to identify observational cross-sectional, case-control and longitudinal studies in which NAFLD was diagnosed by imaging or biopsy...
August 7, 2018: Thyroid: Official Journal of the American Thyroid Association
Simo Liu, Jing Ke, Baoyu Zhang, Caiguo Yu, Yingmei Feng, Dong Zhao
OBJECTIVE: Gitelman syndrome (GS) is known as an autosomal recessive disorder characterized by salt wasting and hypokalemia resulting from mutations in the SLC12A3 (solute carrier family 12 member 3) gene, which codes the thiazide-sensitive Na-Cl cotransporter. To date, more than 488 mutations of the SLC12A3 gene have been discovered in patients with GS. In this study, we reported a GS pedigree complicated by thyroid diseases or thyroid dysfunction. METHODS: Sanger sequencing and next generation sequencing analysis were performed to determine the SLC12A3 gene mutations in a GS pedigree including the 16-year old male patient with GS and his family members within three generations...
August 7, 2018: Endocrine Practice
A V Nikolaeva, L T Pimenov, A V Melnikov, M V Dudarev
AIMS: Assessment of global longitudinal strain of left ventricle and coronary bloodflow in patients with primary subclinical hypothyroidism. MATERIALS AND METHODS: The study involved 23 women with primary subclinical hypothyroidism of age from 55 to 75 years. Physical examination, transthoracic EchoCG, coronary bloodflow assessment and global LV longitudinal strain by speckle tracking method were performed to all patients. The data obtained were compared to the results of 20 women without any thyroid diseases comparable to the main group by age and concomitant diseases...
2018: Kardiologiia
Kashif Aziz, Amir Shahbaz, Muhammad Umair, Mohaddeseh Sharifzadeh, Issac Sachmechi
Hyperprolactinemia is a common finding in primary hypothyroidism, but increased prolactin in the setting of subclinical hypothyroidism (SCH) has been scarcely reported in the literature. This is a rare case of hyperprolactinemia due to SCH that resolved with thyroid hormone replacement therapy. The patient was not on any medications known to cause hyperprolactinemia but she was using isoniazid for her latent tuberculosis. Isoniazid therapy may explain breast pain, but there is no reported relationship between isoniazid use causing subclinical hypothyroidism and hyperprolactinemia...
May 31, 2018: Curēus
Sonali Rajesh Saraf, Nitin M Gadgil, Sheetal Yadav, Alka D Kalgutkar
INTRODUCTION: Hashimoto's thyroiditis (HT) is the most common cause of goitrous hypothyroidism in iodine sufficient areas. The diagnosis of HT is important because it progresses to hypothyroidism, and also, it is associated with thyroid lymphoma and papillary thyroid carcinoma. Apart from thyroid antibodies, assessment of thyroid function test (TFT) levels, ultrasonography (USG), and cytological analysis can help in early diagnosis and management of HT. AIMS AND OBJECTIVES OF THIS STUDY: To know the age incidence and clinical presentation of HT, its association with thyroid hormone levels and with thyroid antibodies and its correlation with the cytologic grade of HT...
July 2018: Journal of Laboratory Physicians
Xiao-Dan Long, Jing Xiong, Zhao-Hui Mo, Chang-Sheng Dong, Ping Jin
BACKGROUND: Pseudohypoparathyroidism type 1A (PHP1A) is a rare genetic disease primarily characterized by resistance to parathyroid hormone along with hormonal resistance and other features of Albright hereditary osteodystrophy (AHO). It is caused by heterozygous inactivating mutations in the maternal allele of the GNAS gene, which encodes the stimulatory G-protein alpha subunit (Gsα) and regulates production of the second messenger cyclic AMP (cAMP). Herein, we report a case of of PHP1A with atypical clinical manifestations (oligomenorrhea, subclinical hypothyroidism, and normocalcemia) and explore the underlying genetic cause in this patient...
