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Subclinic hypothyroidism

Sung Hye Kong, Ji Won Yoon, Sang Yoon Kim, Tae Jung Oh, Kay-Hyun Park, Joong Haeng Choh, Young Joo Park, Cheong Lim
We aimed to investigate long-term cardiovascular sequelae after coronary artery bypass grafting (CABG) in patients with subclinical hypothyroidism (SCH). All-cause and cardiovascular-related mortality, and cardiovascular events were retrospectively reviewed in 222 euthyroid and 36 SCH patients who underwent CABG. During a mean follow-up period of 8.2 ± 4.1years, there were 90 incidents of all-cause deaths, 20 cardiovascular-related deaths, 70 major cardiovascular adverse events, 6 myocardial infarctions, 12 unstable anginas, 31 strokes, 23 hospitalizations due to heart failure, 15 atrial fibrillation (AF) events, and 27 coronary revascularizations...
September 7, 2018: American Journal of Cardiology
Yoon-Ji Lee, Hyun Young Lee, Moon Bae Ahn, Seong-Koo Kim, Won Kyoung Cho, Jae-Wook Lee, Nack-Gyun Chung, Bin Cho, Byung-Kyu Suh
Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0.8-21.8) years old] were reviewed retrospectively. Results In children with leukemia, T3 decreased at 1 month (p<0.001) and recovered 9 months to the levels before HSCT. TSH decreased at 1 month (p<0.001), recovered at 3 months and increased at 12 months (p<0...
October 16, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Sima Nazarpour, Fahimeh Ramezani Tehrani, Maryam Rahmati, Sonia Minooee, Masoumeh Simbar, Mahsa Noroozzadeh, Fereidoun Azizi
Background: Currently, various clinical and laboratory diagnostic methods are used to detect overt hypothyroidism during pregnancy. The Billewicz scoring index, as a clinical scale for detection of hypothyroidism, has been applied in general populations; however, its application during pregnancy remains a controversial subject of ongoing research. Objectives: The purpose of this study was to evaluate the diagnostic value of Billewicz scoring index for overt hypothyroidism in a general population of Iranian pregnant women...
July 2018: International Journal of Endocrinology and Metabolism
F Benoît, K Segers, C Sergeant, J Robberecht, J M Meyts, R Karmali, M Surquin
Over-medicalization is a broad concept, which also concerns the elderly patient. It encompasses both over-diagnosis and over-treatment. An increasing awareness of this issue has emerged since 2013, with the first " Preventing Overdiagnosis " conference. Currently, Evidence-Based Medicine does not prevent over-diagnosis. Indeed, the presence of geriatric characteristics such as multiple comorbidities, polypharmacy and frailty can lead to misdiagnosis and to potentially deleterious treatment. Subclinical hypothyroidism and Alzheimer's disease are two examples of pitfalls in the interpretation of biological and para-clinical data that may lead to the administration of useless treatment...
2018: Revue Médicale de Bruxelles
Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong-Yun Cha, Min-Hee Kim
Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disease encompassing a broad spectrum of pathologic changes in the liver. Metabolic derangements are suggested to be main causes of NAFLD. As thyroid hormone is a main regulator of energy metabolism, there may be a link between NAFLD and thyroid function. In previous studies, the association between NAFLD and thyroid function was not conclusive. The aim of this study was to clarify the relationship between NAFLD and thyroid function, focusing on subclinical hypothyroidism, using nationwide survey data representing the Korean population...
October 11, 2018: Scientific Reports
Suraj Haridas Upadya, M S Rukmini, Sowmya Sundararajan, B Shantharam Baliga, Nutan Kamath
Background: Thalassemia is the most common genetic disorder worldwide. Use of iron chelators has improved survival but endocrine complications have become more frequent. The frequency of hypothyroidism in Beta Thalassemia Major (BTM) children ranges from 6 to 30 %. Thyroid dysfunction mainly occurs by gland infiltration, chronic tissue hypoxia, free radical injury, and organ siderosis. Objectives: (a) To evaluate the thyroid function status in chronically transfused children with BTM, in the first and second decade of life and (b) to study the influence of factors like duration and amount of blood transfusions, serum ferritin level, and iron chelation therapy on thyroid function...
2018: International Journal of Pediatrics
Sun Hee Jung, Jeong Eun Lee, Woo Yeong Chung
Purpose: We compared thyroid hormone profiles in children with nephrotic syndrome (NS) at nephrotic phase and after remission. Methods: This study included thirty-one pediatric NS patients. Thyroid hormone profiles consist of serum T3, T4, TSH and free T4. Results: Of the 31 patients, 16 (51.6%) showed abnormal findings in their thyroid hormone profiles: six, overt hypothyroidism; eight, subclinical hypothyroidism, and two, low T3 syndrome...
October 4, 2018: Korean Journal of Pediatrics
Valentina Velkoska Nakova, Brankica Krstevska, Elizabeta Srbinovska Kostovska, Olivija Vaskova, Ljubica Georgievska Ismail
OBJECTIVE: Treatment of subclinical hypothyroidism (ScH), especially the mild form of ScH, is controversial because thyroid hormones influence cardiac function. We investigate left ventricular systolic and diastolic function in ScH and evaluate the effect of 5-month levothyroxine treatment. SUBJECTS AND METHODS: Fifty-four patients with newly diagnosed mild ScH (4.2 <TSH < 10.0 mU/L) and 30 euthyroid subjects matched by age were analysed. Laboratory analyses and an echocardiography study were done at the first visit and after 5 months in euthyroid stage in patients with ScH...
August 2018: Archives of Endocrinology and Metabolism
Subrat Panda, Ananya Das
Introduction: Perimenopause and menopause is an integral part of every woman's life constituting about 30% of the Indian female population. Hypothyroidism is a condition that can mimic menopausal symptoms very often. Therefore, routine screening of thyroid function in the climacteric and menopausal period to determine subclinical thyroid disease can be recommended. Materials and Methods: With this background, we conducted a prospective study in our institute, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, to evaluate the abnormal thyroid function tests in perimenopausal and postmenopausal women aged 40-80 years...
July 2018: Journal of Mid-life Health
Martin Feller, Marieke Snel, Elisavet Moutzouri, Douglas C Bauer, Maria de Montmollin, Drahomir Aujesky, Ian Ford, Jacobijn Gussekloo, Patricia M Kearney, Simon Mooijaart, Terry Quinn, David Stott, Rudi Westendorp, Nicolas Rodondi, Olaf M Dekkers
Importance: The benefit of thyroid hormone therapy for subclinical hypothyroidism is uncertain. New evidence from recent large randomized clinical trials warrants an update of previous meta-analyses. Objective: To conduct a meta-analysis of the association of thyroid hormone therapy with quality of life and thyroid-related symptoms in adults with subclinical hypothyroidism. Data Sources: PubMed, EMBASE,, Web of Science, Cochrane Library, CENTRAL, Emcare, and Academic Search Premier from inception until July 4, 2018...
October 2, 2018: JAMA: the Journal of the American Medical Association
Susan Mayor
No abstract text is available yet for this article.
October 3, 2018: BMJ: British Medical Journal
Till Ittermann, Katharina Wittfeld, Matthias Nauck, Robin Buelow, Norbert Hosten, Henry Völzke, Hans Grabe
Background Previous patient studies suggest that thyroid dysfunction affects volumes of particular regions of the brain. So far population-based data related to this topic is lacking. Our aim was to investigate associations of serum levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) with total brain volume (TBV), grey matter volume (GMV), white matter volume (WMV) and hippocampal volume (HV) in a population-based study. Methods We pooled data of 2557 individuals from two independent population-based surveys of the Study of Health in Pomerania conducted in Northeast Germany...
September 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Sudeb Mukherjee, Suhana Datta, S C Mandal
Background: The association between subclinical thyroid dysfunction (defined by no symptoms or clinical features of hypothyroidism but biochemically TSH level in the range of above 5 miu/ml but below 10 miu/ml with normal FT4 level) and Acute Coronary Syndrome (ACS) is not known so far. This study was done to calculate the prevalence of subclinical thyroid dysfunction in patients with ACS. Methods: A retrospective chart review of 1100 consecutive patients was done who presented to Emergency Department with symptoms suggestive of ACS and admitted...
2018: Journal of Thyroid Research
Thozhukat Sathyapalan, Alison J Dawson, Alan S Rigby, Natalie J Thatcher, Eric S Kilpatrick, Stephen L Atkin
Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism. Design and setting: Randomized, double-blind, crossover study. Participants: Forty four patients with subclinical hypothyroidism. Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period...