July 30, 2018: BMC Medical Genetics
Maja Vučinić, Vesna Kušec, Sandra Dundović, Jasenka Ille, Miroslav Dumić
Background High goiter prevalence caused by iodine deficiency (medium content 5.6 mg potassium iodide [KI]/kg of salt, median urine iodine concentration [UIC] 68 μg/L) in Croatia was observed in 1991 and 1995 when salt was iodized with 10 mg KI/kg. A new regulation introduced in 1996, specified 25 mg KI/kg of salt resulting in an increase of median UIC to 248 μg/L. Afterwards, goiter prevalence was only assessed in two small studies. Methods In this study, we investigated the prevalence and etiology of goiter in 3594 schoolchildren 17 years after an increase in salt iodization in Croatia...
July 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Fawzia Alyafei, Ashraf Soliman, Fawziya Alkhalaf, Aml Sabt, Vincenzo De Sanctis, Nagwa Elsayed, Reem Waseef
INTRODUCTION: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with the development of abnormal immune responses to specific β-cell autoantigens in addition to other organ-specific autoimmunity. The most frequent associated disorders are thyroid dysfunctions and celiac disease. There are limited studies in the current literature on the prevalence of associated autoimmunity, especially multiple, in children and adolescents with T1DM and Type 2 diabetes mellitus (T2DM). OBJECTIVES: The aim of the present study was to determine the prevalence of autoantibodies and thyroid dysfunctions in a cohort of children and adolescents (aged 0...
May 23, 2018: Acta Bio-medica: Atenei Parmensis
Dawei Chen, Yuerong Yan, Hui Huang, Qiang Dong, Haoming Tian
Objectives: Erectile dysfunction (ED) is highly prevalent among males, and hypothyroidism is previously reported to be related with ED. However there have been rare studies to investigate the association between subclinical hypothyroidism (SCH) and ED, hence our objective was to fill this gap. Methods: ED patients who visited the Urology Outpatients Clinic owere recruited consecutively, and males from the Health Manage Center were included as the controls. Serum thyroid and sexual hormones were estimated, and the International Index of Erectile Function (IIEF-5) questionnaires were evaluated as well...
May 2018: Pakistan Journal of Medical Sciences Quarterly
Giuseppe Barbesino
BACKGROUND: Thyroid hormones have significant effects on the cardiovascular systems. In general, hyperthyroidism is associated with an increased risk of dysrhythmias, while hypothyroidism may cause atherosclerosis. Recent large studies have sought to identify aging-associated changes in thyroid function and their relevance to cardiovascular morbidity and mortality in the elderly. Conflicting results have often been published, likely due to the heterogeneity of the studied populations...
July 20, 2018: Gerontology
Habtamu Azene Tekle, Tesfahun Molla Bobe, Efrata Girma Tufa, Fithamlak Bisetegen Solomon
BACKGROUND: Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone above the upper limit of the reference range (0.45-4.5 mIU/L) with normal serum TT4 and TT3 concentration. The most important implication of subclinical hypothyroidism is high likelihood of progression of clinical hypothyroidism. METHODS: Institution-based cross-sectional study was conducted on medical records of patients referred at endocrine clinic Tikur Anbesa Specialized Hospital, Addis Ababa from 2010 to 2016...
July 20, 2018: Journal of Health, Population, and Nutrition
Fengwei Jiang, Haoyu Wang, Suqing Bao, Haicheng Zhou, Yuanyuan Zhang, Yumeng Yan, Yaxin Lai, Weiping Teng, Zhongyan Shan
To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vitro were investigated. In the current study, SCH rat models were established by the administration of L-T4 injection after thyroidectomy in Wistar rats, as opposed to that in the normal and clinical hypothyroidism (CH) groups...
2018: Frontiers in Endocrinology
Sebastião Freitas de Medeiros, Matheus Antônio Souto de Medeiros, Cinthia Marenza Ormond, Jacklyne Silva Barbosa, Márcia Marly Winck Yamamoto
BACKGROUND/AIMS: Definitive polycystic ovary syndrome (PCOS) diagnosis should exclude thyroid dysfunctions. The purpose of the study is to examine the impact of subclinical hypothyroidism on the characteristics of PCOS patients. METHODS: A meta-analysis of the published observational studies was conducted. Medline, Scopus, and Cochrane database search was performed to identify the studies that compared euthyroid PCOS and subclinical hypothyroidism (SCH)-PCOS patients...
2018: Gynecologic and Obstetric Investigation
Elena Guadalupe Corella Aznar, Ariadna Ayerza Casas, Ana Carboné Bañeres, María Ángeles Carlota Calvo Escribano, José Ignacio Labarta Aizpún, Pilar Samper Villagrasa
BACKGROUND: Survival of childhood acute lymphoblastic leukaemia involves an increasing risk of long-term morbidities. Due to the impact of cancer treatment and comorbidities, AL survivors may experience a decrease in their health-related quality of life. OBJECTIVE: We aimed to describe the long-term comorbidities, related quality of life and their development predictors in these survivors. METHODS: cross-sectional study of 54 survivors aged ≥18 and who have a survival rate of more than 10 years...
July 12, 2018: Medicina Clínica
Rupak Desai, Hemant Goyal, Gautam Kumar, Rajesh Sachdeva
Overt and subclinical hypothyroid states have been depicted as risk factors for a more prominent level of coronary calcification. The utilization of coronary atherectomy with percutaneous coronary intervention (PCI) is on the ascent over the past few years as lesions that are more complex are now attempted with a percutaneous approach. However, the real-world data on hypothyroid status influencing PCI with coronary atherectomy outcomes is very limited. Therefore, we proposed to investigate the outcomes of percutaneous coronary intervention with coronary atherectomy in hypothyroid patients using the largest inpatient database in the United States (US), the National Inpatient Sample (NIS)...
May 9, 2018: Curēus
Rodrigo Donoso M, Sandra Cortés A
BACKGROUND: Nitrate exposure may be associated with thyroid gland dysfunction. AIM: To review the available evidence about the relationship between nitrates in drinking water and thyroid gland dysfunction. MATERIAL AND METHODS: A wide search was performed using Medline, Cochrane, Lilacs, IBECS and Scielo databases using pertinent keywords, finding a total of 66 related studies. After filtering and in depth reviewing, a total of 12 studies were included in this review...
February 2018: Revista Médica de Chile
A von Werder, K von Werder
Substitution with thyroid hormones is indicated in elderly patients with overt hypothyroidism, especially, when they present with typical symptoms of hypothyroidism. In light of the current study situation, the use of levothyroxine to treat clinical hypothyroidism in elderly patients is still controversial. In a recent double-blind, randomized, placebo-controlled study, levothyroxine provided no apparent benefits in older persons with subclinical hypothyroidism. The impact of levothyroxine therapy in patients with subclinical hypothyroidism on cardiovascular risk is not completely clear...
July 11, 2018: Der Internist
Shinje Moon, Sung Hye Kong, Hoon Sung Choi, Yul Hwangbo, Moon-Kyu Lee, Jae Hoon Moon, Hak Chul Jang, Nam Han Cho, Young Joo Park
The aim of this study was to determine the association between subclinical hypothyroidism and cardiovascular (CVD) events, and mortality using the atherosclerotic CVD risk score. We carried out an observational study in a prospective cohort that was followed up for 12years. The study included 3,021 participants aged ≥ 40years at baseline from the Ansung cohort, part of the Korean Genome and Epidemiology Study. Cox regression models were constructed to evaluate the hazards ratio (HR) and 95% confidence interval (CI) for all-cause mortality and CVD events in groups classified according to thyroid status...
May 16, 2018: American Journal of Cardiology
Shinje Moon, Min Joo Kim, Jae Myung Yu, Hyung Joon Yoo, Young Joo Park
Objectives To determine the impact of subclinical hypothyroidism (SCH) on the risk of cardiovascular disease (CVD) and all-cause mortality, we performed a comprehensive meta-analysis, according to the age or coexisting CVD risk status of the participants. Methods Studies regarding the association of SCH with all-cause mortality from PubMed and Embase databases were included. We calculated the pooled relative risk (RR) of CVD and all-cause mortality using the Mantel-Haenszel method. We conducted a subgroup analysis of participants with high CVD risk, including history of coronary, cerebral, or peripheral artery disease; dilated cardiomyopathy; heart failure; atrial fibrillation; venous thromboembolism; diabetes mellitus; or chronic kidney disease...
July 6, 2018: Thyroid: Official Journal of the American Thyroid Association
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