2018: Frontiers in Endocrinology
Zeynep Ergin, Şenay Savaş-Erdeve, Erdal Kurnaz, Semra Çetinkaya, Zehra Aycan
Background The aim of our study was to evaluate clinical, laboratory and imaging findings and to have an idea about the clinical course of subclinical hypothyroidism in children. Methods Our study included 25 patients who were diagnosed with non-autoimmune subclinical hypothyroidism without goitre, between the ages of 3 and 18 and with body mass index (BMI) below the 85th percentile. Results The mean thyroid-stimulating hormone (TSH) level was 6.92±0.92 μIU/mL at diagnosis, 4.77±1.57 μIU/mL in the third month and 4...
October 25, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Min Liu, Weifang Liu, Peiyao Zhang, Jing An, Guang Wang
Cardiovascular Magnetic Resonance (CMR)-based T1 mapping and Heart Deformation Analysis (CMR-HDA) can assess the myocardial tissue characteristic and strain of cardiomyopathy. Whether they can assess cardiac abnormality of hypothyroidism (HT) is unknown. We aim to analysis left ventricular (LV) T1 values and strain of patients with overt HT (OHT) and subclinical HT (SHT) with CMR-based T1 mapping and HDA. This study prospectively included 32 OHT patients, 23 SHT patients and 27 healthy controls who underwent CMR...
September 24, 2018: International Journal of Cardiovascular Imaging
Mauricio Figueroa-Sánchez, Lourdes Núñez-Atahualpa, Mariana Hernández-Zúñiga, Beatriz Teresita Martín-Marquez, Erika Aurora Martínez-García, Eduardo Gómez-Bañuelos, Rosa Elena Navarro-Hernández, Mónica Vázquez-Del Mercado
Introducción: Los pacientes con artritis reumatoide pueden desarrollar enfermedad tiroidea autoinmune (ETA), cuyo diagnóstico clínico puede ser difícil debido a que ambas comparten síntomas como artralgias, mialgias, rigidez matutina o fatiga. Objetivo: Determinar la prevalencia de ETA en pacientes con artritis reumatoide. Método: Estudio transversal que incluyó 78 pacientes con artritis reumatoide y 81 controles clínicamente sanos pareados por edad y sexo...
2018: Gaceta Médica de México
María R Ayala-Moreno, Jennifer Guerrero-Hernández, Arely Vergara-Castañeda, Germán Salazar-Aceves, Diego E Cruz-Mercado
Background: Thyroid dysfunction has been associated with the development of obesity. There are few studies describing their status in Mexican schoolchildren, in whom obesity and subclinical hypothyroidism (SCH) prevail. Methods: Levels of stimulating thyroid hormone (TSH) and thyroid hormones (TH) were correlated with anthropometric variables as indicators of nutritional status in schoolchildren residents of Mexico City. The thyroid status and prevalences of SCH were compared between all the nutritional conditions, considering the degree of pubertal development...
2018: Boletín Médico del Hospital Infantil de México
Meng Rao, Zhengyan Zeng, Shuhua Zhao, Li Tang
BACKGROUND: Evidence suggests that subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes. This systematic review and meta-analysis was conducted to determine whether levothyroxine (LT4) supplementation would improve pregnancy outcomes among infertile women with SCH and/or TAI who underwent in vitro fertilization (IVF) or intracytoplastic sperm injection (ICSI). METHODS: We searched databases of PubMed, EMBASE, Web of Science, Cochrane Controlled Trials Register databases, and Clinicaltrials...
September 24, 2018: Reproductive Biology and Endocrinology: RB&E
Qian Cao, Yundi Jiao, Tongtong Yu, Zhaoqing Sun
BACKGROUND: Thyroid hormones profoundly influence the cardiovascular system, but the effects of mild thyroid dysfunction on the clinical outcome of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are not well defined. This study aimed to determine the effect of mild thyroid dysfunction on 12-month prognosis in ACS patients undergoing PCI. METHODS: In this prospective cohort study with a 12-month follow-up, 1560 individuals were divided into four groups based on thyroid hormone levels upon admission: euthyroidism (used as a reference group), subclinical hypothyroidism, subclinical hyperthyroidism, and low triiodothyronine syndrome (low T3 syndrome)...
September 20, 2018: Cardiology Journal
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